Abstract: The invention relates to a method of treating muscular dystrophy, such as a muscular dystrophy or myopathy resulting from mutations in genes encoding collagen VI, in a mammal. The method involves administering of a compound of the formula (I) or a pharmaceutically acceptable addition salt thereof to the mammal.

Abstract: Methods are disclosed for assaying at the light microscopic level for the presence or absence of nucleolar channel systems (NCSs) in an endometrial tissue sample, as are methods for determining whether or not a postovulatory human endometrium is in a state that is receptive for implantation of a human embryo, where the presence of NCSs indicates that the endometrium is in a state that is receptive for implantation of an embryo and the absence of NCSs indicates that the endometrium is not in a state that is receptive for implantation of the embryo, and methods for determining the effectiveness of a contraceptive in a woman, comprising assaying an endometrial tissue sample for the presence or absence of NCSs.

Abstract: The present invention relates to approaches, methods, pharmaceuticals and uses directed to the curative treating or preventing of Primary Progressive Multiple Sclerosis (PP-MS), by using 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone (Idebenone) as the active agent.

Abstract: A method for making a differential gear casing (22) flow forms a first casing half (30) and forms a second casing half (32), both with hemispherical portions (34 and 52) and with radial flanges (36 and 56) with the latter also having an axial projection (58). An interior positioning surface (38) of the first casing half (30) and an exterior positioning surface (60) of the second casing half (32) position the casing halves with respect to each other.

Abstract: The invention concerns an electronic watch comprising an electric motor (5) for driving analogue display means (6), and a time base (1, 2) comprising an oscillator circuit (2) and a resonator (1), both mounted in the same case (9), characterized in that said case further comprises a control circuit (4) for said electric motor.

Abstract: The invention relates to the use of a compound of the formula (I) or a pharmaceutically acceptable addition salt thereof for the preparation of a medicament for the prophylaxis and/or treatment of muscular dystrophy.

Abstract: In a system for sealing a dummy bar head in a mould of a continuous casting plant for casting large-format preliminary sections, a flat gasket (6) to seal the gap between the dummy bar head and the mould is provided, which is held on a packing plate (7) contained on the dummy bar head. Said packing plate has approximately the cross-sectional shape of the mould profile and covers the flat gasket (6). The packing plate (7) is displaceable towards the centre of the mould by an amount which is a function of the conicity of the mould (3). To this end, it consists of two plate halves (7a, 7b) lying in one plane with respect to each other. This makes it possible, when inserting the dummy bar head, to compensate for the angled course of the mould with the contracting packing plate until the sealing gap between packing plate and mould remains uniform on all sides.

Abstract: A convertible motor vehicle with at least two vehicle seating rows and with at least two side doors is provided. A respectively associated door column is arranged in between the doors, and an active rollover protection system is provided in the region thereof. The door columns end upwards in the region of an associated waistline of the motor vehicle, and the rollover protection system is at least substantially arranged below the waistline of the motor vehicle in a retracted position.

Abstract: A device for determining an edge histogram of an image based on information about a gradient strength and a gradient direction of a local gradient in an image content of a partial image of the image includes an allocator which is implemented to allocate the information about the gradient strength and the gradient direction based on an allocation regulation to an edge image in order to obtain edge type information. The allocation regulation is selected such that with a predetermined gradient direction at least three different allocated edge types exist mirroring the different gradient strengths. The device further includes an edge histogram determiner which is implemented to determine the edge histogram based on the edge type information so that in the edge type histogram at least three edge types having different allocated gradient strengths may be differentiated.

Abstract: Methods are disclosed for assaying at the light microscopic level for the presence or absence of nucleolar channel systems (NCSs) in an endometrial tissue sample, as are methods for determining whether or not a postovulatory human endometrium is in a state that is receptive for implantation of a human embryo, where the presence of NCSs indicates that the endometrium is in a state that is receptive for implantation of an embryo and the absence of NCSs indicates that the endometrium is not in a state that is receptive for implantation of the embryo, and methods for determining the effectiveness of a contraceptive in a woman, comprising assaying an endometrial tissue sample for the presence or absence of NCSs.

Abstract: The invention relates to the use of a compound of the formula (I) or a pharmaceutically acceptable addition salt thereof for the preparation of a medicament for the prophylaxis and/or treatment of muscular dystrophies or myopathies resulting from mutations in genes encoding for collagen VI.

Abstract: A method for making a differential gear casing (22) flow forms a first casing half (30) and forms a second casing half (32), both with hemispherical portions (34 and 52) and with radial flanges (36 and 56) with the latter also having an axial projection (58). An interior positioning surface (38) of the first casing half (30) and an exterior positioning surface (60) of the second casing half (32) position the casing halves with respect to each other.

Abstract: The invention relates to a method and a device for producing nitrogen fertilizer, removing phosphate from organic waste products in liquid phase, sanitizing said waste or reducing emissions, and limiting the potassium concentration. According to the invention, the waste product is heated to temperatures ranging between 40° C. and 90° C. at a subatmospheric pressure, the escaping gas that contains carbon dioxide and ammonia is contacted with a mineral-aqueous suspension, the excess gas is conducted within the circuit while the subatmospheric pressure is autogenously stabilized, and the formed nitrogen fertilizer is discharged.

Abstract: The disclosure concerns a high efficiency electrochemical sensor with high signal yield for determining an analyte in a fluid medium comprising, at least one reference electrode, at least one working electrode having particles of an electrocatalyst in an electrode matrix, and an enzyme that is suitable for determining an analyte is selectively covalently bound to the particles of the electrocatalyst. The disclosure also describes a process for producing the electrochemical sensor and a method for determining an analyte in a fluid medium using the electrochemical sensor. have a high efficiency and thus achieve a high signal yield.

Abstract: Use of idebenone for the preparation of a medicament for the treating of a muscular dystrophy in particular for treating and/or preventing weakness and/or loss of skeletal muscle tissue and/or cardiomyopathy associated with a muscular dystrophy.

Abstract: A drum assembly for use with a coupling arrangement includes an outer member and an inner member that is mountable on the outer member. The outer member includes first and second annular portions and an intermediate portion extending between the annular portions. The first annular portion has a first mating surface that defines a first opening having a first diameter, the second annular portion defines a second opening having a second diameter that is smaller than the first diameter, and the intermediate portion defines a shoulder. The inner member includes a generally radially extending portion having a generally axially facing surface and a second mating surface that is engageable with the first mating surface to interlock the inner and outer members together. When the inner member is mounted on the outer member, the radially extending portion extends into the first opening, and the generally axially facing surface engages the shoulder.

Abstract: A one-way clutch (20) includes a notch plate (22), and a stamped pocket plate (24) having an annular flange (38) and a splined axial sleeve (40). Semi-pierced strut pockets (44) are stamped in the annular flange (38) of the pocket plate (24) and each includes a stamped spring pocket (46) for receiving an associated spring (28) that biases a strut (26) received within the strut pocket. Holes (48i) are initially stamped in the annular flange 38 and the spring pockets (46) are then stamped thereabout prior to the semi-piercing of the strut pockets (44). Semi-pierced pads (50) in the annular flange (38) alternate circumferentially with the strut pockets (44).

Abstract: A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under such conditions that inclusion bodies of said fusion peptide are formed, of: (a) expressing in said host cell a nucleic acid encoding said fusion peptide consisting of a first peptide which is an antifusogenic peptide of a length of about 10 to 50 amino acids and a second peptide of a length of about 4 to 30 amino acids, said first peptide being N-terminally linked to said second peptide; (b) cultivating said host cell to produce said inclusion bodies; and (c) recovering said antifusogenic peptide from said inclusion bodies, wherein said recovered antifusogenic peptide consists of said fusion peptide or a peptide comprising the antifusogenic peptide of about 10 to 50 amino acids and which is a fragment cleaved from said fusion peptide. Inclusion bodies of the peptides are disclosed.

Abstract: An eyewear having a frame, at least one temple attached to the frame, and a radio frequency transceiver for short-distance wireless communication. The radio frequency transceiver is mounted on either the frame or the temple and is configured to form an ad hoc wireless network with a plurality of devices. The radio frequency transceiver communicates with these devices within a frequency band of 2.45 gigahertz (GHz).

Abstract: A method and apparatus (10) provide a flow formed part assembly (12) having mechanically interlocked first and second metallic parts (22) and (24).