Abstract: Systems and methods for providing data for visualization and data for quantification are disclosed herein. The data for visualization may be used to generate images to provide to a user on a display. The data for quantification may be used to calculate various physiologically relevant parameters, such as hepato-renal index (HRI) values. In some examples, the quantification data may not be used to generate images. In some examples, a user may select regions of interest (ROIs) in the images generated from the visualization data and the corresponding quantification data for the ROIs may be used to calculate one or more parameters. The visualization data and quantification data may be generated from different imaging modes or same imaging modes with different data processing in some examples.

Abstract: The present disclosure describes ultrasound systems and methods configured to determine the elasticity of a target tissue. Systems can include an ultrasound transducer configured to acquire echoes responsive to ultrasound pulses transmitted toward the tissue, which may include a region of increased stiffness. Systems can also include a beamformer configured to control the transducer to transmit a push pulse into the tissue, thereby generating a shear wave in the region of increased stiffness. The beamformer can be configured to control the transducer to emit tracking pulses adjacent to the push pulse. Systems can further include a processor configured to determine a displacement amplitude of the shear wave and based on the amplitude, generate a qualitative tissue elasticity map of the tissue. The processor can combine the qualitative map with a quantitative map of the same tissue, and based on the combination, determine a boundary of the region of increased stiffness.

Abstract: Disclosed are a sample analysis apparatus and method which include: obtaining a first light signal by irradiating a first test sample from blood and a first-channel reagent to differentiate neutrophils, eosinophils, lymphocytes, and monocytes; obtaining a second light signal from a second test sample from the blood and a second-channel reagent; counting the nucleated red blood cells and lymphocytes based on the second light signal; determining accuracy of the lymphocyte result from the first test sample; and if inaccurate, correcting the lymphocyte result based on the lymphocyte result of the second test sample.

Abstract: A molding compound dispensing system identifies a semiconductor device strip having a substrate with a plurality of segments allocated for die stacks. The system obtains topological data of the identified semiconductor device strip for each of the segments, including data indicative of any semiconductor components in each respective segment. The system determines an amount of molding compound to be applied to each of the segments based on the topological data for each respective segment, and causes a molding compound dispenser to dispense the determined amounts of molding compound at each of the segments.

Abstract: In an ultrasound imaging system which produces synthetically transmit focused images, the multiline signals used to form image scanlines are analyzed for speed of sound variation, and a map 60 of this variation is generated. In a preferred implementation, the phase discrepancy of the received multilines caused by speed of sound variation in the medium is estimated in the angular spectrum domain for the receive angular spectrum. Once the phase is estimated for all locations in an image, the differential phase between two points at the same lateral location, but different depth, is computed. This differential phase is proportional to the local speed of sound between the two points. A color-coded two- or three-dimensional map 60 is produced from these speed of sound estimates and presented to the user.

Abstract: The present invention relates to a multi-target tyrosine kinase inhibitor, which is a compound having protein kinase inhibitory activity as shown in formula (I). The compound is metabolized into an active small molecule td32-4 that inhibits tumor growth in vivo, so as to achieve the anti-tumor effect. Compared with td32-4, the compound of the present invention has significantly improved solubility and oral bioavailability, and shows strong anti-tumor activity in animal in vivo experiments. The present invention relates to a synthetic method for the compound of formula (I) and an application thereof in the field of pharmaceuticals.

Abstract: A short-circuit protection apparatus includes a first detection branch, a second detection branch, and a controller. The first detection branch includes a first sampling resistor and a first sampling capacitor that is connected in parallel to the first sampling resistor. A difference between an absolute value of a second sampling voltage and an absolute value of a first sampling voltage is a first difference. The controller obtains a comparison result between an absolute value of a first sampling voltage at two terminals of the first sampling resistor and an absolute value of a second sampling voltage at two terminals of the second sampling resistor, and if a difference between the absolute value of the second sampling voltage and the absolute value of the first sampling voltage is a second difference and the second difference is less than the first difference, controls the target circuit to stop working.

Abstract: Systems and methods for multi-level vascular imaging for construction and display of vasculature from large to small vessels and micro-vessels using a combination of varying resolution contrast enhanced ultrasound flow imaging modalities are disclosed. While one or more resolution flow imaging modes may be employed for imaging large to small vessels of a vascular tree within a large region of interest, a high resolution mode, such as super resolution imaging, constructed for delineation of the microvascular morphology and directional microcirculation is provided within one or more small ROIs placed in selected locations within the larger ROI.

Abstract: The present disclosure describes ultrasound systems and methods configured to determine the elasticity of a target tissue. Systems can include an ultrasound transducer configured to acquire echoes responsive to ultrasound pulses transmitted toward the tissue, which may include a region of increased stiffness. Systems can also include a beamformer configured to control the transducer to transmit a push pulse into the tissue, thereby generating a shear wave in the region of increased stiffness. The beamformer can be configured to control the transducer to emit tracking pulses adjacent to the push pulse. Systems can further include a processor configured to determine a displacement amplitude of the shear wave and based on the amplitude, generate a qualitative tissue elasticity map of the tissue. The processor can combine the qualitative map with a quantitative map of the same tissue, and based on the combination, determine a boundary of the region of increased stiffness.

Abstract: Systems and methods for generating adaptive contrast accumulation imaging images are disclosed. A point spread function thinning/skeletonization technique may be performed on contrast enhanced image frames. An aggressiveness parameter of the technique may be adapted temporally and/or spatially. The aggressiveness parameter may be adapted based on various factors, including, but not limited to, time since injection of the contrast agent, signal intensity, and/or vessel size. The images may be temporally accumulated to generate a final sequence of adaptive contrast accumulation imaging images.

Abstract: Systems and methods for calculating hepato-renal index (HRI) values from radiofrequency (RF) data are disclosed herein. The RF data may include fundamental frequency components, harmonic frequency components, or a combination thereof. Signal intensities within regions of interest may be calculated from the RF data. The signal intensities may be averaged to arrive at an average signal intensity value for each region of interest. In some examples, some of the highest and/or lowest signal intensity values may be removed prior to averaging. The ratio of the average signal intensities from the different regions of interest may be then be taken to arrive at the HRI values.

Abstract: Systems and methods for time-varying two-dimensional (2D) color maps for visualizing images or sequences of images are disclosed. The 2D color map may include brightness values of a hue corresponding to different intensities that changes over time. In some 2D color maps, the hue used for the intensity scale may change over time while the brightness of a pixel may not. In some 2D color maps, both the hue and the brightness may change relative to intensity over time.

Abstract: This application discloses a boost power conversion circuit, a method, an inverter, an apparatus, and a system. In the conversion circuit, a voltage control circuit is added on a three-level boost. The voltage control circuit can be connected in series in a third closed loop, and the third closed loop is a loop including an inductor, a first switching transistor, a flying capacitor, a second diode, and an input end. The voltage control circuit clamps a voltage of a common point of the first diode and the second diode when a voltage on an input end of the boost power conversion circuit is less than a startup voltage of the boost power conversion circuit. The voltage borne by the second diode is reduced, so that a diode with relatively small voltage stress can be selected.

Abstract: An ultrasound system produces maps of acoustic attenuation coefficients from B mode image signals. A plurality of maps located in different parallel and elevationally separated planes (A, B, C, D, E) are produced, then compounded in the elevation direction. Confidence maps may also be produced for one or more attenuation coefficient maps, and the confidence map displayed or its measures used to determine weighting for the compounding process. The compounding of elevationally separate planes improves attenuation coefficient estimation in the presence of blood vessels affecting the estimates in one or more of the planes.

Abstract: This application discloses a boost power conversion circuit, a method, an inverter, an apparatus, and a system. In the conversion circuit, a voltage control circuit is added on a three-level boost. The voltage control circuit can be connected in series in a third closed loop, and the third closed loop is a loop including an inductor, a first switching transistor, a flying capacitor, a second diode, and an input end. The voltage control circuit clamps a voltage of a common point of the first diode and the second diode when a voltage on an input end of the boost power conversion circuit is less than a startup voltage of the boost power conversion circuit. The voltage borne by the second diode is reduced, so that a diode with relatively small voltage stress can be selected.

Abstract: A peristaltic pump precise dosing control system includes a driver, a pump head, pipeline switching means, a metering pipeline, and a discharge pipeline. An elastic tubing is provided in the pump head, and the outlet end of the elastic tubing is connected to the pipeline switching means. The driver drives the pump head to rotate to pump the liquid in the elastic tubing to the outlet end of the elastic tubing. The driver is electrically connected to the pipeline switching means so as to be capable of controlling the pipeline switching means to switch to the output pipeline with which the outlet end of the elastic tubing is connected. The pipeline switching means is driven to switch the outlet end of the elastic tubing from a state of connection with the discharge pipeline to a state of connection with the metering pipeline.

Abstract: A bus-barwire is provided. The bus-barwire has a frame, busbars and terminals. The busbars each has a main body and multiple connecting parts connected to the main body. The connecting parts connect wiring ends of motor stator windings. The terminals are connected to the busbars, to connect to a power source. The main bodies of the busbars are arranged in a stack along an axial direction of the frame and are spaced apart from each other. The connecting parts of the busbars are spaced apart along a circumferential direction of the frame. The connecting parts of the busbars are distanced from end surfaces of the stator windings and remain flush in the axial direction of the frame.

Abstract: A system for boundary identification includes a memory (42) to store shear wave displacements through a medium as a displacement field including a spatial component and a temporal component. A directional filter (206, 208) filters the displacement field to provide a directional displacement field. A signal processing device (26) is coupled to the memory to execute a boundary estimator (214) to estimate a tissue boundary in a displayed image based upon a history of the directional displacement field accumulated over time.

Abstract: A therapeutic ultrasound method configured to adaptively transmit ultrasound pulses toward microbubbles in a treatment region to remove an occlusion is described. In some examples, the system may include a treatment pulse unit configured to transmit an ultrasound pulse to a treatment region of a subject, the treatment region including a plurality of microbubbles. An echo detection unit may be configured to receive one or more echoes responsive to the ultrasound pulse. In some examples, the method may also include a data processor configured to identify, using data associated with the echoes, at least one echo signature indicative of a dynamic state of the microbubbles in response to the ultrasound pulse. A controller may be configured to adjust one or more parameters of an additional ultrasound pulse transmitted to the treatment region via the treatment pulse unit based on the at least one echo signature.

Abstract: A therapeutic ultrasound system transmits a staggered or interleaved pattern of therapy beams for use in sonothrombolysis and other Vascular Acoustic Resonators (VAR) mediated therapy. The inventive technique minimizes VAR, e.g. microbubble, destruction due to adjacent beams, ensures uniform sonication of the targeted region by filling in the spaces between the beams in subsequent passes, and further provides a means for bubble replenishment to maximize the clot lysis from ultrasound. The technique is also applicable to diagnostic ultrasound, VAR mediated drug delivery and blood brain barrier opening.