Abstract: The invention relates to a method and a device for guiding and orienting a strand (5) in a continuous casting facility for large-sized round sections made of steel or a similar material. In order to prevent the formation of cracks while the strand is oriented, the outer surface (15) of the strand is heated from above and from below inside the orienting track. For this purpose, porous burners (10, 17) are arranged in the discharge section of the directing track, the hot gas emitted from said burners flowing entirely around the outer surface (15) of the strand.

Abstract: A convertible motor vehicle with at least two vehicle seating rows and with at least two side doors is provided. A respectively associated door column is arranged in between the doors, and an active rollover protection system is provided in the region thereof. The door columns end upwards in the region of an associated waistline of the motor vehicle, and the rollover protection system is at least substantially arranged below the waistline of the motor vehicle in a retracted position.

Abstract: A radio frequency (RF) switch using a field effect transistor has 2nd order intermodulation distortion improved through use of a feed forward capacitor electrically connected between the gate and a voltage coupler connected between the source and drain of the FET. With a control voltage provided at the gate through a gate feed resistor for operation of the FET, the feed forward capacitor feeds an RF voltage from the drain terminal and the source terminal to the gate terminal through the gate feed resistor.

Abstract: The invention relates to the use of a compound of the formula (I) or a pharmaceutically acceptable addition salt thereof for the preparation of a medicament for the prophylaxis and/or treatment of muscular dystrophy.

Abstract: Use of idebenone for the preparation of a medicament for the treating of a muscular dystrophy in particular for treating and/or preventing weakness and/or loss of skeletal muscle tissue and/or cardiomyopathy associated with a muscular dystrophy.

Abstract: A method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting the biomolecule with an S-adenosyl-L-methionine-dependent methyltransferase in the presence of a detectable cofactor of said methyltransferase; and (b) detecting whether the recognition sequence of said methyltransferase has been modified with the cofactor or a derivative thereof, wherein modification of the recognition sequence of said methyltransferase is indicative of an absence of methylation at said recognition sequence. Also disclosed is a cofactor specific for S-adenosyl-L-methionine-dependent methyltransferases, wherein said cofactor is an N-adenosylaziridine derivative with a reporter group attached to the 6 or 7 position of the adenine ring or attached to the aziridine ring. A complex of the cofactor and a methyltransferase a composition comprising the cofactor or the complex and the use of the cofactor or the complex for detecting sequence-specific methylation in DNA molecules are also disclosed.

Abstract: It was found that a fragment of native Thermus aquaticus DNA polymerase (TaqWT) lacking 288 N-terminal amino acids (Taq?288) possesses an increased thermostability over TaqWT, Taq?279, and Taq?289. The present invention therefore provides Taq?288, recombinant expression vectors encoding the same or derivatives thereof, as well as purification protocols for Taq?288. The invention also encompasses kits containing Taq?288 as well as the use of Taq?288 and kits containing Taq?288. In addition, the invention encompasses methods for the sequencing a nucleic acid template and methods for amplifying a target nucleic acid.

Abstract: An apparatus for starting the casting of a continuous casting system has a mould (2) and a strand guide (10; 10?) comprising drive and guide rollers (11, 12; 11?, 12?). Moreover, a dummy bar (22) that can be introduced into the mould (2) by the strand guide (10; 10?) and be withdrawn from said mould is provided. A safety device (20; 20?) for the dummy bar (22) has an element (25) that can be engaged, with form fit, with the dummy bar (22) and limiting the speed of the cold bar (22). It is thus guaranteed that a predetermined maximum strand speed can not be exceeded and that the dummy bar does not slide through.

Abstract: The present invention relates to 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone (idebenone) for treating and/or preventing respiratory illness associated with certain forms of muscular dystrophy.

Abstract: The invention relates to a method and a device for producing nitrogen fertilizer from organic waste products in the liquid phase (suspension, emulsion, solution) and for hygienizing the wastes or reducing the emissions by thermal treatment using mineral or organic additions. According to the invention, this is achieved by a method, wherein the waste product is heated at underpressure to temperatures between 40 and 90° C., the escaping gas containing carbon dioxide and ammonia is cooled down and introduced into an aqueous absorption agent, the nitrogen fertilizer formed thereby is discharged and the excess gas not having been absorbed and containing carbon dioxide is pumped back into the discharge container, wherein the underpressure generated at the beginning of the process by a vacuum pump is autogenously maintained by the progress of the process.

Abstract: The invention relates to a method of treating muscular dystrophy, such as a muscular dystrophy or myopathy resulting from mutations in genes encoding collagen VI, in a mammal. The method involves administering of a compound of the formula (I) or a pharmaceutically acceptable addition salt thereof to the mammal.

Abstract: Methods are disclosed for assaying at the light microscopic level for the presence or absence of nucleolar channel systems (NCSs) in an endometrial tissue sample, as are methods for determining whether or not a postovulatory human endometrium is in a state that is receptive for implantation of a human embryo, where the presence of NCSs indicates that the endometrium is in a state that is receptive for implantation of an embryo and the absence of NCSs indicates that the endometrium is not in a state that is receptive for implantation of the embryo, and methods for determining the effectiveness of a contraceptive in a woman, comprising assaying an endometrial tissue sample for the presence or absence of NCSs.

Abstract: The present invention relates to approaches, methods, pharmaceuticals and uses directed to the curative treating or preventing of Primary Progressive Multiple Sclerosis (PP-MS), by using 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone (Idebenone) as the active agent.

Abstract: A method for making a differential gear casing (22) flow forms a first casing half (30) and forms a second casing half (32), both with hemispherical portions (34 and 52) and with radial flanges (36 and 56) with the latter also having an axial projection (58). An interior positioning surface (38) of the first casing half (30) and an exterior positioning surface (60) of the second casing half (32) position the casing halves with respect to each other.

Abstract: The invention concerns an electronic watch comprising an electric motor (5) for driving analogue display means (6), and a time base (1, 2) comprising an oscillator circuit (2) and a resonator (1), both mounted in the same case (9), characterized in that said case further comprises a control circuit (4) for said electric motor.

Abstract: The invention relates to the use of a compound of the formula (I) or a pharmaceutically acceptable addition salt thereof for the preparation of a medicament for the prophylaxis and/or treatment of muscular dystrophy.

Abstract: A convertible motor vehicle with at least two vehicle seating rows and with at least two side doors is provided. A respectively associated door column is arranged in between the doors, and an active rollover protection system is provided in the region thereof. The door columns end upwards in the region of an associated waistline of the motor vehicle, and the rollover protection system is at least substantially arranged below the waistline of the motor vehicle in a retracted position.

Abstract: In a system for sealing a dummy bar head in a mould of a continuous casting plant for casting large-format preliminary sections, a flat gasket (6) to seal the gap between the dummy bar head and the mould is provided, which is held on a packing plate (7) contained on the dummy bar head. Said packing plate has approximately the cross-sectional shape of the mould profile and covers the flat gasket (6). The packing plate (7) is displaceable towards the centre of the mould by an amount which is a function of the conicity of the mould (3). To this end, it consists of two plate halves (7a, 7b) lying in one plane with respect to each other. This makes it possible, when inserting the dummy bar head, to compensate for the angled course of the mould with the contracting packing plate until the sealing gap between packing plate and mould remains uniform on all sides.

Abstract: A device for determining an edge histogram of an image based on information about a gradient strength and a gradient direction of a local gradient in an image content of a partial image of the image includes an allocator which is implemented to allocate the information about the gradient strength and the gradient direction based on an allocation regulation to an edge image in order to obtain edge type information. The allocation regulation is selected such that with a predetermined gradient direction at least three different allocated edge types exist mirroring the different gradient strengths. The device further includes an edge histogram determiner which is implemented to determine the edge histogram based on the edge type information so that in the edge type histogram at least three edge types having different allocated gradient strengths may be differentiated.

Abstract: Methods are disclosed for assaying at the light microscopic level for the presence or absence of nucleolar channel systems (NCSs) in an endometrial tissue sample, as are methods for determining whether or not a postovulatory human endometrium is in a state that is receptive for implantation of a human embryo, where the presence of NCSs indicates that the endometrium is in a state that is receptive for implantation of an embryo and the absence of NCSs indicates that the endometrium is not in a state that is receptive for implantation of the embryo, and methods for determining the effectiveness of a contraceptive in a woman, comprising assaying an endometrial tissue sample for the presence or absence of NCSs.