Abstract: The invention relates to the use of a compound of the formula (I) or a pharmaceutically acceptable addition salt thereof for the preparation of a medicament for the prophylaxis and/or treatment of muscular dystrophies or myopathies resulting from mutations in genes encoding for collagen VI.

Abstract: A method for making a differential gear casing (22) flow forms a first casing half (30) and forms a second casing half (32), both with hemispherical portions (34 and 52) and with radial flanges (36 and 56) with the latter also having an axial projection (58). An interior positioning surface (38) of the first casing half (30) and an exterior positioning surface (60) of the second casing half (32) position the casing halves with respect to each other.

Abstract: The invention relates to a method and a device for producing nitrogen fertilizer, removing phosphate from organic waste products in liquid phase, sanitizing said waste or reducing emissions, and limiting the potassium concentration. According to the invention, the waste product is heated to temperatures ranging between 40° C. and 90° C. at a subatmospheric pressure, the escaping gas that contains carbon dioxide and ammonia is contacted with a mineral-aqueous suspension, the excess gas is conducted within the circuit while the subatmospheric pressure is autogenously stabilized, and the formed nitrogen fertilizer is discharged.

Abstract: The disclosure concerns a high efficiency electrochemical sensor with high signal yield for determining an analyte in a fluid medium comprising, at least one reference electrode, at least one working electrode having particles of an electrocatalyst in an electrode matrix, and an enzyme that is suitable for determining an analyte is selectively covalently bound to the particles of the electrocatalyst. The disclosure also describes a process for producing the electrochemical sensor and a method for determining an analyte in a fluid medium using the electrochemical sensor. have a high efficiency and thus achieve a high signal yield.

Abstract: Use of idebenone for the preparation of a medicament for the treating of a muscular dystrophy in particular for treating and/or preventing weakness and/or loss of skeletal muscle tissue and/or cardiomyopathy associated with a muscular dystrophy.

Abstract: A drum assembly for use with a coupling arrangement includes an outer member and an inner member that is mountable on the outer member. The outer member includes first and second annular portions and an intermediate portion extending between the annular portions. The first annular portion has a first mating surface that defines a first opening having a first diameter, the second annular portion defines a second opening having a second diameter that is smaller than the first diameter, and the intermediate portion defines a shoulder. The inner member includes a generally radially extending portion having a generally axially facing surface and a second mating surface that is engageable with the first mating surface to interlock the inner and outer members together. When the inner member is mounted on the outer member, the radially extending portion extends into the first opening, and the generally axially facing surface engages the shoulder.

Abstract: A one-way clutch (20) includes a notch plate (22), and a stamped pocket plate (24) having an annular flange (38) and a splined axial sleeve (40). Semi-pierced strut pockets (44) are stamped in the annular flange (38) of the pocket plate (24) and each includes a stamped spring pocket (46) for receiving an associated spring (28) that biases a strut (26) received within the strut pocket. Holes (48i) are initially stamped in the annular flange 38 and the spring pockets (46) are then stamped thereabout prior to the semi-piercing of the strut pockets (44). Semi-pierced pads (50) in the annular flange (38) alternate circumferentially with the strut pockets (44).

Abstract: A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under such conditions that inclusion bodies of said fusion peptide are formed, of: (a) expressing in said host cell a nucleic acid encoding said fusion peptide consisting of a first peptide which is an antifusogenic peptide of a length of about 10 to 50 amino acids and a second peptide of a length of about 4 to 30 amino acids, said first peptide being N-terminally linked to said second peptide; (b) cultivating said host cell to produce said inclusion bodies; and (c) recovering said antifusogenic peptide from said inclusion bodies, wherein said recovered antifusogenic peptide consists of said fusion peptide or a peptide comprising the antifusogenic peptide of about 10 to 50 amino acids and which is a fragment cleaved from said fusion peptide. Inclusion bodies of the peptides are disclosed.

Abstract: An eyewear having a frame, at least one temple attached to the frame, and a radio frequency transceiver for short-distance wireless communication. The radio frequency transceiver is mounted on either the frame or the temple and is configured to form an ad hoc wireless network with a plurality of devices. The radio frequency transceiver communicates with these devices within a frequency band of 2.45 gigahertz (GHz).

Abstract: A method and apparatus (10) provide a flow formed part assembly (12) having mechanically interlocked first and second metallic parts (22) and (24).

Abstract: A snow sled comprising a seating portion that includes a lightweight space frame having a suspension-type seat stretched among the space frame. The sled further includes a steering portion and articulated steering mechanism that links the steering portion to the seating portion. The articulated steering mechanism allows the steering portion to be pivoted laterally relative to the seating portion so as to make the sled readily steerable. A pair of rear skis are removably attachable to the seating portion. The steering portion includes a ski support and a pair of front skis pivotably attached to the ski support. Chatter and movement of the front skis are dampened by a pair of boots that engage the ski support and the respective front skis.

Abstract: The invention relates to the therapeutic use of certain classes of steroid compounds for treatment of muscular diseases, in particular muscle diseases caused by mutations in the gene encoding for dystrophin (Duchenne Muscular Dystrophy, DMD, and Becker Muscular Dystrophy, BMD). The steroid compounds increase the levels of the dystrophin-related protein utrophin in cultured human muscle cells derived from donors affected with Duchenne Muscular Dystrophy.

Abstract: The invention concerns recombinant proteinase K. Furthermore a method for producing recombinant proteinase K is disclosed, which is characterized in that a) a host cell is transformed with a recombinant nucleic acid which codes for the zymogenic precursor of proteinase K, b) the host cell is cultured in such a manner that the zymogenic precursor of proteinase K is formed in the form of inclusion bodies in the host cell, c) the inclusion bodies are isolated and natured under conditions which result in the formation of the protease part of the zymogenic precursor in its natural conformation, d) the natured proteinase K is activated and purified.

Abstract: A drum assembly for use with a coupling arrangement includes an outer member and an inner member that is mountable on the outer member. The outer member includes first and second annular portions and an intermediate portion extending between the annular portions. The first annular portion has a first mating surface that defines a first opening having a first diameter, the second annular portion defines a second opening having a second diameter that is smaller than the first diameter, and the intermediate portion defines a shoulder. The inner member includes a generally radially extending portion having a generally axially facing surface and a second mating surface that is engageable with the first mating surface to interlock the inner and outer members together. When the inner member is mounted on the outer member, the radially extending portion extends into the first opening, and the generally axially facing surface engages the shoulder.

Abstract: The invention relates to a method and a device for producing nitrogen fertilizer from organic waste products in the liquid phase (suspension, emulsion, solution) and for hygienizing the wastes or reducing the emissions by thermal treatment using mineral or organic additions. According to the invention, this is achieved by a method, wherein the waste product is heated at underpressure to temperatures between 40 and 90 ° C., the escaping gas containing carbon dioxide and ammonia is cooled down and introduced into an aqueous absorption agent, the nitrogen fertilizer formed thereby is discharged and the excess gas not having been absorbed and containing carbon dioxide is pumped back into the discharge container, wherein the underpressure generated at the beginning of the process by a vacuum pump is autogenously maintained by the progress of the process.

Abstract: A drum assembly for use with a coupling arrangement includes an outer member and an inner member that is mountable on the outer member. The outer member includes first and second annular portions connected together. The first annular portion has a first mating surface that defines a first opening having a first diameter, and the second annular portion defining a second opening having a second diameter that is smaller than the first diameter. The inner member includes a generally radially extending portion and a flange portion extending generally axially from the radially extending portion. The radially extending portion includes a second mating surface that is engageable with the first mating surface to interlock the inner and outer members together. When the inner member is mounted on the outer member, the radially extending portion extends into the first opening, and the flange portion extends into the second opening.

Abstract: For optimizing a body structure for a passenger car in the area of the vehicle occupant compartment and of the rollover bar device arranged behind the occupant seats, specifically with respect to a high stability under load, low weight and economical manufacturing, a wall structure of the vehicle occupant compartment extending adjacent to the vehicle occupant seats and the rollover bar device consisting of a high-strength non-metallic material, such as a fiber-reinforced plastic material, e.g., CKF, and being constructionally inseparably combined.

Abstract: The method for authorizing access to computer applications is implemented using a computer installation which includes a computer station (1) connected to an inter-computer communication network (9), a read unit (10) connected by an electric cable (2) to the station (1), and at least one personalized portable object (7) in communication with the read unit (10) for the transfer of data. The portable object (7), in particular a wristwatch, includes a memory, several positions of which for access words are kept secret by a read and/or write barrier and at least one position of which for a word is readable. The read unit (10) detects the object (7) close by, reads the readable word and commands the station (1) to connect itself onto a determined server (8) to look in a checking file to see whether the readable word forms part of a list of authorised words. In the affirmative, a password is transmitted to the station (1) so that the read unit (10) sends it to the object (7) to open the read barrier.

Abstract: A transmission component (12, 12?) for transferring torque about a transmission rotational axis A includes a shell output carrier (62) and a ring gear portion (64) of a unitary one-piece construction flow formed from a blank around a mandrel. The transmission component (12, 12?) transfers torque between a planet gear carrier (28) of a first planetary gear set (18) and a ring gear location of a second planetary gear set (20).

Abstract: A drum assembly for use with a coupling arrangement includes an outer member and an inner member that is mountable on the outer member. The outer member includes first and second annular portions connected together. The first annular portion has a first mating surface that defines a first opening having a first diameter, and the second annular portion defining a second opening having a second diameter that is smaller than the first diameter. The inner member includes a generally radially extending portion and a flange portion extending generally axially from the radially extending portion. The radially extending portion includes a second mating surface that is engageable with the first mating surface to interlock the inner and outer members together. When the inner member is mounted on the outer member, the radially extending portion extends into the first opening, and the flange portion extends into the second opening.