Abstract: A medical device securement system is configured to secure medical devices such as catheters in place. The securement system includes an anchor pad that attaches to a patient's skin. A malleable support base is attached to an upper surface of the anchor pad. The support base has front and back inclined surfaces that are separated by an offset surface that extends generally normal to both of the inclined surfaces. A spot of adhesive is applied to one or more of the inclined surfaces. A catheter assembly includes a connector having a first connector portion with a diameter larger than an adjacent second structure. The catheter assembly is attached to the support base with the first connector portion engaged with and supported by the back inclined surface, and the second connector portion engaged with and supported by the front inclined surface.

Abstract: A fiber optic closure assembly includes a base having an opening for receiving an incoming fiber optic cable along a longitudinal axis. A perimeter shoulder extending outwardly from a substantially planar surface of the base. A housing is dimensioned for receipt on the base and has a cover that when joined to the base encloses a cavity. The housing includes a substantially planar wall with at least one opening therethrough parallel to the longitudinal axis and through which an associated bulkhead may be mounted to provide operative communication between an optical fiber operatively connected to the incoming fiber optic cable and an outgoing drop line.

Abstract: We disclose a device that both extracts and preconcentrates volatile analytes in preparation for separation by gas chromatography. The device includes a conduit that may include two, and sometimes three, separate sections that are connected end-to-end, but which may be separated prior to inserting into a gas chromatograph port. The inner surface of each section is coated with one or more sorbents, each with a different affinity for volatile analytes. The sorbents may be positioned along the sections of the column in order of relative affinity for volatile analytes. The sections may be heated independently of each other to release the volatile analytes from the sorbents more quickly. This device reduces the time and the temperature required to achieve separation by gas chromatography. The device may be used to perform gas chromatography in ubiquitous environments such as the home or a mobile situation.

Abstract: A delivery device is for intermittently delivering materials such as liquids or gels over a sustained period of time to a surface in a controlled way. The surface mountable delivery device is capable of delivering, an antimicrobial agent to protect surfaces from microbial contamination and/or to disinfect surfaces, e.g. door handles, push plates, hand rails, etc. as an aid in preventing and/or hindering the spread of infectious agents. The device uses a vertically lapped nonwoven material as the storage medium for the liquid or gel like materials within the device. A non-wicking liquid mediating layer controls transfer of liquid from a reservoir to a contact surface of the device to minimize liquid losses. An elastomeric contact liquid delivery layer is optimized for printability. Use of physical features at the device contact surface prevents pore occlusion on user contact and aids flow of liquid to the contact user.

Abstract: A vapor delivery device is provided that may include any of a number of features. One feature of the vapor delivery device is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate tissues of the prostate. The vapor delivery device can include a handle portion and a cartridge portion. The cartridge portion can be configured to be inserted into a lumen of the handle portion to align and position a vapor coil of the cartridge portion within a RF coil of the handle portion. Methods associated with use of the energy delivery probe are also covered.

Abstract: A tile-based graphics system has a rendering space sub-divided into a plurality of tiles which are to be processed. Graphics data items, such as parameters or texels, are fetched into a cache for use in processing one of the tiles. Indicators are determined for the graphics data items, whereby the indicator for a graphics data item indicates the number of tiles with which that graphics data item is associated. The graphics data items are evicted from the cache in accordance with the indicators of the graphics data items. For example, the indicator for a graphics data item may be a count of the number of tiles with which that graphics data item is associated, whereby the graphics data item(s) with the lowest count(s) is (are) evicted from the cache.

Abstract: An ported marinade injection system useful for injecting flavoring fluids into vacuum-packaged meats. The apparatus may include a package couple, a port support couple, an injection port, a self-sealing port, and a port cover. The apparatus may be used by attaching the package couple and the port support couple to a package, attaching the self-sealing port and the injection port to the port support couple, injecting a marinade or other flavoring, and covering the port to seal the flavoring within the package.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: A leadframe includes a plurality of interconnected support members. A pair of die pads is connected to the support members and configured to receive a pair of dies electrically connected by at least one wire. A support bracket extends between the die pads and includes a surface for maintaining the at least one wire at a predetermined distance from the die pads during overmolding of the leadframe.

Abstract: A method and system for performing a unit test in a self-contained environment. The system may include using an object relationship mapping file to generate data objects that can be used for code for a unit test without having to refer to a database to perform a unit test. The data objects may further provide for simultaneous unit tests and a self-contained environment to perform the unit tests to improve the quality and resources required to perform such unit tests. The system may perform the unit tests independent of access to a database.

Abstract: The present disclosure relates to sensor systems for electronic ophthalmic devices. In certain embodiments, the sensor systems may comprise a first electrode configured to be selectively overlaid by one or more of an upper eyelid and a lower eyelid of a user, a second electrode configured to be selectively overlaid by one or more of an upper eyelid and a lower eyelid of a user, and a system controller cooperatively associated with the first electrode and the second electrode to receive a capacitance measurement therefrom, the system controller configured to determine a position of one or more of the upper eyelid and the lower eyelid in spatial coordinates based on the capacitance measurement received from the first electrode and the second electrode.

Abstract: A piston for a hydraulic hammer assembly is provided. The piston may include an elongate member extending from a distal end to a proximal end and having a first outer diameter, a flange disposed on the elongate member and having a second outer diameter greater than the first outer diameter, and a non-ferrous shoe radially disposed on the flange.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a patient involves obtaining, by a control system associated with the infusion device, user input indicating an activity by the patient, obtaining historical data for the patient corresponding to the activity, determining a probable patient response corresponding to the activity based at least in part on the historical data for the patient, determining an adjustment for delivering the fluid by the infusion device based at least in part on the probable patient response, and operating the infusion device to deliver the fluid to the patient in accordance with the adjustment.

Abstract: Provided are methods for screening a subject for cancer. The methods involve obtaining a blood sample from the subject and determining a level of Bridging Integrator 1 (BIN1) isoforms comprising exon 12a in the sample. Optionally, the method involves determining a level of 12a+/13? BIN isoform (comprising exon 12a but lacking exon 13) in the sample. An elevated level of 12a+(e.g., 12a+/13?) BIN1 isoforms in the blood sample indicates the subject has cancer. Also provided are methods for determining efficacy of a cancer therapy in a subject and methods of treating cancer. Isolated antibodies that selectively bind human 12a+ BIN1 are also provided as well as kits for determining 12a+/13? BIN1 isoforms.

Abstract: An indication system associated with a coupler assembly is provided. The indication system includes a sensing element affixed to the coupler assembly. The sensing element is arranged and positioned proximate to a hydraulic assembly of the coupler assembly. The sensing element is configured to generate a signal indicative of an extension of a piston pin of the hydraulic assembly. The indication system also includes an indicator assembly coupled to the sensing element. The indicator assembly is configured to receive the signal indicative of the extension of the piston pin. The indicator assembly is also configured to determine if the piston pin is in an extended state based on the received signal.

Abstract: A portable display supports gift wrap rolls, and optional accessories, such as ribbon bows and/or adhesive tape dispensers. The wrapping paper roll displays disclose stash the rolls vertically as in a first embodiment, as well as to stack in the rolls horizontally in a further embodiment. The portable displays holds rolls of gift wrapping paper, and optionally decorative ribbon bow packages, and/or adhesive tape dispensers. A top panel above the top of the vertically supported gift wrap rolls supports gift wrap ribbon bows on displays. The portable gift wrap roll display panels have cutout, foldable, C-shaped restraint portions which are bent outwardly and upwardly from the flat panel with a recess provided therein for insertion of one or more gift wrap rolls therein.

Abstract: A method for treating autism. Light energy is applied externally to a patient's scalp on the skull near the frontal lobes. Optionally the light is also applied to the temporal lobes and the base of the brain. The treatment can be enhanced by activating the cranial nerves while the light is applied. In a preferred embodiment the applied light is in the red range and more preferably about of 635 nm±10 nm. In a preferred embodiment, the applied light energy is applied with a pulse frequency or frequencies of 8 Hz, 53 Hz, 73 Hz and 101 Hz. The light can be emitted from the same light emitter or from multiple emitters. Preferably the light is laser light and is emitted as a line from a hand-held laser device, and the line is waved manually across a person's skull in the desired area in a continuous, sweeping manner.

Abstract: Provided is a process of configuring a dashboard of a graphical user interface, the process including: obtaining identifiers of metrics; obtaining features that are properties of the metrics; accessing in a graph-effectiveness matrix effectiveness scores corresponding to the features; selecting a plurality of graphs to graphically represent the metrics in a dashboard; and instructing a computing device to display the dashboard.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed towards wound dressings comprising a liquid and gas permeable transmission layer, an absorbent layer for absorbing wound exudate, the absorbent layer overlying the transmission layer, a gas impermeable cover layer overlying the absorbent layer and comprising a first orifice, wherein the cover layer is moisture vapor permeable. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: The present disclosure relates to atomizers for an aerosol delivery device such as a smoking article. The atomizer may include a liquid transport element and a wire extending along at least a portion of a longitudinal length thereof. The wire may define contact portions configured to engage heater terminals and a heating portion configured to produce heat. The heating portion may include a variable coil spacing. In other atomizers, the wire may extend at least partially through the liquid transport element proximate the contact portions. Related inputs, cartridges, aerosol production assemblies, and methods of forming atomizers are also provided.