Abstract: Provided herein are methods for treating or preventing a cancer, in particular solid tumors and hematological cancers, comprising administering to a subject in need thereof an effective amount of a compound of formula (I):

Abstract: In one aspect, an ultrasound receive beamformer is configured for one-way only beamforming of transmissive ultrasound using one-way delays. The receive beamforming in some embodiments is used to track, in real time, a catheter, needle or other surgical tool within an image of a region of interest. The tool can have embedded at its tip a small ultrasound transmitter or receiver for transmitting or receiving the transmissive ultrasound. Optionally, additional transducers are fixed along the tool to provide the orientation of the tool.

Abstract: Ultrasonic sonothrombolysis systems to produce two acoustic pressure levels of insonation during stroke therapy, mid/high acoustic pressure insonation directed to the site of a blood clot where microbubbles are present to induce microbubble-mediated blood clot lysis, and low acoustic insonation directed to the region surrounding the site of the blood clot where microbubbles are present to stimulate microvascular reperfusion of the surrounding tissue. The systems simultaneously produce blood clot lysis at the site of an occlusion and stimulate reperfusion of tissue affected by the occlusion.

Abstract: An apparatus for ultrasound irradiation of a body part (208) includes a first ultrasound transducer (216), and a second ultrasound transducer (212) mounted oppositely, and is configured: a) such that at least two ultrasound receiving elements, for determining a relative orientation of the first to the second transducer, are attached to the first transducer; b) for a beam, from the first transducer, causing cavitation, and/or bubble destruction of systemically circulating microbubbles, within the body part; or c) both with the attached elements and for the causing. The apparatus registers, with said first transducer, the second transducer, by using as a reference respectively the features a) and/or b).

Abstract: In one aspect, an ultrasound receive beamformer (212) is configured for one-way only beamforming (112) of transmissive ultrasound using one-way delays. The receive beamforming in some embodiments is used to track, in real time, a catheter, needle or other surgical tool within an image of a region of interest. The tool can have embedded at its tip a small ultrasound transmitter or receiver for transmitting or receiving the transmissive ultrasound. Optionally, additional transducers are fixed along the tool to provide the orientation of the tool.

Abstract: In one aspect, an ultrasound receive beamformer is configured for one-way only beamforming of transmissive ultrasound using one-way delays. The receive beamforming in some embodiments is used to track, in real time, a catheter, needle or other surgical tool within an image of a region of interest. The tool can have embedded at its tip a small ultrasound transmitter or receiver for transmitting or receiving the transmissive ultrasound. Optionally, additional transducers are fixed along the tool to provide the orientation of the tool.

Abstract: Provided herein are methods for treating or preventing a cancer, in particular solid tumors and hematological cancers, comprising administering to a subject in need thereof an effective amount of a compound of formula (I):

Abstract: A medical imaging probe (102) for contact with an imaging subject includes an indicium placement apparatus for, while the probe is in contact, selectively performing an instance of marking the subject so as to record a position of the probe. The device may further include a feed-back module for determining whether an orientation, with respect to a the mark, that currently exists for a medical imaging probe of the device meets a criterion of proximity to a predetermined orientation. Responsive to the determination that the criterion is met, a quantitative evaluation may be made automatically and without need for user intervention, vis live imaging via the probe, of a lesion that was, prior to the determination, specifically identified for the evaluation. Change, such as growth (116), in the lesion, like a brain lesion, may thereby be tracked over consistent sequential imaging acquisitions, such as through ultrasound.

Abstract: A head frame is configured for the head of a medical patient (108) and includes support for a probe and a neck support. The frame wraps around said head, and can be used in the supine position. The support may include a probe holder (116) slidable under the head and to contact or engage the neck support. In some embodiments, conformal shaping to the head and/or neck, the frame's rigid construction, the alignment of the optionally separable holder to the neck support (110), and weight of the head all serve to keep the distal tip of the ultrasound probe in place against the temporal region of the head, without need for attaching the frame to the head as by straps, providing an arrangement robust against patient/vehicle movement in an emergency medical services setting. Head immobilizing walls may be folded away (316) in some versions, retaining probe alignment.

Abstract: A method of a mobile station receiving data packets from a serving base station via a multicast or broadcast connection in a wireless network is provided for performing a handover from the serving base station to a target base station. The method comprises, at the level of the mobile station, the steps of: upon the detection of the quantity of buffered data packets in the mobile station being lower than a first threshold value, establishing a unicast connection with the serving base station to receive data packets from the serving base station; and upon detection of the level of buffered data packets reaching the predetermined threshold level, performing a handover from the serving base station to the target base station. According to the invention, a seamless handover of a mobile station in a wireless network providing Multicast and Broadcast Service (MBS service) can be achieved to prevent the MBS service interruption during the handover.

Abstract: It is provided a method for providing a service guide in a network providing a plurality of multicast services, said network comprising at least one client device connected to a first device, wherein a subset of said plurality of multicast services is being multicast to said at least one client device via said first device, and the service guide provides a list of the plurality of multicast services in a second order; and at the side of a client device, the method comprises the steps of determining a list of the plurality of multicast services in a first order, wherein the order is changed from the second order to the first order based on the multicast services of the subset; and presenting said list of multicast services in said first order.

Abstract: Electromagnetic energy is applied to thereby oscillate a bubble that is then insonified to produce an echo (260) for reception and analysis to afford imaging of the region of the bubble. To create the bubble, the energy may be applied to a nano particle (232) of a contrast agent whose consequent internal nano- or micro-bubbles offer, with novel pulsing techniques, greater sensitivity, and which can permeate outside vasculature (216) prior to being energized thereby affording quantification of vascular permeability and delivery of targeting molecules. The particle can include an absorbing and an evaporating parts, the irradiation (204), as by near-infrared laser, causing the phase change that gives rise to the bubble. The echo may occur in response to ultrasound interrogation (220) of the activated contrast agent, which could entail pulse inversion, power modulation or contrast pulse sequence imaging, with persistence processing.

Abstract: Bubbles (118-122) are utilized in some embodiments as part of a photoacoustic contrast agent (162) and, in some embodiments, to localize one or more locations (126-38) of a source of acoustic energy. The bubbles, such as microbubbles, can be used in proximity of nanoparticles of a first photoacoustic contrast agent, thereby affording a second photoacoustic contrast agent. The bubbles can intercept and re-radiate acoustic energy emitted by light-based activation of the first photoacoustic contrast agent in the immediate vicinity of the bubbles. As a further option, if the nanoparticles permeate further to tissue structures but remain in close enough proximity, their positions can be triangulated by the nearby bubbles, based on direction (144-148) and time delays (150-160) of ultrasound received by a transducer array.

Abstract: A method for reporting state information is provided. The receiver device receives a service, which is encoded in at least two layers over a communication channel, through a subset of said at least two layers; it measures a channel quality parameter; and in response to the channel quality parameter reaching a predetermined threshold value, it receives the service through a modified subset of the at least two layers as a function of the measured channel quality parameter and transmitting state information of the receiver device. Thus, the signal overhead is reduced.

Abstract: In one aspect, an ultrasound receive beamformer (212) is configured for one-way only beamforming (112) of transmissive ultrasound using one-way delays. The receive beamforming in some embodiments is used to track, in real time, a catheter, needle or other surgical tool within an image of a region of interest. The tool can have embedded at its tip a small ultrasound transmitter or receiver for transmitting or receiving the transmissive ultrasound. Optionally, additional transducers are fixed along the tool to provide the orientation of the tool.

Abstract: It provides a method for multicast group management. The apparatus determines a request for joining a multicast service derived during establishment of a connection for carrying multicast service between a first device and a second device, and it sends a message indicative of joining said multicast service based on the request for joining if the multicast service is not available in said network device. As a consequence, it reduces the messages exchanged in unreliable wireless connection so as to reduce the probability of service interruption.

Abstract: A method of a mobile station receiving data packets from a serving base station via a multicast or broadcast connection in a wireless network is provided for performing a handover from the serving base station to a target base station. The method comprises, at the level of the mobile station, the steps of: upon the detection of the quantity of buffered data packets in the mobile station being lower than a first threshold value, establishing a unicast connection with the serving base station to receive data packets from the serving base station; and upon detection of the level of buffered data packets reaching the predetermined threshold level, performing a handover from the serving base station to the target base station. According to the invention, a seamless handover of a mobile station in a wireless network providing Multicast and Broadcast Service (MBS service) can be achieved to prevent the MBS service interruption during the handover.

Abstract: A method and apparatus are described for content delivery, including receiving content from a first network, moving into a coverage area of a second network, performing a handover, receiving content from the second network and dropping any duplicate content packets. Also described are a method and apparatus for content delivery including receiving content from a first network, performing a handover, receiving content from a second network, determining if any content is missing and requesting the missing content.

Abstract: A method and apparatus are described for performing a handover in a content delivery system, including performing the handover from a first network to a second network at a protocol layer determined based on whether a content stream identification file used by said first network is paired with a content stream identification file used by said second network. Also described are a method and apparatus for performing a handover in a content delivery system, including performing the handover from a first network to a second network at a protocol layer determined based on whether a same content stream identification file used by the first network is used by the second network. Further described are a method and apparatus for performing a handover in a content delivery system, including performing the handover from a first network to a second network at one of an application layer, a network layer and a media access control layer.

Abstract: Electromagnetic energy is applied to thereby oscillate a bubble that is then insonified to produce an echo (260) for reception and analysis to afford imaging of the region of the bubble. To create the bubble, the energy may be applied to a nano particle (232) of a contrast agent whose consequent internal nano- or micro-bubbles offer, with novel pulsing techniques, greater sensitivity, and which can permeate outside vasculature (216) prior to being energized thereby affording quantification of vascular permeability and delivery of targeting molecules. The particle can include an absorbing and an evaporating parts, the irradiation (204), as by near-infrared laser, causing the phase change that gives rise to the bubble. The echo may occur in response to ultrasound interrogation (220) of the activated contrast agent, which could entail pulse inversion, power modulation or contrast pulse sequence imaging, with persistence processing.