Abstract: The present invention provides methods of use of oxadiazoanthracene derivatives of the formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, C, R, R1, R2, R3, R4 and R5 are as herein described, and wherein said methods of use include uses for the treatment of disorders and diseases, such as diabetes.

Abstract: Systems and methods are provided for collaborative mobile device applications. Mobile device applications for a mobile device are stored in a database. The mobile device applications include an interface defining how each mobile device application interacts with the other mobile device applications. Each mobile device application provides a set of services and/or features for a virtual application, wherein the virtual application is defined by the mobile device applications and their associated interfaces. The mobile device applications are configured such that a mobile device can download at least two different subsets of the mobile device applications, wherein each subset provides different functionality for the virtual application.

Abstract: Compounds having Formula I: wherein the variables Ar1, Ar2, R1, R2 and R3 are defined herein, pharmaceutical compositions, and methods of using such compounds or compositions for inhibiting Bmi-1 expression.

Abstract: Systems and methods are provided for associating structured tags with files in a computer system. In one method, the method includes requesting a user, by the computer system, to provide the structured tag for the file, where the structured tag includes a tag type, a value type, and a tag value. The method can further include receiving the structured tag from the user, associating the structured tag and the file, and storing the association of the structured tag and the file in a non-transitory storage medium.

Abstract: The methods described herein provide nucleic acid constructs and screening methods for identifying and validating compounds for use in the treatment of cancer, wherein the compounds down-regulate the post-transcriptional expression of Bmi-1.

Abstract: The present invention provides methods of use of oxadiazoanthracene derivatives of the formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, C, R, R1, R2, R3, R4 and R5 are as herein described, and wherein said methods of use include uses for the treatment of disorders and diseases, such as diabetes.

Abstract: A high voltage (HV) interface housing is provided that includes an assembly of levers within the housing that detect whether or not the HV lines are coupled to the interface housing. If the HV lines are not in place, the lever assembly prevents the interface cover from being fully installed onto the interface housing, thereby preventing the HV interlock loop switch from being closed. As a result, when the HV cables are not in place, the HV interlock loop switch prevents power from being applied to the HV circuit. If, however, the HV lines are properly positioned within the interface housing, the levers of the lever assembly automatically retract, thus allowing the interface cover to be fully installed onto the interface housing. In this state, the interface cover closes the HV interlock loop switch, thus closing the HV interlock loop and allowing power to be applied to the HV circuit.

Abstract: The present invention provides methods of use of oxadiazoanthracene derivatives of the formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, C, R, R1, R2, R3, R4 and R5 are as herein described, and wherein said methods of use include uses for the treatment and/or prevention of disorders and diseases, such as diabetes.

Abstract: An embodiment of the invention provides a method for determining a patient-specific probability of transplant glomerulopathy. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of transplant glomerulopathy is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of transplant glomerulopathy.

Abstract: Compounds that selectively inhibit viral replication or the production of viral RNA or DNA, viral protein or virus induced cytopathic effects and compositions comprising such Compounds are described. Also described are methods of inhibiting viral replication or the production of viral RNA or DNA, viral protein or virus induced cytopathic effects using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.

Abstract: A ski instructional apparatus and method for teaching young children that allows for dry land training of a student on skis. The apparatus includes a pole that the student straddles. The pole has a cross piece that extends behind the students legs and beneath the buttocks and handlebars for the student to hold onto. Pulling the pole forward causes the cross piece to push the student from behind so little or none of the student's arm strength is needed to pull the student on skis along a dry surface. The tips of the skis are connected by a tether and a line attached to the tether is connected to the pole. The arrangement allows the instructor to move the student forward and, at the same time, to move the ski tips one towards the other or allow the tips to move apart by respectively raising or lowering the pole.

Abstract: An application deployment model for enterprise applications to enable applications to be deployed to and executed from a globally distributed computing platform, such as an Internet content delivery network (CDN). According to the invention, application developers separate their Web application into two layers: a highly distributed edge layer and a centralized origin layer. In a representative embodiment, the edge layer supports a servlet container that executes a Web tier, typically the presentation layer of a given Java-based application. Where necessary, the edge layer communicates with code running on an origin server to respond to a given request. In an alternative embodiment, the edge layer supports a more fully-provisioned application server that executes both Web tier (e.g., presentation) and Enterprise tier application (e.g., business logic) components.

Abstract: The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.

Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

Abstract: In accordance with certain embodiments of the present disclosure, a method for hydrolysis of a chemical hydride is provided. The method includes adding a chemical hydride to a reaction chamber and exposing the chemical hydride in the reaction chamber to a temperature of at least about 100° C. in the presence of water and in the absence of an acid or a heterogeneous catalyst, wherein the chemical hydride undergoes hydrolysis to form hydrogen gas and a byproduct material.

Abstract: A system and method for creating and replicating foliage patterns comprising: a first stencil, where the first stencil forms the shape of a leaf; and a second stencil, where the second stencil forms the shape of an arrangement of veins and stems of a leaf, wherein a user may selectively arrange and attach the first and second stencil to create a foliage pattern. The leaf may include either an oak leaf or a maple leaf. The user may selectively apply at least one paint color to the stencils to create a depiction of the foliage pattern. In one particular embodiment, the system may comprise a layer of clear coat paint or sealant over the painted surface in order to protect the appearance of the pattern of foliage.

Abstract: Content is dynamically assembled at the edge of the Internet, preferably on content delivery network (CDN) edge servers. A content provider leverages an “edge side include” (ESI) markup language that is used to define Web page fragments for dynamic assembly at the edge. Dynamic assembly improves site performance by caching objects that comprise dynamically-generated pages at the edge of the Internet, close to the end user. Instead of being assembled by an application/web server in a centralized data center, the application/web server sends a page template and content fragments to a CDN edge server where the page is assembled. Each content fragment can have its own cacheability profile to manage the “freshness” of the content. Once a user requests a page, the edge server examines its cache for the included fragments and assembles the page on-the-fly.

Abstract: A hard disk drive enclosure with conductive paths. A base plate comprising an electrically conductive material with at least one contact surface that allows for an electrically conductive path, wherein the at least one contact surface has a substantially flat surface. A cover comprising an electrically conductive material comprising at least one tab with a substantially flat surface for contacting the at least one contact surface of the base plate, wherein the at least one tab contacts the at least one contact surface of the base plate with a force and forms an electrically conductive path between the cover and the based plate, and wherein the at least one tab deforms upon the contact with the at least one contact surface of the base plate with the force.

Abstract: An electronic device enclosure configured to shield against electromagnetic interference (EMI). The electronic device enclosure includes an electronic device-enclosure base and at least one laterally disposed blunt boss. The electronic device-enclosure base includes a bottom, and sides and attached to the bottom in a boxlike configuration. The laterally disposed blunt boss is configured so as to be disposed between, and to couple electrically, a side of the electronic device-enclosure base and a vertical flange of an electronic device-enclosure cover. The electronic device-enclosure base and the electronic device-enclosure cover are configurable with respect to said laterally disposed blunt boss to shield an interior space enclosed by the electronic device-enclosure base and the electronic device-enclosure cover against EMI at a resonant frequency of a slot of the electronic device enclosure.

Abstract: An apparatus to facilitate field assessment of static structure sites to provide data in a predetermined format acceptable to a taxing authority, including a personal computing device having a graphic display screen, a user interface, and application software. The user interface is arranged to accept alphanumeric data provided by a user of the apparatus and also accept graphic input from the user representative of structural features of the static structure. The application software is arranged to provide a real-time display on the graphic display screen of dimensional data associated with the graphic inputs as they are entered by the user. The application software is also arranged to compute dimensional attributes of enclosed polygons resulting from the graphic input by the user.