Abstract: The present disclosure provides a compound represented by structural formula (I): (I), or a pharmaceutically acceptable salt thereof useful for treating a cancer.

Abstract: An oscillatory respiratory therapy device (100) has a rocker aim (105) that opens and closes a valve seat (106) by breathing through the device. The device (100) also includes a gas treatment arrangement including an HME (122) and filter (121) located such that both inhaled and exhaled gas passes through the HME and filter.

Abstract: An oscillatory PEP device has four valve openings (201) to (204) mounted on a support (205) beneath a rocker arm (106) supporting a valve closure (107). The support is rotatable to position a selected one of the valve openings beneath the valve closure and in line with a breathing path between an inlet (103). (104) and an outlet (111). The rocker arm (106) supports a soft-iron pin (108) at one end, which interacts with one of two permanent magnets (212) or (213) of different strengths on a turntable (211) to apply a force tending to pull the arm down and close the valve opening. The turntable (211) can be rotated to position the desired magnet (212) or (213) to interact with the soft-iron pin on the rocker arm.

Abstract: Some implementations of a retaining ring has an inner surface having a first portion formed of multiple planar facets and a second portion that adjoins the first portion along a boundary and includes a frustoconical surface that is sloped downwardly from outside in. Some implementations of the retaining ring have a crenellated or serpentine inner surface, and/or an inner surface with alternating region of different surface properties or different tilt angles.

Abstract: A power supply system for a toilet includes a controller power supply circuit, including an input end electrically connected to an external power supply and an output end. The system includes an assembly driving power supply circuit, including an input end electrically connected to the external power supply and an output end. The power supply system also includes a controller circuit, including a power supply end electrically connected to the output end of the controller power supply circuit and an output end communicably connected to a control end of a switch control circuit of the assembly driving power supply circuit. The system also includes a driving component circuit, including a power supply end electrically connected to the output end of the assembly driving power supply circuit. An output power of the controller power supply circuit is lower than an output power of the assembly driving power supply circuit.

Abstract: The instant disclosure relates generally to oral inoculation and specifically to methods to prepare nasopharyngeal and oral material for oral inoculation of COVID-19. Severe acute respiratory syndrome coronavirus 2 (“SARS-CoV-2”) viral particles are collected from at least one of a nasopharyngeal specimen and an oral specimen each derived from a patient infected with SARS-CoV-2 or a SARS-CoV-2 variant. Mammalian cells (e.g., Vero-E6 and/or Vero-CCL81 cells) are infected with the SARS-CoV-2 viral particles to produce infected mammalian cells. The infected mammalian cells are cultured to produce a mammalian cell culture. SARS-CoV-2 viral particles are collected from the mammalian cell culture to produce isolated viral particles. The isolated viral particles are frozen to produce a frozen isolate. The frozen isolate is partitioned into a plurality of tablets each having a therapeutically effective amount of the SARS-CoV-2 viral particles. An enteric coating is applied to each tablet.

Abstract: The technology disclosed herein enables detection of domain hijacking when a DNS resolver is performing a DNS lookup. In a particular embodiment, a method provides receiving a DNS request from a requesting computing system. The DNS request includes a domain name for which the requesting computing system is requesting resolution of a network address associated with the domain name in the DNS. The method further provides, in response to receiving the DNS request, identifying a nameserver, via a root nameserver of the DNS, to handle the DNS request and determining the nameserver is not a proper nameserver for the domain name specifically. The proper nameserver is defined by nameserver criteria generated specifically for the domain name. The method also provides preventing the nameserver from being used to resolve the DNS request in response to determining that the nameserver is not a proper nameserver for the domain name.

Abstract: Disclosed herein is a modular suspended ceiling grid system that uses joining hubs to connect tee frame members into a load-bearing framework. The tee frame members have coupling structures on each end that attach to the joining hubs. The joining hubs also have central holes that allow a sprinkler system or other hardware to be installed without altering any of the grid system elements. A plurality of hangers adapted to engage a top rail of the tee frame members via either a snap fit or a sliding fit may be utilized to connect the ceiling grid system to the building structure.

Abstract: An HME device (2) for a tracheal tube (1) has an outer housing (21) with an HME element (20) spaced from the housing at its patient end by an annular recess (40). The HME element (20) is retained with the outer housing (21) by a clip fitting (29) and (30). The inside surface (26) of the housing (21) is tapered to fit on the outside of a connector (13) on the tube (1) so that the connector extends in the recess (40). The HME element (20) extends internally of the connector (13) and can be removed from the tube (1) by releasing the clip fitting with the outer housing (21).

Abstract: A hygiene device for use with a body orifice of a living being, the hygiene device including a head adapted for use in the body orifice, the head being formed of one or more absorbent materials that are adapted to collect substances from the body orifice and a handle connected to the head to enable the head to be inserted into and removed from the body orifice with the collected substances. Method of using the hygiene device are also provided.

Abstract: Systems, methods, and software described herein manage server connection resets based on domain name server (DNS) information. In one implementation, a firewall may receive a reverse DNS request from a computing system and communicate a request to a DNS security service to determine whether a destination associated with the reverse DNS request is malicious. The firewall further receives a response from the DNS security service that indicates that the destination is malicious and, when the response indicates that the destination is malicious, communicates a reset command to the destination to reset a connection between the destination and the computing system.

Abstract: A food composition capable of maintaining a crunchy texture after freezing and reheating is disclosed. The food composition includes a crust or an outer casing having a dough-based matrix or a batter-based matrix with a thickness of about 2 to about 150 mm, and texture modifying particles dispersed throughout the matrix. The texture modifying particles generally comprise about 12 to about 40% by weight of the food composition and provide the food composition with a crunchy texture. The texture modifying particles may be crushed particles of food products, such as fried grain chips, fried vegetable chips, extruded cereals, extruded crackers, or combinations thereof.

Abstract: A system, method and computer-readable storage medium are disclosed herein. The system includes one or more servers, one or more processors and a memory storing computer-readable instructions that, when executed by the one or more processors, cause the system to perform operations. The operations include receiving data and information associated with a user, and executing a first ML algorithm to select which other ML algorithm to execute to determine a value profile associated with a collateral asset. Additional ML algorithms are executed to generate a collateral profile associated with the collateral asset, an activity profile associated with a user, and a household profile associated with the user. Data from among the profiles is combined to generate a digital asset, and advanced analytics are applied to the digital asset, in connection with rules and policies, to identify a user-specific product offering. The user-specific product offering is communicated to the user.

Abstract: An HME device (1) has an outer housing (10) in two parts removably connected with one another by bayonet lugs (17) on one part (13) inserted in bayonet slots (48) on the other part (14) and twisted. An HME unit (50) has a tapered coupling at one end fitted on an internal port (45) in one part (14) so that it can be removed and replaced by separating the two parts of the housing. The outside of the HME unit (50) is spaced from the inside of the housing (10) by an annular bypass channel (55). A selector (31) has a rotatable plate that can be moved to cover either the passage through the HME unit or the bypass channel.

Abstract: A closed system suction catheter (3) is connected with a tracheal tube (1) by means of a Y-shape connector (2) having one port (202) connected with the tracheal tube, a second port (203) connected with a breathing tube (200) and a third port (204) connected with the closed system suction catheter. The third port of the connector includes a normally-closed flap valve (320) that is opened by insertion of the patient end fitting (306) of the closed system suction catheter and closes when the suction catheter is removed from the connector so that ventilation pressure is maintained and contamination is prevented.

Abstract: The present disclosure provides a compound represented by structural Formula (I): or a pharmaceutically acceptable salt thereof useful for treating a cancer.

Abstract: A system for fabricating a dental restoration to restore a tooth at a restoration site in a dentition of a patient is disclosed. The dentition includes a restoration dental arch and an opposing dental arch. The restoration dental arch includes the restoration site and the opposing dental arch is opposite the restoration dental arch. The system includes an impression apparatus, a motion capture apparatus, an interface apparatus, and a restoration design system. The impression apparatus is configured to capture an impression of the dentition of the patient. The motion capture apparatus is configured to capture a plurality of location data points that represent the locations of the opposing dental arch relative to the restoration dental arch. The interference model generation system is configured to generate an interference model for the restoration site. The restoration design system is for designing a restoration using the interference model.

Abstract: An HME device has a housing (10) containing an HME element (25). The device has a first gas-flow passage through the device via the HME element (25) and a second gas-flow passage that by-passes the HME element. Flow is switched between the first or second flow passage by a pivoted shutter (30) that can be displaced by a rotatable knob (32).

Abstract: The technology disclosed herein enables detection of domain hijacking when a DNS resolver is performing a DNS lookup. In a particular embodiment, a method provides, in response to a request to resolve a network address corresponding to a domain name, determining that a nameserver for the domain name is suspect based on satisfaction of nameserver criteria associated with the domain name. The method further includes preventing the nameserver from being used to resolve the request in response to determining that the nameserver is suspect.

Abstract: The present disclosure provides a compound represented by structural Formula (I): or a pharmaceutically acceptable salt thereof useful for treating a cancer.