Abstract: The invention encompasses methods of using racemic and enantiomerically pure norfluoxetine, as well as pharmaceutical compositions, pharmaceutical unit dosage forms, and kits comprising racemic and enantiomerically pure norfluoxetine. In particular, the invention encompasses a method of inhibiting or reducing the production of PGE2. The invention further encompasses a method of treating or preventing inflammation in a patient, as well as a method of treating or preventing a disease or disorder such as, but not limited to, autoimmune diseases, arthritis, neurologic diseases, inflammatory diseases, fibromyalgia, pain resulting from inflammation, neuropathic pain, and cancer.

Abstract: Compounds are disclosed of the formula in which R3 is C8 to C24 hydrocarbon or the residue of misoprostol. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.

Abstract: A blind rivet includes a hollow rivet body having a longitudinally extending indented groove. The groove may be shaped to impart rivet setting characteristics that may be varied to provide desirable fastening characteristics for joints in a number of industries. The shape of the indentation on the rivet body may be varied to cause a portion of the rivet body to collapse and form a secondary head at a predetermined longitudinal location.

Abstract: The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in chromatin separation during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.

Abstract: A platy pigment substrate having a carbon-containing coating thereon is provided wherein the coating comprises a pyrolyzed carbon-containing ionic species. The products of the present invention may be used in any application where pearlescent pigments have been used heretofore including but not limited to automotive and industrial paint applications.

Abstract: The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell cycle progression during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.

Abstract: With the growing demand of oil products in the world, this invention can help curb the fuel consumption rate of trucks/large motor vehicles without reducing peak power outputs. A vehicle having a “dual series” hybrid power systems includes two liquid fueled internal combustion engines, each engine having a generator directly connected. There is an electric motor for drivability directly connected to one or more ground engaging wheels. A first electrical storage device (battery pack) stores electricity that powers the electric motor. Two voltage reducers are coupled between both of the generators and the first electrical storage device and has an accessory voltage output, which has a lower voltage than the charging power output of the generators, to keep the accessory second electrical storage device fully charged.

Abstract: The invention relates to a blind rivet, related method of removal and a tool. The removable blind rivet has a rivet body that receives a mandrel. The rivet body has a flange with a line of weakness formed therein. The line of weakness is adapted to shear under an axial load, whereby the flange is severed, substantially as a single item, from the rivet body. The invention extends to a tool for removing the rivet, the tool having: a body and a punch surface, the punch surface adapted to apply an axial force to a region of the flange, whereby the flange is severed from the rivet body in the form of an annulus, leaving a hollow rivet body that may be removed from a workpiece. The advantage of the invention is that it enables the flange to be removed form the rivet body as a single item.

Abstract: A platy pigment substrate having a carbon-containing coating thereon is provided wherein the coating comprises a pyrolyzed carbon-containing ionic species. The products of the present invention may be used in any application where pearlescent pigments have been used heretofore including but not limited to automotive and industrial paint applications.

Abstract: The present invention provides methods and compositions related to the discovery of molecules capable of both inducing an immune response to an antigen in a mammal and also effecting clearance of the antigen, with such molecules comprising a first moiety comprising an antigen binding portion which binds specifically to complement receptor 1 (CR1) and does not substantially bind to complement receptor 2 (CR2), linked to a second moiety which comprises the antigen or binds to the antigen. Methods of producing such molecules and their therapeutic and/or prophylactic uses are also featured.

Abstract: A honing guide and bevel setting jig for removable attachment to the honing guide to properly position the angle and projection of a tool to be sharpened in the jig to enable the tool to be honed at the proper angle and position. An adjustable roller that contacts an abrasive surface during use of the guide facilitates formation of micro bevels. A tool securing bar having a generally triangular shape in the bar's middle section forces the arris-defining back of the tool being honed against a reference surface in the guide by tightening thumb nuts around threaded studs projecting from the bar. Jigs for use with both square and skew edge chisel and blades are described. A concave surface clamp bar honing guide provides enhanced gripping of the tool being honed, and wedges and adjustable structures expand the range of bevel angles that can be honed.

Abstract: Recombinant VSV viral particles and the use thereof as vaccines for immunization are described.

Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

Abstract: The present invention relates to a durable high-efficiency thermoelectric device. More specifically, the present invention relates to a thermoelectric device formed with a novel thermoelectric material and system which incorporates a vaporizable scaffolding to create microscopic gaps between the thermoelectric elements which are filled with a high-density, shrink-resistant aerogel.

Abstract: A softening composition for treating tissue products is disclosed. The softening composition comprises a combination of particular amino-functional polysiloxanes and alkoxylated alcohols in particular proportionate amounts. When applied to tissue products at add-on levels of less than about 5% by weight, the softening composition has been found not only to improve the softness of the product but also not to substantially interfere with the wettability characteristics of the sheet.

Abstract: The present invention relates to a castable, aerogel-based, ultra-low thermal conductivity opacified insulation to suppress sublimation. More specifically, the present invention relates to an aerogel opacified with various opacifying or reflecting constituents to suppress sublimation and provide thermal insulation in thermoelectric modules. The opacifying constituent can be graded within the aerogel for increased sublimation suppression, and the density of the aerogel can similarly be graded to achieve optimal thermal insulation and sublimation suppression.

Abstract: This invention describes materials and methods to rapidly densify carbon-carbon composite preforms utilizing a continuous flow closed-loop liquid precursor.

Abstract: A method and apparatus for a generator coil includes a plurality of stacked windings in a rotor where individual turns are stacked in parallel sided radial slots in the rotor. Each successive turn has the same width substantially corresponding to a constant width of each slot, wherein a first turn has a first thickness and a second turn has a second thickness thicker than said first thickness. The second turn is employed in regions of high temperature thereby reducing the temperature thereof.