Abstract: Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.

Abstract: A pulse generator includes a latch module for storing first/second states, a pulse clock module for generating a clock pulse, and a delay module for delaying the clock pulse at a second latch-module input. The latch module has a first latch-module input coupled to a clock, the second latch-module input, and a latch-module output. The pulse clock module has a first pulse-clock-module input coupled to the clock, a second pulse-clock-module input coupled to the latch-module output, and a pulse-clock-module output. The delay module is coupled between the latch-module output and second pulse-clock-module input or between the pulse-clock-module output and second latch-module input. The delay module provides functionally I1IA at a delay module output, where I1 is a function of I and IA is a function of IN0 and B0, and where I is a delay module input, B0 is a first input bit, and IN0 is a first net input.

Abstract: Systems, methods, and computer readable media for handling overcurrent and undercurrent conditions in subsea control subsystem components include determining, by a current sensor operatively coupled to a solenoid valve, that an input current to the solenoid is greater or lower than a predetermined threshold value, de-energizing, by a processor operatively coupled to the current sensor, the solenoid for a first period of time, re-energizing the solenoid at least three times after the first period of time, determining, by the current sensor, that during each of the at least three times the input current to the solenoid is greater or lower than the predetermined threshold value, and de-energizing the solenoid and transmitting a control signal to a control unit.

Abstract: A chocolate composition and a method for manufacturing the chocolate composition include a solid material, e.g., nutritive carbohydrate sweetener that has a particle size from about 50 to about 1000 nanometers. The solid material may comprise a sugar, such as but not limited to, sucrose. By including within the chocolate composition the solid material that has the particle size from about 50 to about 1000 nanometers, the chocolate composition has enhanced temperature resistance properties.

Abstract: Described herein is an optical channel monitor (1) including a protective housing (3), an input port (5) disposed in the housing (3) and configured for receiving at least one input optical signal (7) including one or more optical channels separated by wavelength. A wavelength configurable laser (9) is located within the housing (3) and is configured to provide an optical reference signal (11) at a first wavelength (?r). The laser (9) is adapted to scan across a range of wavelengths covering the one or more optical channels. An optical mixing module (13) is coupled to the input port (5) and the laser (9) for mixing the input optical signal (7) with the optical reference signal (11) to produce a mixed output signal. A receiver module (15) is configured to receive the mixed output signal and extract signal information indicative of at least the optical power of the at least one input optical signal at the first wavelength (?r).

Abstract: Methods for positioning neighboring nozzles of a gas turbine engine are provided. A method includes assembling a first nozzle assembly. The first nozzle assembly includes a first nozzle and a first nozzle support structure. The method further includes assembling a second nozzle assembly. The second nozzle assembly includes a second nozzle and a second nozzle support structure. The method further includes adjusting the first nozzle assembly and the second nozzle assembly such that an engineering dimension between the first nozzle and the second nozzle is within a predetermined engineering tolerance, and joining the first nozzle support structure and the second nozzle support structure together.

Abstract: Techniques and systems for providing miniaturized unmanned aerial vehicles (UAVs) are disclosed. The techniques and systems can include significant off-board processing support for the UAVs to enable the UAVs to be smaller, lighter, and less expensive than conventional UAVs. The techniques and systems can include routines to provide enhanced support for police during routine traffic stops. The techniques and systems can also include routines to locate objects or people including, for example, locating a lost child in a crowd or a lost vehicle in a parking lot. The miniaturized UAVs can provide enhances perception for the user to enable the user to over and around objects for improved visibility and safety, among other things.

Abstract: Described herein is a spatial light modulator (15) for modulating the phase, retardation or polarization state of an incident optical signal propagating in a first dimension. The optical phase modulator (15) includes a liquid crystal material (17) and a pair of electrodes (19 and 21) for supplying an electric potential across the liquid crystal material (17) to drive liquid crystals in a predetermined configuration. Modulator (15) also includes a diffractive optical element (29) disposed adjacent a first electrode (19). Element (29) includes a first array of diffractive elements (31) formed of a first material having a first refractive index and extending in a second dimension substantially perpendicular to the first dimension. Elements (31) are at least partially surrounded by a second material (33) formed of a lower refractive index.

Abstract: A surgical instrument including an elongate shaft terminating in an end effector, the end effector including two pairs of opposable jaws, the pairs being spaced apart and independently operable to cause the jaws of that pair to grip or release an object located therebetween, wherein the jaws of each pair are movable to an open configuration in which the most distal point on each of those jaws is less distal than the mid-point of that pair of jaws when that pair of jaws is closed with its jaws in their most distally extended configuration.

Abstract: This invention provides a multistage emulsion polymer including, as copolymerized units: from 0.5% to 5%, by weight P-acid monomer, based on the weight of the emulsion polymer; from 0% to 0.05% by weight multiethylenically unsaturated monomer, based on the weight of the emulsion polymer; and at least one second monoethylenically unsaturated monomer; the emulsion polymer having a calculated Tg of from ?20° C. to 50° C.; the emulsion polymer is formed by the “pulsed” addition of 75% to 100% of the P-acid monomer during a stage including from 10% to 50% of the total monomer weight, preferably added during the relatively early stages of the polymerization. A multistage polymer/TiO2 composite particle and an aqueous coating composition including the composite particle are also provided.

Abstract: The invention provides a method of selectively pro-oranti-angiogenic treatment of a mammalian subject, comprising site-specific control of alternative splicing during processing of VEGF pre-mRNA transcribed from the C terminal exon 8 of the VEGF gene using controlling agents for the splicing, wherein one or more controlling agent which favors proximal splice site (PSS) splicing in said processing is used in the pro-angiogenic treatment and one or more controlling agent which favors distal splice site (DSS) splicing in said processing is used in the anti-angiogenic treatment.

Abstract: One or more techniques and/or systems are disclosed for a device that can be used to seal an opening of a package to mitigate loss of package contents, and to effectively transfer contents of the package to a target device or system. The device can comprise a base cap that engages with a package opening, such as a fitment, and a nozzle portion. Alternately, the fitment may comprise a fixedly engaged base. The nozzle portion can comprise a portion that selectably engages with two or more target systems, such as through a filling port, and may also selectably engage with a closing cap that can be used to close the opening, by sealing a spout portion of the nozzle.

Abstract: A drive system for a mobile machine is disclosed. The drive system includes a power source configured to generate mechanical power, and a transmission driven by the power source, a traction device driven by the transmission. The drive system further includes a first input device configured to generate a signal to operate the machine, a second input device configured to receive an operator selection of one of a plurality of transmission modes, and a controller in communication with the first input device and the transmission. The controller is configured to adjust operation of the transmission to control a speed rate of change of the traction device in response to the signal from the first input device and based on the operator-selected one of the plurality of transmission modes.

Abstract: The invention provides a process for hydrolytically converting aloeresin A to aloesin by the following reaction: The amount of aloesin available for extraction from sap of aloe plants is thereby increased and the extraction and purification of the aloesin is also made easier and less costly. As aloesin is more commercially valuable than aloeresin A, the process also increases the commercial value of the sap or aloe bitters from the aloe plant. The process optionally also includes the step of separating the aloesin from the p-coumaric acid. Typical hydrolysis steps that are used in the process are acid hydrolysis, base hydrolysis and enzymatic hydrolysis. In the case of acid hydrolysis, the acid is any suitable organic or inorganic acid, such as hydrochloric acid, sulfuric acid, nitric acid or phosphoric acid. In the case of enzymatic hydrolysis, the hydrolytic enzyme is typically an esterase, a lipase or a protease.

Abstract: A method for producing a template of a binding site of a target protein is provided. A target protein is modeled in silico. A binding site is hydrated with water molecules by finding areas within the binding site where water molecules remain localized during a molecular dynamic simulation. Interactions of the water molecules with the hydration sites are classified as a hydrogen bond acceptor interaction (A) or a hydrogen bond donor interaction (D). The classified interactions are mapped to provide a template of hydrogen bond interactions with the protein.

Abstract: A rescue device for a choking victim and a method of rescuing a choking victim is provided. The device includes a first tube that is configured to be inserted into the victim's mouth so as to assist in dislodging a foreign object in the victim's windpipe by creating a low-pressure environment within the victim's mouth. The device further includes a second tube that is configured to allow a rescuer to create the low-pressure environment in the victim's mouth by sucking on a second tube of the device. A filter is positioned between the first and second tubes to reduce sanitary concerns and to prevent the foreign object from becoming lodged in the rescuer's windpipe.

Abstract: Systems and methods for powering up circuits are described herein. In one embodiment, a method for power up comprises comparing a voltage of a first supply rail with a voltage of a second supply rail, and determining whether the voltage of the first supply rail is within a predetermined amount of the voltage of the second supply rail for at least a predetermined period of time based on the comparison. The method also comprises initiating switching of a plurality of switches coupled between the first and second supply rails upon a determination that the voltage of the first supply rail is within the predetermined amount of the voltage of the second supply rail for at least the predetermined period of time.

Abstract: A collapsible device for filtering air comprising a base, a fan functionally attached to the base, an air filter releasably attached to the base, and a substantially air impermeable outer sleeve is provided.

Abstract: An improved method for purifying albumin, a variant or fragment thereof, a fusion protein comprising albumin, a variant or fragment thereof, or a conjugate comprising albumin, a variant or fragment thereof is disclosed.

Abstract: Provided are methods and products for obtaining cardiovascular lineage cells from hPSCs.