Abstract: The invention relates particularly to syn compounds of the formula ##STR1## wherein R.sup.2 is C.sub.1 -C.sub.8 alkyl, R.sup.5 is carboxy or pharmaceutically acceptable esterified carboxy and R.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.

Abstract: 7-Substituted 3-cephem or cephem compounds characterized by the grouping, in the 7-position thereof, of the formula:R'--A--CONH--where R' is thiadiazolyl or amino thiazolyl, and a is methylene carrying oxyiimino, or R' is haloacetyl and A may also be methylene, their preparation, and pharmaceutical uses.

Abstract: The invention relates to novel 7-acylamino-3-vinylcephalosporanic acid derivatives of antimicrobial activity, and to methods of preparation thereof from novel intermediate compounds of the formula: ##STR1## in which R.sub.C is amino or a group of the formula: ##STR2## wherein R.sup.8 is aryl,A.sup.12 is lower alkylene having a group of the formula: .dbd.N.about.OR.sup.4, wherein R.sup.4 is hydrogen, cyclo(lower) alkenyl, lower alkynyl, lower alkenyl, lower alkenyl substituted by carboxy or a protected carboxy group, lower alkyl, or lower alkyl substituted by one or more substituent(s) selected from carboxy, a protected carboxy group, amino, a protected amino group, cyano, phosphono, a protected phosphono group and a heterocyclic group which may have suitable substituent(s),R.sup.a is a protected amino group,R.sup.b is a protected carboxy group,R.sup.c and R.sup.d are combined to form oxo or a protected oxo group, and X.sup.1 is halogen, andR.sup.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity, said compounds being of the formula: ##STR1## wherein R.sup.1 is a group of the formula: ##STR2## in which R.sup.5 is amino or a protected amino group; and R.sup.6 is lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cyclo(lower)alkenyl, aryl, ar(lower)alkyl, or halogen-substituted ar(lower)alkyl;R.sup.2 is carboxy or a protected carboxy group;A is hydroxy(lower)alkylene, amino(lower)alkylene, protected amino(lower)alkylene, lower alkenylene, hydroxyimino(lower)alkylene, lower alkoxyimino(lower)alkylene, or lower alkenyloxyimino(lower)alkylene; andR.sup.3 is carboxy or a protected carboxy group, and pharmaceutically acceptable salts thereof.

Abstract: The invention relates to new cephem compounds of high antimicrobial activity, the compounds having the formula ##STR1## wherein R.sup.1 is amino or a protected amino groupR.sup.2 is a saturated 4 to 8-membered heteromonocyclic group containing one sulfur atom;R.sup.3 is carboxy or a protected carboxy group andR.sup.4 is hydrogen, lower alkyl, or a group of the formula:--CH.sub.2 R.sup.4awhereR.sup.4a is acyloxy a heterocyclicthio group which may have suitable substituents or pyridinio which may have suitable substituents with the proviso that R.sup.3 is COO.sup.- when R.sup.4a is pyridinio which may have suitable substituents.

Abstract: A 3,7-disubstituted-3-cephem-4-carboxylic acid of the general formula: ##STR1## having antibacterial activity, processes for preparing same, and pharmaceutical compositions thereof for treating infectious diseases in humans and animals.

Abstract: The invention relates to novel 7-acylamino-3-substituted cephalosporanic acid derivatives of high antimicrobial activity, of the formula ##STR1## in which R.sup.5 is amino or a protected amino group,R.sup.2 is methoxymethyl,R.sup.3 is carboxy or a protected carboxy group, andR.sup.6 is lower alkyl, and a pharmaceutically acceptable salt thereof.

Abstract: This invention relates to novel 7-acylamino-3-vinyl-cephalosporanic acid derivatives and pharmaceutically acceptable salts thereof, of high antimicrobial activity.

Abstract: The invention relates to new cephem compounds, of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.3 is halogen or lower alkoxy, andR.sup.4 is carboxy or protected carboxy,and a pharmaceutically acceptable salt thereof.

Abstract: This invention relates to a new cephem compound of the formula: ##STR1## wherein R.sup.1 is amino or a substituted amino group;R.sup.2 is carboxy or a protected carboxy group;R.sup.3 is a tetrazolyl group having a lower alkynyl group; andX is --S-- or ##STR2## and pharmaceutically acceptable salts thereof, of high antimicrobial activity.

Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.2 is an aliphatic hydrocarbon residue substituted with halogen, carboxy or esterified carboxy,R.sup.4 is halogen or a group of the formula:--O--R.sup.7, in which R.sup.7 is lower alkyl,R.sup.5 is carboxy or functionally modified carboxy andR.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, processes for making the compounds, pharmaceutical compositions containing them and their use to treat infectious diseases.

Abstract: A compound of the formula: ##STR1## wherein R.sup.2 is hydrogen or lower alkyl, R.sup.3 is carboxy or a protected carboxy group, X is --S-- or ##STR2## and the dotted line bridging the 2- to 4-positions of the formula indicates that the compound may be the 2- or 3-cephem derivative, and pharmaceutically acceptable salts thereof.

Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.1 is thiadiazolyl,R.sup.2 is hydrogen or an aliphatic hydrocarbon residue which may be substituted with halogen, carboxy or esterified carboxy andR.sup.5 is carboxy or functionally modified carboxy, and pharmaceutically acceptable salt thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.

Abstract: The invention relates to new cephem compounds of high antimicrobial activity, the new cephem compounds comprising aminothiazole cycloalkenyloxyimino acetamido cephem derivatives.

Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.2 is hydrogen or an aliphatic hydrocarbon which may be substituted with halogen, carboxy or pharmaceutically acceptable esterified carboxy,R.sup.5 is carboxy or pharmaceutically acceptable esterified carboxy,R.sup.6 is amino or protected amino andR.sup.7 is lower alkanesulfonyl or arenesulfonyl and pharmaceutically acceptable salt thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.

Abstract: This invention relates to new compounds comprising alkoxyimino dioxy butyric acid cepham derivatives, useful as intermediates in the production of antimicrobial agents.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity, to processes for preparation of said compounds, and to pharmaceutical compositions containing said compounds, the cephem compounds being of the formula ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is lower alkyl of from one to six carbon atoms substituted with aryl hydrocarbon of from 6 to 10 carbon atoms or substituted aryl hydrocarbon with at least one halogen, hydroxy, amino (lower) alkyl, amido (lower) alkyl, or lower alkyl substituent,R.sup.3 is carboxy or protected carboxy, andR.sup.4 is hydrogen,and its pharmaceutically acceptable salt.

Abstract: The invention relates to new cephalosporin compounds of high antimicrobial activity, the compounds being of the formula: ##STR1## wherein R.sup.1 is a group of the formula ##STR2## in which X is sulfur, oxygen, imino or lower-alkanoyl-substituted imino, R.sup.2 is hydrogen, lower alkyl or lower alkenyl,R.sup.3 is hydrogen or lower alkyl,R.sup.4 is hydrogen, halogen, lower alkyl, carbamoyloxymethyl or lower alkanoyloxymethyl, andR.sup.5 is carboxy or its ester, and a non-toxic, pharmaceutically acceptable salt thereof.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,A is lower alkylene which may be substituted with oxo, hydroxy, amino, protected hydroxy or protected amino,R.sup.2 is hydrogen, halogen or hydroxy, andR.sup.3 is carboxy or functionally modified carboxy, its nontoxic, pharmaceutically acceptable salt and a bioprecursor thereof.

Abstract: This invention relates to new compounds of high antibiotic activity of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group; andR.sup.2 is C.sub.2 to C.sub.6 alkyl.