Abstract: A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position (if m=0 then R3 is in position 2?, and if m=1 then R3 is on position 1?); R is ethyl or vinyl; R1 is hydrogen or (C1-6)alkyl, R2 is hydrogen or (C3-6)cycloalkyl, or unsubstituted (C1-6)alkyl, or (C1-6)alkyl substituted by one or more of hydroxy; preferably one or two, methoxy, halogen, and (C3-6)cycloalkyl, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatom e. g.

Abstract: This application provides cross-linked block copolymers comprising at least one block comprising repeating units derived from monomers comprising lactam and acryloyl moieties. The application further provides compositions comprising the block copolymers and applications thereof in various industrial areas including personal care. The application furthermore provides Pickering emulsion compositions comprising the block copolymers.

Abstract: Distributing audio signals from a plurality of audio inputs to a plurality of outputs in response to a user-defined distribution is shown. The user-defined distribution is processed by a layered stack of function matrices, each layer including a two-dimensional array of function nodes. Node functions in a layer are updated in response to user-input signals to implement functionality such as signal masking and signal routing. The user-defined distribution is transformed by processing it through the layered stack to define a transformed distribution. The layered stack facilitates comprehensive mixing facilities on low cost signal processing hardware. The transforming layers include a virtual bus-applying layer to reduce the dimensions of the transformed distribution, minimizing the cost of hardware further.

Abstract: A device for operating a seating arrangement that can be folded out of or into a vehicle. Includes a control unit that receives and executes an activation command by an authorized vehicle user and third parties for folding the seating arrangement out of a region inside the vehicle into a region accessible from outside the vehicle.

Abstract: The invention provides non-crosslinked and crosslinked block copolymers comprising at least one block A comprising repeating units derived from monomers comprising one or more C1-C3 alkyl (meth)acrylamides and/or (meth)acrylates and at least one block B comprising repeating units derived from monomers comprising one or more C4-C40 alkyl (meth)acrylamides. The invention further provides compositions comprising the block copolymers and applications thereof in various industrial areas including personal care. The invention furthermore provides compositions comprising colloidal particles of the block copolymers. The variables x, y, R1, and R2 are described herein.

Abstract: An integrated sensor (110) includes a temperature sensor (202) configured to measure the absolute temperature of internal air exhaled from the body at the nasal ala, and the absolute temperature of external air inhaled into the body at the nasal ala. A system (100) is adapted to estimate an internal (core) temperature and to estimate ambient temperature at an application site of the integrated sensor (110).

Abstract: A liquid device generates a liquid jet on an outer region of a motor vehicle. The liquid device includes a liquid outlet via which the liquid jet, generated by a pump and fed from a tank, emerges in the outer region of the motor vehicle. The liquid device also includes a liquid container having a liquid inlet in which the liquid jet emerging from the liquid outlet can be received in the outer region of the motor vehicle and which is connected via a conduit to the tank.

Abstract: A system for monitoring a patient is described. The system includes a first sensor disposed at a central site, and adapted to provide a first signal; a second sensor disposed at a distal site, and adapted to provide a second signal; a processor; and a memory that stores executable instructions. When executed by the processor, the instructions cause the processor to: correlate a first perfusion index based on the first signal from the first sensor and a second perfusion index based on the second signal from the second sensor, and determine a trend based analysis of perfusion based on the first signal and in the second signal.

Abstract: The invention provides non-crosslinked and crosslinked block copolymers comprising at least one block A comprising repeating units derived from monomers comprising one or more C1-C3 alkyl (meth)acrylamides and/or (meth)acrylates and at least one block B comprising repeating units derived from monomers comprising one or more C4-C40 alkyl (meth)acrylamides. The invention further provides compositions comprising the block copolymers and applications thereof in various industrial areas including personal care. The invention furthermore provides compositions comprising colloidal particles of the block copolymers. The variables x, y, R1, and R2 are described herein.

Abstract: The invention provides for bifunctional molecules comprising an Rpn11 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Rpn11 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.

Abstract: The invention provides a process for removal of a thio-based end group from a polymer comprising repeating units derived from at least one monomer comprising at least one acryloyl moiety and at least one functionalized or unfunctionalized lactam moiety by subjecting the polymer to radiation in a reaction medium devoid of any chemical reagent. Exemplary process involves removal of thio-based end groups from polymers prepared by reversible addition-fragmentation chain transfer polymerization of at least one monomer comprising at least one acryloyl moiety and at least one functionalized or unfunctionalized lactam moiety by exposing the polymer to visible radiation in a reaction medium devoid of any chemical reagent.

Abstract: The invention provides a method for preparation of homopolymers and non-homopolymers comprising polymerizing in an aqueous medium a monomer comprising at least one acryloyl moiety and at least one functionalized or unfunctionalized lactam moiety, and optionally at least one hydrophilic or hydrophobic comonomer, in the presence of at least one chain transfer agent and at least one non-radiation initiator. Exemplary diblock polymers prepared by the method have the structure: where subscripts x, y, and z and variables R, R8, R9 and R10 are described herein.

Abstract: A method for outputting recommendations for energy efficient operation of a vehicle having at least two modes of operation, from which an operating mode is respectively selected by a drive controller, depending on the occurrence of specified triggers, for operating the vehicle. A change of operating mode caused by the trigger is determined. A frequency of the change of operating mode is incremented at every determination of the change of operating mode caused by the trigger. The frequency is analyzed by comparing the frequency of the change of operating mode a predetermined value. A message is generated on a case-by-case basis. The message is output via at least one output comprised by the vehicle.

Abstract: The present invention relates to specific types of pharmaceutical formulations and compositions comprising cannabinoids for use in the treatment of various disorders.

Abstract: The present invention relates to specific types of pharmaceutical formulations and compositions comprising cannabinoids for use in the treatment of various disorders.

Abstract: A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position (if m=0 then R3 is in position 2?, and if m=1 then R3 is on position 1?); R is ethyl or vinyl; R1 is hydrogen or (C1-6)alkyl, R2 is hydrogen or (C3-6)cycloalkyl, or unsubstituted (C1-6)alkyl, or (C1-6)alkyl substituted by one or more of hydroxy; preferably one or two, methoxy, halogen, (C3-6)cycloalkyl, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatom e. g. selected from N or O, or R1 is hydroxy and R2 is formyl; R3 is OH, OR4, a halogen atom, or R3 is bound to 2? and represents —O—(CH2)p—O— with p is 2 or 3; R4 is unsubstituted (C1-6)alkyl or (C3-6)cycloalkyl, or a pharmaceutically acceptable salt, solvate, prodrug or metabolite thereof for the specific use in the treatment or prevention of a disease mediated by a virus.

Abstract: A medical device includes a handle; flexible tubing extending from the handle and having a proximal end fixed to the handle; flexible tip attached to the distal end of the flexible tubing; a tip actuator assembly adjusting the bending plane of the tip relative to the distal end and adjusting the degree of bending of the tip in the bending plane; user operable controls on the handle and moveable in a first, rotational direction relative to the handle and to a tip actuator assembly around an axis causing the tip actuator assembly to adjust the bending plane of the tip substantially and moveable relative to the handle and the tip actuator assembly along a second, substantially linear direction towards and away from the proximal end of the flexible tubing, causing the tip actuator assembly to adjust bending of the tip in the bending plane without adjusting the bending plane.

Abstract: A method for outputting recommendations for energy efficient operation of a vehicle having at least two modes of operation, from which an operating mode is respectively selected by a drive controller, depending on the occurrence of specified triggers, for operating the vehicle. A change of operating mode caused by the trigger is determined. A frequency of the change of operating mode is incremented at every determination of the change of operating mode caused by the trigger. The frequency is analyzed by comparing the frequency of the change of operating mode a predetermined value. A message is generated on a case-by-case basis. The message is output via at least one output comprised by the vehicle.

Abstract: A method adapts vehicle functionality that is automatically carried out by an assistance system. In a method in which misunderstandings between driver and vehicle are prevented in predetermined driving situations, when the driver aborts the automatically carried out functionality, this abortion is recorded and saved. If the abortion frequency exceeds a predetermined threshold value, the aborted functionality is replaced by a modified or new functionality.