Abstract: The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## in which R.sup.1 is amino-substituted-heterocyclic group which may have halogen, protected amino-substituted-heterocyclic group which may have halogen, or a group of the formula: ##STR2## wherein R.sup.3 is lower alkyl,R.sup.2 is carboxy or a protected carboxy group, andA is lower alkylene which may have a substituent selected from the group consisting of amino, a protected amino group, hydroxy, oxo and a group of the formula: .dbd.N.about.OR.sup.4, wherein R.sup.4 is hydrogen, cyclo(lower)alkenyl, lower alkynyl, lower alkenyl, lower alkenyl substituted by carboxy or a protected carboxy group, lower alkyl, or lower alkyl substituted by one or more substituents selected from carboxy, a protected carboxy group, amino, a protected amino group, cyano, phosphono, a protected phosphono group and a heterocyclic group which may have suitable substituents.

Abstract: The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or acylamino; andR.sup.9 is a group of the formula: ##STR2## wherein R.sup.2 is organic group,X is CH or N,Z is acid residueY is CH or N and n is O; orY is N.sup..sym. --R.sup.2 wherein R.sup.2 is as defined above and n is 1,or a group of the formula:--A--N.sup..sym. (R.sup.10).sub.3whereinR.sup.10 is lower alkyl andA is lower alkylene.

Abstract: This invention relates to the intermediates of formula ##STR1## wherein A.sub.b is hydroxy (lower) alkylene, amino (lower) alkylene, protected amino (lower) alkylene, lower alkenylene, lower alkylene having an oxo group, or hydroxyimino (lower) alkylene wherein the hydrogen atom of the hydroxyimino group may be replaced with a lower aliphatic hydrocarbon group, and R.sup.3 is carboxy or a protected carboxy group, and a salt thereof.

Abstract: 7-substituted 3-cephem or cepham compounds characterized by the grouping, in the 7-position thereof, of the formula:R'--A--CONH--where R' is thiadiazolyl or amino thiazolyl, and A is methylene carrying oxyiimino, or R' is haloacetyl and A may also be methylene, their preparation, and pharmaceutical uses.

Abstract: This invention relates to a new cephem compound of the formula: ##STR1## wherein R.sup.1 is amino or a substituted amino group;R.sup.2 is carboxy or a protected carboxy group;R.sup.3 is a tetrazolyl group having a lower alkynyl group; andX is --S-- or ##STR2## and pharmaceutically acceptable salts thereof, of high antimicrobial activity.

Abstract: The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## in which R.sup.1 is amino or a protected amino group, andR.sup.2 is carboxy or a protected carboxy group, and a pharmaceutically acceptable salt thereof.

Abstract: 3,5-Di hydroxy morpholine derivatives having antitumor activity and methods of preparation thereof, are disclosed.

Abstract: This invention relates to new aminoglycoside derivatives and pharmaceutically acceptable salts thereof. More particularly it relates to new aminoglycoside derivatives and pharmaceutically acceptable salts thereof which have anti-viral activity, and immuno-stimulating activity and pharmaceutical compositions comprising the same. In addition, this invention also relates to methods of preparing the aminoglycoside derivatives and salts thereof.

Abstract: The invention relates to cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or acylamino,R.sup.2 is lower alkyl, andY is CH or N.

Abstract: 3,7-disubstituted-3-cephem-4-carboxylic acid compounds having bacteriostatic properties and the following formula: ##STR1## in which R.sup.1 is thiadiazolyl or isothiazolyl, each of which may have suitable substituent(s), or thiazolyl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is carboxy or protected carboxy; R.sup.4 is hydrogen, acyloxy or a heterocyclicthio group which may have suitable substituent(s); and R.sup.5 is hydrogen or lower alkoxy, process for making same and treating infectious diseases therewith.

Abstract: The present invention relates to a new syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof. More particularly, it relates to new syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof which have antibacterial activities and to processes for the preparation thereof, to pharmaceutical composition comprising the same, and to a method of using the same therapeutically in the treatment of infectious diseases in human beings and animals. New cephems disclosed herein are ##STR1## wherein R.sup.1 is ##STR2## R.sup.2 is lower alkyl, R.sup.3 is carboxy, R.sup.4 is carbamoyloxy methyl which may be substituted with a trihalo- (lower) alkanoyl; and R.sup.7 is amino, lower alkanoylamino or halo (lower)alkanoylamino.

Abstract: Thiazole intermediates for cepham compounds are described.

Abstract: This invention relates to novel cephem compounds, of high antimicrobial activity, and to novel compounds which are useful as intermediates therefor, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group; andR.sup.2 is cyclo (lower) alkenyl, or salt thereof.

Abstract: The invention relates to new compounds comprising alkoxyimino dioxy butyric acid cephem derivatives of high antimicrobial activity.

Abstract: This invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.2 is carboxy or protected carboxy,R.sup.3 is hydrogen or lower alkyl, andR.sup.4 is lower alkyl, lower alkoxy, acyloxymethyl, lower alkylthiomethyl, lower alkoxymethyl, halogen, lower alkenyl or hydrogen,and pharmaceutically acceptable salts thereof.

Abstract: The invention relates to novel cephem compounds, of antimicrobial activity, of the formula ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.3 is lower alkoxy, andR.sup.4 is carboxy or protected carboxy,and a pharmaceutically acceptable salt thereof.

Abstract: This invention relates to novel, 1,4-diaminocyclitol derivatives of antimicrobial and immunostimulating activity of the formula: ##STR1## wherein X.sup.1, X.sup.2 and X.sup.3 are each amino or protected amino, X.sup.4 is hydrogen or hydroxy,R.sup.1 is hydrogen or lower alkyl, andR.sup.2 is higher alkanoyl permissably substituted with hydroxy, amino, azido, epoxy, protected hydroxy or protected amino, or higher alkenoyl, or higher alkylcarbanoyl,and pharmaceutically acceptable salts thereof.

Abstract: This invention relates to novel compounds useful as intermediates in the preparation of cephalosporin compounds of antibacterial activity, having the formula ##STR1## wherein R.sup.1 is a group of the formula ##STR2## in which X is sulfur, oxygen or substituted or unsubstituted imino, andR.sup.2 is hydrogen or a saturated or unsaturated aliphatic hydrocarbon residue,a derivative at the carboxy group thereof and salt thereof.

Abstract: This invention relates to novel cephem compounds, of antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is carboxy (C.sub.1 -C.sub.6) alkyl or esterified carboxy (C.sub.1 -C.sub.6) alkyl,R.sup.2 is carboxy or an esterified carboxy group, andR.sup.3 is (C.sub.1 -C.sub.6) alkanoylamino, (C.sub.1 -C.sub.6) alkanesulfonyl, triazolylthio, tetrazolylthio having (C.sub.1 -C.sub.6) alkyl, pyridazinylthio having (C.sub.1 -C.sub.6) alkyl, thiadiazolylthio having (C.sub.1 -C.sub.6) alkyl, triazolopyridazinylthio or tetrazolopyridazinylthio, and pharmaceutically acceptable salts thereof.

Abstract: There are disclosed compounds of the formula: ##STR1## in which R is lower alkoxycarbonyloxy(lower)alkyl or 1-propionyloxyethyl, or a salt thereof, pharmaceutical compositions containing the same and their use to treat infectious diseases.