Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract: A system which creates a disable seal between adjacent horizontal panels, including those that may be curved or subject to temperature expansion and contraction or mechanical shear. The durable seal system incorporates a plurality of ribs, a flexible member between the cover plate and the ribs and may incorporate a load transfer plate to provide support, to the rib from below, and/or cores of differing compressibilities.

Abstract: An example shopping cart is described. The example shopping cart includes a frame, a basket portion mounted to the frame, two or more wheels mounted to the frame for transporting the shopping cart within a geographic area, and an assistance unit mounted to the frame. The assistance unit includes a radio-frequency identification tag configured to transmit a signal for receipt by a radio-frequency identification reader. The assistance unit includes an actuator configured to be selectively actuated between a first position that prevents the radio-frequency identification tag from transmitting the signal from the assistance unit and a second position that facilitates transmissions of the signal from the assistance unit.

Abstract: A system and method for detecting a phase-to-ground fault in an AC electrical machine operates to receive measurements of three-phase voltages and currents provided to the AC electrical machine, compute at least one of a zero sequence component and a negative sequence component of voltage and current from the three-phase voltages and currents, and calculate a fault severity index (F SI) based on the zero or negative sequence component of voltage and current, so as to identify a phase-to-ground fault in the AC electrical machine. Calculating the FSI further includes determining a total value of the zero or negative sequence current, determining a noise-contributed value of the zero or negative sequence current included in the total value, determining a compensated value of the zero or negative sequence current based on the total value and the noise-contributed value, and calculating the FSI based on the compensated value.

Abstract: A temperature control system, the system comprising a cooling block configured to be in conductive communication with a heat source, said cooling block comprising a stem and a base, a cooling fluid configured to circulate through the base of the cooling block, and an electrical barrier formed in the base of the cooling block between the heat source and the cooling fluid.

Abstract: Wafers for fabrication of devices that include a body contact, device structures with a body contact, methods for forming a wafer that supports the fabrication of devices that include a body contact, and methods for forming a device structure that includes a body contact. The wafer includes a buried oxide layer and a semiconductor layer on the buried oxide layer. The semiconductor layer includes a section with a top surface and a plurality of islands projecting from the section of the semiconductor layer into the buried oxide layer. The section of the semiconductor layer is located vertically between the islands of the semiconductor layer and the top surface of the semiconductor layer.

Abstract: The present disclosure is generally directed to profiling peptides, compositions, and kits, as well as methods of use thereof. The profiling peptides comprise an Mcl-1 binding domain, and optionally a cellular uptake moiety. The methods of using such profiling peptides include predicting sensitivity of a cancer, selecting a treatment, treating a cancer, producing a sensitivity profile, and the like.

Abstract: A hydrofoil and hydrofoil system for a surfboard is disclosed. The surfboard has a planar hull defined by a top surface, a bottom surface, a nose, a tail, and opposing side rails extending from the nose to the tail and that define a transition from the top surface to the bottom surface. The hydrofoil system includes one or more attachment mechanisms mounted with the planar hull at or proximate to at least one of the opposing side rails of the planar hull, each of the one or more attachment mechanisms comprising an attachment site oriented substantially laterally from the planar hull. The hydrofoil system further includes a hydrofoil configured to attach to the attachment site of one of the one or more attachment mechanisms, the hydrofoil further being configured to extend substantially laterally from the planar hull at or proximate to the at least one of the opposing side rails of the planar hull.

Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with autoinflammatory diseases such as psoriasis. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.

Abstract: The present disclosure relates to correcting misalignment of image data within an overlap region in acquired scan data. By way of example, systems and methods for applying a post-reconstruction interpolation are described to correct mis-registration of features within overlap regions in either sequentially acquired axial scans or single scan acquisitions.

Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections.

Abstract: A method for installing a mounting hole through a wall of a fan case of a gas turbine engine is disclosed. The method may comprise: 1) installing a pilot hole through the wall of the fan case at an angle perpendicular to an outer surface of the wall, 2) inserting a boss through the pilot hole, 3) bonding the boss to the wall of the fan case, and 4) installing the mounting hole through the boss at an off-axis angle with respect to the angle perpendicular to the outer surface of the wall.

Abstract: A device includes a handle, an expandable structure including a plurality of splines extending from a proximal hub to a distal hub, a first electrode on a first spline of the plurality of splines, an outer tube extending from the handle to the proximal hub, and a shaft extending through the outer tube from the handle to the distal hub. The expandable structure has a collapsed state and a self-expanded state. The handle is configured to retract the shaft. Retracting the shaft may expand the expandable structure outward of the self-expanded state.

Abstract: A spray gun adapter establishes fluid communication between a fluid pump of a handheld airless spray gun and an applicator accessory. The adapter comprises an adapter body, a head attached to the adapter body, and a protrusion. The adapter body comprises an upper portion, a lower portion, a radial inlet located in a sidewall of the adapter body between the upper and lower portions, and an adapter bore having a first diameter in fluid communication with the radial inlet. The head attached to the adapter body is attached at the upper portion of the adapter body. The head comprises a cavity in fluid communication with the adapter bore and having a second diameter larger than the first diameter, an adapter outlet located in the upper portion of the adapter body and in fluid communication with the cavity, and a handle extending radially from the head. The protrusion extends radially from the adapter body between the upper portion and the lower portion of the adapter body.

Abstract: A portioned moist tobacco product with a super-hydrated membrane coating and method of manufacturing is disclosed. The super-hydrated membrane coating is formed by ionic cross-linking using two polymers. The soluble component of the super-hydrated membrane coating dissolves upon placement in the mouth, while the insoluble component maintains the tobacco within the coating for the duration of the use of the product. The moist tobacco product is soft and flexible so as to fit comfortably in an oral cavity when placed therein.

Abstract: An extension mechanism for a zip track system within a playground environment is provided. The extension system comprises a crossover unit configured to attach to a zip track. The crossover unit comprises a crossover arch, configured to couple to the zip track. The crossover unit also comprises a support pole configured to couple to an end of the crossover arch, such that the support pole does not obstruct a path of movement under the zip track. The extension mechanism also comprises a connection mechanism configured to connect the crossover unit to the zip track system such that the crossover unit distributes the weight of the track through the crossover arch and the crossover support poles.

Abstract: Blood flow into vascular tissue is filtered in a manner that can also be useful for trapping particulates while allowing the flow of blood. Consistent with one or more embodiments, a filter apparatus includes a filter, an outer delivery sheath such as a catheter, and one or more shafts that are operable to manipulate the shape of the filter for positioning within vascular tissue. The filter conforms to various types of vascular tissue, and filters blood flow passing through openings in the vascular tissue. In some implementations, the filter is used to trap particulates that have been collected on the filter, and collapses to trap and draw the particulates into the outer delivery sheath.

Abstract: A processor may receive, from one or more electronic control units (ECUs) of a particular vehicle, vehicle-system data including information about a state of one or more vehicle-systems of the particular vehicle. Also, the processor may receive, from one or more data sources other than the one or more ECUs, other input data indicative of a state of the particular vehicle. Based on the vehicle-system data and on the other input data, the processor may determine repair information to be specified in a repair order (RO) associated with the particular vehicle. Further, the processor may generate an RO specifying at least the determined repair information, wherein the generated RO is associated with the particular vehicle. Then, the processor may direct a display device to display at least one visual indication representative of the generated RO.

Abstract: Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

Abstract: A steerable optical transmit and receive terminal includes a MEMS-based N×1 optical switch network. Each optical switch in the optical switch network uses an electrostatic MEMS structure to selectively position a translatable optical grating close to or far from an optical waveguide. In the close (“ON”) position, light couples between the translatable optical grating and the optical waveguide, whereas in the far (“OFF”) position, no appreciable light couples between the translatable optical grating and the optical waveguide. The translatable optical grating is disposed at or near a surface of the optical switch network. Thus, the translatable optical grating emits light into, or receives light from, free space. The steerable optical transmit and receive terminal also includes a lens and can steer a free space optical beam in a direction determined by which port of the N×1 optical switch network is ON.