Patents by Inventor SuPing Lyu

SuPing Lyu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10179198
    Abstract: Methods include monitoring indicators of blood pH or blood electrolyte levels during a blood fluid removal session and adjusting concentrations of pH buffers or electrolytes in dialysate or replacement fluid used during the session based on the monitored indicators. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: January 15, 2019
    Assignee: MEDTRONIC, INC.
    Inventors: Martin Gerber, John Burnes, Suping Lyu, VenKatesh R. Manda, Bryant Pudil
  • Publication number: 20180354892
    Abstract: A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCl HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.
    Type: Application
    Filed: May 7, 2018
    Publication date: December 13, 2018
    Applicant: TYRX, Inc.
    Inventors: Satish Pulapura, Fatima Buevich, Xiangji Chen, Suping Lyu
  • Publication number: 20180355104
    Abstract: A method for hydrogenating tyrosine derived polyarylates includes dissolving a second polyarylate with DMF in a flask to produce a first solution. A catalyst is added to the first solution to produce a polymer solution. The polymer solution is filtered through a Celite bed to produce a filtrate. The filtrate is added to water and stirred to precipitate the polyarylate.
    Type: Application
    Filed: May 7, 2018
    Publication date: December 13, 2018
    Applicant: Tyrx, Inc.
    Inventors: SATISH PULAPURA, DAN THANH LE, XIANGJI CHEN, SUPING LYU, FATIMA BUEVICH
  • Publication number: 20180355103
    Abstract: A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.
    Type: Application
    Filed: May 7, 2018
    Publication date: December 13, 2018
    Applicant: TYRX, Inc.
    Inventors: SATISH PULAPURA, FATIMA BUEVICH, XIANGJI CHEN, SUPING LYU
  • Patent number: 10064985
    Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patent parameters. By comparing the patient's current parameters to past parameters in response to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: September 4, 2018
    Assignee: Medtronic, Inc.
    Inventors: Martin Gerber, Suping Lyu, Bryant Pudil
  • Patent number: 10040021
    Abstract: Frame structures, assemblies and methods for use in implantable medical devices. The frames may include one or more first polymeric portions and one or more second polymeric portions coupled to the one or more first polymeric portions. The one or more first polymeric portions may have a higher durometer than the one or more second polymeric portions. The one or more second polymeric portions may provide an interference fit between the one or more second polymeric portions and the housing and/or between the one or more second polymeric portions and one or more components disposed in the housing.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: August 7, 2018
    Assignee: Medtronic, Inc.
    Inventors: Andrew J. Ries, SuPing Lyu, Catherine M. Asgian, David Engmark, Ananta Pandey, Todd Schaefer, Erik Scott, Joachim Hossick-Schott
  • Patent number: 9974896
    Abstract: Methods and related apparatuses for sorbent recharging are provided. The methods and related apparatuses for recharging can recharge a specific rechargeable layer of a sorbent material such as zirconium phosphate in a sorbent cartridge. The methods and apparatuses include passing solutions containing combinations of acids, bases and salts through a module containing a rechargeable sorbent material such as zirconium phosphate in order to replace ions bound to the zirconium phosphate with hydrogen and sodium ions. The method allows for a customizable zirconium phosphate, with control over the ratios of sodium to hydrogen on the recharged zirconium phosphate.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: May 22, 2018
    Assignee: Medtronic, Inc.
    Inventors: Bryant J. Pudil, SuPing Lyu, Eric Grovender, Christopher M. Hobot, Martin T. Gerber
  • Patent number: 9968721
    Abstract: A method includes monitoring an indicator of fluid volume of a patient via a sensor device, and setting an initial fluid volume removal prescription for a blood fluid removal session based on the monitored indicator of fluid volume. The method may further include transmitting data regarding the indicator of fluid volume from the implantable sensor device to fluid removal device. The system includes a blood fluid removal device and control electronics configured to set the initial fluid removal volume and rate prescription. In some embodiments, the fluid removal device sets or calculated the initial fluid volume removal prescription based on the data received from the implantable sensor. The indicator of fluid volume may be an indicator of tissue fluid volume or an indicator of blood fluid volume.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: May 15, 2018
    Assignee: MEDTRONIC, INC.
    Inventors: Martin Gerber, John Burnes, Suping Lyu, VenKatesh R. Manda, Bryant Pudil
  • Publication number: 20170361006
    Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.
    Type: Application
    Filed: September 1, 2017
    Publication date: December 21, 2017
    Inventors: Martin Gerber, John Burnes, SuPing Lyu, VenKatesh R. Manda, Bryant Pudil
  • Patent number: 9750862
    Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: September 5, 2017
    Assignee: Medtronic, Inc.
    Inventors: Martin Gerber, John Burnes, Suping Lyu, VenKatesh R. Manda, Bryant Pudil
  • Patent number: 9707330
    Abstract: Disclosed are systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, a sorbent cartridge with at least two separate flow paths, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: July 18, 2017
    Assignee: Medtronic, Inc.
    Inventors: Thomas D. Kelly, SuPing Lyu
  • Patent number: 9700661
    Abstract: Methods include monitoring blood pH or electrolyte levels and setting initial fluid parameters, such as dialysate fluid parameters or replacement fluid parameters, for a blood fluid removal session based the monitored data. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: July 11, 2017
    Assignee: Medtronic, Inc.
    Inventors: Martin Gerber, Suping Lyu, Bryant Pudil
  • Publication number: 20170189669
    Abstract: An implantable medical leads has a conductor that includes one or more metal wires and one or more carbon nanotube wires extending in substantially the same direction as the one or more metal wires. Such conductors may result in less MRI-induced heating at electrodes of leads than conductors that do not contain carbon nanotubes.
    Type: Application
    Filed: June 24, 2015
    Publication date: July 6, 2017
    Inventors: Mallika Kamarajugadda, Mark Breyen, Suping Lyu, Bernard Q. Li, Qin Zhang, Jacob Popp
  • Patent number: 9642960
    Abstract: A method includes monitoring an indicator of fluid volume of a patient via a sensor device, and setting an initial fluid volume removal prescription for a blood fluid removal session based on the monitored indicator of fluid volume. The method may further include transmitting data regarding the indicator of fluid volume from the implantable sensor device to fluid removal device. The system includes a blood fluid removal device configured to set the initial fluid removal volume and rate prescription. In some embodiments, the fluid removal device sets or calculated the initial fluid volume removal prescription based on the data received from the implantable sensor. The indicator of fluid volume may be an indicator of tissue fluid volume or an indicator of blood fluid volume.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: May 9, 2017
    Assignee: MEDTRONIC, INC.
    Inventors: Martin Gerber, John Burnes, Suping Lyu, Manda R. VenKatesh, Bryant Pudil
  • Publication number: 20170100529
    Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patent parameters. By comparing the patient's current parameters to past parameters in response to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.
    Type: Application
    Filed: December 20, 2016
    Publication date: April 13, 2017
    Inventors: Martin Gerber, Suping Lyu, Bryant Pudil
  • Patent number: 9597440
    Abstract: A method includes initiating a blood fluid removal session of a patient; monitoring an indicator of tissue fluid volume of the patient, or a portion thereof, during the blood fluid removal session; monitoring an indicator of blood fluid volume of the patient during the blood fluid removal session; determining whether a ratio of the indicator of tissue fluid volume to indicator of blood fluid volume is outside of a predetermined range; and altering the rate of fluid removal during the blood fluid removal session if the ratio is determined to be outside of the predetermined range. A blood fluid removal system may be configured to carry out the method.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: March 21, 2017
    Assignee: MEDTRONIC, INC.
    Inventors: Martin Gerber, John Burnes, Suping Lyu, VenKatesh R. Manda, Bryant Pudil
  • Patent number: 9561316
    Abstract: Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patent parameters. By comparing the patient's current parameters to past parameters in response to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: February 7, 2017
    Assignee: Medtronic, Inc.
    Inventors: Martin Gerber, Suping Lyu, Bryant Pudil
  • Publication number: 20160206801
    Abstract: Monitoring of the performance of a blood fluid removal medium of a blood fluid removal device includes monitoring of condition, such as fluid flow rate or concentration of blood waste product, downstream of the medium. Upstream monitoring of the condition may also be performed to enhance the ability to determine whether the blood fluid removal medium is performing within predetermined ranges.
    Type: Application
    Filed: March 11, 2016
    Publication date: July 21, 2016
    Applicant: Medtronic, Inc.
    Inventors: Martin Gerber, Suping Lyu, Bryant Pudil
  • Patent number: 9302036
    Abstract: Monitoring of the performance of a blood fluid removal medium of a blood fluid removal device includes monitoring of condition, such as fluid flow rate or concentration of blood waste product, downstream of the medium. Upstream monitoring of the condition may also be performed to enhance the ability to determine whether the blood fluid removal medium is performing within predetermined ranges.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: April 5, 2016
    Assignee: Medtronic, Inc.
    Inventors: Martin Gerber, Suping Lyu, Bryant Pudil
  • Publication number: 20160038666
    Abstract: Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
    Type: Application
    Filed: October 19, 2015
    Publication date: February 11, 2016
    Applicant: MEDTRONIC, INC.
    Inventors: Thomas D. Kelly, SuPing Lyu, Bryant J. Pudil, Thomas E. Meyer