Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: Various embodiments related to three dimensional printers, and reinforced filaments, and their methods of use are described. In one embodiment, a void free reinforced filament is fed into a conduit nozzle. The reinforced filament includes a core, which may be continuous or semi-continuous, and a matrix material surrounding the core. The reinforced filament is heated to a temperature greater than a melting temperature of the matrix material and less than a melting temperature of the core prior to drag the filament from the conduit nozzle.

Abstract: The disclosure relates to a syringe support for supporting an axial position of a syringe relative to a housing of an autoinjector. The syringe support comprises a projecting portion, which projects from the syringe support in a distal direction and a flexible portion which axially adjoins the projecting portion. The flexible portion is adapted to axially bias the syringe in the distal direction within the housing. The disclosure further relates to an autoinjector.

Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients with insufficient glycemic control despite a therapy with an oral and/or a non-oral antidiabetic drug.

Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: Methods to assess a pediatric subject having a single ventricle heart include identifying a difference between concentration levels of metabolic biomarkers and reference concentration levels and then assessing the pediatric subject based on the identified differences.

Abstract: Patient support apparatuses include a frame, support surface, and a controller. The controller provides notification to a user of a service event relating to the patient support apparatus. The controller limits functionality of a component of the patient support apparatus based upon a severity of the service event. The controller may also, or alternatively, detect when a control is activated by a user and, in response to such activation, determine whether the patient support apparatus has been marked for use or marked for servicing. If marked for use, the controller responds in a first manner, and if marked for service, the controller responds in a different manner. In other embodiments, a method is provided for determining an order in which multiple patient support apparatuses should be service. In still other embodiments, the patient support apparatus automatically changes to an unusable configuration when in need of high priority service.

Abstract: There is disclosed system for oxygenating a patient in relation to anaesthesia using high flow gas delivery. The system has a flow source, and a controller for determining oxygenation requirements of the patient before or during anaesthesia. A method of oxygenating a patient in relation to anaesthesia using high flow gas delivery is also disclosed. The method determines oxygenation requirements of the patient before or during anaesthesia.

Abstract: A component formed of a refractory metal has a surface that is at least partially coated with a layer of yttria. There is also described a method of manufacturing a coated component, and the application of Y2O3 as a release agent in high temperature applications.

Abstract: A component formed of a refractory metal has a surface that is at least partially coated with a layer of titanium diboride. There is also described a method of manufacturing the component and the application of TiB2 as a release agent in high-temperature applications.

Abstract: An attachment for a haircare appliance, the attachment including an air inlet, an air outlet, a hollow body defining a flow path between the air inlet and the air outlet, and a curved surface adjacent to and downstream of the air outlet, the curved surface extending outwardly from the hollow. A haircare appliance having an air inlet, an air outlet, and an airflow generator for generating an airflow from the air outlet to the air outlet. The haircare appliance has a hollow body defining a flow path between the air inlet and the air outlet, and a curved surface adjacent to and downstream of the air outlet. The curved surface extends outwardly from the hollow body.

Abstract: A haircare appliance having an air inlet, an air outlet, and an airflow generator for generating an airflow from the air inlet to the air outlet and an attachment for a haircare appliance, the attachment including an air inlet, an air outlet. A curved surface adjacent to and downstream of the air outlet. The haircare appliance or the attachment has a curved surface adjacent to and downstream of the air outlet. The haircare appliance or the attachment is configured such that airflow exiting the air outlet generates a first force to attract hair toward the curved surface, and a second force to push hair away from the curved surface.

Abstract: In some illustrative examples, a bridge suitable for treating a tissue site may include a bridge sealing member and one or more bridge wicking layers. The bridge sealing member may extend along a length of the bridge, and may define an internal passageway in fluid communication between a receiving end of the bridge and a transmitting end of the bridge. The one or more bridge wicking layers may be disposed within the internal passageway of the bridge sealing member. Other apparatus, systems, and methods are disclosed.

Abstract: A haircare appliance having an air inlet, an air outlet, and an airflow generator for generating an airflow from the air inlet to the air outlet and an attachment for a haircare appliance, the attachment including an air inlet, an air outlet. A curved surface adjacent to and downstream of the air outlet. The haircare appliance or the attachment has a curved surface adjacent to and downstream of the air outlet. The haircare appliance or the attachment is configured such that airflow exiting the air outlet generates a first force to attract hair toward the curved surface, and a second force to push hair away from the curved surface.

Abstract: A system includes a matrix transpose component, a matrix processing component, a data modification component, and a data reduction component. The matrix transpose component is configured to transpose a stored matrix to an output matrix. The matrix processing component is configured to multiply the output matrix with a mask vector to determine a result vector. The data modification component is configured to modify at least a portion of the result vector to determine a modified vector. The data reduction component is configured to sum at least a portion of elements included in the modified vector.

Abstract: An interface assembly comprises a nasal mask that includes a seal having a rolling portion. The rolling portion of the seal rolls over a portion of a clip that secures the seal to a frame. The frame has a ball and socket connection to a connector. The connector comprises an elbow having integrally formed exhaust holes and a swivel.