Abstract: Described herein is a delivery device and methods for delivering an ocular implant into an eye. The delivery device includes a proximal handle portion; a distal delivery portion coupled to a distal end of the handle portion and configured to releasably hold an ocular implant and includes a sheath positioned axially over a guidewire; and a metering system configured to provide visual guidance regarding depth of advancement of an implant positioned on the guidewire into an anatomic region of the eye. Also disclosed is a device and method for loading an implant onto the delivery device.

Abstract: The invention provides a device for the detection and mapping of radiation, the device comprising a polymeric core (18) located within an external shell material (1), wherein the polymeric core comprises a plurality of stacked polymeric sheets comprising at least one radiation sensitive component which is sensitive to said radiation emitted by said radioactive materials and the external sheath comprises a collimation sheath (1). Preferably, the polymeric core comprises a cubic, cylindrical, spherical or truncated spherical shape which is encased within the external shell. The external shell is preferably comprised of a metal, most preferably tungsten.

Abstract: This disclosure relates generally to methods and devices for use in treating eye conditions with implantable drug delivery devices. One method includes introducing an implant into the suprachoroidal space, wherein the interior volume of the implant is plugged with a drug-release material comprising at least one active agent that elutes through at least one opening in the implant, wherein the drug-release material degrades from the interior volume of the implant over a period time.

Abstract: An analytical test strip with inert carrier substrate for use with a test meter includes an analytical test strip module and an electrochemically and electrically inert carrier substrate. The analytical test strip module has a first electrode portion, a second electrode portion in an opposing relationship to the first electrode portion, and first and second electrical contact pads configured in a stacked unidirectional configuration. The electrochemically and electrically inert carrier substrate has an upper surface and an outer edge. Moreover, the analytical test strip module is attached to the upper surface of the electrochemically and electrically inert carrier substrate such that the first and second electrical contact pads extend beyond the outer edge of the electrochemically and electrically inert carrier substrate and such that the electrochemically and electrically inert carrier substrate extends beyond the analytical test strip module.

Abstract: An elbow assembly for a mask system includes an elbow including a slot and a port, an anti-asphyxia valve adapted to be received within the slot and including a flap portion adapted to selectively close the port depending on the presence of pressurized gas, and a clip member to secure the anti-asphyxia valve to the elbow. The clip member includes a slot that is adapted to interlock with a protrusion provided to the anti-asphyxia valve.

Abstract: Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.

Abstract: The invention provides a composition comprising (S)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.

Abstract: A cleaner head for a cleaning appliance includes a rotatable agitator and an agitator chamber housing the agitator. The agitator includes a flexible body and surface engaging members mounted on the body. The agitator chamber includes a downwardly-directed opening through which debris energized by the surface engaging members enters the cleaner head. The opening is located in a plane. The cleaner head includes a drive mechanism for rotating the agitator about a rotational axis which is inclined both relative to the plane of the opening and towards the rear of the opening so that, with rotation of the agitator, the surface engaging members protrude through the opening towards the front of the opening.

Abstract: A mine roller assembly for a mine roller is provided for detonating mines located in or on an underlying ground surface. A bracket is adapted for attachment to a mine roller system frame. An arm is pivotally connected to the bracket. A spring and damper system extends between the bracket and the arm. A wheel assembly is rotatably connected to the arm and is configured to interact with the underlying surface.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: A cleaner head for a vacuum cleaning appliance includes a first rotatable agitator and a second rotatable agitator for sweeping debris from a surface, each agitator comprising a disc-shaped body and a plurality of resilient members, preferably in the form of bristles, mounted on the body for engaging the surface. The agitators are housed within an agitator chamber which includes a downwardly-directed opening through which debris energized by the bristles enters the cleaner head. The opening is located in a plane, and each body is inclined relative to the plane of the opening so that, with rotation of the agitator, the bristles protrude through the opening. The bristles of the first agitator are angularly offset from the bristles of the second agitator.

Abstract: In embodiments of eyebox adjustment for interpupillary distance, a first optical lens receives light of an image from a display optic at a projected orientation of the light, and the first optical lens deviates the light of the image by a deviation angle from the projected orientation of the light. A second optical lens receives the light of the image from the first optical lens at the deviation angle, and the second optical lens alters the deviated light of the image back to the projected orientation of the light for viewing the image. Left and right eyeboxes align with respective left and right eyes that view the image, and a distance between the left and right eyeboxes approximately correlates to an interpupillary distance between the left and right eyes. The light of the image can be laterally shifted to increase or decrease the distance between the left and right eyeboxes.

Abstract: Systems and methods for estimating the minimum geographic coverage of a wireless base station. In an embodiment, the present invention estimates coverage by (1) receiving real-time wireless base station information from the mobile device; (2) extracting a set of location points and system specific information based on the real-time wireless base station information; (3) determining a coverage area based on the set of location points and the system specific information; (4) adjusting for errors based on various factors (5) storing the determined coverage area.

Abstract: Methods, computer systems, and computer-readable storage media for modifying an advertising bid for delivering behaviorally-targeted advertising based on affinity scores are provided. A set of affinity scores associated with users belonging to a behavioral targeting segment is received. A bid adjustment factor is dynamically calculated based on a first affinity score of the set of affinity scores; the first affinity score is associated with a first user of the set of users. The bid adjustment factor is used to modify the advertising bid such that the bid reflects an affinity of the first user for the topic associated with the behavioral targeting segment.

Abstract: A cleaner head for a cleaning appliance includes a rotatable agitator and an agitator chamber housing the agitator. The agitator includes a drive shaft, a flexible body connected to the drive shaft and surface engaging members mounted on the flexible body. The agitator chamber includes a downwardly-directed opening through which debris energized by the surface engaging members enters the cleaner head. The opening is located in a plane relative to which the flexible body is inclined so that, with rotation of the agitator, the surface engaging members protrude through the opening, preferably towards the front of the opening.

Abstract: A mobile lighting apparatus includes a portable frame such as a moveable trailer or skid having a light tower thereon. The light tower is moveable from a stowed position to a deployed position. A hydrogen-powered fuel cell is located on the portable frame to provide electrical power to an array of the energy efficient lights located on the light tower.

Abstract: An unmanned aerial vehicle (UAV) in the form of a “tail sitter” flying wing adapted for vertical take off and landing and transitions between flight as a helicopter and wing-borne flight. The vehicle is electrically powered from onboard batteries and equipped with rotors on miniature helicopter rotor heads at the tips of the wing for both lift, during take off and landing, and forward thrust. In planform the wing comprises, to each side of its longitudinal axis, an inner section with swept back leading and trailing edges, and an outer section with a leading edge more perpendicular to the longitudinal axis, being only mildly swept back or substantially unswept, and a swept forward trailing edge.

Abstract: A DRAM cell and method for storing information in a dynamic random access memory using an electrostatic actuator beam to make an electrical connection between a storage capacitor and a bit line.