Abstract: Membrane elements that use multiple membrane leaves may have a limited total active membrane area due to an increased diameter at the ends of the element. Membrane leaves may comprise a permeate carrier positioned between one or more membrane sheets. Adhesive may be used to seal one or more edges of the membrane leaf. The membrane sheets, permeate carrier and the adhesive contribute to the thickness of the edges of the membrane leaf and the diameter at the ends of the element. A reduced thickness of the edges of the permeate carrier may reduce the diameter at the ends of an element. Another permeate carrier sheet may also be used that is distanced from at least one edge of the membrane sheet so the permeate carrier sheet does not contribute towards the increased diameter at the ends of the element.

Abstract: The present invention relates to a novel means to use a fundamental model of the parts of the brain that are dysfunctional in Parkinson's disease, and related dynamical diseases of the brain, as part of a feedback control system to modulate the signs and symptoms of disease. Fundamental computational models that embody our knowledge of the anatomy, neurons, and dynamics of the parts of the brain we wish to control, and use those models to reconstruct what is inaccessible to our measurements. Through emulation the controller synchronizes to the parts of the brain we wish to observe and track. By passing simultaneous control pulses to both the model controller, as well as the brain, we control both the model and the brain. The detailed framework to embed fundamental models of the brain within a control scheme to control symptoms of Parkinsons and related dynamical diseases of the brain are disclosed.

Abstract: This disclosure relates generally to methods and devices for use in viewing and positioning an eye with a gonio lens system, such as during ocular exams and ocular surgeries. Some embodiments of the gonio lens system can include a gonio lens for viewing one or more tissues and structures of the eye. In addition, the gonio lens system can include one or more positioning features for controlling movement positioning of the eye.

Abstract: The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed. Examples of compounds of the invention include the compounds according to Formula Ia, or a pharmaceutically acceptable salt thereof, and the compounds of the examples.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: A floating vessel is equipped with perforated plates which exhibit both an added-mass effect and a damping effect. The addition of porosity to an added mass plate phase-shifts the added mass force so that it becomes at least partially a damping force which does not depend on large velocities to develop a large damping force. Preferred porosity is in the range of about 5% to about 15% of total plate area. A semi-submersible vessel may have damper plates fitted between its surface-piercing columns, within a support grid in the area between the pontoons and/or extending from the sides of its pontoons. A truss spar offshore platform may have damper plates installed within its truss structure intermediate its hull and ballast tank. Drill ships and similar vessels may be equipped with damper plates extending from the sides of their hulls to reduce both heave and roll.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; solid forms of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I-1: wherein the variables are as defined herein. Additionally, the compounds of this invention have formula II: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.

Abstract: A disclosed system, method and computer readable storage medium includes mechanism for controlling cascade price movements in an electronic trading system. Price limits control the prices at which traders can place orders. An upper price limit prevents traders from placing orders above the upper limit and a lower price limit prevents traders from placing orders below the lower limit. The gap between the upper limit and the indicative market price as well as the gap between lower limit and the indicative market price is controlled so as to cause a breaking effect on very rapidly changing market price.

Abstract: The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

Abstract: A modular cutdown machine for window coverings includes a center control module and first and second cutting modules at opposite ends of the center control module. Control, power and cleanup functions are contained within the center control module and are distributed to each of the cutting modules. One cutting module can be operated without the other cutting module in place, and repair or service can be performed by the interchange of modules.

Abstract: A computed tomography (CT) system that includes a rotational gantry and a stationary structure communicatively coupled to the rotational gantry is provided. The rotational gantry includes an X-ray source configured to emit an X-ray beam through a subject, an X-ray detector comprising one or more detector elements that receive incoming X-rays and to convert the incoming X-rays to image signals, and a data acquisition unit that processes the image signals to generate processed image data. The stationary structure is coupled to the rotational gantry via one or more slip rings that transfer the processed image data from the rotational gantry to stationary memory integral with the stationary structure via a bidirectional serial data exchange protocol.

Abstract: A mouth cushion for a mask system includes a side wall, an undercushion extending away from the side wall, and a membrane provided to substantially surround the undercushion and adapted to form a continuous seal around an exterior of a patient's mouth in use. The side wall includes spaced-apart prong support structures that provide annular recesses adapted to support respective nasal prongs, and at least a portion of the undercushion includes a question-mark or sickle-shape configuration when in cross-section.

Abstract: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: Aspects include a multistage collector to receive outputs from plural processing elements. Processing elements may comprise (each or collectively) a plurality of clusters, with one or more ALUs that may perform SIMD operations on a data vector and produce outputs according to the instruction stream being used to configure the ALU(s). The multistage collector includes substituent components each with at least one input queue, a memory, a packing unit, and an output queue; these components can be sized to process groups of input elements of a given size, and can have multiple input queues and a single output queue. Some components couple to receive outputs from the ALUs and others receive outputs from other components. Ultimately, the multistage collector can output groupings of input elements. Each grouping of elements (e.g., at input queues, or stored in the memories of component) can be formed based on matching of index elements.

Abstract: The invention provides a device for the detection and mapping of radiation, the device comprising a polymeric core located within an external shell material, wherein the polymeric core comprises at least one radiation sensitive component and the external sheath comprises a collimation sheath. Preferably, the polymeric core comprises a spherical core which is encased within the external shell. The external shell is preferably comprised of a metal, most preferably lead or tungsten.

Abstract: A segmented wear ring 40 for a tracked vehicle 10 road wheel 22 that cooperates with a track guide 32. The segmented wear ring 40 has at least two wear ring segments 42, and each of the wear ring segments 42 have a wear surface 50. The wear ring segments 42 are attached to a tracked vehicle wheel 22 such that the wear surfaces of each of the wear ring segments 42 form a substantially uninterrupted wear surface 50 designed to cooperate with a track guide 32.

Abstract: A multi-mode cavity filter comprises: a dielectric resonator; a coupling structure for at least one of coupling input signals to the dielectric resonator and extracting filtered output signals from the dielectric resonator; a covering of conductive material around the dielectric resonator and comprising an aperture; and a printed circuit board structure having at least one ground plane layer arranged over said aperture and electrically coupled to the covering of conductive material.

Abstract: A multi-mode cavity filter, comprising: at least one dielectric resonator body incorporating a piece of dielectric material, the piece of dielectric material having a shape such that it can support at least a first resonant mode and at least a second substantially degenerate resonant mode; and a coupling structure comprising a patterned conductive layer for at least one of coupling signals to the piece of dielectric material and coupling signals from the piece of dielectric material.

Abstract: A cavity filter, including a dielectric resonator structure comprising a piece of dielectric material having a shape such that it can support a first resonant mode and a second resonant mode which is substantially degenerate with the first resonant mode; and a coupling structure for exciting a resonant mode within the piece of dielectric material or extracting energy from a resonant mode within the piece of dielectric material; wherein the coupling structure consists of a single patch element in contact with a surface of the piece of dielectric material, the patch element being arranged to couple directly to said first and second resonant modes simultaneously.