Abstract: The present invention relates to a dosing mechanism including: a body; and a pump unit (3) that is attached to the body, in which the pump unit (3) includes: a pump (31) in which a volume of a solution feeding part therein repeats expansion and shrinkage, thereby sucking a medicine from a medicine vessel and discharging the medicine to a patient; a suction-side pipe (333) that extends from the pump (31) toward the medicine vessel; a discharge-side pipe (343) that extends from the pump (31) toward the patient; a relief pipe (35, 35a) whose one end (351) is connected to the discharge-side pipe (343) while the other end (352) is located in a part whose pressure is lower than pressure inside the discharge-side pipe when the medicine is dosed; and a relief pipe on-off valve (36, 36a) that opens and closes the relief pipe (35, 35a), a use method of a dosing mechanism, and a pump unit for a dosing mechanism.

Abstract: An object detecting device includes a detector and a determination unit. The detector detects presence or absence of an object based on whether a receiving unit that converts a mechanical vibration into an electric signal receives a reflected ultrasonic wave transmitted intermittently from a transmitting unit. The determination unit determines that the transmitting unit is normal when the electric signal is not detected in a determination section set within a predetermined time from a starting time point of the transmission of the ultrasonic wave. The determination unit determines that the transmitting unit is abnormal when a correlation value of waveforms of a plurality of electric signals detected in the plurality of determination sections is greater than or equal to a specified value. The determination unit determines that the transmitting unit is normal when the correlation value is less than the specified value.

Abstract: The object of the present invention is to provide a glycosylated polypeptide having uniform sugar chain structure which has interferon ? activity. It was found that a glycosylated polypeptide having uniform sugar chain structure as well as having interferon ? activity can be prepared by a method comprising a step of synthesizing a glycosylated peptide fragment and at least two peptide fragments and a step of linking the glycosylated peptide fragment and the at least two peptide fragments.

Abstract: The object of the present invention is to provide an artificial skin having hair follicles, sebaceous glands, and hair pores. The present invention provides a method for manufacturing artificial skin having hair follicles, sebaceous glands, and hair pores, characterized in that it comprises each of the following steps: (A): a step of preparing an artificial skin having dermal and epidermal layers or an artificial skin having only a dermal layer; and (B): a step of transplanting isolated hair follicles to the artificial skin prepared in step (A); wherein said isolated hair follicle comprises a sebaceous gland, and said isolated hair follicle is transplanted to said artificial skin so that the surface of said dermal Layer of said artificial skin is in alignment with the position of the hair pore portion of said isolated hair follicle.

Abstract: For perfusion, blood vessels protruding from a removed organ or tissue and cannulas for circulating perfusate are tightened and bound at positions away from the cut ends of the blood vessels toward a proximal side viewed from the organ. The cut ends of the aforementioned blood vessels that are anastomosed to blood vessels of a living body are spaced from the binding positions at which the cannulas are secured. The direction to the blood vessels of the living body can be conducted while moving the cannulas in various postures relative to the blood vessels protruding from the organ or tissue. This enables performing an anastomosis operation while maintaining the perfusion state. In this way, organs and tissues that include at least one artery route and at least one vein route can be anastomosed to blood vessels of a living body while maintaining the perfusion state.

Abstract: The purpose of the present invention is to propose a method for measuring the level of health of a subject, with which it is possible: to perform health examination that is non-invasive to the human body and that employs a simple method; to provide highly reliable analysis results having a scientific basis; and to, additionally, provide appropriate solutions to the subject. Another purpose of the present invention is to propose a health-level determining apparatus employing said method and a new business model employing said method. The present invention is a method for measuring the level of health of a subject, including a hair analyzing step (A) for analyzing hair of the subject. It is preferable that the aforementioned hair analyzing step (A) include a step (A-1) for analyzing hair in the occipital region. In addition, it is preferable that the aforementioned hair analyzing step (A) include a step (A-2) for analyzing hair in a site other than the occipital region.

Abstract: A perfusion device and a perfusion method can allocate two routes of perfusate inflow pathways and two routes of perfusate outflow pathways for a liver graft. The perfusate inflow pathways have perfusate inflow cannulas connected respectively to the portal vein and the hepatic artery. The perfusate outflow pathways have perfusate outflow cannulas connected respectively to the suprahepatic inferior vena cava and the infrahepatic inferior vena cava. Perfusate is allowed to enter the liver from the perfusate inflow cannulas, and the perfusate in the liver is allowed to drain off from the perfusate outflow cannulas. This significantly shortens the time length of the liver graft being in an ischemic condition when the liver is removed or transplanted. That is, the onset of disorder in the liver graft can be suppressed. This increases the success rate of liver transplantation. Thus, deterioration of organ grafts during surgery is prevented in organ transplantation surgery that requires long hours.

Abstract: An ultrasonic sensor is provided with a mount that is fixed to an inside-face of the bumper, and a sensor body that is coupled to the mount so as to be exposed outside the bumper through an exposure hole that is provided in the bumper. Compared with a case where an ultrasonic sensor is fixed to a bumper by sandwiching the bumper from inside and outside of the bumper, appearance can be improved, since protrusion outward from the bumper is eliminated.

Abstract: The present invention is directed to a hair growth agent for external use comprising chiro-inositol, which is provided as an excellent hair growth agent.

Abstract: A silicon carbide semiconductor device includes an n-type drift layer and a p-type epitaxial base layer deposited on an n-type silicon carbide substrate, as well as first trenches and second trenches. N-type source regions are formed in the surface layer of the p-type epitaxial base layer, in the sidewalls of the first trenches, and in the bottoms of the first trenches. The thickness of the p-type epitaxial base layer is set so that a concentration of ion species or point defects running along dislocations in the p-type epitaxial base layer is so low that regions surrounding the dislocations do not conduct current due to the ion species or the point defects.

Abstract: An object detecting device includes a detector and a determination unit. The detector detects presence or absence of an object based on whether a receiving unit that converts a mechanical vibration into an electric signal receives a reflected ultrasonic wave transmitted intermittently from a transmitting unit. The determination unit determines that the transmitting unit is normal when the electric signal is not detected in a determination section set within a predetermined time from a starting time point of the transmission of the ultrasonic wave. The determination unit determines that the transmitting unit is abnormal when a correlation value of waveforms of a plurality of electric signals detected in the plurality of determination sections is greater than or equal to a specified value. The determination unit determines that the transmitting unit is normal when the correlation value is less than the specified value.

Abstract: A semiconductor device includes an n-type silicon carbide epitaxial layer formed on an n+-type silicon carbide semiconductor substrate, p+-type base regions formed in the n-type silicon carbide epitaxial layer, a dense n-type region formed in the n-type silicon carbide epitaxial layer, a p-type base layer formed on the dense n-type region, an n+-type source region and a p++-type contact region formed in the p-type base layer, a trench penetrating the p-type base layer in a depth direction of a part of one of the p+-type base regions, and a gate electrode formed on a gate insulating film in the trench. The n+-type source region is formed using two dopant types, phosphorus and carbon. A dose amount DC of carbon satisfies 0.7?DC/Dp?1.3 with respect to a dose amount Dp of phosphorus. An impurity concentration of the n+-type source region ranges from 1018 to 1021.

Abstract: To provide a method of efficiently producing full thickness skin having skin accessory organs. [Solution] This method of producing full thickness skin having skin accessory organs is characterized by involving the following steps (a) to (d): (a) a step for stimulating an embryoid body with a physiologically active substance that can activate the Wnt pathway, (b) a step for preparing a conjugate that includes all or part of the embryoid body stimulated in step (a) and a scaffolding material, (c) a step for transplanting the conjugate prepared in step (b) into an animal, and (d) a step for producing, in the animal, full thickness skin derived from said conjugate.

Abstract: The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X1 represents —NH? or —CH?, X2 represents —CH? or —N?, R1 and R2 each represent a C1 to C6 alkoxy group or the like, R3 represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R4 represents a C1 to C6 alkylthio group or a C2 to C6 alkenyl group (the C1 to C6 alkylthio group and the C2 to C6 alkenyl group are each optionally substituted by one carboxy group or the like) or the like.

Abstract: A p-type region, a p? type region, and a p+ type region are selectively disposed in a surface layer of a silicon carbide substrate base. The p-type region and the p? type region are disposed in a breakdown voltage structure portion that surrounds an active region. The p+ type region is disposed in the active region to make up a JBS structure. The p? type region surrounds the p-type region to make up a junction termination structure. A Schottky electrode forms a Schottky junction with an n-type silicon carbide epitaxial layer. The Schottky electrode overhangs an interlayer insulation film covering a portion of the p-type region and this overhanging portion acts as a field plate. The p+ type region has an acceptor concentration greater than or equal to a predetermined concentration and can make a forward surge current larger.

Abstract: The object of the present invention is to provide an implant that enables functional periodontium formation around the implant after transplantation of a dental implant. In some aspects of the present invention, a tooth germ tissue-derived or a periodontal membrane tissue-derived cell mass is placed on the surface of the implant, and the surface of the implant on which the cell mass is placed is the whole or a part of the surface which is surrounded by the alveolar bone of the recipient at the time of implant transplantation.

Abstract: A method for producing a regenerative organ germ for transplantation includes using regenerative organ germ for transplantation ensuring continuity with a recipient after transplantation and facilitating transplantation procedures. A method for producing a regenerative organ germ provided with a guide for transplantation includes preparing a regenerative organ germ by closely contacting a first cell mass, which substantially consists of mesenchymal cells, and a second cell mass, which substantially consists of epithelial cells, culturing these cell masses within a support, and inserting the guide into the regenerative organ germ.

Abstract: In a method of manufacturing a silicon carbide semiconductor device, an n-type drift layer and a p-type epitaxial base layer are sequentially deposited onto an n-type silicon carbide substrate. Next, n-type source regions and a p-type base contact region are formed in the surface layer of the p-type epitaxial base layer. Then, laser annealing is performed by irradiating the surface layer of the n-type source regions and the surface layer of the p-type base contact region with a laser.

Abstract: A silicon carbide semiconductor device includes an n-type drift layer and a p-type epitaxial base layer deposited on an n-type silicon carbide substrate, as well as first trenches and second trenches. N-type source regions are formed in the surface layer of the p-type epitaxial base layer, in the sidewalls of the first trenches, and in the bottoms of the first trenches. The thickness of the p-type epitaxial base layer is set so that a concentration of ion species or point defects running along dislocations in the p-type epitaxial base layer is so low that regions surrounding the dislocations do not conduct current due to the ion species or the point defects.

Abstract: The object of the present invention is to provide a technology that enables long-term preservation while maintaining the function of an organ or tissue for transplantation. A further object is utilizing this technology to provide a technology for suppressing tissue disorder accompanying warm ischemia and reperfusion as well as restoring an organ from a cardiac arrest donor to a level compatible for transplantation. A method that employs perfusion by a perfusate etc. is provided, comprising each of the following steps of: (a) connecting a perfusate instream cannula for streaming said perfusate into said “organ or tissue,” (b) connecting a perfusate outstream cannula for streaming said perfusate out from said “organ or tissue,” and (c) perfusing a perfusate comprising an oxygen carrier and a blood coagulation inhibitor into said organ or tissue.