Abstract: The invention provides a method for producing a retinal pigment epithelial cell by (1) maintaining and/or expanding human pluripotent stem cells comprising culturing the human pluripotent stem cells in the absence of a feeder cell in a medium comprising a factor for maintaining an undifferentiated state, (2) a first step for culturing the maintained and/or expanded human pluripotent stem cells in a medium comprising a MEK inhibitor in the absence of feeder cells for a period of not less than 2 days and not more than 30 days, wherein the culture condition in the first step is a condition sufficient for inducing gene expression of at least one eye field transcription factor, and (3) a second step for culturing the cells obtained in the first step in the presence of a Nodal signal transduction pathway inhibitor and/or a Wnt signal transduction pathway inhibitor to form a retinal pigment epithelial cell.

Abstract: The present invention provides a method for more efficiently producing retinal pigment epithelial cells from pluripotent stem cells. The method of the present invention for producing retinal pigment epithelial cells includes the following steps: (1) a first step for culturing a pluripotent stem cell in a medium comprising an FGF receptor inhibitor and/or an MEK inhibitor for a period of not more than 30 days, and (2) a second step for culturing the cell obtained in the first step in the presence of a Nodal signal transduction pathway inhibitor and/or a Wnt signal transduction pathway inhibitor to form a retinal pigment epithelial cell.

Abstract: The present invention provides a production method of a retinal pigment epithelial cell containing the following steps: (1) a first step for culturing a pluripotent stem cell in a medium containing at least one kind selected from the group consisting of an FGF receptor inhibitor and an MEK inhibitor for a period of not more than 30 days, and (2) a second step for culturing the cell obtained in the first step in a medium containing at least one kind selected from the group consisting of a Rho signal transduction pathway inhibitor and an apoptosis inhibitor to form a retinal pigment epithelial cell. The method can produce retinal pigment epithelial cells from pluripotent stem cells more efficiently and conveniently.

Abstract: A small flying vehicle flown by radio control or autonomously by an auto pilot is equipped with an airbag device. The small flying vehicle has a main body part including a controller and a battery, a frame, a propeller, a motor, and a transmitting and receiving antenna. The airbag device has a gas supplier, a sensor, a controller, and an airbag. The airbag device is attached to the main body part, and the gas supplier is provided with a gas cylinder that releases a compressed gas when a closure member sealing the gas cylinder is broken, a breaker, including an electric igniter, that breaks the closure member, and introduction device that introduces the gas discharged from the gas cylinder and providing the pressurized gas into the airbag to inflate the airbag.

Abstract: A small flying vehicle capable of mitigating the shock at the time of falling and colliding with the ground or the like is provided. A small flying vehicle equipped with an airbag device, capable of flying by radio control or autonomously flying by autopilot, and having a maximum length of 2 m or less, wherein the small flying vehicle has a main body part including a controller and a battery, a frame, a propeller, a motor, and a transmitting and receiving antenna; the airbag device has gas supply means, a sensor, a control device and an airbag, and is attached to the main body part; and the gas supply means is provided with a gas cylinder capable of releasing an internal gas when a closure member is broken and opened, breaking means including an electric igniter for opening the closure member of the gas cylinder, and introduction means for introducing the pressurized gas in the gas cylinder into the airbag to inflate the airbag.

Abstract: The present invention provides a production method of a retinal pigment epithelial cell containing the following steps: (1) a first step for culturing a pluripotent stem cell in a medium containing at least one kind selected from the group consisting of an FGF receptor inhibitor and an MEK inhibitor for a period of not more than 30 days, and (2) a second step for culturing the cell obtained in the first step in a medium containing at least one kind selected from the group consisting of a Rho signal transduction pathway inhibitor and an apoptosis inhibitor to form a retinal pigment epithelial cell. The method can produce retinal pigment epithelial cells from pluripotent stem cells more efficiently and conveniently.

Abstract: The present invention provides a smoke screen generator with a high diffusion rate of a smoke screen. Ends at both sides of a cylindrical housing are closed by a first closure 20 and a second closure 30 respectively, and a flow path changing member 60 is attached at an interval in an axial direction from the second closure 30. At the time of actuation, a smoke screen source passes through a smoke screen source discharge port 38, first discharge flow paths 44, 45 and 46, and a second discharge flow path 47 and is discharged from a final discharge port 48. Since the smoke screen source is radially discharged from the final discharge port 48, a diffusion rate of a smoke screen increases.

Abstract: An electronic device that has a circuit network therein and conducts at least one of power reception and communication with an external device through a wire harness includes a detection circuit and a resonance frequency shift circuit. The detection circuit detects a voltage variation caused by a noise that has a frequency component near a resonance frequency and superimposes on at least one of the wire harness and the circuit network. The resonance frequency is determined based on a characteristic impedance of the wire harness and the circuit network. The resonance frequency shift circuit shifts the resonance frequency by changing at least one of a capacitance and an inductance of the circuit network based on a level of the voltage variation detected by the detection circuit.

Abstract: The present invention provides a smoke screen generator with a high diffusion rate of a smoke screen. Openings at both ends of a cylindrical housing are closed by a first closure 20 including an igniter and a second closure 30 having a smoke screen source discharge port 38 respectively. A porous cylindrical body 50 is arranged between the first closure 20 and the second closure 30. When an igniter 5 is actuated, a smoke screen generating agent 56 in a smoke screen generating agent-accommodating chamber 55 is ignited and burned, and a smoke screen source is generated. The smoke screen source moves and passes through the porous cylindrical body 50 and, after passing through a smoke screen source discharge port 38, the smoke screen source is discharged to the outside to generate a smoke screen.

Abstract: The present invention provides a method for more efficiently producing retinal pigment epithelial cells from pluripotent stem cells. The method of the present invention for producing retinal pigment epithelial cells includes the following steps: (1) a first step for culturing a pluripotent stem cell in a medium comprising an FGF receptor inhibitor and/or an MEK inhibitor for a period of not more than 30 days, and (2) a second step for culturing the cell obtained in the first step in the presence of a Nodal signal transduction pathway inhibitor and/or a Wnt signal transduction pathway inhibitor to form a retinal pigment epithelial cell.

Abstract: The present invention provides a smoke screen generator with a high diffusion rate of a smoke screen. Openings at both ends of a cylindrical housing are closed by a first closure 20 including an igniter and a second closure 30 having a smoke screen source discharge port 38 respectively. A porous cylindrical body 50 is arranged between the first closure 20 and the second closure 30. When an igniter 5 is actuated, a smoke screen generating agent 56 in a smoke screen generating agent-accommodating chamber 55 is ignited and burned, and a smoke screen source is generated. The smoke screen source moves and passes through the porous cylindrical body 50 and, after passing through a smoke screen source discharge port 38, the smoke screen source is discharged to the outside to generate a smoke screen.

Abstract: The present invention provides a smoke screen generator with a high diffusion rate of a smoke screen. Ends at both sides of a cylindrical housing are closed by a first closure 20 and a second closure 30 respectively, and a flow path changing member 60 is attached at an interval in an axial direction from the second closure 30. At the time of actuation, a smoke screen source passes through a smoke screen source discharge port 38, first discharge flow paths 44, 45 and 46, and a second discharge flow path 47 and is discharged from a final discharge port 48. Since the smoke screen source is radially discharged from the final discharge port 48, a diffusion rate of a smoke screen increases.

Abstract: The present invention provides a production method of a retinal cell or retinal tissue, including the following steps: (1) a first step of culturing mammalian pluripotent stem cells in the absence of a feeder cell for a period not exceeding 30 days in a medium comprising 1) a factor for maintaining an undifferentiated state and 2) an MEK inhibitor, (2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence of a BMP signal transduction pathway activating substance to obtain an aggregate containing retinal cells or a retinal tissue.

Abstract: The present invention relates to a perforator for breaking a closing member at a gas outlet of a gas bottle to allow a gas to flow out. The perforator includes a cylindrical housing having three openings, namely, a first opening at a first end portion, a second opening at a second end portion which is opposite to the first end portion, and a third opening formed in a circumferential wall portion, an ignition device being fixed at the first opening, the second opening to be connected to the gas bottle and the third opening serving as a gas discharge portion, and when a pressure created by actuation of the ignition device is received, the first piston moving in an axial direction, and the second piston moving towards the second opening by receiving the movement of the first piston.

Abstract: The present invention provides a perforator for breaking a closing member at a gas outlet of a gas bottle to allow a gas to flow out, including the cylindrical housing having three openings, namely, a first opening at a first end portion, a second opening at a second end portion which is opposite to the first end portion, and a third opening formed in a circumferential wall portion, an ignition device being fixed at the first opening, the second opening to be connected to the gas bottle and the third opening serving as a gas discharge portion, an first piston and a second piston being disposed, in the order of the first piston and the second piston, from the side of the ignition device to the side of the second opening in the cylindrical housing, and when a pressure created by actuation of the ignition device is received, the first piston moving in an axial direction inside the cylindrical housing, and the second piston moving towards the second opening inside the cylindrical housing by receiving the movem

Abstract: An electronic device that has a circuit network therein and conducts at least one of power reception and communication with an external device through a wire harness includes a detection circuit and a resonance frequency shift circuit. The detection circuit detects a voltage variation caused by a noise that has a frequency component near a resonance frequency and superimposes on at least one of the wire harness and the circuit network. The resonance frequency is determined based on a characteristic impedance of the wire harness and the circuit network. The resonance frequency shift circuit shifts the resonance frequency by changing at least one of a capacitance and an inductance of the circuit network based on a level of the voltage variation detected by the detection circuit.

Abstract: A gas generator includes a metallic housing, an ignition device including an igniter assembly, and gas generating agent, the igniter assembly including an igniter main body fixed to a metallic cylindrical fixing member with a resin and a connector-connecting portion for fitting a connector, at least part of the metallic cylindrical fixing member being electro-conductive to the housing, and including an exposed portion exposed to an inner surface of the connector-connecting portion, the exposed portion of the metallic cylindrical fixing member serving as a ground terminal, when the connector is connected to the connector-connecting portion, the ground terminal being in contact with an earth terminal of the connector, a grounding lead wire of the connector being grounded to a ground circuit located outside the gas generator.

Abstract: The present invention provides a gas generator including a metallic housing, an ignition device including an igniter assembly, and gas generating agent, the igniter assembly including an igniter main body fixed to a metallic cylindrical fixing member with a resin and a connector-connecting portion for fitting a connector, at least part of the metallic cylindrical fixing member being electro-conductive to the housing, and including an exposed portion exposed to an inner surface of the connector-connecting portion, the exposed portion of the metallic cylindrical fixing member serving as a ground terminal, when the connector is connected to the connector-connecting portion, the ground terminal being in contact with an earth terminal of the connector, a grounding lead wire of the connector being grounded to a ground circuit located outside the gas generator.

Abstract: A control circuit controls a driving transistor connected in series with an electrical load between a power supply voltage and a ground. The control circuit includes a pull-up resistor connected at one end to a power supply voltage side of the driving transistor, a current detection resistor for detecting an electric current flowing from the driving transistor to the ground, a current mirror circuit including a starting transistor connected between the pull-up transistor and the current detection resistor. The current mirror circuit supplies a mirror current of the electric current. The control circuit further includes a current source circuit for supplying a driving current to a control terminal of the driving transistor in accordance with the mirror current to turn ON the driving transistor in response to an external control signal.

Abstract: A control circuit controls a driving transistor connected in series with an electrical load between a power supply voltage and a ground. The control circuit includes a pull-up resistor connected at one end to a power supply voltage side of the driving transistor, a current detection resistor for detecting an electric current flowing from the driving transistor to the ground, a current mirror circuit including a starting transistor connected between the pull-up transistor and the current detection resistor. The current mirror circuit supplies a mirror current of the electric current. The control circuit further includes a current source circuit for supplying a driving current to a control terminal of the driving transistor in accordance with the mirror current to turn ON the driving transistor in response to an external control signal.