Abstract: The present disclosure relates to a drug delivery device having a case adapted to retain a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament from the medicament container, and at least one feedback mechanism that is in operative connection with the plunger. The feedback mechanism includes a collar, a needle shroud, and a control spring biasing the needle shroud in a distal direction relative to the collar. The collar is operatively coupled to the case in an axial direction and prevented from axially decoupling from the case by the plunger when in the proximal position. The plunger, during movement from the proximal position towards the distal position, allows axial decoupling of the collar from the case driven by the control spring until the collar's movement is halted, which creates an audible and/or tactile feedback.

Abstract: Various embodiments related to three dimensional printers, and reinforced filaments, and their methods of use are described. In one embodiment, a void free reinforced filament is fed into a conduit nozzle. The reinforced filament includes a core, which may be continuous or semi-continuous, and a matrix material surrounding the core. The reinforced filament is heated to a temperature greater than a melting temperature of the matrix material and less than a melting temperature of the core prior to drag the filament from the conduit nozzle.

Abstract: The disclosure relates to a syringe support for supporting an axial position of a syringe relative to a housing of an autoinjector. The syringe support comprises a projecting portion, which projects from the syringe support in a distal direction and a flexible portion which axially adjoins the projecting portion. The flexible portion is adapted to axially bias the syringe in the distal direction within the housing. The disclosure further relates to an autoinjector.

Abstract: An interface assembly comprises a nasal mask that includes a seal having a rolling portion. The rolling portion of the seal rolls over a portion of a clip that secures the seal to a frame. The frame has a ball and socket connection to a connector. The connector comprises an elbow having integrally formed exhaust holes and a swivel.

Abstract: A system includes a matrix transpose component, a matrix processing component, a data modification component, and a data reduction component. The matrix transpose component is configured to transpose a stored matrix to an output matrix. The matrix processing component is configured to multiply the output matrix with a mask vector to determine a result vector. The data modification component is configured to modify at least a portion of the result vector to determine a modified vector. The data reduction component is configured to sum at least a portion of elements included in the modified vector.

Abstract: A patient interface can have a frame supporting a sealing member. Various features of the sealing member can improve comfort and sealing performance in the context of forming seals with the nares of a user, as well as contact with other facial surfaces. The sealing member can include convex portions, concave portions and thickness variations for providing various sealing, comfort, and deformability effects.

Abstract: An arrangement for a drug delivery device includes a housing with a proximal end and a distal end, a needle shield remover configured to be rotationally locked to a needle shield covering a needle, and a guiding interface. The needle shield remover is releasably connectable to the housing. The guiding interface is configured such that, when the needle shield remover rotates with respect to the housing from a state in which the needle shield remover is connected to the housing, the guiding interface guides a movement of the needle shield remover relative to the housing in a direction away from the proximal end of the housing to disconnect the needle shield remover from the housing. Movement of the needle shield remover relative to the housing to disconnect the needle shield remover includes an axial movement and a rotational movement of the needle shield remover relative to the housing.

Abstract: According to one aspect, embodiments herein provide a furnace for debinding and sintering additively manufactured parts comprising a unitarily formed retort having at least one open side, a heater for heating a sintering volume within the retort to a debinding temperature and to a sintering temperature, an end cap sealing the at least one open side, a forming gas line penetrating the end cap for supplying forming gas at a flowrate, and a heat exchanger within the retort, outside the sintering volume, and adjacent a heated wall of the retort, the heat exchanger having an inlet connected to the forming gas line and an outlet to the sintering volume, wherein the heat exchanger includes a heat exchange tube length sufficient to heat the forming gas to within 20 degrees Celsius of the sintering temperature before the forming gas exits the outlet.

Abstract: The invention relates to an autoinjector comprising a housing (125) which is configured to receive a reservoir (120) with a fluid, a pump arrangement (100), which is configured to drive the fluid from the reservoir (120) towards and through an outlet (180) of the autoinjector in a dispensing operation.

Abstract: The invention relates to an autoinjector comprising —a housing (105) which is configured to receive an operating reservoir (120, 220) with a fluid, —a pump arrangement (100, 200), which is configured to drive the fluid from the operating reservoir (120, 220) towards and through an outlet (180) of the autoinjector in a dispensing operation.

Abstract: The invention relates to an autoinjector (100) comprising —a housing (170) which is gas-tight to the outside, —a fluid reservoir (110) with a fluid, wherein the fluid reservoir (110) comprises a flexible material, —a container (140) which comprises at least a first section which is configured to contain a first substance which comprises gas or which can be converted into gas, wherein ?the container (140) is configured to assume two different states, ?a first state in which the first section is sealed so that the at least first substance is contained in the first section, ?a second state in which the at least first substance is released from the first section into the housing (170) causing an increase of gas pressure within the housing (170) which acts on the fluid reservoir (110) causing the fluid inside the fluid reservoir (110) to move through the fluid reservoir (110) towards and through an outlet (230) of the autoinjector (100).

Abstract: A diffuser element for use over a vent opening of a breathing assistance apparatus. In some configurations, the diffuser element is formed by knitting or weaving one or more threads together into an interlocking pattern. In some configurations, the diffuser pad has a first surface and an opposing second surface and at least the first surface includes a surface texture. Arrangements for coupling the diffuser element to a structure that defines or carries the vent are also disclosed.

Abstract: A drug delivery device includes a housing element, a release member, a plunger rod, a transfer member arranged rotatably with respect to the housing element, an energy member, a displaceable element being displaceable between a first position and a second position, wherein the transfer member and the plunger rod are operatively coupled such that a rotation of the transfer member is converted into an axial movement of the plunger rod, the drug delivery device has a first locked state, wherein, in the first locked state, (i) a releasable first locking mechanism prevents a rotational movement of the transfer member, (ii) the release member is in an initial position and arranged to hold the displaceable element in the first position, and (iii) the transfer member is coupled to the displaceable element held in the first position via an axial-lock interface which prevents an axial movement of the transfer member.

Abstract: A drug delivery device includes a housing element, a release member, a plunger rod, an energy member, and a displaceable element. The drug delivery device has a first locked state in which the release member is in a distal position and arranged to hold the displaceable element in a first radial position to prevent a movement of the plunger rod in distal direction by the energy member. The drug delivery device is configured to be switched from the first locked state into a released state by moving the release member from the distal position into a proximal position. In the released state, the release member no longer holds the displaceable element in the first radial position, which enables a movement of the displaceable element from the first radial position into a second radial position to release the plunger rod such that the plunger rod moves in the distal direction.

Abstract: A drug delivery device includes a housing element, a protection member, a moveable member, a first stop feature, a second stop feature configured to interact with the first stop feature, wherein the drug delivery device is configured to perform a drug delivery operation, wherein the drug delivery device is configured to be switchable from an initial state into a released state, wherein in the released state (i) the protection member is in a proximal position, and (ii) the moveable member moves into a locking position, and wherein the drug delivery device is configured to be switchable from the released state into a post-released state by moving the protection member from the proximal position in a distal direction into a post-release position, wherein in the post-released state (i) the protection member is in the post-release position and (ii) the moveable member is in the locking position.

Abstract: A drug delivery device includes a housing element, a protection member, a movable member, wherein the drug delivery device has an initial state, in which (i) the protection member is in an extended position to cover the drug delivery element, (ii) the protection member is movable in a proximal direction from the extended position into a retracted position in order to expose the drug delivery element, and (iii) the protection member is coupled to the movable member in distal direction and proximal direction such that an axial movement of the protection member in both, the distal and proximal direction, results in an axial movement of the movable member in the same direction. The drug delivery device is configured such that, starting from the initial state, movement of the protection member in proximal direction initiates a rotation of the movable member relative to the protection member by a predetermined angle.

Abstract: Disclosed herein are system, method, and computer program product aspects for validating protolanes. For example, the method includes determining a protolane level flowchart from one or more flowcharts corresponding to one or more gates of a protolane selected from a set of protolanes of a geonet, wherein the one or more flowcharts correspond to conditions that can be encountered by an actor approaching the corresponding one or more gates, and wherein the geonet comprises a plurality of lane segments associated with the set of protolanes. A graph through the protolane level flowchart is generated that corresponds to actions of an actor. Reasoning of the actor is validated by testing the actions of the actor against the graph through the protolane level flowchart.

Abstract: An arrangement for a drug delivery device includes a housing element, a plunger rod that is axially movable with respect to the housing element, a feedback element that is axially movable with respect to the housing element and with respect to the plunger rod, a feedback energy member configured to provide energy to induce a movement of the feedback element relative to the plunger rod in a first axial direction, and a radially displaceable stop feature and an impact feature. The arrangement has an initial state in which the plunger rod is in a proximal position, the feedback element is arranged in a cavity of the plunger rod, and the feedback element is limited in movement relative to plunger rod in the first axial direction by the stop feature being in a first radial position. The arrangement is configured to be switched from the initial state into a released state.