Abstract: The present invention relates to the preparation of carbamoylpyridone derivatives such as the compound of formula (VIIIa):

Abstract: A television playout system provided in a broadcast provider system receives a playout schedule, which corresponds to a live video feed of a channel broadcasted to one or more multichannel video program distributors (MVPDs), from a playout schedule source, and generates a new channel comprising one or more video on demand (VOD) content assets, based on one or more scheduling rules of the playout schedule, to be transmitted to a plurality of MVPDs at a time specified in the received playout schedule. The received live video feed of the channel is sanitized by removal of a lower third graphical content overlay from the live video feed for the generation of the new channel. A discontinuity is inserted between program segments to allow dynamic ad insertion (DAI) within the program segments of the live video feed for the new channel.

Abstract: Apparatus and method are provided for tying together an HTTP request to a function in the database which returns media data. The invention provides for receiving an HTTP request for data from a web client, wherein the HTTP request includes a URL and dynamic values specific to the web client. The URL can be parsed to determine the resource path and parameters, if any exist. Many databases have functions, also referred to as logical elements, built into the database that can be called to retrieve data. The database function specified in the URL is called using the specified parameters, if any exist, and using the dynamic values from the client. The results can be streamed to the user.

Abstract: A wellbore tool is provided that can withstand applied pressure tests without becoming hydraulically actuated. The wellbore tool includes a tubular housing including an inner bore; a tool mechanism responsive to fluid pressure; and an indexing mechanism that indexes responsive to tubing pressure cycles of at least an indexing pressure. The indexing mechanism is configured to activate the tool mechanism after a preset number of indexes. The wellbore tool can be pressure tested at pressures above an activation pressure without activating the tool mechanism.

Abstract: A container for forming a solution for use in a hemodialysis device comprises a first portion comprising a powder, a second portion disposed separate from and in fluid communication with the first portion, and a filter disposed between the first portion and the second portion. The container is configured to receive a fluid flow into the first portion to at least partially dissolve the powder thereby forming a solution, such that the solution and at least a portion of the dissolved powder is passable through the filter into the second portion, and further such that any undissolved portion of the powder is not passable through the filter into the second portion. The filter may be configured such that the solution of the fluid and the at least the portion of the dissolved powder is filtered into the second portion of the container is homogenous.

Abstract: Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

Abstract: Methods of analyzing glycosylated biomolecules include the steps of producing a deglycosylation mixture of biomolecules deglycosylated by natural or synthetic enzymatic or chemical techniques; providing a reagent solution having a labeling reagent in a polar aprotic, non-nucleophilic organic solvent; and mixing the deglycosylation mixture with the reagent solution in an excess of labeling reagent to produce derivatized glycosylamines. The method steps can be carried out purposefully without depletion of protein matter. A quenching solution can be added to the reaction mixture so that the pH of the reaction mixture is shifted to above 10. The yield of derivatized glycosylamines can be in an amount of about 80 to about 100 mole percent of the reaction mixture with minimal overlabeling, less than 0.2 mole percent.

Abstract: Calendar management devices and systems are disclosed that are configured with hardware to generate a calendar object and a calendar share identifier associated with the calendar object, and to cause the calendar share identifier to be provided to each of a plurality of calendar users. User input is received indicating a new event associated with the calendar object, and in response to the user input, the device(s) are configured to determine an authorization level of the new event based on the user input, generate a calendar event object comprising the authorization level, and automatically send a publication request to a remote server over a network, wherein said sending the publication request directs the remote server to determine a subset of the plurality of calendar users based on the authorization level and to send the event object to each of the subset of the plurality of calendar users.

Abstract: Disclosed herein are conjugated polymers comprising a polymer and an all-trans retinoic acid (ATRA) prodrug covalently bound to the polymer by a hydrolysable linker L or a pharmaceutically acceptable salt thereof, and methods of using same to treat certain disorders. In an embodiment, the conjugated polymer comprises poly (vinyl alcohol) covalently bound to ATRA through an ester linkage.

Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.

Abstract: Systems and methods are provided for indicating schedules in welding-type torches. A welding-type system may comprise a welding-type power source, a welding-type torch, driven by the welding-type power source, and a welding-type connector configured for connecting the welding-type power source to the welding-type torch. The welding-type torch may comprise one or more indication components configured for providing, to a user of the welding-type system, indications relating to at least one of operations of the welding-type torch, status of welding-type operations, or welding-type parameters. The one or more indications comprise an indication of a present value of a particular welding-type parameter that pertains to configuration of the welding-type power source; and the one or more indication components are configured to provide the indication of present value of the particular welding-type parameter without requiring a change to structure of the welding-type connector.

Abstract: Provided are compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

Abstract: A system and method for determining hierarchical link quality metrics in a communication system, and performing different routines to optimize operation of the communication system based on the link quality metrics. Data is collected for a predetermined interval, and a carrier link quality is determined for each terminal utilizing different carriers in the communication system. A link quality is determined for each terminal type, and a beam link quality is determined for each beam in the system. Different thresholds are set so that optimization routines can be performed based on the current link quality values.

Abstract: Provided herein are compounds of the General Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.

Abstract: An improved version of the capillary bridge viscometer that compensates for the effect of solvent compressibility is disclosed. A novel, yet simple and inexpensive modification to a conventional capillary bridge viscometer design can improve its ability to reject pump pulses by more than order of magnitude. This improves the data quality and allows for the use of less expensive pumps. A pulse compensation volume is added such that it transmits pressure to the differential pressure transducer without sample flowing there through. The pressure compensation volume enables the cancelation of the confounding effects of pump pulses in a capillary bridge viscometer.

Abstract: A power converter for converting direct current (DC) power to alternating current (AC) power includes a first power converter section and a second power converter section connected in parallel with the first power converter section. A power rating of the first power converter section is substantially greater than a power rating of the second power converter section. A controller is operatively coupled to the first power converter section and the second power converter section, the controller configured to enable at least the first power controller section when a power demand placed on the power converter exceeds a prescribed power level, and disable the first power controller and enable the second power controller section when the power demand placed on the power converter is below the prescribed power level. An advantage of the power converter in accordance with the present disclosure is that it minimizes parasitic losses associated with larger power sections of the converter.

Abstract: A system to control an electrical device, such as a lighting component or set of components. The system may include a set of connection lines, a power control module and a load interface component. The power control module is responsive to an alternating current source being connected to one of a first connection line or a second connection line, to provide a regulated voltage signal output. A load interface component receives the regulated voltage signal output to control the load device.

Abstract: An analysis system may perform operations on an analyte that may be combined with multiple regents prior to being introduced into a flow cell. The instrument may include a volume into which the reagents to be combined with the analyte are aspirated one-by-one. The volume may be formed as a serpentine channel in a valve manifold associated with sippers for aspirating the reagents. The reagents may then be mixed by cycling a pump to move the reagents within the mixing volume or channel.

Abstract: Kits for assaying response to platelet-activating factor receptor (PAFR) to stress and/or bacterial challenge, along with various methods for detecting PAFR response to stress and/or bacterial challenge in animals in order to detect or predict an animal's susceptibility to BRD are disclosed.

Abstract: An apparatus for moving a display rack, merchandise table and/or merchandise fixture include a dolly device having a vertical member, a horizontal support member, at least one hook and two legs connected to wheels.