Abstract: Systems and methods for visualizing microbubbles for contrast-enhanced imaging are described herein. Microbubbles may be visualized by multi-pixel spots by identifying and localizing individual microbubbles. Motion compensation may be provided for localized microbubbles or for contrast images prior to microbubble identification and localization. Users may determine the size of the multi-pixel spot by adjusting a filter, for example, adjusting a threshold value of the filter. Altering the size of the multi-pixel spot may alter the resolution. As the number of pixels increases, the resolution decreases, but the acquisition time may also decrease. As the number of pixels decreases, the resolution increases, but the acquisition time may increase.

Abstract: The present disclosure describes ultrasound systems configured to perform microbubble-based contrast imaging with enhanced sensitivity. The systems can enhance echo signals derived from microbubbles while suppressing echo signals derived from tissue by detecting phase shifts exhibited by microbubbles in resonance. To detect the phase shifts, and thereby distinguish between microbubble-based signals and tissue-based signals, the systems can transmit a series of ultrasound pulses into a target region in accordance with a predefined sequence. The sequence can include an initiation pulse configured to stimulate microbubbles into nonlinear oscillation, a detection pulse configured to detect the nonlinear oscillation, and a summation pulse formed by transmitting an initiation pulse and detection pulse with a small time delay therebetween.

Abstract: The present disclosure describes a therapeutic ultrasound system configured to adaptively transmit ultrasound pulses toward microbubbles in a treatment region to remove an occlusion. In some examples, the system may include a treatment pulse unit configured to transmit an ultrasound pulse to a treatment region of a subject, the treatment region including a plurality of microbubbles. An echo detection unit may be configured to receive one or more echoes responsive to the ultra sound pulse. In some examples, the system may also include a data processor configured to identify, using data associated with the echoes, at least one echo signature indicative of a dynamic state of the microbubbles in response to the ultrasound pulse. A controller may be configured to adjust one or more parameters of an additional ultrasound pulse transmitted to the treatment region via the treatment pulse unit based on the at least one echo signature.

Abstract: Various embodiments of the present disclosure include a thermal ablation probabilistic controller (30) employing an ablation probability model (32) trained to render a pixel ablation probability for each pixel of an ablation scan image illustrative of a static anatomical ablation. In operation, the thermal ablation probabilistic controller (30) spatially aligns a temporal sequence of ablation scan datasets representative of a dynamic anatomical ablation, and applies the ablation probability model (32) to the spatial alignment of the temporal sequence of ablation scan datasets to render the pixel ablation probability for each pixel of the ablation scan image illustrative of the static anatomical ablation.

Abstract: Provided in the present invention are a crystal form of a small molecule immune compound, a preparation method therefor and a pharmaceutical composition containing the same; the compound is (3Z,6Z)-3-[((E)-3-(5-tert-butyl)-1H-imidazolyl-4-yl)methylene]-6-((E)-3-(3-fluorophenyl)-2-propenylene)piperazine-2,5-dione; the crystal form thereof has stable morphology, good chemical stability, high temperature resistance, and is used for treating hyperproliferative diseases. The structural formula of the compound is as shown in formula (I).

Abstract: A peristaltic pump precise dosing control system includes a driver, a pump head, pipeline switching means, a metering pipeline, and a discharge pipeline. An elastic tubing is provided in the pump head, and the outlet end of the elastic tubing is connected to the pipeline switching means. The driver drives the pump head to rotate to pump the liquid in the elastic tubing to the outlet end of the elastic tubing. The driver is electrically connected to the pipeline switching means so as to be capable of controlling the pipeline switching means to switch to the output pipeline with which the outlet end of the elastic tubing is connected. The pipeline switching means is driven to switch the outlet end of the elastic tubing from a state of connection with the discharge pipeline to a state of connection with the metering pipeline.

Abstract: An apparatus for patient-specific adjusting of ultrasound output pressure includes a controller (118) configured for adjusting, based on an estimate of thickness of a temporal bone (140) in a head of a medical treatment recipient, a pressure setting. It may also be based on treatment depth (134). Ultrasound at the adjusted pressure setting is applied. A user interface may be provided for user entry of the estimate, the user interface being further configured for user indication of the treatment depth. Both the entered estimate and the indicated treatment depth may be used in calculating ultrasound attenuation (148). The user indication can be interactive by virtue of designating, on a display, a location of a treatment target. The calculated attenuation may be a value, in decibels, that is in a range from 0.9×(2.70×0.1+16.60×T+0.87×(D?T?0.1)+3.02) to 1.1×(2.70×0.1+16.60×T+0.87×(D?T?0.1)+3.02), where T is the estimate in centimeters and D is the treatment depth in centimeters.

Abstract: In an ultrasound imaging system which produces synthetically transmit focused images, the multiline signals used to form image scanlines are analyzed for speed of sound variation, and a map 60 of this variation is generated. In a preferred implementation, the phase discrepancy of the received multilines caused by speed of sound variation in the medium is estimated in the angular spectrum domain for the receive angular spectrum. Once the phase is estimated for all locations in an image, the differential phase between two points at the same lateral location, but different depth, is computed. This differential phase is proportional to the local speed of sound between the two points. A color-coded two- or three-dimensional map 60 is produced from these speed of sound estimates and presented to the user.

Abstract: The present disclosure describes ultrasound systems and methods configured to determine the elasticity of a target tissue. Systems can include an ultrasound transducer configured to acquire echoes responsive to ultrasound pulses transmitted toward the tissue, which may include a region of increased stiffness. Systems can also include a beamformer configured to control the transducer to transmit a push pulse into the tissue, thereby generating a shear wave in the region of increased stiffness. The beamformer can be configured to control the transducer to emit tracking pulses adjacent to the push pulse. Systems can further include a processor configured to determine a displacement amplitude of the shear wave and based on the amplitude, generate a qualitative tissue elasticity map of the tissue. The processor can combine the qualitative map with a quantitative map of the same tissue, and based on the combination, determine a boundary of the region of increased stiffness.

Abstract: The present disclosure describes ultrasound systems and methods configured to determine the elasticity of a target tissue. Systems can include an ultrasound transducer configured to acquire echoes responsive to ultrasound pulses transmitted toward the tissue, which may include a region of increased stiffness. Systems can also include a beamformer configured to control the transducer to transmit a push pulse into the tissue, thereby generating a shear wave in the region of increased stiffness. The beamformer can be configured to control the transducer to emit tracking pulses adjacent to the push pulse. Systems can further include a processor configured to determine a displacement amplitude of the shear wave and based on the amplitude, generate a qualitative tissue elasticity map of the tissue. The processor can combine the qualitative map with a quantitative map of the same tissue, and based on the combination, determine a boundary of the region of increased stiffness.

Abstract: An apparatus for ultrasound irradiation of a body part (208) includes a first ultrasound transducer (216), and a second ultrasound transducer (212) mounted oppositely, and is configured: a) such that at least two ultrasound receiving elements, for determining a relative orientation of the first to the second transducer, are attached to the first transducer; b) for a beam, from the first transducer, causing cavitation, and/or bubble destruction of systemically circulating microbubbles, within the body part; or c) both with the attached elements and for the causing. The apparatus registers, with said first transducer, the second transducer, by using as a reference respectively the features a) and/or b).

Abstract: Ultrasonic sonothrombolysis systems to produce two acoustic pressure levels of insonation during stroke therapy, mid/high acoustic pressure insonation directed to the site of a blood clot where microbubbles are present to induce microbubble-mediated blood clot lysis, and low acoustic insonation directed to the region surrounding the site of the blood clot where microbubbles are present to stimulate microvascular reperfusion of the surrounding tissue. The systems simultaneously produce blood clot lysis at the site of an occlusion and stimulate reperfusion of tissue affected by the occlusion.

Abstract: Provided in the present invention are a crystal form of a small molecule immune compound, a preparation method therefor and a pharmaceutical composition containing the same; the compound is (3Z,6Z)-3-[((E)-3-(5-tert-butyl)-1H-imidazolyl-4-yl)methylene]-6-((E)-3-(3-fluorophenyl)-2-propenylene)piperazine-2,5-dione; the crystal form thereof has stable morphology, good chemical stability, high temperature resistance, and is used for treating hyperproliferative diseases. The structural formula of the compound is as shown in formula (I).

Abstract: This application discloses a boost power conversion circuit, a method, an inverter, an apparatus, and a system. In the conversion circuit, a voltage control circuit is added on a three-level boost. The voltage control circuit can be connected in series in a third closed loop, and the third closed loop is a loop including an inductor, a first switching transistor, a flying capacitor, a second diode, and an input end. The voltage control circuit clamps a voltage of a common point of the first diode and the second diode when a voltage on an input end of the boost power conversion circuit is less than a startup voltage of the boost power conversion circuit. The voltage borne by the second diode is reduced, so that a diode with relatively small voltage stress can be selected.

Abstract: An apparatus for deriving tissue temperature from thermal strain includes a thermal strain measuring module. The module uses ultrasound (156, 158) to measure thermal strain in a region, within a subject, that surrounds a location (166a, 166f) where a temperature sensor is disposed. Also included is a temperature measurement module configured for, via the sensor, measuring a temperature at the sensor while the sensor is inside the subject. Further included is a patient-specific thermal-strain-to-temperature-change proportionality calibration module. The calibration module is configured for calibrating (S238) a coefficient and for doing so based on a measurement of a temperature parameter at that location derived from output of the temperature measurement module and on a measurement of thermal strain at that location obtained via the strain measuring module.

Abstract: An ultrasound system performs cranial therapy using a headset mounted to the head of a subject which contains a therapy transducer and a motion detecting transducer. At the outset of therapy, echo signals are acquired by the motion detecting transducer and stored. Thereafter, echo signals are acquired again by the motion detecting transducer and compared or correlated with the signals stored at the outset of therapy. When a difference is determined between the compared or correlated signals, an alert is issued by the system that transducer motion or acoustic decoupling may have occurred.

Abstract: Provided herein are methods for treating or preventing a cancer, including solid tumors and hematological cancers, comprising administering an effective amount of aminopurine compounds of formula (I), and compositions comprising an effective amount of such compounds.

Abstract: The present disclosure describes a therapeutic ultrasound system configured to adaptively transmit ultrasound pulses toward microbubbles in a treatment region to remove an occlusion. In some examples, the system may include a treatment pulse unit configured to transmit an ultrasound pulse to a treatment region of a subject, the treatment region including a plurality of microbubbles. An echo detection unit may be configured to receive one or more echoes responsive to the ultra sound pulse. In some examples, the system may also include a data processor configured to identify, using data associated with the echoes, at least one echo signature indicative of a dynamic state of the microbubbles in response to the ultrasound pulse. A controller may be configured to adjust one or more parameters of an additional ultrasound pulse transmitted to the treatment region via the treatment pulse unit based on the at least one echo signature.

Abstract: An ultrasound system utilizes an array transducer to perform sonothrombolysis treatment. The system also produces a vascular map of flow characteristics in the vicinity of the therapy site in a subject. The vascular map is used to formulate a treatment plan which includes the number, focusing, timing, and steering of beams of a pattern of therapy beams transmitted during a transmission interval. Formulation of the treatment plan considers factors such as the direction of microbubble flow toward a therapy site, the flow velocity, the spacing between successive therapy beam transmissions, the number of therapy beams needed to “paint” a therapy region, and grating lobe locations, many of which can be determined from the vascular map.

Abstract: The present disclosure provides a method and an apparatus for making an animation. The method includes: acquiring an animation subject; binding the animation subject to a corresponding structural template; and actuating the structural template to drive the animation subject bound to the structural template to perform a corresponding action. With embodiments of the disclosure, it is possible for a user who does not master knowledge of professional animation principles to easily create an animation that the user likes and has professional effects by simple operations, and thus the solutions is simple and convenient to operate, vivid and interesting and has a wide range of applications.