Abstract: A boot comprises: an outsole and a polymeric upper affixed to the outsole. The upper comprises an upper body and a gusset, which comprises a relaxed position and an expanded position, wherein the gusset moves from the relaxed position to the expanded position to accommodate a wearer's leg upon donning of the boot.

Abstract: A system for protecting a surface of an electronic device includes a protective film and a liner. The protective film includes an adhesive-coated surface. The liner, which covers the adhesive-coated surface until the protective film is secured to the surface of an electronic device, includes a main element that covers a majority of the adhesive-coated surface and a strip element that covers a smaller strip of the adhesive-coated surface, which strip is located adjacent to an edge of the adhesive-coated surface. One or both of the strip element and the main element of the liner may also include a tab for facilitating their removal from the adhesive-coated surface of the protective film. Methods for using the system to apply a protective film to a surface, such as a surface of a display screen, of an electronic device are also disclosed.

Abstract: Enhanced multi-channel sensor interfaces with programmable signal adjustments are provided. An example sensor interface may include an input selector that selects one or more sensor signals from a plurality of sensor signals based on input selection control signal; an offset generator that generates an offset signal based on an offset control signal; and a programmable signal adjuster that adjusts at least one selected sensor signal based on the generated offset signal and a signal adjustment control signal. The sensor interface may include a control interface unit that generates the input selection control signal, the offset control signal, and the signal adjustment control signal. The sensor interface may include a comparator that compares output of the programmable signal adjuster with a reference signal, and provides based on the comparison an output configured for use in performing offset correction. The programmable signal adjuster may generate a number of selectable gains.

Abstract: A cannula insertion tool includes a body having a first end portion, a second end portion, and a grip located between the first end portion and the second end portion. The body defines a channel extending through the first end portion and the grip. The insertion tool also includes a slider having a drive member and an actuator. The drive member is positioned within the channel of the body. The actuator extends outwardly from the second end portion of the body. The insertion tool further includes a needle coupled to the drive member adjacent the first end portion of the body. The needle is movable with the slider between a retracted position, in which the needle is positioned substantially within the first end portion of the body, and an extended position, in which at least a portion of the needle extends outwardly from the first end portion of the body.

Abstract: A traction stud comprises: a carrier comprising a post, a hollow defined by the post that opens at a distal end of the post, and a multi-pronged flange at a proximal end of the post; and a tip bonded in the hollow and extending past the distal end of the post. The carrier may be metal and/or the tip is ceramic. The multi-pronged flange may comprise two or more prongs, each prong having a first face, a second face, a thickness, and one or more holes extending from the first face to the second face, wherein the first and second faces are substantially perpendicular to the post. Outsoles comprise the traction studs and boots and/or overshoes comprise the outsoles. The traction studs are securely retained by polymeric material of the outsoles. The studs penetrate and/or grip slippery surfaces such as ice and packed snow.

Abstract: An intrauterine pressure-sensing catheter for detecting pressure changes within the uterus of a patient is disclosed having a tube with a primary lumen extending from a proximal end to a distal end of the elongate tube. A monitor lumen is positioned within the elongate tube between the primary lumen and a wall of the elongate tube and extends from a proximal end of the elongate tube to a distal end of the elongate tube. A compliant balloon is disposed about an exterior of the elongate tube adjacent a distal end tip. A sleeve is slidably mounted on an exterior of the elongate tube and disposed over the compliant balloon during insertion of the catheter within the patient. The distal end tip is configured to prevent movement of the sleeve over the tip and is further configured to provide a zone of protection for the compliant balloon.

Abstract: A zip includes: a pair of stringer tapes, each of which supports a row of teeth; the teeth on the two tapes being mutually opposing and capable of interdigitation thereby to fasten one stringer tape to another; a slider, adapted to move along and whose motion is guided by the rows of teeth, the slider being adapted to cause interdigitation of the teeth as a result of motion along the teeth in a first direction, and to disconnect the teeth by motion along the teeth in a second direction; wherein the first and second stringer tapes are formed of a matrix of threads interspersed with a waterproof material.

Abstract: A zip fastener comprises two opposing and mutually engageable rows of zip teeth each being mounted upon a respective stringer tape; first and second sliders movably mounted upon the teeth, each slider being movable forward along the teeth to cause interdigitation of the teeth thereby to fasten the zip and backwards to cause extradigitation and unfastening of the zip, the sliders being mounted on the teeth in opposing directions such that motion of the sliders towards and away from each other results in the same action (e.g. fastening or unfastening) on the zip teeth; a docking member, mounted upon the teeth and being movable along the teeth, the docking member being mounted between the two sliders; and each slider being engageable with the docking member thereby to fasten the zip.

Abstract: A safety barrier system for use in roofing and other roof-top projects requiring perimeter safety fencing or railing. Multiple, adjustable components allow for separation of support members from a rooftop deck for application of roofing material, adaptation for installations involving a varieties of rooftop perimeter configurations and obstacles, and, in some embodiments, later reinstallation without requirements for reinstallation of building side anchor components.

Abstract: A highly integrated programmable sensor interface with improved sensor signal calibration and conditioning functions is described. The programmable sensor interface according to the present invention sensor interface provides programmable gain, digital offset correction and bias for one or more signal channels on one chip on a per channel basis. According to another aspect of the invention, the sensor interface provides reference voltage and sensor biasing by using an on-chip precision voltage regulator. According to one aspect of the invention, multiple inputs are multiplexed and each is applied to a variable gain instrumentation amplifier, which connects to the output. The offset of a given channel is controlled by an on-chip DAC which has multiple digital storage registers, allowing each channel to have a unique, stored offset. Offsets and gains are programmed externally.

Abstract: The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor metabolite. Catecholic butane metabolites can serve as dual kinase inhibitors for purposes of methods described herein.

Abstract: A highly integrated programmable sensor interface with improved sensor signal calibration and conditioning functions is described. The programmable sensor interface according to the present invention sensor interface provides programmable gain, digital offset correction and bias for one or more signal channels on one chip on a per channel basis. According to another aspect of the invention, the sensor interface provides reference voltage and sensor biasing by using an on-chip precision voltage regulator. According to one aspect of the invention, multiple inputs are multiplexed and each is applied to a variable gain instrumentation amplifier, which connects to the output. The offset of a given channel is controlled by an on-chip DAC which has multiple digital storage registers, allowing each channel to have a unique, stored offset. Offsets and gains are programmed externally.

Abstract: A method of inhibiting drug-resistant HIV-1 integrase in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is N, C(OH), or CH; Y is H or OH; each of Z1-Z5 is independently H or halogen; R4 is H, OH, NH2, NHR8, NR8R9 or R8; R5, R6, and R7 is each independently H, halogen, OR8, R8, NHR8, NR8R9, CO2R8, CONR8R9, SO2NR8R9, or R5 and R6 together with the carbon atoms to which R5 and R6 are attached form an optionally-substituted carbocycle or optionally-substituted heterocycle; and R8 and R9 is each independently H, optionally-substituted alkyl, optionally-substituted alkenyl, optionally-substituted alkynyl, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted cycloalkylene, optionally-substituted heterocycle, optionally-substituted amide, optionally-substituted ester, or R8 and R9 together with the nitrogen t

Abstract: Telemedicine systems and methods are described. In a telemedicine system operable to communicate with a remote operations center, communications can be transmitted/received using a transceiver having an antenna. The antenna can include first and second di-pole antenna elements, the first di-pole antenna element being vertically polarized and the second di-pole antenna element being horizontally polarized. A controller of the system can establish, using the transceiver, a telemedicine session with the operations center using a Transport Morphing Protocol (TMP), the TMP being an acknowledgement-based user datagram protocol. The controller can also mask one or more transient network degradations to increase resiliency of the telemedicine session.

Abstract: A liquid formulation of (S)—N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the liquid formulation in the treatment of pain, cancer, inflammation, and certain infectious diseases are disclosed.

Abstract: An instrument for processing a biological sample includes a chassis. Connected to the chassis is a tape path along which a tape with a matrix of wells can be automatically advanced through the instrument, a dispensing assembly for dispensing the biological sample and a reagent into the matrix of wells of the tape to form a biological sample and reagent mixture, a sealing assembly for sealing the biological sample and reagent mixture in the tape, and an amplification and detection assembly for detecting a signal from the biological sample and reagent mixture in the matrix of wells in the tape.

Abstract: A method of inhibiting drug-resistant HIV-1 integrase in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is N, C(OH), or CH; Y is H or OH; each of Z1-Z5 is independently H or halogen; R4 is H, OH, NH2, NHR8, NR8R9 or R8; R5, R6, and R7 is each independently H, halogen, OR8, R8, NHR8, NR8R9, CO2R8, CONR8R9, SO2NR8R9, or R5 and R6 together with the carbon atoms to which R5 and R6 are attached form an optionally-substituted carbocycle or optionally-substituted heterocycle; and R8 and R9 is each independently H, optionally-substituted alkyl, optionally-substituted alkenyl, optionally-substituted alkynyl, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted cycloalkylene, optionally-substituted heterocycle, optionally-substituted amide, optionally-substituted ester, or R8 and R9 together with the nitrogen t

Abstract: Embodiments in accordance with the present invention provide for the use of polycycloolefins in electronic devices and more specifically to the use of such polycycloolefins as interlayers applied to fluoropolymer layers used in the fabrication of electronic devices, the electronic devices that encompass such polycycloolefin interlayers and processes for preparing such polycycloolefin interlayers and electronic devices.

Abstract: Embodiments in accordance with the present invention provide for the use of polycycloolefins in electronic devices and more specifically to the use of such polycycloolefins as gate insulator layers used in the fabrication of electronic devices, the electronic devices that encompass such polycycloolefin gate insulator and processes for preparing such polycycloolefin gate insulator layers and electronic devices encompassing such layers.