Patents by Inventor SuPing Lyu
SuPing Lyu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210030937Abstract: Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.Type: ApplicationFiled: October 11, 2020Publication date: February 4, 2021Applicant: Medtronic, Inc.Inventors: Thomas D. Kelly, SuPing Lyu, Bryant J. Pudil, Thomas E. Meyer
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Publication number: 20210008265Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.Type: ApplicationFiled: September 28, 2020Publication date: January 14, 2021Inventors: Martin Gerber, John Burnes, SuPing Lyu, VenKatesh R. Manda, Bryant Pudil
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Patent number: 10882945Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.Type: GrantFiled: March 20, 2019Date of Patent: January 5, 2021Assignee: Medtronic, Inc.Inventors: Kimberly A. Chaffin, Xiangji Chen, Matthew Jolly, SuPing Lyu, Peter L. Thor, Darrel F. Untereker, Zhaoxu Wang
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Patent number: 10857277Abstract: Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.Type: GrantFiled: August 15, 2012Date of Patent: December 8, 2020Assignee: Medtronic, Inc.Inventors: Thomas D. Kelly, SuPing Lyu, Bryant J. Pudil, Thomas E. Meyer
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Publication number: 20200354514Abstract: A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.Type: ApplicationFiled: July 23, 2020Publication date: November 12, 2020Applicant: MEDTRONIC, INC.Inventors: SATISH PULAPURA, FATIMA BUEVICH, XIANGJI CHEN, SUPING LYU
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Publication number: 20200330674Abstract: Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.Type: ApplicationFiled: June 22, 2020Publication date: October 22, 2020Inventors: Thomas D. Kelly, SuPing Lyu, Bryant J. Pudil, Thomas E. Meyer
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Patent number: 10793670Abstract: A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.Type: GrantFiled: May 7, 2018Date of Patent: October 6, 2020Assignee: MEDTRONIC, INC.Inventors: Satish Pulapura, Fatima Buevich, Xiangji Chen, Suping Lyu
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Publication number: 20200306439Abstract: Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.Type: ApplicationFiled: May 19, 2020Publication date: October 1, 2020Inventors: Thomas D. Kelly, SuPing Lyu, Bryant J. Pudil, Thomas E. Meyer
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Patent number: 10767006Abstract: A method for hydrogenating tyrosine derived polyarylates includes dissolving a second polyarylate with DMF in a flask to produce a first solution. A catalyst is added to the first solution to produce a polymer solution. The polymer solution is filtered through a Celite bed to produce a filtrate. The filtrate is added to water and stirred to precipitate the polyarylate.Type: GrantFiled: May 7, 2018Date of Patent: September 8, 2020Assignee: MEDTRONIC, INC.Inventors: Satish Pulapura, Dan Thanh Le, Xiangji Chen, Suping Lyu, Fatima Buevich
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Patent number: 10722636Abstract: Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.Type: GrantFiled: October 19, 2015Date of Patent: July 28, 2020Assignee: MEDTRONIC, INC.Inventors: Thomas D. Kelly, SuPing Lyu, Bryant J. Pudil, Thomas E. Meyer
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Patent number: 10695481Abstract: Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.Type: GrantFiled: August 2, 2012Date of Patent: June 30, 2020Assignee: MEDTRONIC, INC.Inventors: Thomas D. Kelly, SuPing Lyu, Bryant J. Pudil, Thomas E. Meyer
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Patent number: 10442757Abstract: A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCI HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.Type: GrantFiled: May 7, 2018Date of Patent: October 15, 2019Assignee: Medtronic, Inc.Inventors: Satish Pulapura, Fatima Buevich, Xiangji Chen, Suping Lyu
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Publication number: 20190292302Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.Type: ApplicationFiled: March 20, 2019Publication date: September 26, 2019Inventors: Kimberly A. CHAFFIN, Xiangji CHEN, Matthew JOLLY, SuPing LYU, Peter L. THOR, Darrel F. UNTEREKER, Zhaoxu WANG
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Publication number: 20190292327Abstract: A poly(ether-carbonate)-based polymer and a medical device that includes such polymer, wherein the poly(ether-carbonate)-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments include poly(ether-carbonate) residues and at least one of polyisobutylene (PIB) residues and hydrogenated polybutadiene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.Type: ApplicationFiled: March 20, 2019Publication date: September 26, 2019Inventors: Kimberly A. CHAFFIN, Xiangji CHEN, Matthew JOLLY, SuPing LYU, Peter L. THOR, Darrel F. UNTEREKER, Zhaoxu WANG
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Patent number: 10406268Abstract: Monitoring of the performance of a blood fluid removal medium of a blood fluid removal device includes monitoring of condition, such as fluid flow rate or concentration of blood waste product, downstream of the medium. Upstream monitoring of the condition may also be performed to enhance the ability to determine whether the blood fluid removal medium is performing within predetermined ranges.Type: GrantFiled: March 11, 2016Date of Patent: September 10, 2019Assignee: Medtronic, Inc.Inventors: Martin Gerber, Suping Lyu, Bryant Pudil
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Patent number: 10384050Abstract: An implantable medical leads has a conductor that includes one or more metal wires and one or more carbon nanotube wires extending in substantially the same direction as the one or more metal wires. Such conductors may result in less MRI-induced heating at electrodes of leads than conductors that do not contain carbon nanotubes.Type: GrantFiled: June 24, 2015Date of Patent: August 20, 2019Assignee: MEDTRONIC, INC.Inventors: Mallika Kamarajugadda, Mark Breyen, Suping Lyu, Bernard Q. Li, Qin Zhang, Jacob Popp
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Patent number: 10293092Abstract: Methods include monitoring indicators of blood pH or blood electrolyte levels during a blood fluid removal session and adjusting concentrations of pH buffers or electrolytes in dialysate or replacement fluid used during the session based on the monitored indicators. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.Type: GrantFiled: August 18, 2015Date of Patent: May 21, 2019Assignee: MEDTRONIC, INC.Inventors: Martin Gerber, John Burnes, Suping Lyu, VenKatesh R. Manda, Bryant Pudil
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Publication number: 20190111186Abstract: A medical device, a method for preparation thereof, and use thereof are provided. The medical device comprises a thermoplastic elastomer that is composed of soft segments and hard segments. The method for preparing a medical device comprising a thermoplastic elastomer, comprises forming the thermoplastic elastomer into tubing or other shapes via extrusion, molding, or coating, assembling the tubing or other shapes with other parts including: cables, coils, coated cables, or coated coils, and bonding the tubing, cables, or coils with other components including: other tubing components, cables, coils, sleeves, electrical pulse generator, defibrillation shock generator, electrodes, sensors, or drug release components. The medical device is used for correcting cardiac rhythm, defibrillating, assisting hearts, sensing, stimulating neurological systems, gastrointestinal system, or skeletomuscular tissues or organs.Type: ApplicationFiled: March 2, 2017Publication date: April 18, 2019Inventors: Suping LYU, XiangJi CHEN, Jing CHEN, Haining NA, Jin ZHU
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Publication number: 20190112411Abstract: Disclosed is a segmented thermoplastic elastomer that can be a polyurethane, polyurea, or polyurethane-urea comprising soft segments and hard segments, wherein the soft segments are made of polyolefin diols or polyolefin diamine that may have 0 to 1000 carbon atoms in the main chain, wherein each carbon atom in the main chain may have 0 to 2 side chains and each side chain may have 0 to 30 carbon atoms, the hard segment is made of a diisocyante and a chain extender, the hard segments make up 10-60% of the elastomer and the soft segments make up the rest, the number-average molecular weight of the elastomer is 5×103-1000×103 g/mol, the ultimate elongation of the elastomer is 100-1000%, the Young's modulus is 1 to 3,000 MPa, and the ultimate tensile strength is 10-100 MPa. Also disclosed are a method for preparing the segmented thermoplastic elastomer and use of segmented thermoplastic elastomer.Type: ApplicationFiled: March 2, 2017Publication date: April 18, 2019Inventors: Jing CHEN, Haining NA, Jin ZHU, Suping LYU, XiangJi CHEN
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Patent number: 10179198Abstract: Methods include monitoring indicators of blood pH or blood electrolyte levels during a blood fluid removal session and adjusting concentrations of pH buffers or electrolytes in dialysate or replacement fluid used during the session based on the monitored indicators. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.Type: GrantFiled: August 18, 2015Date of Patent: January 15, 2019Assignee: MEDTRONIC, INC.Inventors: Martin Gerber, John Burnes, Suping Lyu, VenKatesh R. Manda, Bryant Pudil