Abstract: Devices, systems, and methods are provided for enhanced rider pairing of an autonomous vehicle (AV). A system may pair a first user profile of a first user located at a first location with a first autonomous vehicle (AV) to complete a trip to a destination selected by the first user. The system may detect a second AV at the first location, wherein the second AV is associated with a second user profile. The system may connect the second AV with the first user using a connection mechanism. The system may select a profile status of the first user profile based on the connection to the second AV. The system may pair the first user profile with the second AV based on the profile status.

Abstract: The present disclosure relates to a fluid dispensing device (1) comprising: —a housing (10) to accommodate a container (110) filled a fluid, —a outlet orifice (3), —a discharge mechanism (130) operable for spray discharging multiple doses of the fluid via the outlet orifice (3), —a mechanical energy storage (50) coupled to the discharge mechanism (130), reversibly transferable between a preloaded state and an unloaded state and configured to store mechanical energy in the preloaded state effective to produce the spray discharging of the fluid, —a releasable interlock (70) configured to retain the mechanical energy storage (50) in the preloaded state, —a trigger mechanism (90) operationally engageable with the interlock (70) and operable i) to release a first portion of the mechanical energy stored in the mechanical energy storage (50) when actuated for a first time and ii) to release at least a second portion of the mechanical energy stored in the mechanical energy storage (50) when actuated for a second time

Abstract: A gas delivery apparatus includes an inlet portion and an outlet portion. The inlet portion can comprise a plurality of inlet ports configured to receive gas from a gas source. The inlet portion can also comprise a corresponding plurality of tapered surfaces associated with the plurality of inlet ports. Each tapered surface of the plurality of tapered surfaces surrounds a corresponding inlet port of the plurality of inlet ports. The outlet portion can be configured to deliver the gas to a gas showerhead of a process chamber. Each tapered surface of the plurality of tapered surfaces can comprise a first region and a second region. The first region is associated with a first curvature. The second region is associated with a second curvature. The first curvature can be different from the second curvature.

Abstract: The present disclosure relates to a fluid dispensing device (10), the fluid dispensing device (1) comprising: a housing (10) to accommodate a container (110) filled with a fluid, wherein the housing (10) comprises a sidewall 118) extending along a longitudinal direction (z), —an outlet orifice (3), —a discharge mechanism (130) operable for spray discharging at least one or multiple doses of the fluid via the outlet orifice (3), —a protective cap (12) pivotally supported on or by the housing (10) between an open position and a closed position, wherein when in the closed position the outlet orifice (3) is effectively covered by the protective cap (12), —a mechanical energy storage (50) coupled to the discharge mechanism (130), reversibly transferable between a preloaded state and an unloaded state and configured to store mechanical energy in the preloaded state effective to produce the spray discharging of the fluid, —a biasing mechanism (150) comprising a biasing member (160) operationally coupled to the prote

Abstract: The present invention relates to methods for treating atopic dermatitis in a subject using an interleukin-13 (IL-13) binding protein, such as an anti-IL-13 antibody or an IL-13-binding fragment thereof.

Abstract: A drug delivery device with an adjustable injection depth comprises a housing, a support element, and a container retaining space for receiving a container comprising a drug. The support element supports the container within the housing, and the drug delivery device comprises a spacer element. In a first state of the drug delivery device, a first axial position of the container relative to the housing is adjusted by the spacer element being in a first spacer position, and in a second state of the drug delivery device, a second axial position of the container is adjusted by the spacer element being in a second position within the housing or being outside of the housing. The first axial position enables a smaller injection depth of a needle coupled to the container compared to the injection depth enabled if the container is in the second axial position.

Abstract: The present disclosure relates to a mechanical energy storage for a fluid dispensing device (10), the mechanical energy storage comprising:—a first drive spring (51) extending along a longitudinal direction (z),—the drive spring (51) comprising a first longitudinal end (53) to engage with a housing (10) of the fluid dispensing device (1) and a second longitudinal end (54) opposite to the first longitudinal end (53) to engage with a driver (30) movable relative to the housing (10) along the longitudinal direction (z),—wherein the mechanical energy storage (50) is reversibly transferable into a pre-loaded state by resiliently compressing the first drive spring (51) in the longitudinal direction (z) to thereby induce a resilient deformation of the first drive spring (51) in a first direction (y) transverse to the longitudinal direction (z), and-wherein the mechanical energy storage (50) is transferable from the pre-loaded state into an unloaded state by allowing the first drive spring (51) to relax into or towar

Abstract: A patient interface can have a frame supporting a sealing member. Various features of the sealing member can improve comfort and sealing performance in the context of forming seals with the nares of a user, as well as contact with other facial surfaces. The sealing member can include convex portions, concave portions and thickness variations for providing various sealing, comfort, and deformability effects.

Abstract: A lock mechanism having a bolt movable between a thrown position and a retracted position, and a deadbolt assembly includes a sliding deadbolt configured to slide between a locked position in which the sliding deadbolt inhibits retraction of the bolt and an unlocked position. The sliding deadbolt includes a first anti-thrust cam configured to restrain the sliding deadbolt in the locked position, and a release driver arranged such that, when driven, the release driver releases the first anti-thrust cam from restraining the sliding deadbolt in the locked position and slides the deadbolt to the unlocked position.

Abstract: Interfaces for positive pressure therapy having various vent designs are disclosed herein. The interfaces include a bias flow vent with design geometries that help reduce and/or minimize draft and noise levels of the fluids exiting the vents. Some of the vent designs include particular vent hole geometries, plenum spaces, diffusers and fibrous media.

Abstract: A headgear, for use in combination with a breathing apparatus, has a plastic or elastomer core and a fabric or textile casing. The headgear, or portions thereof, may also include a length adjustment arrangement that permits adjustment of a length of a section of the headgear. The length adjustment arrangement can comprise overlapping strap portions of the headgear. In some configurations, the overlapping strap portions can be covered by a sleeve. The sleeve can be secured to the headgear by overmolded end caps. A nasal respiratory interface can include a frame having a front surface, a rear surface, and an aperture extending from the front surface to the rear surface. The frame can have an oval form with a truncated height portion. The interface can also include a seal for a nasal pillow. The seal can be attached to the frame.

Abstract: A drug delivery arrangement includes a drug delivery device with a housing adapted to receive a needle that is configured to pierce a skin of a user. The drug delivery device comprises a drive energy source, and is configured to perform a drug delivery operation using the energy obtainable from the drive energy source. The drug delivery device is an autoinjector. An injection depth adjusting member is connectable to or connected to a device member of the drug delivery device. The injection depth adjusting member is configured to provide an adjuster bearing surface with which the drug delivery arrangement bears on the skin during use when the injection depth adjusting member is connected to the device member. When connected to the device member, the injection depth adjusting member is configured to define the injection depth by which the needle can penetrate the skin.

Abstract: The present disclosure concerns an assembly for an injection device, e.g. an auto-injector device, comprising: a medicament container comprising a medicament container body and a needle protruding from a distal end of the medicament container body and fluidly connected to an interior of the medicament container body, a housing comprising a first bearing surface configured to support the medicament container in a distal direction, a distancing element arranged on the needle and providing a second bearing surface configured to contact a patient's skin during use of the injection device, thereby preventing insertion of the needle into the patient's body beyond a predetermined injection depth.

Abstract: A drug delivery arrangement (1) comprising a drug delivery device (2), having a housing (3), and a needle, and a tissue receiving element (6), having a needle passage opening (7) and a tissue receiving portion (8), wherein the tissue receiving element is configured to interact with the skin (9) in order to lift tissue into the tissue receiving portion to reduce the risk of injury due to deep punctures.

Abstract: An assembly for an injection device, such as an auto-injector device, includes a housing comprising a first bearing surface to support a medicament container in a distal direction, and a needle cover comprising a second bearing surface to protrude from the housing further than a needle of the medicament container at least in a first state and in a first position. The needle cover is arranged in the housing to move telescopically in the housing when a force is exerted upon it in a proximal direction, and the needle cover comprises an opening for the needle to pass through when the needle cover is moved into the housing to a second position. The assembly also includes a coupling element to cause the medicament container to move into the proximal direction in parallel with the needle cover when the needle cover is moved into the proximal direction past the second position.

Abstract: The disclosure relates to a drug delivery device including a plunger disposed within a case and an audible indicator that comprises a resilient element. The plunger is slidable from a proximal position to a distal position within the case and the resilient element is in a first configuration when the plunger is in the proximal position, such that the resilient element is deflected radially outwards to a second configuration during movement of the plunger from the proximal position towards the distal position. The resilient element moves from the second configuration towards the first configuration when the plunger moves towards or reaches the distal position, thereby generating an audible and tactile signal.

Abstract: A clean out plug for removably plugging a clean out opening in a fluid line has an externally threaded body with an upper surface having an opening into a cavity in the body which houses a reversable key which is removeable from said body, and which has a smooth surface on one side and a tool engaging projection on the reverse side. In a first position in the cavity, the key presents a smooth flush surface with said plug body, with said projection projecting down into said cavity. In its reverse second position said key presents said tool engageable projection projects above said upper surface of said clean out plug body, such that a tool can be used to engage said projection and remove the clean out plug from the opening it plugs.

Abstract: The disclosure relates to a drug delivery device comprising a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament (M) from the medicament container, an audible indicator that is arranged within a case pocket lateral to the plunger and that is in operative connection with the plunger, the audible indicator comprises at least one indicator spring and at least one locking element, wherein the indicator spring is biased by the locking element, and the indicator spring relaxes due to a release of the locking element by a movement of the plunger.

Abstract: Disclosed herein are system, method, and computer program product aspects for validating protolanes. For example, the method includes determining a protolane level flowchart from one or more flowcharts corresponding to one or more gates of a protolane selected from a set of protolanes of a geonet, wherein the one or more flowcharts correspond to conditions that can be encountered by an actor approaching the corresponding one or more gates, and wherein the geonet comprises a plurality of lane segments associated with the set of protolanes. A graph through the protolane level flowchart is generated that corresponds to actions of an actor. Reasoning of the actor is validated by testing the actions of the actor against the graph through the protolane level flowchart.

Abstract: The disclosure relates to a drug delivery device comprising: a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament from the medicament container, at least one feedback mechanism that is in operative connection with the plunger, the feedback mechanism comprising a collar, a control spring biasing the collar in a distal direction, a needle shroud, operatively axially abutting the collar in a first coupled state and prevented from axially decoupling the collar by the plunger in its proximal position, wherein the plunger, when approaching the distal position during movement from the proximal position towards the distal position, is adapted to allow axial decoupling of the needle shroud from the collar, thus allowing for a limited axial movement of the collar relative to the needle shroud until the collar axially abuts the needle shroud in a second coupled state.