Abstract: The disclosure relates to a drug delivery device comprising: a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament from the medicament container, at least one feedback mechanism that is in operative connection with the plunger, the feedback mechanism comprising a collar, a control spring biasing the collar in a distal direction, a needle shroud, operatively axially abutting the collar in a first coupled state and prevented from axially decoupling the collar by the plunger in its proximal position, wherein the plunger, when approaching the distal position during movement from the proximal position towards the distal position, is adapted to allow axial decoupling of the needle shroud from the collar, thus allowing for a limited axial movement of the collar relative to the needle shroud until the collar axially abuts the needle shroud in a second coupled state.

Abstract: The disclosure relates to an audible indicator for use with a drug delivery device comprising a bistable resilient force member capable of residing in two states. In a biased state, the resilient force member is biased and stores energy In a relaxed state, the resilient force member is relaxed. The resilient force member releases the stored energy when transitioning from the biased state into the relaxed state, thereby generating an audible signal.

Abstract: The present disclosure relates to a drive subassembly for a drug delivery device, the drive subassembly comprising a housing and a plunger, wherein the plunger is adapted to be rotated between a locked position, in which the plunger is prevented from advancing, and a released position, in which the plunger is advancable, wherein at least one restraining component is provided to restrain rotation of the plunger from the locked position towards the released position.

Abstract: The present disclosure relates to a cap assembly for a medicament delivery device comprising a cap body configured to be detachably mounted to a housing of a medicament delivery device, and a cap lid configured to be attached to the cap body, wherein the cap body is configured to receive a needle sleeve and the cap lid when the cap assembly is attached to a medicament delivery device, the cap lid comprising an anti-recapping element configured to prevent the cap assembly from being reattached to a housing of a medicament delivery device once the cap assembly has been removed and the medicament delivery device has been used, wherein the anti-recapping element comprises a projection configured to engage a needle sleeve of a medicament delivery device to prevent the cap assembly being reattached to a housing of a medicament delivery device once the medicament delivery device has been used.

Abstract: A respiratory mask system is provided. The respiratory mask system has a patient interface that is secured to a user's head by a headgear. The patient interface comprises a seal, a frame and a gas delivery conduit. The frame is configured to secure the seal and gas delivery conduit together. The frame comprises a recessed channel and/or headgear retaining features configured to connect the headgear to the patient interface. The frame can include an inlet collar that connects to a gas delivery conduit. The inlet collar can include bias flow holes. The headgear comprises a top strap, a pair of side arms, a yoke and a rear strap. The yoke is configured to connect to the recessed channel of the frame. The top strap, side arms and yoke form an integrally formed closed loop. The top strap can include two portions adjustably connected to each other.

Abstract: A liquid medicament administration device includes a body configured to contain and support a medicament container. The body includes an aperture. The aperture includes a viewing window that is coincident with the medicament container when the medicament container is present. The device is configured such that the viewing window is size-adjustable. Also disclosed are associated methods of manufacture.

Abstract: Disclosed is a drug delivery device including a housing extending along a longitudinal axis of the drug delivery device, and a distal device portion. The distal device portion includes a distal portion, a proximal portion and at least one intermediate portion. The distal portion includes a distal opening allowing passage of a needle and a bearing surface. The intermediate portion includes at least one wall portion extending proximally from the distal portion to the proximal portion. In at least one state of the drug delivery device, a first radial outer extension of the distal portion in a region axially adjoining the bearing surface is smaller than a second radial outer extension in the intermediate portion, and an outer face of the intermediate portion is inclined relative to the longitudinal axis in a cross section along the longitudinal axis.

Abstract: Devices, systems, and methods are provided for enhanced rider pairing of an autonomous vehicle (AV). A system may pair a first user profile of a first user located at a first location with a first autonomous vehicle (AV) to complete a trip to a destination selected by the first user. The system may detect a second AV at the first location, wherein the second AV is associated with a second user profile. The system may connect the second AV with the first user using a connection mechanism. The system may select a profile status of the first user profile based on the connection to the second AV. The system may pair the first user profile with the second AV based on the profile status.

Abstract: The present disclosure relates to a fluid dispensing device (1) comprising: —a housing (10) to accommodate a container (110) filled a fluid, —a outlet orifice (3), —a discharge mechanism (130) operable for spray discharging multiple doses of the fluid via the outlet orifice (3), —a mechanical energy storage (50) coupled to the discharge mechanism (130), reversibly transferable between a preloaded state and an unloaded state and configured to store mechanical energy in the preloaded state effective to produce the spray discharging of the fluid, —a releasable interlock (70) configured to retain the mechanical energy storage (50) in the preloaded state, —a trigger mechanism (90) operationally engageable with the interlock (70) and operable i) to release a first portion of the mechanical energy stored in the mechanical energy storage (50) when actuated for a first time and ii) to release at least a second portion of the mechanical energy stored in the mechanical energy storage (50) when actuated for a second time

Abstract: The present invention relates to methods for treating atopic dermatitis in a subject using an interleukin-13 (IL-13) binding protein, such as an anti-IL-13 antibody or an IL-13-binding fragment thereof.

Abstract: A gas delivery apparatus includes an inlet portion and an outlet portion. The inlet portion can comprise a plurality of inlet ports configured to receive gas from a gas source. The inlet portion can also comprise a corresponding plurality of tapered surfaces associated with the plurality of inlet ports. Each tapered surface of the plurality of tapered surfaces surrounds a corresponding inlet port of the plurality of inlet ports. The outlet portion can be configured to deliver the gas to a gas showerhead of a process chamber. Each tapered surface of the plurality of tapered surfaces can comprise a first region and a second region. The first region is associated with a first curvature. The second region is associated with a second curvature. The first curvature can be different from the second curvature.

Abstract: The present disclosure relates to a fluid dispensing device (10), the fluid dispensing device (1) comprising: a housing (10) to accommodate a container (110) filled with a fluid, wherein the housing (10) comprises a sidewall 118) extending along a longitudinal direction (z), —an outlet orifice (3), —a discharge mechanism (130) operable for spray discharging at least one or multiple doses of the fluid via the outlet orifice (3), —a protective cap (12) pivotally supported on or by the housing (10) between an open position and a closed position, wherein when in the closed position the outlet orifice (3) is effectively covered by the protective cap (12), —a mechanical energy storage (50) coupled to the discharge mechanism (130), reversibly transferable between a preloaded state and an unloaded state and configured to store mechanical energy in the preloaded state effective to produce the spray discharging of the fluid, —a biasing mechanism (150) comprising a biasing member (160) operationally coupled to the prote

Abstract: The present disclosure relates to a mechanical energy storage for a fluid dispensing device (10), the mechanical energy storage comprising:—a first drive spring (51) extending along a longitudinal direction (z),—the drive spring (51) comprising a first longitudinal end (53) to engage with a housing (10) of the fluid dispensing device (1) and a second longitudinal end (54) opposite to the first longitudinal end (53) to engage with a driver (30) movable relative to the housing (10) along the longitudinal direction (z),—wherein the mechanical energy storage (50) is reversibly transferable into a pre-loaded state by resiliently compressing the first drive spring (51) in the longitudinal direction (z) to thereby induce a resilient deformation of the first drive spring (51) in a first direction (y) transverse to the longitudinal direction (z), and-wherein the mechanical energy storage (50) is transferable from the pre-loaded state into an unloaded state by allowing the first drive spring (51) to relax into or towar

Abstract: A drug delivery device with an adjustable injection depth comprises a housing, a support element, and a container retaining space for receiving a container comprising a drug. The support element supports the container within the housing, and the drug delivery device comprises a spacer element. In a first state of the drug delivery device, a first axial position of the container relative to the housing is adjusted by the spacer element being in a first spacer position, and in a second state of the drug delivery device, a second axial position of the container is adjusted by the spacer element being in a second position within the housing or being outside of the housing. The first axial position enables a smaller injection depth of a needle coupled to the container compared to the injection depth enabled if the container is in the second axial position.

Abstract: Interfaces for positive pressure therapy having various vent designs are disclosed herein. The interfaces include a bias flow vent with design geometries that help reduce and/or minimize draft and noise levels of the fluids exiting the vents. Some of the vent designs include particular vent hole geometries, plenum spaces, diffusers and fibrous media.

Abstract: A lock mechanism having a bolt movable between a thrown position and a retracted position, and a deadbolt assembly includes a sliding deadbolt configured to slide between a locked position in which the sliding deadbolt inhibits retraction of the bolt and an unlocked position. The sliding deadbolt includes a first anti-thrust cam configured to restrain the sliding deadbolt in the locked position, and a release driver arranged such that, when driven, the release driver releases the first anti-thrust cam from restraining the sliding deadbolt in the locked position and slides the deadbolt to the unlocked position.

Abstract: A patient interface can have a frame supporting a sealing member. Various features of the sealing member can improve comfort and sealing performance in the context of forming seals with the nares of a user, as well as contact with other facial surfaces. The sealing member can include convex portions, concave portions and thickness variations for providing various sealing, comfort, and deformability effects.

Abstract: A drug delivery arrangement (1) comprising a drug delivery device (2), having a housing (3), and a needle, and a tissue receiving element (6), having a needle passage opening (7) and a tissue receiving portion (8), wherein the tissue receiving element is configured to interact with the skin (9) in order to lift tissue into the tissue receiving portion to reduce the risk of injury due to deep punctures.