Abstract: The present invention provides compositions and methods for regulating the BK channel using rottlerin and derivatives thereof. In particular, the present invention provides pharmaceutical compositions for use in treating or preventing BK channel medicated disorders including hypertension and various hyperexcitability disorders. Also provided are compositions and methods for use in post-stroke neuroprotection and in treating or preventing erectile dysfunction. The present invention further provides kits for use in treating or preventing BK channel mediated disorders, comprising the compositions of the present invention.

Abstract: A method is provided for manufacturing an electronically functional structural component adapted to integrate a plurality of electronic functions into a laminate cover, layer, and/or laminate component, for protecting, supporting, and/or forming a complete electronic device (such as a multimedia device). The method includes laminating a plurality of structural and/or protective layers interspersed with electronically functional layers or electronic components in communication with the multimedia device to form a supportive and electronically functional layer, cover, protective layer, and/or electronic device. Thus, the manufacturing methods provided allow for the cost-effective addition of thin and lightweight functional, protective, and/or decorative layers to a multimedia device or other electronic device at a sales location or other customization location.

Abstract: A media player, as may be employed in conjunction with a streaming media enhancement authoring application, is embedded in a browser window. A software program, operable to detect and extract information describing enhancements contained within an enhanced streaming media file and operable to generate HTML or other browser enhancement code to render the enhancements within the browser window as the enhanced streaming media file is played, is also embedded in the browser. The software program may be further operable, in response to enhancement information contained in a streaming media file, to pause a streaming media presentation, open a separate browser window, display a streaming media advertisement in the window, close the window, and resume display of the streaming media presentation. An editor is employed to perform any changes and the modified enhancement may be again viewed prior to viewing a next enhancement.

Abstract: Various disclosures of an oxygen generator apparatus and methods of using such are disclosed.

Abstract: The present invention provides an applicator for directing a flow of medically pure, therapeutic gas onto a selected portion of the body of a patient. The applicator receives the flow of medically pure, therapeutic gas, such as oxygen, from a source, via a conduit coupled to the source and to the applicator. The applicator can be an adhesive bandage having an inlet for receiving the flow of gas, and one or more outlets for directing the flow of gas. The applicator can also be a mask, patch or similar article configured to be applied to the skin of a patient and connected to a source of medically pure, therapeutic gas via a conduit. The applicator can also having other therapeutic materials impregnated therein. The applicator can also be configured to deliver other therapeutic substances introduced into the flow of gas.

Abstract: An apparatus for testing of medical products such as a feminine hygiene product, is presented. The apparatus includes a body, a pump and a vaginal canal assembly. The body includes an internal chamber and a bottom surface having a bore open to the internal chamber. The pump provides a fluid to the body. In one embodiment, the fluid is a menses simulant. The vaginal canal assembly includes an interior canal accepting the product. The vaginal canal assembly includes a passage providing the fluid to the interior canal. The apparatus includes a pressure regulator controlling pressure exerted on the vaginal canal assembly from a volume of air within the internal chamber. The apparatus includes a stand. The stand includes a retaining device and a locking device. The locking device cooperates with the retaining device to selectively secure the body in at least one of a rotational position and an angular position.

Abstract: Grip actuated control system to provide operational control of vehicle functions at a gripping surface of handlebar equipped vehicles. The system can be provided as original equipment and as an aftermarket addition or replacement for existent vehicle controls. The system includes one or more grip controls positioned adjacent a user's fingertips in a grip or glove assembly which are in communication with a control module. The control module is connected to existent or provided vehicle wiring and thus to respective operational equipment such that user actuation of a grip control induces the control module to provide a corresponding output to activate/deactivate or regulate the operation of the respective vehicle equipment. Communication between the grip controls and control module can be wireless for increased flexibility in installation and placement of the module on the vehicle. Combinations, sequences, and relative timing of the grip controls can provide numerous distinct control functions.

Abstract: This invention provides a stent for implantation in a blood vessel or other tissue, wherein the stent is coated with or contains C3 exoenzyme, a chimeric version thereof or an inhibitor of RhoA. This invention also provides a method for treating or inhibiting the onset of restenosis in a subject which comprises implanting one of the instant stents in the subject's blood vessel.

Abstract: A bipolar high output current buffer is disclosed using a negative feedback current mirror to supply the base drive to an output transistor. Small quiescent currents are used wherein the buffer demonstrates low quiescent power dissipation. The current mirror supplies the incremental base drive to the output transistor to support high output currents. When the output drive may source or sink the high output currents, two current mirrors may be used, one for each of the source and the sinking circuitry. This invention provides for minimal loss of dynamic range.

Abstract: This invention relates to a method for testing a plastic sleeve for use with an image cylinder or a blanket cylinder in an electrophotographic process.

Abstract: An orthodontic implant comprised of one or two bony attachments, and, if there are two, one is smaller and affixed to the opposite end of the emerging portion, while the other utilizes a screw placed through an aperture. The smaller affixed portion is a tapered tac with the opposite emerging portion receiving an “O” ring removable cap onto which an adjustable rod can be contoured as needed after the implant has been affixed to bone.

Abstract: A system for moving a refrigeration device is disclosed and includes a frame for supporting the refrigeration device. At least one pair of stationary casters are removably coupled to the frame. At least one pair of adjustable casters are removably coupled to the frame and are adjustable relative to the frame within a range between an extended position and a retracted position. A positioner provided on at least one of the frame and the adjustable casters establishes a position for the adjustable casters relative to the frame within the range, so that the stationary casters and the adjustable casters are capable of providing a desired degree of stability during movement of the refrigeration device and the stationary casters and the adjustable casters are removable following movement of the refrigeration device.

Abstract: This invention provides a stent for implantation in a blood vessel or other tissue, wherein the stent is coated with or contains C3 exoenzyme, a chimeric version thereof or an inhibitor of RhoA. This invention also provides a method for treating or inhibiting the onset of restenosis in a subject which comprises implanting one of the instant stents in the subject's blood vessel.

Abstract: An improved method for producing a metallic core for use in the production of a blanket cylinder or an image cylinder sleeve for use in electrophotographic processes. The sleeves includes aluminum or other suitable metal, which is rendered more suitable for use as a sleeve surface by oxidation.

Abstract: A front plane laminate useful in the manufacture of electro-optic displays comprises, in order, a light-transmissive electrically-conductive layer, a layer of an electro-optic medium in electrical contact with the electrically-conductive layer, an adhesive layer and a release sheet. This front plane laminate can be prepared as a continuous web, cut to size, the release sheet removed and the laminate laminated to a backplane to form a display. Methods for providing conductive vias through the electro-optic medium and for testing the front plane laminate are also described.

Abstract: There is disclosed an antenna device comprising an elongate dielectric radiating element having a longitudinal axis and a feeding mechanism for generating displacement currents in the dielectric radiating element. The radiating element is configured to support displacement current resonance modes parallel to the longitudinal axis but to inhibit displacement current resonance modes transverse to the longitudinal axis.

Abstract: A system for automatically configuring a communication interface module is disclosed. The communication interface module may include a plurality of data link ports and auto-configuration logic. The auto-configuration logic may be configured to determine a data link type for a data link connected to at least one of the plurality of data link ports and determine whether a local configuration file corresponding to the data link type is available. The auto-configuration logic may be configured to acquire a remote configuration file for the data link from an external source if a local configuration file is not available. The auto-configuration logic may configure the communication interface module, using the local configuration file or the remote configuration file, to communicate over the data link.

Abstract: A buffer circuit includes an input terminal operable to receive an input signal and an output terminal at which an output signal for the buffer circuit is provided. In the buffer circuit, three transistors at most provide signal currents. Two of the three transistors can be matched. Means are provided for feeding back the output signal so that the two matched transistors are balanced in response to a change in the input signal appearing at the input terminal.

Abstract: An orthodontic anchor appliance having elongated titanium anchor plate adapted for attachment to bone, anchoring tab formed on the emerging end of the anchor plate, a nontitanium sleeve enveloping the anchoring tab, and an elongated bar attached to the sleeve.

Abstract: A gauge for indicating a measured variable such as pressure. The gauge includes a motion detection device including a drive magnet that is adapted to be moveable in response to changes in the variable. The pointer rotation device includes a pivot member, a power magnet coupled to the pivot member, and one or more director members located adjacent the power magnet. Each director member includes a generally helical flange. A pointer is coupled to the pointer rotation device. The director members and the power magnet form a magnetic field adapted to magnetically couple the pointer rotation device to the drive magnet. The pointer rotation device is adapted to rotate about a rotational axis. Movement of the drive magnet in response to changes in the variable rotates the pointer rotation device and the pointer about the rotational axis such that the pointer indicates the measured variable.