Abstract: The present invention provides a process for the preparation of key intermediate for the synthesis 5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1-indanone hydrochloride (donepezil hydrochloride). The present invention particularly provides a process for the preparation of 5,6-dimethoxy-2-(4-pyridylmethylene)-1-indanone comprising condensation of 5,6-dimethoxy-1-indanone with 4-pyridinecarboxaldehyde using an alkali metal hydroxide as a mild base in the presence of demineralized water as a solvent at a temperature in the range of 15° C. to 45° C. to yield 5,6-dimethoxy-2-(4-pyridylmethylene)-1-indanone, which is subsequently benzylated using benzyl bromide in the presence of solvent at a reflux temperature to yield 1-benzyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium bromide.

Abstract: This disclosure relates generally to sequential state elements (SSEs). More specifically, embodiments of flip-flops are disclosed, along with computerized methods and systems of designing the same. In one embodiment, the flip-flop includes a substrate and subcircuits that are formed on the substrate. The subcircuits provide subfunctions, wherein each of the subcircuits provides at least one of the subfunctions. More specifically, the subfunctions are provided in a sequential logical order by the subcircuits so that the flip-flop provides a flip-flop function. However, the subcircuits are interleaved out of the sequential logical order with respect to a corresponding subfunction provided by each of the subcircuits along a vector defined by the substrate. In this manner, interleaving the subcircuits along the vector of the substrate can provide separation between charge collection nodes without requiring increases in size. Thus, the flip-flop can be more compact and less expensive to manufacture.

Abstract: The present invention provides a method of tandem cropping for increased production of up to 40% in wheat and mustard crops using varieties with phenological plasticity and temperature tolerance traits. The cereal bread wheat and oil seed mustard are traditional winter season (Rabi) crops in north India/Indo-Gangetic plains. This area experiences receding levels of warm weather and long days in September, October and November, progressive increase and then decrease of cold conditions and short days between November and March and onset of warm weather turning into summer and relatively longer days in March and April. Conventionally a seasonal crop of wheat or mustard or wheat followed by mustard or vice versa could be taken in the winter Rabi season of Indo-Gangetic plains to increase the production of these commodities.

Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.

Abstract: A method of enhancing the ductility of magnesium alloy sheets containing 85% or more by weight of magnesium is described. An annealed, substantially strain free, sheet of generally uniform grain size is locally deformed in local regions to develop strained ‘islands’ of a predetermined strain embedded in a substantially strain-free matrix and then annealed. The deformed regions undergo recrystallization and grain growth while the remainder of the sheet suffers only minor change in grain size, leading to sheet with grains having a bimodal size distribution. The ductility of alloys processed in this way is significantly greater than the ductility of the unprocessed, uniform grain size alloy without compromise to the tensile strength of the alloy.

Abstract: A process for the preparation of nano structured silicon thin film using radio frequency (rf) plasma discharge useful for light emitting devices such as light emitting diode, laser etc. which allows precise control of the nanocrystal size of silicon and its uniform distribution without doping using a plasma processing for obtaining efficient photoluminescence at room temperature.

Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.

Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.

Abstract: Methods for determining a recovery state of a metal alloy are disclosed herein. In one example, a fluctuation in a crystallographic grain orientation of the metal alloy is determined by utilizing electron backscatter diffraction (EBSD) data of the metal alloy. A processor of an electron backscatter diffraction machine utilizes a local orientation deviation quantifier to correlate the fluctuation in the crystallographic grain orientation of the metal alloy with a plastic strain recovery of the metal alloy. Other examples of the method are also disclosed herein.

Abstract: Retrieving content items based on a social distance between a user and content providers. The social distance is determined based on, for example, user interaction with the content providers. The content providers are ranked, for the user, based on the determined social distance. Prior to a request from the user, the content items are pre-fetched based on the ranked content providers and constraints such as storage space, bandwidth, and battery power level of a computing device of the user. In some embodiments, additional content items are retrieved, or retrieved content items are deleted, as a variable-size cache on the computing device fills or changes size.

Abstract: Novel intermediates, process for their preparation and their use in the preparation of therapeutically effective antineoplastic agents, in particular Temsirolimus of formula (I).

Abstract: A method of enhancing the ductility of magnesium alloy sheets containing 85% or more by weight of magnesium is described. An annealed, substantially strain free, sheet of generally uniform grain size is locally deformed in local regions to develop strained ‘islands’ of a predetermined strain embedded in a substantially strain-free matrix and then annealed. The deformed regions undergo recrystallization and grain growth while the remainder of the sheet suffers only minor change in grain size, leading to sheet with grains having a bimodal size distribution. The ductility of alloys processed in this way is significantly greater than the ductility of the unprocessed, uniform grain size alloy without compromise to the tensile strength of the alloy.

Abstract: A computer implemented method comprising: identifying an API function call directed to a broker process, wherein a plurality of information requested by an originator is directly relevant to a sandbox process; trapping an API function call directed to a broker process using a computer, wherein the API function call references the broker process, wherein the broker process is a process that executes one or more operations on the behalf of a sandbox process, and wherein the sandbox process has an insufficient permission level to execute the one or more operations; passing the trapped API function call to the sandbox process using the computer; executing the trapped API function call within the sandbox process to generate a result in reference to the sandbox process using the computer; passing the result from the sandbox process to the broker process using the computer; and passing the result from the broker process to an originator using the computer.

Abstract: Disclosed herein are novel intermediates and process for large scale production of (S)-3-[(1-dimethylamino)ethyl]phenyl-N-ethyl-N-methyl-carbamate (rivastigmine) or its pharmaceutically acceptable salts employing the novel intermediates. Further provided are methods for producing the novel intermediates thereof.

Abstract: A menu structure is provided which allows a user of a computing device to more easily consolidate and navigate images and/or albums regardless of their location. Moreover, the menu structure is dynamically tailored to individual users based on their previous interactions with the people appearing in the images/albums. The menu includes icons representing images (e.g., photos) or collections of images that have been categorized based in part on metadata respectively associated with the images. The metadata may have been provided by tagging the images or posting the images on one or more social networking sites. The order in which the icons are presented on the menu or interface may be based on their relative relevance or importance to the user.

Abstract: The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.

Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).

Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).

Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).

Abstract: Disclosed herein, a process for producing sulphoxide compound of the Formula (I) by asymmetrically oxidizing a prochiral sulphide of the Formula (II) with an effective amount of oxidizing agent in the presence of a chiral transition metal complex without using an organic solvent and base.