Abstract: Inhibitors of sepiapterin reductase and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed.

Abstract: One example discloses an optical communication interface for a handheld device: wherein the handheld device, has an external surface; wherein the external surface includes an interior facing side and an exterior facing side; a first optical receiver, on the interior facing side of the handheld device, having an optical input and an electrical output; wherein the electrical output is coupled to circuitry; and wherein the optical input is configured to be optically coupled to a second optical transmitter on the exterior facing side of the handheld device.

Abstract: A technique is disclosed for facilitating editing of editable code in an interface device or similar apparatus. Properties of device elements are enumerated by a general purpose engine resident on the interface device. The general purpose engine enumerates the properties in response to a query in a design-time environment. The device element includes a specific property type and editable code consistent with the property type. A server module on the device serves the editable code and an editing environment from the interface device to a configuration station. The code can be edited on the configuration station in the editing environment and restored to the interface device. The technique alleviates the need for separate editing software or storage of the editable code in any location other than on the interface device itself.

Abstract: Techniques for deploying a server stack having a cross-server dependency are disclosed. A deployment engine initiates a deployment process for a server stack. The deployment engine provisions servers of one server type (“requisite servers”). The deployment engine attempts to provision servers of another server type (“dependent servers”). The deployment engine executes a test that requires the dependent servers to invoke a service executed by the requisite servers. Based on the test results, the deployment engine determines that an operational requirement of the dependent servers is not satisfied. The deployment engine modifies a configuration for the requisite servers to satisfy the operational requirement of the dependent servers. The deployment engine re-provisions the requisite servers using the modified configuration. The deployment engine completes the deployment process for the server stack.

Abstract: An exemplary embodiment of wire wrap welding system generally includes a headstock; a bed; a bed mounted tailstock linearly moveable in relation to the headstock; a linear induction drive system adapted to move the tailstock; a linear encoder system having a series of position encoders disposed on the bed; a servomotor adapted to rotate a headstock mounted spindle; a welding system positioned on the headstock, a servomotor positioned on the tailstock and adapted to rotate a tailstock mounted spindle; and a control system. An exemplary embodiment of a method for controlling slot openings between wire segments in a wire wrap welding process generally includes controlling movement of a bed mounted tailstock in relation to the rate of rotation of a headstock mounted spindle, utilizing a linear induction drive system, a linear encoder system, and a control system.

Abstract: An ionic liquid ion source can include a microfabricated body including a base and a tip. The body can be formed of a porous material compatible with at least one of an ionic liquid or room-temperature molten salt. The body can have a pore size gradient that decreases from the base of the body to the tip of the body, such that the at least one of an ionic liquid or room-temperature molten salt is capable of being transported through capillarity from the base to the tip.

Abstract: The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 ?M and/or have an off-rate (koff) of 1×10?3S?1 or slower.

Abstract: A tissue graft suspension device includes a platform member, a graft connecting element coupled to the platform member such that a portion of the graft connecting element forms a loop for attachment to a tissue graft, and an enclosure member coupled to the loop of the graft connecting element and configured to enclose a biologic material. The enclosure member defines an opening configured to receive the biologic material. The graft connecting element and the enclosure member are configured such that, during use, the tissue graft is coupled to the loop and in contact with the enclosure member.

Abstract: An ionic liquid ion source can include a microfabricated body including a base and a tip. The body can be formed of a porous material compatible with at least one of an ionic liquid or room-temperature molten salt. The body can have a pore size gradient that decreases from the base of the body to the tip of the body, such that the at least one of an ionic liquid or room-temperature molten salt is capable of being transported through capillarity from the base to the tip.

Abstract: One example discloses an apparatus for voice communication, including: a first wireless device including a first pressure sensor having a first acoustical profile and configured to capture a first set of acoustic energy within a time window; wherein the first wireless device includes a near-field magnetic induction (NFMI) signal input; wherein the first wireless device includes a processing element configured to: receive, through the NFMI signal input, a second set of acoustic energy captured by a second pressure sensor, having a second acoustical profile, within a second wireless device and within the time window; apply a signal enhancement technique to the first and second sets of acoustic energy based on the first and second acoustical profiles; and output an enhanced voice signal based on applying the signal enhancement.

Abstract: A lid assembly that can be placed on a pan having a bottom surface that is configured for placement on a burner of the stove top with one or more foods to be cooked supported above an inner bottom surface of the pan by a rack. The lid assembly covers the pan and thereby encloses the one or more foods to be cooked and the rack within a cavity defined by the pan and the lid assembly. An air flow generator mounted on a shaft that extends through a cover portion of the lid from a motor disposed on an opposite side of the cover portion rotates the shaft to produce airflow within the cavity. The lid assembly cooks foods in less time and using less energy than normally required with a conventional oven.

Abstract: Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Abstract: An ionic liquid ion source can include a microfabricated body including a base and a tip. The body can be formed of a porous material compatible with at least one of an ionic liquid or room-temperature molten salt. The body can have a pore size gradient that decreases from the base of the body to the tip of the body, such that the at least one of an ionic liquid or room-temperature molten salt is capable of being transported through capillarity from the base to the tip.

Abstract: A system for fabricating a dental restoration to restore a tooth at a restoration site in a dentition of a patient is disclosed. The dentition includes a restoration dental arch and an opposing dental arch. The restoration dental arch include the restoration site and the opposing dental arch is opposite the restoration dental arch. The system includes an impression apparatus, a motion capture apparatus, an interface apparatus, and a restoration design system. The impression apparatus is configured to capture an impression of the dentition of the patient. The motion capture apparatus is configured to capture a plurality of location data points that represent the locations of the opposing dental arch relative to the restoration dental arch. The interference model generation system is configured to generate an interference model for the restoration site. The restoration design system is for designing a restoration using the interference model.

Abstract: Embodiments of an apparatus of the present invention generally include a filtration assembly having a louvered shroud circumferentially positioned around a perforated inner pipe, such that at least a substantial portion of the shroud's inner surface contacts and frictionally engages the outer surface of the inner pipe. Embodiments of a method of the present invention generally include spirally wrapping a substantially flat strip of louvered material around the inner pipe, wherein adjoining edges of the louvered material abut and are at least partially welded together, to provide the shrouded pipe. Other method embodiments generally include an inner pipe having a louvered shroud positioned there around being introduced to a device operable to, dynamically or statically, radially compress the shroud such that at least a substantial portion of the shroud's inner surface contacts and frictionally engages at least a substantial portion of the outer surface of the inner pipe.

Abstract: A system for fabricating a dental restoration to restore a plurality of teeth in a dentition of a patient is described. The dentition includes a restoration dental arch and an opposing dental arch. The restoration dental arch includes a restoration site and the opposing dental arch is opposite the restoration dental arch. The system includes an impression apparatus, a motion capture apparatus, an interference model generation system, and a restoration design system. The impression apparatus is configured to capture an impression of the dentition of the patient. The motion capture apparatus is configured to capture a plurality of location data points that represent the locations of the opposing dental arch relative to the restoration dental arch. The interference model generation system is configured to generate an interference model for the restoration site. The restoration design system is for designing a restoration using the interference model.

Abstract: One example discloses an apparatus for near-field magnetic induction (NFMI) based robustness, including: a first wireless device including a first wireless signal interface and a first NFMI signal interface; wherein the first wireless signal interface is configured to receive a data set from a third wireless device; wherein the first NFMI signal interface is configured to communicate with a second wireless device through a second NFMI signal interface; and wherein the first wireless device is configured to detect an error in the data set received from the third wireless device and in response to detecting the error configure the first NFMI signal interface to receive the data set from the second wireless device through the second NFMI signal interface.

Abstract: One example discloses an apparatus for voice communication, including: a first wireless device including a first pressure sensor having a first acoustical profile and configured to capture a first set of acoustic energy within a time window; wherein the first wireless device includes a near-field magnetic induction (NFMI) signal input; wherein the first wireless device includes a processing element configured to: receive, through the NFMI signal input, a second set of acoustic energy captured by a second pressure sensor, having a second acoustical profile, within a second wireless device and within the time window; apply a signal enhancement technique to the first and second sets of acoustic energy based on the first and second acoustical profiles; and output an enhanced voice signal based on applying the signal enhancement.

Abstract: One example discloses an apparatus for sound signal detection, comprising: a first wireless device including a first pressure sensor having a first acoustical profile and configured to capture a first set of acoustic energy within a time window; wherein the first wireless device includes a wireless signal input; wherein the first wireless device includes a processing element configured to: receive, through the wireless signal input, a second set of acoustic energy captured by a second pressure sensor, having a second acoustical profile, within a second wireless device and within the time window; apply a signal enhancement technique to the first and second sets of acoustic energy based on the first and second acoustical profiles; search for a predefined sound signal within the enhanced sets of acoustic energy; and initiate a subsequent set of sound signal detection actions if the search finds the sound signal.

Abstract: Devices and methods of detecting a predetermined audio signal in audio signals are provided. A device includes a processor coupled to a clock signal generator, a power controller and an audio detector. The power controller controls a clock rate provided to the processor by the clock signal generator, to control the device to operate in a low power mode having a relatively low power consumption or in a normal power mode having a relatively high power consumption. The audio detector receives audio signals and detects, in the low power mode, probable presence of a predetermined audio signal in the audio signals. The power controller controls the device to switch from the low power mode to the normal power mode responsive to the detected presence of the predetermined audio signal by the audio detector.