Abstract: Described herein are embodiments of a diffractive optical element (23) such as a grism. In one embodiment, the diffractive optical element (23) includes an input surface (31) configured to receive an input optical signal (29), a diffractive surface (33) adapted to spatially disperse the input optical beam (29) into a dispersed signal and an output surface (35) configured to output the dispersed signal from the diffractive optical element. The input surface (31) and the diffractive surface (33) are non-parallel and the diffractive surface (33) is formed in situ by a photolithographic technique.

Abstract: Methods are disclosed herein for identifying a compound of use in treating a condition treatable by metformin. The methods include determining if the test compound binds a subunit of the mitochondrial electron transport complex IV, and/or alters the function of the mitochondrial electron transport complex IV. Methods for treating a subject with a condition treatable by metformin, are also disclosed. In some embodiments, the condition is type II diabetes.

Abstract: The present invention provides a method of treating a mutant IDH cancer in a subject comprising administering to a subject in need thereof a therapeutically effective amount of Compound (I): and the use of said compound for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders bearing an IDH mutation, as a sole agent or in combination with other active ingredients.

Abstract: Described herein is a diffraction grating (1) for use in an optical system. The diffraction grating includes a substrate (2) and an array of elongate diffracting elements (3) arranged in a grating profile across the substrate. The grating profile imparts a predefined phase change to optical beams to at least partially correct the beams for optical aberrations present in the optical system.

Abstract: An adjustable mud ring assembly is provided that includes a base plate, a movable ring, and an indexing screw con-figured to move the movable ring with respect to the base plate between a first position and a second position. The base plate has a junction box connecting portion, a support connecting portion, and a stationary ring. The base plate can have an offset distance (D2) between the junction box connecting portion and the sup-port connecting portion where the offset distance is sufficient to allow the movable ring to move into stationary ring to the first position without protruding, at a lowermost point, into a junction box connected to the junction box connecting portion.

Abstract: A submerged combustion melting system includes a submerged combustion melter having a housing that defines a melting chamber and one or more vibration damping devices operatively coupled to the housing.

Abstract: An Indoor location mapping and wayfinding system for mapping waypoints on an interactive mapping system that can function both indoors and outdoors based on user selections and location. It can include a shopping system that allows users to pre-select items for purchase, maps the items on an indoor map of the store, and provides a route to the user for the collection of the selected items.

Abstract: A fall detection/fall indicator device (20) that automatically senses when a user (14) of fall protection equipment, such as a fall harness (10), has experienced an arrested fall, the fall harness (10) having an electrical circuit (45) that is a closed circuit (46) in a first state and an open circuit (48) in a second state after an arrested fall, and an alert device (62) that is automatically responsive to the open circuit (48) to emit an alert/alarm to other personnel that an arrested fall has been experienced.

Abstract: Methods and apparatuses are disclosed for reporting texture footprint information. A texture footprint identifies the portion of a texture that will be utilized in rendering a pixel in a scene. The disclosed methods and apparatuses advantageously improve system efficiency in decoupled shading systems by first identifying which texels in a given texture map are needed for subsequently rendering a scene. Therefore, the number of texels that are generated and stored may be reduced to include the identified texels. Texels that are not identified need not be rendered and/or stored.

Abstract: An integrated seismic system and method for monitoring seismic parameters of a subsurface structure is provided. The integrated seismic system includes a base station; a plurality of mobile satellite nodes, each of the plurality of mobile satellite nodes having sensor stations for collecting seismic data from the subsurface structure; and a fiber optic cable extending from the base station to the plurality of mobile satellite nodes and operatively linking the plurality of mobile satellite nodes and the sensor stations; the base station comprising: a light source for sending a light through the fiber optic cable, the light being distributed to the sensor stations and, in the sensor stations, experiencing a change or phase shift related to a physical property being measured; and a seismic acquisition unit for receiving seismic signals from the plurality of mobile satellite nodes via the fiber optic cable and generating seismic parameters therefrom.

Abstract: A housing for a seismic sensor station has a base and a removable lid, which when assembled together form a shell whereby the base and the removable lid both have a shell side and an exterior side. A sensor spike, protruding outward from the shell, may be attached to the base on the exterior side of the base. The housing is further provided with two cable docking ports, each allowing passage of a fiber optical cable from outside to inside the shell. The two cable docking ports are exclusively provided in the removable lid.

Abstract: The present invention provides novel liver-targeted prodrugs of mitochondrial proton ionophores. These compounds have utility in medicine including their use in treatment of diseases such as NASH and NAFLD.

Abstract: A robot arm comprising a joint mechanism for articulating one limb of the arm relative to another limb of the arm about two non-parallel rotation axes, the mechanism comprising: an intermediate carrier attached to a first one of the limbs by a first revolute joint having a pitch rotation axis and to a second one of the limbs by a second revolute joint having a yaw rotation axis; a first drive gear disposed about the pitch rotation axis, the first drive gear being fast with the carrier; a second drive gear disposed about the yaw rotation axis, the second drive gear being fast with the second one of the limbs; a first drive shaft for driving the first drive gear to rotate about the pitch rotation axis, the first drive shaft extending along the first one of the limbs and having a first shaft gear thereon, the first shaft gear being arranged to engage the first drive gear; a second drive shaft for driving the second drive gear to rotate about the yaw rotation axis, the second drive shaft extending along the first

Abstract: The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, useful as a BACE1 inhibitor.

Abstract: Systems, methods, and computer readable media for handling overcurrent and undercurrent conditions in subsea control subsystem components include determining, by a current sensor operatively coupled to a solenoid valve, that an input current to the solenoid is greater or lower than a predetermined threshold value, de-energizing, by a processor operatively coupled to the current sensor, the solenoid for a first period of time, re-energizing the solenoid at least three times after the first period of time, determining, by the current sensor, that during each of the at least three times the input current to the solenoid is greater or lower than the predetermined threshold value, and de-energizing the solenoid and transmitting a control signal to a control unit.

Abstract: A surface cleaning apparatus is described including a housing supporting a suction source including a motor with an axle which rotates a fan and a dirt collection container. The motor is positioned within a motor chamber and the motor chamber is positioned within a further chamber, and there being an opening in the motor chamber for permitting exhaust air to pass therefrom to the further chamber. The housing includes an exhaust outlet and wherein air from the motor chamber passes to the exhaust outlet around opposing sides of the motor chamber. In an alternative embodiment air from the motor chamber passes to the exhaust outlet through an air diffusing member.

Abstract: A seismic sensor station employs a sensor unit that is mounted on a central mounting post attached to the base of a sensor station housing. The only path of mechanically supporting contact that exists between the sensor unit and the base is through the central mounting post.

Abstract: Methods and systems are provided for monitoring optical transceiver devices. In one embodiment, a method comprises predicting degradation of an optical transceiver device based on values of an operating parameter of the optical transceiver device obtained over time, and generating a notification of the degradation of the optical transceiver device. In this way, an optical transceiver device that is susceptible to degradation may be pre-emptively identified and replaced, thereby preventing failures of a communication system including the optical transceiver device.

Abstract: A cushioning device includes a machine-washable polyurethan viscoelastic foam and a cavity for receiving a filler.