Abstract: This invention relates to novel cephem compounds of high antimicrobial activity of the formula ##STR1## wherein R.sup.1 is amino;R.sup.2 is carboxy or a protected carboxy group;A is hydroxy (lower) alkylene, amino (lower) alkylene, protected amino (lower) alkylene, lower alkenylene, hydroxyimino (lower) alkylene, lower alkoxyimino (lower) alkylene, or lower alkenyloxyimino (lower) alkylene; andR.sup.3 is carboxy or a protected carboxy group,and pharmaceutically acceptable salts thereof.

Abstract: Preparation of pharmaceutical composition comprising, treatment of human and animal diseases with, and compound of, 3,7-disubstituted-3-cephem-4-carboxylic acid.

Abstract: Aminoglycoside derivatives and pharmaceutically acceptable salts thereof which are useful as prophylactic and therapeutic agents for infectious diseases caused by pathogenic microorganisms, processes for the preparation thereof and a pharmaceutical composition comprising the same.

Abstract: This invention relates to novel 7-acylamino-3-vinylcephalosporanic acid derivatives of high antimicrobial activity, to processes for preparation thereof from novel intermediates, and to said intermediates of the formula: ##STR1## in which R.sub.A is a group of the formula: ##STR2## wherein R.sup.1 is amino-substituted-heterocyclic group which may have halogen, protected amino-substituted-heterocyclic group which may have halogen, or a group of the formula: ##STR3## wherein R.sup.3 is lower alkyl,R.sup.8 is aryl,A is lower alkylene which may have a substituent selected from the group consisting of amino, a protected amino group, hydroxy, oxo and a group of the formula:.dbd.N.about.OR.sup.4,whereinR.sup.

Abstract: Bacteriostatic cephem compounds and processes for preparing same having the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is lower alkyl, amino(lower)alkyl, protected amino(lower)alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, lower alkylthio(lower)alkyl, carboxy(lower)alkyl, esterified carbony(lower)alkyl, (C.sub.3 -C.sub.8)cycloalkyl, lower alkenyl or lower alkynyl,R.sup.3 is a heterocyclic group substituted with amino(lower)alkyl, protected amino(lower)alkyl, hydroxy(lower)alkyl or both amino and lower alkyl,R.sup.4 is carboxy or protected carboxy, provided that R.sup.3 is a heterocyclic group substituted with hydroxy(lower)alkyl or both amino and lower alkyl, when R.sup.2 is lower alkyl, and its pharmaceutically acceptable salt.

Abstract: The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl, andR.sup.3 is carboxy or protected carboxy,and a pharmaceutically acceptable salt thereof.

Abstract: This invention relates to novel 7-acylaminocephalosporanic acid derivatives of high antimicrobial activity, to processes for their preparation, and to pharmaceutical compositions comprising said derivatives, said derivatives being of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is dialkanoyloxy(lower)alkyl; alkyl having one or more substituents selected from the group consisting of hydroxy, protected hydroxy, alkoxy, carboxy, protected carboxy, cycloalkylcarbonyloxy and heterocyclic group; lower alkoxycarbonyloxy(lower)alkyl; azido(lower)alkoxycarbonyloxy(lower)alkyl; aroyloxy(lower)alkyl; higher alkanoyloxy(lower)alkyl; phthalidyl; or phthalidylidene(lower)alkyl,R.sup.3 is lower alkyl,Y is thio (--S--) or sulfinyl (--S--), and the dotted line represents 2- or 3-cephem nuclei.

Abstract: 7-(.alpha.,.alpha.-disubstituted-acetamido)-3-substituted-3-cephem-4-carbox ylic acids having antibacterial properties and the following formula are disclosed: ##STR1## wherein R.sup.1 is hydrogen, halogen, hydroxy, nitro, lower alkoxy or acylamino, R.sup.2 is hydrogen or acyl andR.sup.3 is lower alkanoyloxy, carbamoyloxy which may have lower alkyl, aryl or protective group for amino or a heterocyclicthio which may have lower alkyl.

Abstract: New antimicrobial azetidinone derivatives and their salt of the formula: ##STR1## wherein R.sub.1 amino or acylamino, and A is selected from a variety of groups.

Abstract: A compound of the formula: ##STR1## in which R.sup.1 is thiadiazolyl,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.3 is hydrogen, halogen or lower alkenyl, andR.sup.4 is carboxy or a protected carboxy group, and pharmaceutically acceptable salts thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity comprising the syn-isomers of 7-substituted-3-cephem-4-carboxylic acid esters of the formula: ##STR1## wherein R is lower alkanoyloxy (C.sub.2 -C.sub.6)alkyl, isobutyryloxymethyl, 2-ethylbutyryloxymethyl or 3,3-dimethylbutyryloxymethyl,or salts thereof.

Abstract: The invention relates to novel cephem compounds, of antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is carboxy (C.sub.1 -C.sub.6) alkyl or esterified carboxy (C.sub.1 -C.sub.6) alkyl, R.sup.2 is carboxy or esterified carboxy, and R.sup.3 is (C.sub.1 -C.sub.6) alkanoyloxy (C.sub.1 -C.sub.6) alkyl, tetrazolopyridazinylthio (C.sub.1 -C.sub.6) alkyl, tetrazolothio (C.sub.1 -C.sub.6) alkyl, or (C.sub.1 -C.sub.6) alkyl tetrazolothio (C.sub.1 -C.sub.6) alkyl, and pharmaceutically acceptable salts thereof.

Abstract: Anti-microbial cephalosporins of the formula ##STR1## in which R.sup.2 is methoxymethyl or methylthiomethyl, and R.sup.6 is carboxy (lower) alkyl have been prepared.

Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.2 is hydrogen or an aliphatic hydrocarbon residue which may be substituted with halogen, carboxy or esterified carboxy,R.sup.5 is carboxy or functionally modified carboxy and R.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, their preparation and their pharmaceutical uses.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino substituted thiazolyl selected from the group consisting of 2-aminothiazol-4-yl, 2-aminothiazol-5-yl, 4-aminothiazol-2-yl, 2-amino-5-halothiazol-4-yl, 2-amino-4-halothiazol-5-yl, and 4-amino-5-halothiazol-2-yl,protected amino substituted thiazolyl selected from said group,lower alkylamino substituted thiazolyl,amino substituted thiadiazolyl,protected amino substituted thiadiazolyl,amino substituted pyridyl,protected amino substituted pyridyl,furyl,thiazolyl,thiadiazolyl,phenyl, ornaphthyl,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.3 is lower alkylthio, andR.sup.4 is carboxy or protected carboxy, and pharmaceutically acceptable salts thereof.

Abstract: This invention relates particularly to a syn compound of the formula: ##STR1## wherein R.sup.2 is hydrogen or an aliphatic hydrocarbon residue which may be substituted with halogen, carboxy or esterified carboxy, R.sup.3 and R.sup.4 are each lower alkyl, R.sup.5 is carboxy or functionally modified carboxy and R.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, to pharmaceutical compositions containing the same and method of using the same for treating infectious disease.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;R.sup.2 is lower alkenyl, lower alkynyl, unsubstituted cycloalkyl, phenyl (lower) alkyl, phenyl (lower) alkyl substituted with halogen, or lower alkylthio (lower) alkyl; andR.sup.3 is hydrogen, carbamoyl or hydroxy (lower) alkyl, and pharmaceutically acceptable salts thereof.

Abstract: This invention relates to novel 7-acylaminocephalosporanic acid derivatives and pharmaceutically acceptable salts thereof, of high antimicrobial activity, said novel derivatives having the formula ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is carboxy(lower)alkyl, protected carboxy(lower)alkyl, carboxy(lower)alkenyl, protected carboxy(lower)alkenyl, or lower unsaturated aliphatic hydrocarbon,R.sup.3 is hydrogen, halogen, methyl, lower alkoxy, lower alkylthiomethyl, lower alkanoyloxymethyl or a heterocyclicthiomethyl which may have suitable substituents(s),R.sup.4 is carboxy or protected carboxy,R.sup.5 is hydrogen or lower alkyl, andX is halogen,provided that when R.sup.3 is lower alkanoyloxymethyl, then R.sup.2 is lower unsaturated aliphatic hydrocarbon, and pharmaceutically acceptable salts thereof.

Abstract: The present invention relates to new syn-isomers of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising the same, which have antibacterial activities in the treatment of infectious diseases in human beings and animals.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sub.1 is amino, lower alkanoylamino or halo(lower)alkanoylamino,R.sub.2 is lower alkyl, lower alkylthio(lower)alkyl, lower alkenyl, lower alkynyl, carboxy(lower)alkyl or esterified carboxy(lower)alkyl, andX is halogen;and pharmaceutically acceptable salts thereof.