Abstract: A drug delivery device includes a housing element, a release member, a plunger rod, an energy member, and a displaceable element. The drug delivery device has a first locked state in which the release member is in a distal position and arranged to hold the displaceable element in a first radial position to prevent a movement of the plunger rod in distal direction by the energy member. The drug delivery device is configured to be switched from the first locked state into a released state by moving the release member from the distal position into a proximal position. In the released state, the release member no longer holds the displaceable element in the first radial position, which enables a movement of the displaceable element from the first radial position into a second radial position to release the plunger rod such that the plunger rod moves in the distal direction.

Abstract: A drug delivery device includes a housing element, a protection member, a moveable member, a first stop feature, a second stop feature configured to interact with the first stop feature, wherein the drug delivery device is configured to perform a drug delivery operation, wherein the drug delivery device is configured to be switchable from an initial state into a released state, wherein in the released state (i) the protection member is in a proximal position, and (ii) the moveable member moves into a locking position, and wherein the drug delivery device is configured to be switchable from the released state into a post-released state by moving the protection member from the proximal position in a distal direction into a post-release position, wherein in the post-released state (i) the protection member is in the post-release position and (ii) the moveable member is in the locking position.

Abstract: A drug delivery device includes a housing element, a protection member, a movable member, wherein the drug delivery device has an initial state, in which (i) the protection member is in an extended position to cover the drug delivery element, (ii) the protection member is movable in a proximal direction from the extended position into a retracted position in order to expose the drug delivery element, and (iii) the protection member is coupled to the movable member in distal direction and proximal direction such that an axial movement of the protection member in both, the distal and proximal direction, results in an axial movement of the movable member in the same direction. The drug delivery device is configured such that, starting from the initial state, movement of the protection member in proximal direction initiates a rotation of the movable member relative to the protection member by a predetermined angle.

Abstract: An arrangement for a drug delivery device includes a housing element, a plunger rod that is axially movable with respect to the housing element, a feedback element that is axially movable with respect to the housing element and with respect to the plunger rod, a feedback energy member configured to provide energy to induce a movement of the feedback element relative to the plunger rod in a first axial direction, and a radially displaceable stop feature and an impact feature. The arrangement has an initial state in which the plunger rod is in a proximal position, the feedback element is arranged in a cavity of the plunger rod, and the feedback element is limited in movement relative to plunger rod in the first axial direction by the stop feature being in a first radial position. The arrangement is configured to be switched from the initial state into a released state.

Abstract: Disclosed herein are system, method, and computer program product aspects for validating protolanes. For example, the method includes determining a protolane level flowchart from one or more flowcharts corresponding to one or more gates of a protolane selected from a set of protolanes of a geonet, wherein the one or more flowcharts correspond to conditions that can be encountered by an actor approaching the corresponding one or more gates, and wherein the geonet comprises a plurality of lane segments associated with the set of protolanes. A graph through the protolane level flowchart is generated that corresponds to actions of an actor. Reasoning of the actor is validated by testing the actions of the actor against the graph through the protolane level flowchart.

Abstract: A device includes a matrix transpose component, a matrix processing component, a data alignment component, and a data reduction component. The matrix transpose component is configured to transpose an input matrix of elements to output an output matrix of the elements that have been transposed. The matrix processing component is configured to multiply a first multiplication input matrix with a second multiplication input matrix, wherein the output matrix of the matrix transpose component is utilized as the first multiplication input matrix and a mask vector is utilized as the second multiplication input matrix. The data alignment component is configured to modify at least a portion of elements of a result of the matrix processing component. The data reduction component is configured to sum at least the elements of the modified result of the matrix processing component to determine a sum of the group of values.

Abstract: A patient interface can have a frame supporting a sealing member. Various features of the sealing member can improve comfort and sealing performance in the context of forming seals with the nares of a user, as well as contact with other facial surfaces. The sealing member can include convex portions, concave portions and thickness variations for providing various sealing, comfort, and deformability effects.

Abstract: A drug delivery device comprises an outer surface and a region for receiving a medicament container. The region has an inner surface to contact and support a medicament container received therein. The device also includes a thermal bridge extending between the inner surface and the outer surface to conduct heat between the inner surface and the outer surface. The thermal bridge has a thermal conductivity equal to or greater than 10W/mk.

Abstract: Techniques for proving authenticity of data files, such as digital photos. An authentication/indexing server content from a client device such as a mobile device, and generates or receives other related data such as a reference to the content object, a fingerprint for the content object, and other metadata indicating for example a timestamp related to the content object. The fingerprint is inserted into a distributed ledger, with the distributed ledger returning a ledger address. A manifest object containing the transaction object, the ledger address, and a list of the content object and, optionally, related edits is then created and stored. The server may index fingerprints. Thus, a fingerprint can be used to authenticate subsequently received object against the stored metadata.

Abstract: A three-dimensional geometry is received, and sliced into layers. A first anisotropic fill tool path for controlling a three dimensional printer to deposit a substantially anisotropic fill material is generated defining at least part of an interior of a first layer. A second anisotropic fill tool path for controlling a three dimensional printer to deposit the substantially anisotropic fill material defines at least part of an interior of a second layer. A generated isotropic fill material tool path defines at least part of a perimeter and at least part of an interior of a third layer intervening between the first and second layers.

Abstract: Various embodiments related to three dimensional printers, and reinforced filaments, and their methods of use are described. In one embodiment, a void free reinforced filament is fed into an extrusion nozzle. The reinforced filament includes a core, which may be continuous or semi-continuous, and a matrix material surrounding the core. The reinforced filament is heated to a temperature greater than a melting temperature of the matrix material and less than a melting temperature of the core prior to extruding the filament from the extrusion nozzle.

Abstract: Needle shroud assemblies comprising a needle shroud and a support component. At least one of the needle shroud assemblies includes: a shroud body having an inner surface forming a cavity; a shroud beam arranged on the shroud body and biased radially outwards, wherein the support component is arranged on the inner surface of the shroud body and configured to form an inner radial support surface for the shroud body and/or for the shroud beam.

Abstract: The disclosure refers to a an assembly for a drug delivery device comprising: a housing having a proximal end and a distal end a longitudinal axis extending between the proximal end and the distal end, wherein the housing is adapted to receive and retain a drug reservoir and a needle, a needle cover which is movable between at least two different axial positions relative to the housing, a locking position and a non-locking position, wherein the needle cover has a needle cover locking feature which is arranged to block proximal movement of the needle cover relative to the housing in the locking position of the needle cover, wherein the needle cover has an outer surface delimiting an interior of the needle cover, and wherein the needle cover locking feature is disposed in the interior of the needle cover.

Abstract: The disclosure refers to a drive arrangement for a drug delivery device including a housing having a proximal end and a distal end, a longitudinal axis extending between the proximal end and the distal end, a plunger rod movable relative to the housing, a drive unit arranged to bias the plunger rod in the distal direction, a plunger rod release member, which includes at least one plunger rod release feature, wherein the plunger rod release member is movable relative to the housing from a first position into a second position, wherein, in the first position, the plunger rod release feature engages the retention feature such that the plunger rod is prevented from moving relative to the plunger rod release member, and wherein, in the second position, the plunger rod release feature is disengaged from the retention feature, thereby allowing the plunger rod to move in the distal direction.

Abstract: The disclosure relates to a syringe support for supporting an axial position of a syringe relative to a housing of an autoinjector. The syringe support comprises a projecting portion, which projects from the syringe support in a distal direction and a flexible portion which axially adjoins the projecting portion. The flexible portion is adapted to axially bias the syringe in the distal direction within the housing. The disclosure further relates to an autoinjector.

Abstract: The present specification relates to a drug delivery device including a housing adapted to receive a primary container with a piston, a plunger slidably disposed in the housing and adapted to drive the piston for delivering a medicament, a drive spring pre-loaded between the housing and the plunger so as to urge the plunger in a distal direction, an audible and/or tactile indicator, and a trigger mechanism arranged between the indicator and the plunger. The trigger mechanism is configured to support the indicator in an initial state of the device and during delivery of the medicament and to couple with the plunger to activate the audible and/or tactile indicator at or near an end of delivery.

Abstract: A drug delivery device includes a housing, a blocking feature rotationally secured relative to the housing, a drive unit, a rod operatively coupled to the drive unit and arranged to move distally relative to the housing when the rod is released, and a movable trigger member. The rod is rotatable relative to the housing and has an unprimed state and a primed state. In the unprimed state, the blocking feature is arranged to block a rotation of the rod into the release position, and in the primed state, a trigger member feature is arranged to block rotation of the rod into the release position. The trigger member is arranged to move relative to the housing to release the rod. To switch from the unprimed state into the primed state, the trigger member moves and a movement is converted into an axial movement of the rod relative to the blocking feature.

Abstract: A respiratory mask includes a frame and a cushion module. The frame can include a front wall having a vent and/or a gas inlet opening and a collar extending away from the front wall. The collar surrounds the vent and/or the gas inlet opening. The cushion module comprises a cushion and a housing, which is made of a material more rigid than the cushion. The housing defines a connection opening. A friction coupling selectively couples the cushion module to the frame and comprises an elastomeric friction member coupled to a portion of the housing that defines the connection opening. In some arrangements, an outer surface of the friction member is exposed when the cushion module is coupled to the frame. In some arrangements, the housing extends through the peripheral surface.

Abstract: An information handling system bus port above a subject information handling system bus device may host an information handling system bus out of band message access control list of information handling system bus target device identifiers of other information handling system bus connected devices that the subject device is permitted to communicate with. The port may compare an information handling system bus target device identification field in out of band messages from the subject device to the list and route only out of band messages from the subject device in which the target device identification in the target device identification field is on the access control list through the information handling system bus. The port may discard (and generate error notifications, statuses, etc.) for out of band messages in which the target device identification in the target device identification field is not on the access control list.

Abstract: A lock mechanism having a bolt movable between a thrown position and a retracted position, and a deadbolt assembly includes a sliding deadbolt configured to slide between a locked position in which the sliding deadbolt inhibits retraction of the bolt and an unlocked position. The sliding deadbolt includes a first anti-thrust cam configured to restrain the sliding deadbolt in the locked position, and a release driver arranged such that, when driven, the release driver releases the first anti-thrust cam from restraining the sliding deadbolt in the locked position and slides the deadbolt to the unlocked position.