Abstract: A tile-ready shower basin, and methods of manufacturing and installing the same. A sloped structural core is provided having a topside and a bottom side. A first waterproof panel or coating is applied to the topside and a second waterproof panel or coating is applied to the bottom side. A thin fiberglass flange is provided about at least a portion of the perimeter of the core to create a lip. The basin further includes a first hole or recess formed into the basin, which does not extend through the basin, and a second hole, axially aligned with the first, which does extend through the basin, for directly receiving and coupling a drain therein.

Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing serum, plasma, and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

Abstract: A tile-ready shower basin, and methods of manufacturing and installing the same. A sloped structural core is provided having a topside and a bottom side. A first waterproof panel or coating is applied to the topside and a second waterproof panel or coating is applied to the bottom side. A thin fiberglass flange is provided about at least a portion of the perimeter of the core to create a lip. The basin further includes a first hole or recess formed into the basin, which does not extend through the basin, and a second hole, axially aligned with the first, which does extend through the basin, for directly receiving and coupling a drain therein.

Abstract: A photovoltaic-thermal (PV-T) system and a method of cooling photovoltaic (PV) cells in the system is described herein. Energy from an excitation source such as the sun hits the PV cells in the PV-T system causing heating that reduces PV efficiency. The PV cells are cooled by fluid in an intact heat-transfer system making a heated water byproduct while the PV cells release a form of energy. In addition, the PV-T system can be implemented in a desalination plant to harvest energy and heat for desalination processes. The present invention also includes methods for transferring heat from PV cells to the earth to improve PV performance and reduce thermal shock to the PV cells.

Abstract: A hard disk drive includes a base plate, a cover mounted to the base plate and a corner filter disposed proximate to a corner of the hard disk drive. A corner filter seal disposed between the base plate and the cover. The corner filter seal is configured to prevent leakage of filter air flow through a clearance between the base plate and the cover. The clearance is at least laterally proximate the corner filter.

Abstract: A method for preventing inflammation, comprising administering to a subject a lymphocyte sequestrating or depletion agent before the onset of inflammation. A method for treating inflammation caused by an injury or an infection, comprising depleting immune lymphocyte of a subject by administering to said subject a lymphocyte sequestrating or depletion agent during or after said event. A method for preventing or treating abdominal adhesion comprising administering to a subject a lymphocyte sequestering or a lymphocyte depletion agent.

Abstract: An airflow diverter in a hard disk drive system. A top portion configured to couple with a top housing of the disk drive system. A thickness configured to create a top clearance between the diverter and a top actuator arm of the disk drive system wherein the top clearance approximates a bottom clearance between a bottom housing of the disk drive system and a bottom actuator arm of the disk drive system. At least one surface configured to divert the airflow in the disk drive system during the operation of the disk drive system.

Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing serum, plasma, and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

Abstract: An embodiment of the invention provides a method for determining a patient-specific probability of disease. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of disease is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of disease.

Abstract: An embodiment of the invention provides a method for determining a patient-specific probability of transplant glomerulopathy. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of transplant glomerulopathy is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of transplant glomerulopathy.

Abstract: An embodiment of the invention provides a method for determining a patient-specific probability of disease. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of the healing rate of an acute traumatic wound is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of the healing rate of an acute traumatic wound.

Abstract: A method and apparatus for electrostatically spraying a plural component fast set polymer is disclosed. The system comprises a spray gun and at least two hoses connected to the head of the spray gun. The system also includes a proportioner connected to an end of the at least two hoses and a high voltage generator electrically and pneumatically in communication with the spray gun. The electrostatic spray system will allow for a fast set polymer to be imparted with electrical charge after mixing of a first and second component in a spray head thereof prior to expulsion via a nozzle to a grounded target that is being coated with the electrostatic spray coating.

Abstract: The compounds, pharmaceutical compositions, and methods of using such compounds or compositions thereof described herein are useful for treating a disease modulated by B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein expression.

Abstract: The methods described herein provide nucleic acid constructs and screening methods for identifying and validating compounds for use in the treatment of cancer, wherein the compounds down-regulate the post-transcriptional expression of Bmi-1.

Abstract: The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.

Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

Abstract: A hard disk drive including a base plate and a drive cover. The hard disk drive also includes a capacitive coupling feature disposed between the base plate and the drive cover. The capacitive coupling feature is configured to provide grounding between the base plate and the drive cover.

Abstract: A novel co-culture system using human brain endothelial cells (HUBEC) which promotes the expansion of human CD34+CD38? cells consistent with the PMVEC system is disclosed. HUBEC were isolated from cadaveric donors, passed in primary culture, cloned and found to be Von Willebrand Factor positive. Cultivation of purified bone marrow CD34+ cells on HUBEC monolayers supplemented with GM-CSF+IL-3+IL-6+SCF+flt-3 ligand caused a 14.5-fold increase in total cells, an 6.6-fold increase in CD34+ cells, and, most remarkably, a 440-fold increase in CD34+CD38? cells after 7 days. Further, CFU-GM production increased 15.1-fold, BFU-E increased 8-fold, and CFU-Mix increased 5.2-fold. Optimal generation was dependent upon the continued presence of exogenous supplied cytokines. In comparison, identically treated stroma-free suspension cultures supported a 10.2-fold expansion of total cells, a 3-fold increase in CD34+ cells and maintained the CD34+CD38? cell pool after 7 days of culture.

Abstract: The present invention provides methods of use of oxadiazoanthracene derivatives of the formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, C, R, R1, R2, R3, R4 and R5 are as herein described, and wherein said methods of use include uses for the treatment and/or prevention of disorders and diseases, such as diabetes.

Abstract: In accordance with certain embodiments of the present disclosure, a method for hydrolysis of a chemical hydride is provided. The method includes adding a chemical hydride to a reaction chamber and exposing the chemical hydride in the reaction chamber to a temperature of at least about 100° C. in the presence of water and in the absence of an acid or a heterogeneous catalyst, wherein the chemical hydride undergoes hydrolysis to form hydrogen gas and a byproduct material.