Abstract: Inhibitors of sepiapterin reductase and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed.

Abstract: The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 ?M and/or have an off-rate (koff) of 1×10?3 S?1 or slower.

Abstract: This invention relates to microphone accessories for use with a hand-held microphone, and to a method of using a microphone. The microphone accessory in accordance with the invention has a body comprising an attachment formation for attaching the microphone accessory to the handle of the microphone, a holding portion to be engaged by a hand of the user, a cover portion coupled to the holding portion and substantially spaced therefrom so as to define a holding zone between the holding portion and the cover portion for receipt of the hand of the user to engage the holding portion, in use, wherein the cover portion substantially shields or covers the holding zone and/or the hand of the user; and a static non-electronically variable display device and/or an electronically variable display device. The invention also relates to a wearable microphone accessory.

Abstract: A method, apparatus, and aircraft tracker system for reporting state information for an aircraft. A state of the aircraft is identified using sensor data received from an aircraft sensor system in the aircraft. The state information is transmitted at a reporting rate set using the state of the aircraft identified from the sensor data, at least one of a crew command or a ground command when at least one of the crew command is received from a crew interface or the ground command is received from a ground source, and a policy defining priorities for reporting that are based on at least one of the crew command, the ground command, or the state of the aircraft identified from the sensor data.

Abstract: This invention relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants.

Abstract: It is provided an apparatus for transferring energy to an accumulator, the apparatus having a core and a wire wound around the core thereby forming a coil, wherein the coil is adapted to receive energy from a magnetic field, wherein the wire is connectable to the accumulator to transfer the received energy to the accumulator. A charging station for generating a magnetic field for transferring energy to an accumulator is provided, and a system for charging an electric accumulator is provided, wherein the system includes an apparatus as described above; and a charging station having a further wire wound such as to form a further coil.

Abstract: A printhead support structure may have a receiving portion to receive a printhead, first and second portions having an adjustment mechanism therebetween for converting a translational movement of the first portion to a rotational movement of the second portion, and a coupling mechanism coupling the second portion to the receiving portion for adjusting the rotational angle of the printhead. A method for adjusting a position of a printhead coupled to a printhead support may include applying a force to a first portion of the printhead support to effect a translational movement of the first portion, converting the translational movement of the first portion into a rotational movement of a second portion of the printhead support, and applying the rotational movement of the second portion to the printhead.

Abstract: One example discloses a health monitoring device, including: a communications circuit configured to receive a set of health sensor data based on a body surface; and a near-field antenna, coupled to the circuit, and conformally coupled to the body surface.

Abstract: A shelving system includes a frame including a pair of spaced apart riser members and at least one shelf extending between the riser members. The at least one shelf is adhesively bonded to the riser members. The at least one shelf may be substantially L-shaped and may include a first surface extending outwards from the riser members and a second surface angled with respect to the first surface and bonded to the riser members.

Abstract: Compounds and compositions useful for treating disorders related to Kit are described herein.

Abstract: The present disclosure relates to an interference screw having a body with a proximal end, distal end, and longitudinal axis extending between thereinbetween. The screw further includes threads for fixing the screw into bone. The screw further includes a through bore defined by the body. The through bore extends between the proximal and distal ends along the longitudinal axis, and has a surface. The screw further includes a controlling member formed by the through bore surface. To install the screw into bone, a surgeon turns the screw with a driver that engages with the controlling member. The driver only engages the controlling member when it is in a driving orientation with respect to the controlling member. Advantageously, with this “one-way” engagement the surgeon can control and confirm the orientation of the driver without seeing the driver and/or screw.

Abstract: An instrument includes a flexible shaft portion and a hook portion. The flexible shaft portion has a proximal end and a distal end and includes markings along an outer surface of the shaft portion. The hook portion is located at the distal end of the shaft portion. The shaft portion and the hook portion define a lumen that terminates in an opening at the hook portion.

Abstract: Electrically conductive aerogel and methods of making the same are disclosed. A solution is provided. The solution is cured to form a polymer. The polymer is carbonized to form the conductive aerogel.

Abstract: This invention relates to microphone accessories for use with a hand-held microphone, and to a method of using a microphone. The microphone accessory in accordance with the invention has a body comprising an attachment formation for attaching the microphone accessory to the handle of the microphone, a holding portion to be engaged by a hand of the user, a cover portion coupled to the holding portion and substantially spaced therefrom so as to define a holding zone between the holding portion and the cover portion for receipt of the hand of the user to engage the holding portion, in use, wherein the cover portion substantially shields or covers the holding zone and/or the hand of the user; and a static non-electronically variable display device and/or an electronically variable display device. The invention also relates to a wearable microphone accessory.

Abstract: Embodiments of a jumper tube connector assembly generally include a jumper tube, one or more fasteners affixed to and biased toward the exterior thereof, and two connectors slideable thereon, wherein each fastener is biased against a connector exterior, whereby upon slidably engaging each connector with a shunt tube, biases cease and a fastener end surface prevents connector backsliding. Embodiments of a jumper tube connection assembly generally include a retention clip having a locking surface, or a pin-locking retention clip having a pin, wherein the retention clip/pin-locking retention clip is affixed to a shunt tube, wherein upon slidably engaging a connector therewith, reverse axial connector movement is prevented by the locking surface/pin. Embodiments of a leak-off tube retention system generally include a leak-off tube having one or more spring-loaded buttons and adapted to releasably engage upper and lower retainer fittings via orifices therein. Methods of using these embodiments are also provided.

Abstract: The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumor cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 ?M and/or have an off-rate (koff) of 1×10?3 S?1 or slower.

Abstract: Some implementations of a retaining ring has an inner surface having a first portion formed of multiple planar facets and a second portion that adjoins the first portion along a boundary and includes a frustoconical surface that is sloped downwardly from outside in. Some implementations of the retaining ring have a crenellated or serpentine inner surface, and/or an inner surface with alternating region of different surface properties or different tilt angles.

Abstract: Compounds and compositions useful for treating disorders related to Kit are described herein.

Abstract: Identification cards at a processing server may be secured in certain embodiments by intercepting data associated with the identification card. The data may be prevented from being accessed by an application that is of a particular priority level. The data may be encrypted and provided to a server, which may provide replacement data that is formatted to be processed as a substitute for the data. This substitute data may then be provided to the application that was prevented from accessing the data.