Abstract: Bacteriostatic cephem compounds and processes for preparing same having the formula: ##STR1## wherein R.sup.1 is amino; R.sup.2 is optionally substituted alkyl, C.sub.3-8 cycloalkyl, lower alkenyl, or lower alkynyl; R.sup.3 is amino and/or alkyl substituted heterocyclic group; and R.sup.4 carboxy.

Abstract: Syn-isomers of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof which have anti-bacterial activities and the processes for the preparation thereof, to pharmaceutically composition comprising the same, and to a method of using the same therapeutically and the treatment of infectious diseases in animals and human beings.

Abstract: This invention relates to novel cepham compounds of antimicrobial activity, useful as intermediates in the preparation of antibiotics, said novel cepham compounds being of the formula: ##STR1## wherein R.sup.1 is phenyl (lower) alkanoylamino, phenoxy (lower) alkanoylamino or aminothiazolyl (lower) alkanoylamino substituted with a lower alkoxyimino group,R.sup.2 is carboxy or a protected carboxy group,R.sup.3 is formyl, hydroxymethyl or acyloxymethylene, andX is --S-- or --SO--, and its salt.

Abstract: A new process for preparing 3-methylenecepham compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group, andR.sup.2 is a carboxy or a protected carboxy group,or a salt thereof,which comprises reducing a compound of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are each as defined above, andR.sup.3 is halogen or heterocyclicthio which may have suitable sutstituent, or a salt thereof, with a combination of a metal selected from the group consisting of zinc, tin and iron, and an ammonium salt of an acid selected from the group consisting of ammonium halide, ammonium carbonate and ammonium acetate, said 3-methylenecepham compounds being useful as intermediates for preparing antimicrobially active 3-cephem compounds.

Abstract: 3,7-disubstituted-3-cephem-4-carboxylic acid compounds having bacteriostatic properties and the following formula: ##STR1## in which R.sup.1 is thiadiazolyl or isothiazolyl, each of which may have suitable substituent(s), or thiazolyl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is carboxy or protected carboxy; R.sup.4 is hydrogen, acyloxy or a heterocyclicthio group which may have suitable substituent(s); and R.sup.5 is hydrogen or lower alkoxy, process for making same and treating infectious diseases therewith.

Abstract: A compound of the formula: ##STR1## wherein R is a bridged alicyclic group selected from the group consisting of norbornyl, norbornenyl, bicyclo[2,2,2]-heptyl and adamantyl optionally substituted by at least one substituent selected from the group consisting of lower alkyl, carboxy, lower alkoxycarbonyl, alkylidenedioxy, N,N-di(lower)alkylcarbamoyl, amino, loweralkoxycarbonylamino and halogen. The present compound is useful in the therapeutic treatment of cancer in human beings and animals.

Abstract: Bacteriostatic cephem compounds and processes for preparing same having the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is lower alkyl, amino-(lower)-alkyl, protected amino-(lower)-alkyl, hydroxy-(lower)-alkyl, protected hydroxy-(lower)-alkyl, lower alkylthio-(lower)-alkyl, carboxy-(lower)-alkyl, esterified carboxy-(lower)-alkyl, (C.sub.3 to C.sub.8) cycloalkyl, lower alkenyl or lower alkynyl,R.sup.3 is a heterocyclic group substituted with amino(lower)alkyl, protected amino(lower)-alkyl, hydroxy(lower)alkyl or both amino and lower alkyl,R.sup.4 carboxy or protected carboxy,provided that R.sup.3 is a heterocyclic group substituted with hydroxy(lower)alkyl or both amino and lower alkyl, when R.sup.2 is lower alkyl,and its pharmaceutically acceptable salt.

Abstract: Syn isomers of 3-substituted 7-[2-substituted imino-2-substituted acetamido]-3-cephem-4-carboxylic acid and salt bacteriostatic-compounds and pharmaceutical compositions thereof and processes for preparing same.

Abstract: New syn-isomers of 3-cephem-4-carboxylic acids having anti-bacterial activities, processes for preparation thereof, pharmaceutical compositions thereof, with the acids being substituted at the 3 position with acyloxymethyl, hydroxymethyl, formyl or heterocyclic thiomethyl groups and at the 7 position with alkoxyiminoacetamido substituted with substituted phenyl or substituted thiazolyl.

Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl, R.sup.2 is carboxy or protected carboxy, R.sup.3 is amino or protected amino and R.sup.4 is lower alkyl substituted by halogen or a lower unsaturated aliphatic group, and pharmaceutically acceptable salts thereof.

Abstract: Preparation of pharmaceutical composition comprising, treatment of human and animal diseases with, and compound of, 3,7-disubstituted-3-cephem-4-carboxylic acid.

Abstract: Compounds of the formula: ##STR1## wherein R.sup.1 is (C.sub.1 to C.sub.6) alkyl. R.sup.2 is carboxy or a protected carboxy group,R.sup.3 is amino or a protected amino group andA is hydroxyimino (C.sub.1 to C.sub.6) alkylene or (C.sub.1 to C.sub.6)-alkoxyimino (C.sub.1 to C.sub.6) alkylene, andpharmaceutically acceptable salt thereof, have been found to be active against various pathogenic microorganisms.

Abstract: The invention relates to new antimicrobially active 3-cephem compounds, processes for preparing such compounds, new intermediate compounds comprising alkoxyimino dioxy butyric acid derivatives useful in said processes, and processes for preparation of said intermediates.

Abstract: The invention relates to new thiadiazolyl or thiazolyl-substituted cephem and cepham compounds, the pharmaceutically acceptable salts and bioprecursors thereof, of antimicrobial activity, processes for preparation thereof, intermediates for preparing the new compounds and to pharmaceutical compositions comprising the new compounds, and methods of using the compositions for treatment of infectious diseases.

Abstract: Novel 3-phosphonocephalosporanic acid derivatives and pharmaceutically acceptable salts thereof, which have antimicrobial activities; processes for the preparation thereof; pharmaceutical compositions comprising the same; and a method of using the same therapeutically for the treatment of infectious diseases in human beings or animals are disclosed.

Abstract: Preparation of pharmaceutical composition comprising, treatment of human and animal diseases with, and compound of 3,7-disubstituted-3-cepham-4-carboxylic acid.

Abstract: This invention relates to new cephem compounds. More particularly, it relates to new 7-substituted-3-cephem-4-carboxylic acid, its pharmaceutically acceptable salt and pharmaceutically acceptable bioprecursor thereof, which have antimicrobial activities, and processes for preparation thereof, to intermediate for preparing the same and processes for preparation thereof, and to pharmaceutical composition comprising the same and methods of using the same prophylactically and therapeutically for treatment of infectious diseases in human beings and animals.The cephem compounds of this invention include the compound represented by the formula (I): ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.

Abstract: New syn-isomers of 3-cephem-4-carboxylic acids having anti-bacterial activities, processes for preparation thereof, pharmaceutical compositions thereof, with the acids being substituted at the 3 position with acyloxymethyl, hydroxymethyl, formyl or heterocyclic thiomethyl groups and at the 7 position with alkoxyiminoacetamido substituted with substituted phenyl or substituted thiazolyl.

Abstract: 3,7-Disubstituted-3-cephem-4-carboxylic acid compounds having bacteriostatic properties and the following formula: ##STR1## in which R.sup.1 is thiadiazolyl or isothiazolyl, each of which may have suitable substituent(s), or thiazolyl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is carboxy or protected carboxy; R.sup.4 is hydrogen, acyloxy or a heterocyclicthio group which may have suitable substituent(s); and R.sup.5 is hydrogen or lower alkoxy, process for making same and treating infectious diseases therewith.

Abstract: 7-(2-Hydroxyimino-2-hydroxyphenyl-acetamido)-3-substituted-3-cephem-4-carbo xylic acids are disclosed which possess an antibacterial activity.