Abstract: According to an aspect, an inflatable penile prosthesis includes a reservoir configured to hold fluid, an inflatable member, and a pump assembly configured to facilitate a transfer of a fluid from the reservoir to the inflatable member. The pump assembly includes a pump bulb, and a valve body defining a fluid passageway. The valve body includes a refill valve disposed in the fluid passageway. The refill valve includes a valve member. In response to the pump bulb being compressed, the valve member moves within the fluid passageway in a first direction to a closed position in which the valve member blocks the fluid from being transferred around the refill valve. In response to the pump bulb being uncompressed, the valve member moves within the fluid passageway in a second direction to an open position in which the valve member allows the fluid to transfer around the refill valve.

Abstract: Disclosed is a system for monitoring the water level proximate to a vehicle. The system comprises a control unit and at least one sensor in communication with the control unit. The at least one sensor is configured such that the control unit can determine a pitch of a trailer coupled to the vehicle and the height of a surface of water proximate to the trailer. The system includes a display screen displaying a representation of the trailer including the pitch of the trailer, and a representation of the surface of water proximate to the trailer.

Abstract: A bead for releasably securing a glazing unit to a frame member, comprising a body having a first end and a second end, and a resiliently deformable member secured to the body and having a first finger extending from the body to a first end, and a second finger extending from the first finger to a second end. The first end of the body and the first end of the first finger are configured to engage with respective first and second ends of a frame member so as to secure the bead to the frame member. The second end of the body is configured to releasably secure a gasket in a first position so as to secure a glazing unit against an opposed end of the frame member.

Abstract: A side-impact crash structure may be positioned proximate an end of a vehicle to reduce impact forces imparted to an occupant during a side collision. The side-impact crash structure may include energy absorbers positioned on lateral sides of the vehicle between the passenger compartment and a longitudinal end of the vehicle. The energy absorbers may be configured to absorb impact forces over a limited ride-down distance (the distance over which the deceleration occurs) to prevent damage to both the occupants and one or more components or systems of the vehicle. The energy absorbers can be configured to deform along an oblique axis of the vehicle under a compressive force. The side-impact crash structure may include one or more load spreaders disposed between the energy absorbers that disperse the impact force to other portions of the vehicle.

Abstract: A filter that may increase and extend, the bass frequency response of a speaker of an audio device. The filter may be space-efficient. The filter may be part of a device that does not necessarily have a large rear cavity and that does not necessarily have porting and/or passive radiating. The low-frequency extension filter may be used, for example, with a smaller rear cavity while essentially simulating the acoustic effects of a much larger rear cavity. The low-frequency extension filter may include a plurality of acoustic pathways, such as tubes, which may wind around along a tortuous path and which may resemble a labyrinthine design. The tubes may be selected to resonate with particular predetermined low frequency channels. For example, the tubes may be approximately a quarter wavelength of the center of the corresponding frequency channel, or even slightly shorter.

Abstract: According to an aspect, an implant includes an inflatable member and a pump assembly configured to facilitate a transfer of a fluid from the reservoir to the inflatable member. The inflatable member has a sidewall that defines a lumen. The sidewall has an outer surface and an inner surface disposed opposite the outer surface. The inner surface has a series of undulations.

Abstract: The present invention relates generally to the determination and the notification of shipping dock detention delays for regulated and non-regulated vehicle drivers.

Abstract: The present invention concerns a method and apparatus for the modulation of an acoustic field for providing tactile sensations. A method of creating haptic feedback using ultrasound is provided. The method comprises the steps of generating a plurality of ultrasound waves with a common focal point using a phased array of ultrasound transducers, the common focal point being a haptic feedback point, and modulating the generation of the ultrasound waves using a waveform selected to produce little or no audible sound at the haptic feedback point.

Abstract: The present invention relates to polymersomes capable of eliciting an immune response, comprising: an antigen selected from the group consisting of: (a) a polypeptide; (b) a carbohydrate; (c) a polynucleotide; and (d) a combination of (a) and/or (b) and/or (c); wherein the antigen is conjugated to the exterior surface of the polymersome via a covalent bond. The present invention further relates to a method for production of antigens conjugated to a polymersome as well as to polymersomes produced by said method. The present invention further relates to compositions comprising a polymersome of the present invention, isolated antigen presenting cells or hybridoma cells exposed to the polymersome or composition of the present invention.

Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

Abstract: A side-impact crash structure may be positioned proximate an end of a vehicle to reduce impact forces imparted to an occupant during a side collision. The side-impact crash structure may include energy absorbers positioned on lateral sides of the vehicle between the passenger compartment and a longitudinal end of the vehicle. The energy absorbers may be configured to absorb impact forces over a limited ride-down distance (the distance over which the deceleration occurs) to prevent damage to both the occupants and one or more components or systems of the vehicle. The energy absorbers can be configured to deform along an oblique axis of the vehicle under a compressive force. The side-impact crash structure may include one or more load spreaders disposed between the energy absorbers that disperse the impact force to other portions of the vehicle.

Abstract: According to an aspect, an inflatable penile prosthesis includes a reservoir configured to hold fluid, an inflatable member, and a pump assembly configured to facilitate a transfer of a fluid from the reservoir to the inflatable member. The pump assembly includes a pump bulb, and a valve body defining a fluid passageway. The valve body includes a refill valve disposed in the fluid passageway. The refill valve includes a valve member. In response to the pump bulb being compressed, the valve member moves within the fluid passageway in a first direction to a closed position in which the valve member blocks the fluid from being transferred around the refill valve. In response to the pump bulb being uncompressed, the valve member moves within the fluid passageway in a second direction to an open position in which the valve member allows the fluid to transfer around the refill valve.

Abstract: In some examples, authorized user profiles and generic models are generated using historical interaction data of authorized users. The authorized user profiles provide an experience profile for authorized users. The generic models are data models used to model authorized user actions. The authorized user profiles and generic models are used to generate support elements. The support elements are presented to authorized users and feedback is collected. Based on the feedback, the authorized user profiles and generic models are updated.

Abstract: Improved algorithm techniques may be used for superior operation of haptic-based systems. An eigensystem may be used to determine for a given spatial distribution of control points with specified output the set of wave phases that are the most efficiently realizable. Reconstructing a modulated pressure field may use emitters firing at different frequencies. An acoustic phased-array device uses a comprehensive reflexive simulation technique. There may be an exchange of information between the users and the transducer control processors having the ability to use that information for optimal haptic generation shadows and the like. Applying mid-air haptic sensations to objects of arbitrary 3D geometry requires that sensation of the object on the users hand is as close as possible to a realistic depiction of that object. Ultrasonic haptics with multiple and/or large aperture arrays have high-frequency update rates required by the spatio-temporal modulation.

Abstract: In some examples, systems, methods, and devices are described that generate contextual suggestions for patients. Generation of the contextual suggestions is triggered by certain events performed by a medical professional with respect to a patient (e.g., updating a patient record). The contextual suggestions are related to addressing health conditions of the patient and represent tasks or considerations which the medical professional should be made aware. The contextual suggestions are generated in a way that is considerate of patient context, medical professional context, and contexts of similar patients. The contextual suggestions can be presented to the medical professional for selection and execution.

Abstract: A system providing various improved processing techniques for haptic feedback is described. An acoustic field is defined by one or more control points in a space within which the acoustic field may exist. Each control point is assigned an amplitude value equating to a desired amplitude of the acoustic field at the control point. Transducers are then controlled to create an acoustic field exhibiting the desired amplitude at each of the control points. When human skin interacts with the acoustic field, vibrations of the skin are interpreted by mechanoreceptors being excited and sending signals to the brain via the nervous system. Improved processing techniques allow for more efficient real-world operation.

Abstract: Obsoleting values stored in registers in a processor based on processing obsolescent register-encoded instructions is disclosed. The processor is configured to support execution of read and/or write instructions that include obsolescence encoding indicating that one or more of its source and/or target register operands are to be obsoleted by the processor. A register encoded as obsolescent means the data value stored in such register will not be used by subsequent instructions in an instruction stream, and thus does not need to be retained. Thus, such register can be set as being in an obsolescent state so that the data value stored in such register can be ignored to improve performance. As one example, data values for registers having an obsolescent state can be ignored and thus not stored in a saved context for a process being switched out, thus conserving memory and improving processing time for a process switch.

Abstract: In one example in accordance with the present disclosure, a fluid manipulation system is described. The fluid manipulation system includes a microfluidic channel through which fluid is to flow. The fluid includes particles to be separated. The fluid manipulation system includes a first electrode pair on a first side of the microfluidic channel. The first electrode pair includes a top electrode formed on a lid of the microfluidic channel and a bottom electrode formed on a floor of the microfluidic channel. The fluid manipulation system also includes a second electrode pair on a second side of the microfluidic channel. The second electrode pair also includes a top electrode and a bottom electrode. The electrode pairs are to generate an alternating electrical field across the microfluidic channel.

Abstract: An impact energy management system for a vehicle includes an impact energy absorbing structure to absorb energy from an impact with an external object, and an energy management structure to manage energy from an impact with an internal displaceable object (e.g., a motor or steering rack) with one or more protected objects (e.g., a passenger compartment or battery). The energy management structure may include one or more swingarms or other members configured to protect the protected object from impact by directing the displaceable object down and/or away from the protected object during a collision.

Abstract: Provided herein are compounds that are useful in the treatment of pain in a subject.