Abstract: A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position (if m=0 then R3 is in position 2?, and if m=1 then R3 is on position 1?); R is ethyl or vinyl; R1 is hydrogen or (C1-6)alkyl, R2 is hydrogen or (C3-6)cycloalkyl, or unsubstituted (C1-6)alkyl, or (C1-6)alkyl substituted by one or more of hydroxy; preferably one or two, methoxy, halogen, and (C3-6)cycloalkyl, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatom e. g.

Abstract: This application provides cross-linked block copolymers comprising at least one block comprising repeating units derived from monomers comprising lactam and acryloyl moieties. The application further provides compositions comprising the block copolymers and applications thereof in various industrial areas including personal care. The application furthermore provides Pickering emulsion compositions comprising the block copolymers.

Abstract: Distributing audio signals from a plurality of audio inputs to a plurality of outputs in response to a user-defined distribution is shown. The user-defined distribution is processed by a layered stack of function matrices, each layer including a two-dimensional array of function nodes. Node functions in a layer are updated in response to user-input signals to implement functionality such as signal masking and signal routing. The user-defined distribution is transformed by processing it through the layered stack to define a transformed distribution. The layered stack facilitates comprehensive mixing facilities on low cost signal processing hardware. The transforming layers include a virtual bus-applying layer to reduce the dimensions of the transformed distribution, minimizing the cost of hardware further.

Abstract: A device for operating a seating arrangement that can be folded out of or into a vehicle. Includes a control unit that receives and executes an activation command by an authorized vehicle user and third parties for folding the seating arrangement out of a region inside the vehicle into a region accessible from outside the vehicle.

Abstract: The invention provides non-crosslinked and crosslinked block copolymers comprising at least one block A comprising repeating units derived from monomers comprising one or more C1-C3 alkyl (meth)acrylamides and/or (meth)acrylates and at least one block B comprising repeating units derived from monomers comprising one or more C4-C40 alkyl (meth)acrylamides. The invention further provides compositions comprising the block copolymers and applications thereof in various industrial areas including personal care. The invention furthermore provides compositions comprising colloidal particles of the block copolymers. The variables x, y, R1, and R2 are described herein.

Abstract: An integrated sensor (110) includes a temperature sensor (202) configured to measure the absolute temperature of internal air exhaled from the body at the nasal ala, and the absolute temperature of external air inhaled into the body at the nasal ala. A system (100) is adapted to estimate an internal (core) temperature and to estimate ambient temperature at an application site of the integrated sensor (110).

Abstract: A system for monitoring a patient is described. The system includes a first sensor disposed at a central site, and adapted to provide a first signal; a second sensor disposed at a distal site, and adapted to provide a second signal; a processor; and a memory that stores executable instructions. When executed by the processor, the instructions cause the processor to: correlate a first perfusion index based on the first signal from the first sensor and a second perfusion index based on the second signal from the second sensor, and determine a trend based analysis of perfusion based on the first signal and in the second signal.

Abstract: The invention provides non-crosslinked and crosslinked block copolymers comprising at least one block A comprising repeating units derived from monomers comprising one or more C1-C3 alkyl (meth)acrylamides and/or (meth)acrylates and at least one block B comprising repeating units derived from monomers comprising one or more C4-C40 alkyl (meth)acrylamides. The invention further provides compositions comprising the block copolymers and applications thereof in various industrial areas including personal care. The invention furthermore provides compositions comprising colloidal particles of the block copolymers. The variables x, y, R1, and R2 are described herein.

Abstract: The invention provides for bifunctional molecules comprising an Rpn11 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Rpn11 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

Abstract: The invention provides a process for removal of a thio-based end group from a polymer comprising repeating units derived from at least one monomer comprising at least one acryloyl moiety and at least one functionalized or unfunctionalized lactam moiety by subjecting the polymer to radiation in a reaction medium devoid of any chemical reagent. Exemplary process involves removal of thio-based end groups from polymers prepared by reversible addition-fragmentation chain transfer polymerization of at least one monomer comprising at least one acryloyl moiety and at least one functionalized or unfunctionalized lactam moiety by exposing the polymer to visible radiation in a reaction medium devoid of any chemical reagent.

Abstract: The invention provides a method for preparation of homopolymers and non-homopolymers comprising polymerizing in an aqueous medium a monomer comprising at least one acryloyl moiety and at least one functionalized or unfunctionalized lactam moiety, and optionally at least one hydrophilic or hydrophobic comonomer, in the presence of at least one chain transfer agent and at least one non-radiation initiator. Exemplary diblock polymers prepared by the method have the structure: where subscripts x, y, and z and variables R, R8, R9 and R10 are described herein.

Abstract: A method for outputting recommendations for energy efficient operation of a vehicle having at least two modes of operation, from which an operating mode is respectively selected by a drive controller, depending on the occurrence of specified triggers, for operating the vehicle. A change of operating mode caused by the trigger is determined. A frequency of the change of operating mode is incremented at every determination of the change of operating mode caused by the trigger. The frequency is analyzed by comparing the frequency of the change of operating mode a predetermined value. A message is generated on a case-by-case basis. The message is output via at least one output comprised by the vehicle.

Abstract: A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position (if m=0 then R3 is in position 2?, and if m=1 then R3 is on position 1?); R is ethyl or vinyl; R1 is hydrogen or (C1-6)alkyl, R2 is hydrogen or (C3-6)cycloalkyl, or unsubstituted (C1-6)alkyl, or (C1-6)alkyl substituted by one or more of hydroxy; preferably one or two, methoxy, halogen, (C3-6)cycloalkyl, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatom e. g. selected from N or O, or R1 is hydroxy and R2 is formyl; R3 is OH, OR4, a halogen atom, or R3 is bound to 2? and represents —O—(CH2)p—O— with p is 2 or 3; R4 is unsubstituted (C1-6)alkyl or (C3-6)cycloalkyl, or a pharmaceutically acceptable salt, solvate, prodrug or metabolite thereof for the specific use in the treatment or prevention of a disease mediated by a virus.

Abstract: A medical device includes a handle; flexible tubing extending from the handle and having a proximal end fixed to the handle; flexible tip attached to the distal end of the flexible tubing; a tip actuator assembly adjusting the bending plane of the tip relative to the distal end and adjusting the degree of bending of the tip in the bending plane; user operable controls on the handle and moveable in a first, rotational direction relative to the handle and to a tip actuator assembly around an axis causing the tip actuator assembly to adjust the bending plane of the tip substantially and moveable relative to the handle and the tip actuator assembly along a second, substantially linear direction towards and away from the proximal end of the flexible tubing, causing the tip actuator assembly to adjust bending of the tip in the bending plane without adjusting the bending plane.

Abstract: An apparatus for producing a three-dimensional object by spray deposition including a powder conveyance line A arranged to channel a flow of spray material entrained in a carrier gas to a nozzle (a first flow). The apparatus also has a process line B arranged to channel a flow of gas to the nozzle (a second flow). The apparatus also has a spray nozzle. The apparatus is such that pressure and temperature parameters of the first flow are controlled in real time, but for the second flow these parameters are not controlled in real time. The two flows merge to cause spray material to be propelled from the nozzle to a substrate to create a three-dimensional object.

Abstract: A method of 3D printing an item, includes printing part of the item in three dimensions on a substrate, reorienting the part with respect to holding means that holds the part or substrate, and printing a further part of the item in three dimensions on the first mentioned part.

Abstract: Described herein is a system and method for utilizing data flow analysis to perform data classification with respect to a source dataset and a generated derived dataset. A flow confidence for a field is calculated using an adaptive algorithm in accordance with the action performed and the derived dataset. An associated derived confidence for a particular tag is calculated in accordance with an associated confidence and the flow confidence. When the associated derived confidence is greater than or equal to a first threshold, the particular tag is copied to the derived dataset. In some embodiments, when the associated derived confidence is less than or equal to a second threshold, the particular tag is not copied to the derived dataset. Otherwise an action to be taken is identified. A response to the action is received and the adaptive algorithm is modified in accordance with the received response.

Abstract: According to one aspect of the present disclosure, a computing device is provided, including non-volatile memory storing a database including a plurality of database entries. The computing device may further include a processor configured to sort the plurality of database entries into a plurality of database entry length sets. For each database entry length set, each database entry included in the database entry length set may be within a predefined length range. For each database entry length set, the processor may be further configured to generate a probabilistic data structure based on the one or more database entries included in the database entry length set.

Abstract: The invention provides for bifunctional molecules comprising an UchL5 binding partner and a target protein binding partner linked via a flexible linker. A bifunctional molecule according to the invention binds to UchL5 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.