Abstract: File selection techniques that can handle overlapping module contexts provide flexible and reversible backup, restore, migration, deployment and synchronization operations. Both remote (administrative) control and local (user) control of the file selection are provided. Application and configuration specific templates are provided to a user from the remote administrator for further customization by selecting or de-selecting configurations, applications and/or individual files or configuration entries. The templates may be controlled geographically by the IP address or identity associated with the user. A user's interaction with the customization is saved and the order of changes is maintained, so that when the templates are updated, the user's customizations can be re-applied. The administrator may override user settings based on rules, which may also be geographically determined. The file selection may also be altered based on media type and location, e.g., local backup vs. server backup.

Abstract: A system and method for controlling a vehicle include a manual transmission operated by a controller in communication with shift actuators and programmed to, in response to each controller reset less than a threshold number of resets, control each shift actuator that was not moving at the time of the reset based on respective shift actuator positions stored prior to the reset, and to control the shift actuators to limit available gear ratios in response to the reset exceeding the threshold number of resets.

Abstract: An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.

Abstract: A low power amplifier architecture that employs a single-ended (single triode) push-pull (SEPP) vacuum tube and output transformer arrangement, and that cancels unwanted amplifier signal components such as hum and noise. The SEPP amplifier operates to cancel power supply ripple and local EMI induced noise in the output transformer by providing reverse polarity of the primary coils of the output transformer.

Abstract: Laser-personalizable security articles include multi-layer security documents. The multi-layer security document includes an optically transparent cover layer, a composite image and an imagable layer adjacent to the cover layer. The first surface of the cover layer is at least partially a microstructured surface, where the microstructured surface forms microlenses or a lenticular surface. The composite image is made by a collection of complete or partial images viewed through the microstructured surface of the cover layer. The composite image is located on or within the second surface of the cover layer. The imagable layer is a laser imagable layer. When imaged, a personalized second composite three dimensional image is created on or in the imagable layer.

Abstract: Pairing data associated with a second device may be received at a first device. The pairing data may be received from a server. A first authentication proof may be generated based on the pairing data received from the server. A second authentication proof may be received from the second device. Furthermore, an authentication status of the second device may be updated based on a comparison of the first authentication proof that is based on the pairing data received from the server and the second authentication proof that is received from the second device.

Abstract: A method and apparatus for managing a subscription to a plurality of content providers and the irretrievably referring users to an interface of the content provider to directly consume media programs provided by the content providers is disclosed. The method irretrievably passes users to content providers so that the user can view media programs from those content providers using the content provider's application, while providing a central source for users to locate media programs available from a plurality of content providers and to subscribe for access to such media programs. This construct permits content providers to retain control over the user viewing experience and to encourage the user to view further media programs from the same content provider.

Abstract: Disclosed is a compound of formula (I): crystalline forms thereof, and solvates thereof; pharmaceutical compositions comprising a pharmaceutically effective amount of the compound of formula (I), or a crystalline form thereof, or a solvate thereof, and a pharmaceutically acceptable carrier or diluent; and the use of a compound of formula (I), or a crystalline form thereof, or a solvate thereof, for treating a patient suffering from, or subject to, a pathological condition capable of being ameliorated by inhibiting an E1 activating enzyme, particularly NAE, including, e.g., cancer.

Abstract: Methods and devices for altering the power of a lens, such as an intraocular lens, are disclosed. In one method, the lens comprises a single polymer matrix containing crosslinkable pendant groups, wherein the polymer matrix increases in volume when crosslinked. The lens does not contain free monomer. Upon exposure to ultraviolet radiation, crosslinking causes the exposed portion of the lens to increase in volume, causing an increase in the refractive index. In another method, the lens comprises a polymer matrix containing photobleachable chromophores. Upon exposure to ultraviolet radiation, photobleaching causes a decrease in refractive index in the exposed portion without any change in lens thickness. These methods avoid the need to wait for diffusion to occur to change the lens shape and avoid the need for a second exposure to radiation to lock in the changes to the lens.

Abstract: This disclosure relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants, such as compounds of Formula (I):

Abstract: The present invention relates to novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds of the invention are storage stable, water soluble and have low to no odor. Further, the compounds of the present invention can be formed from non-petroleum based renewable materials. The compounds of the present invention can be used as antimicrobials, and bleaching agents. The compounds of the present invention are also suitable for use as coupling agents.

Abstract: Methods of electroplating metal on a substrate while controlling azimuthal uniformity, include, in one aspect, providing the substrate to the electroplating apparatus configured for rotating the substrate during electroplating, and electroplating the metal on the substrate while rotating the substrate relative to a shield such that a selected portion of the substrate at a selected azimuthal position dwells in a shielded area for a different amount of time than a second portion of the substrate having the same average arc length and the same average radial position and residing at a different angular (azimuthal) position. For example, a semiconductor wafer substrate can be rotated during electroplating slower or faster, when the selected portion of the substrate passes through the shielded area.

Abstract: An electrically controlled spectacle includes a spectacle frame and optoelectronic lenses housed in the frame. The lenses include a left lens and a right lens, each of the optoelectrical lenses having a plurality of states, wherein the state of the left lens is independent of the state of the right lens. The electrically controlled spectacle also includes a control unit housed in the frame, the control unit being adapted to control the state of each of the lenses independently.

Abstract: Disclosed are compositions containing chemical constituents from plants, uses of these compositions and methods for making them. In various embodiments, the present invention relates to an improved modes of administration of herbal remedies.

Abstract: An apparatus for connecting a mobile device to a vehicle-based network includes a USB or similar accessory connector enclosed in a protective housing. The connector housing may include a Bluetooth or similar wireless connector for establishing a wireless link between the mobile device and the vehicle-based network via the USB port. The connector housing may include a hinged panel allowing access to the USB connector while open, and securing the USB connector to a USB port of the mobile device while closed. The connector housing may include a flexible impact absorber for isolating the connector from shocks or vibrations conducted by the vehicle mount by which the mobile device is mounted to a dashboard or interior surface of the vehicle.

Abstract: Disclosed herein are novel charge mode readout circuits and associated methods of signal processing. The devices and methods of the invention allow for the improved processing of stored signals by a charge mode readout amplifier, wherein the readout level may be shifted to a desired range and wherein a fully differential output swing may be imparted. The invention advantageously employs a single pair of capacitors to serve the dual roles of modulating amplifier gain and level shifting the output.

Abstract: Certain exemplary embodiments can provide a method comprising automatically rendering a message to a webpage user, the message created by a webpage operator via an automatic merger of a customized message content that corresponds to a message-generator-selected message identifier with a message template that corresponds to a message-generator-selected message template identifier, the message-generator-selected message identifier and the message-generator-selected message template identifier provided by the message generator to the webpage operator responsive to receipt of data gathered from the webpage user by the webpage operator.

Abstract: Methods and systems are described for generating a vehicle-to-vehicle traffic alert and updating a vehicle-usage profile. Various aspects include detecting, via one or more processors associated with a first vehicle, that an abnormal traffic condition exists in an operating environment of the first vehicle. An electronic message is generated and transmitted wirelessly, via a vehicle-mounted transceiver associated with the first vehicle, to alert a nearby vehicle of the abnormal traffic condition and to allow the nearby vehicle to avoid the abnormal traffic condition. The first vehicle receives telematics data regarding operation of the nearby vehicle after the nearby vehicle received the electronic message, and transmits the telematics data to a remote server for updating a vehicle-usage profile associated with the nearby vehicle.