Patents by Inventor Timothy J. Miller

Timothy J. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11501972
    Abstract: An apparatus and method of processing a workpiece is disclosed, where a sacrificial capping layer is created on a top surface of a workpiece. That workpiece is then exposed to an ion implantation process, where select species are used to passivate the workpiece. While the implant process is ongoing, radicals and excited species etch the sacrificial capping layer. This reduces the amount of etching that the workpiece experiences. In certain embodiments, the thickness of the sacrificial capping layer is selected based on the total time used for the implant process and the etch rate. The total time used for the implant process may be a function of desired dose, bias voltage, plasma power and other parameters. In some embodiments, the sacrificial capping layer is applied prior to the implant process. In other embodiments, material is added to the sacrificial capping layer during the implant process.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: November 15, 2022
    Assignee: Applied Materials, Inc.
    Inventors: Vikram M. Bhosle, Nicholas P. T. Bateman, Timothy J. Miller, Jun Seok Lee, Deven Raj Mittal
  • Publication number: 20220313698
    Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.
    Type: Application
    Filed: August 13, 2020
    Publication date: October 6, 2022
    Inventors: Alexander Russell Abela, Corey Don Anderson, Brett C. Bookser, Brett B. Busch, Jeremy J. Clemens, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Senait G. Ghirmai, Peter Grootenhuis, Anton V. Gulevich, Sara Sabina Hadida Ruah, Yoshihiro Ishihara, Haripada Khatuya, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Andreas Termin, Sara E. Swift, Johnny Uy, Carl V. Vogel, Jinglan Zhou
  • Patent number: 11453655
    Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: September 27, 2022
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alexander Russell Abela, Timothy Alcacio, Corey Anderson, Paul Timothy Angell, Minson Baek, Jeremy J. Clemens, Thomas Cleveland, Lori Ann Ferris, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Anton V. Gulevich, Sara Sabina Hadida Ruah, Clara Kuang-Ju Hsia, Robert M. Hughes, Pramod Virupax Joshi, Ping Kang, Ali Keshavarz-Shokri, Haripada Khatuya, Paul John Krenitsky, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Jean Denis Pierre, Yi Shi, Muna Shrestha, David Andrew Siesel, Kathy Stavropoulos, Andreas P. Termin, Fredrick F. Van Goor, Johnny Uy, Timothy John Young, Jinglan Zhou
  • Patent number: 11446036
    Abstract: An apparatus includes a body, a shaft, a stapling head assembly, and an anvil. The body includes a motor, a first user input feature, and a second user input feature. The first user input feature is operable to activate the motor. The shaft extends distally from the body. The stapling head assembly is positioned at a distal end of the shaft. The stapling head assembly includes an anvil coupling feature, at least one annular array of staples, and a staple driver. The second user input feature is operable to drive the anvil coupling feature longitudinally. The staple driver is operable to drive the at least one annular array of staples. The motor is operable to drive the staple driver. The anvil is configured to couple with the anvil coupling feature. The anvil is further configured to deform the staples driven by the staple driver.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: September 20, 2022
    Assignee: Cilag GmbH International
    Inventors: Brian F. DiNardo, Brian W. Bear, Charles J. Scheib, Christopher C. Miller, Craig S. Smith, Emily A. Schellin, Frederick E. Shelton, IV, Jason E. Zerkle, Jeffrey C. Gagel, John P. Measamer, Johnny H. Alexander, III, Joseph T. Kluener, Kevin D. Sackett, Kevin L. Houser, Mark D. Overmyer, Matthew H. Bolton, Omar J. Vakharia, Richard F. Schwemberger, Richard L. Leimbach, Rodney V. Clingaman, Timothy E. Goode, William D. Fox, William R. Stager
  • Publication number: 20220290679
    Abstract: A battery powered fan assembly includes a fan housing that at least partially defines an airflow chamber, a plurality of fan blades positioned within the airflow chamber, a motor operable to rotate the plurality of fan blades, a battery receptacle configured to receive a removably battery pack to power the motor, and a base assembly configured to be placed on a support surface. The base assembly includes a first frame segment coupled to the fan housing, a second frame segment pivotally coupled to the first frame segment, and a third frame segment pivotally coupled to the second frame segment. The base assembly is configured to be collapsed into a storage configuration in which each of the first, second, and third frame segments are folded onto each other and expanded to a first deployed configuration in which the fan housing is elevated above the support surface by a first height.
    Type: Application
    Filed: March 14, 2022
    Publication date: September 15, 2022
    Inventors: Christopher S. Spaulding, Alexander J. Goodman, Austin F. de Veer, Ellen M. Owens, Scott T. Moeller, John S. Scott, Timothy J. Campbell, Jules F. Miller, Christopher J. Metcalf
  • Publication number: 20220290693
    Abstract: A battery powered fan assembly for use with a stackable storage system includes a base defining a storage area, a fan housing that at least partially defines an airflow chamber, a plurality of fan blades positioned within the airflow chamber, a motor operable to rotate the plurality of fan blades, a battery receptacle configured to receive a removable battery pack to power the motor, a mating interface formed on at least one of the base and the fan housing, and a latch mounted to the base. The mating interface is configured to interact with a complementary mating interface formed on a stackable element of the stackable storage system, and the latch is configured to selectively inhibit relative movement between the fan assembly and the stackable element while the mating interface of the fan assembly interacts with the complementary mating interface of the stackable element.
    Type: Application
    Filed: March 14, 2022
    Publication date: September 15, 2022
    Inventors: Christopher S. Spaulding, Alexander J. Goodman, Austin F. de Veer, Ellen M. Owens, Scott T. Moeller, John S. Scott, Timothy J. Campbell, Jules F. Miller, Christopher J. Metcalf
  • Publication number: 20220290690
    Abstract: A battery powered box-type fan assembly includes a fan housing that at least partially defines an airflow chamber, a plurality of fan blades positioned within the airflow chamber, a motor operable to rotate the plurality of fan blades, a battery receptacle positioned on the fan housing, the battery receptacle configured to receive a removable battery pack to power the motor, and a base coupled to the fan housing and configured to be placed on a support surface. The base elevates the fan housing above the support surface and is operable to support the fan housing in multiple configurations. The base also includes a stand pivotable relative to the fan housing between a collapsed position, in which the stand is flipped up toward the fan housing, and a deployed position, in which the stand extends away from the fan housing and is configured to contact the support surface.
    Type: Application
    Filed: March 14, 2022
    Publication date: September 15, 2022
    Inventors: Christopher S. Spaulding, Alexander J. Goodman, Austin F. de Veer, Ellen M. Owens, Scott T. Moeller, John S. Scott, Timothy J. Campbell, Jules F. Miller, Christopher J. Metcalf
  • Patent number: 11435120
    Abstract: The disclosure provides a heat pump cycle that allows for an improved matching of the T(Q) slopes of the heat pump cycle. More particularly, the high temperature heat exchange is separated into two stages. Furthermore, a portion of the working fluid that was cooled in the first stage, is further cooled by expansion before being mixed with a heated working fluid for input to the recuperating heat exchanger.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: September 6, 2022
    Assignee: ECHOGEN POWER SYSTEMS (DELAWARE), INC.
    Inventors: Timothy J. Held, Jason D. Miller
  • Patent number: 11426407
    Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: August 30, 2022
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Mark Thomas Miller, Corey Anderson, Vijayalaksmi Arumugam, Brian Richard Bear, Hayley Marie Binch, Jeremy J. Clemens, Thomas Cleveland, Erica Conroy, Timothy Richard Coon, Bryan A. Frieman, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Sara Sabina Hadida-Ruah, Haripada Khatuya, Pramod Virupax Joshi, Paul John Krenitsky, Chun-Chieh Lin, Gulin Erdogan Marelius, Vito Melillo, Jason McCartney, Georgia McGaughey Nicholls, Fabrice Jean Denis Pierre, Alina Silina, Andreas P. Termin, Johnny Uy, Jinglan Zhou
  • Publication number: 20220193268
    Abstract: Methods for treating IBD or an IBD related disorder in a subject in need thereof are provided that comprise combined intrathecal administration of a polynucleotide comprising a CLN1 open reading frame and intravenous administration of the polynucleotide. The polynucleotide comprising the CLN1 open reading frame is a wild-type CLN1 polynucleotide. In another aspect, the polynucleotide comprising the CLN1 open reading frame comprises codon-optimized polynucleotide sequence of the polynucleotide or its complement and is codon-optimized for expression in a human cell.
    Type: Application
    Filed: April 29, 2020
    Publication date: June 23, 2022
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Timothy J. MILLER, Steven J. GRAY
  • Publication number: 20220090129
    Abstract: Provided herein are recombinant AAV vectors, AAV viral vectors, and capsid proteins for improved gene therapy, and methods for their manufacture and use.
    Type: Application
    Filed: December 4, 2019
    Publication date: March 24, 2022
    Inventors: Timothy J. MILLER, Linas PADEGIMAS
  • Publication number: 20220028693
    Abstract: An apparatus and method of processing a workpiece is disclosed, where a sacrificial capping layer is created on a top surface of a workpiece. That workpiece is then exposed to an ion implantation process, where select species are used to passivate the workpiece. While the implant process is ongoing, radicals and excited species etch the sacrificial capping layer. This reduces the amount of etching that the workpiece experiences. In certain embodiments, the thickness of the sacrificial capping layer is selected based on the total time used for the implant process and the etch rate. The total time used for the implant process may be a function of desired dose, bias voltage, plasma power and other parameters. In some embodiments, the sacrificial capping layer is applied prior to the implant process. In other embodiments, material is added to the sacrificial capping layer during the implant process.
    Type: Application
    Filed: July 22, 2020
    Publication date: January 27, 2022
    Inventors: Vikram M. Bhosle, Nicholas P.T. Bateman, Timothy J. Miller, Jun Seok Lee, Deven Raj Mittal
  • Publication number: 20210384041
    Abstract: A method of processing and passivating an implanted workpiece is disclosed, wherein, after passivation, the fugitive emissions of the workpiece are reduced to acceptably low levels. This may be especially beneficial when phosphorus, arsine, germane or another toxic species is the dopant being implanted into the workpiece. In one embodiment, a sputtering process is performed after the implantation process. This sputtering process is used to sputter the dopant at the surface of the workpiece, effectively lowering the dopant concentration at the top surface of the workpiece. In another embodiment, a chemical etching process is performed to lower the dopant concentration at the top surface. After this sputtering or chemical etching process, a traditional passivation process can be performed.
    Type: Application
    Filed: August 19, 2021
    Publication date: December 9, 2021
    Inventors: Cuiyang Wang, Timothy J. Miller, Jun Seok Lee, Il-Woong Koo, Deven Raj Mittal, Peter G. Ryan, JR.
  • Publication number: 20210375590
    Abstract: An apparatus may include a main chamber, a substrate holder, disposed in a lower region of the main chamber, and defining a substrate region, as well as an RF applicator, disposed adjacent an upper region of the main chamber, to generate an upper plasma within the upper region. The apparatus may further include a central chamber structure, disposed in a central portion of the main chamber, where the central chamber structure is disposed to shield at least a portion of the substrate position from the upper plasma. The apparatus may include a bias source, electrically coupled between the central chamber structure and the substrate holder, to generate a glow discharge plasma in the central portion of the main chamber, wherein the substrate region faces the glow discharge region.
    Type: Application
    Filed: August 13, 2021
    Publication date: December 2, 2021
    Applicant: APPLIED Materials, Inc.
    Inventors: Vikram M. Bhosle, Christopher J. Leavitt, Guillermo Colom, Timothy J. Miller
  • Patent number: 11178827
    Abstract: A synthetic growing media, such as for a hydroponic growing system, includes a plastic body having multiple legs pointing in different directions. One or more of the legs has a bulbous tip. A synthetic growing medium comprising an aggregate of synthetic growing media and hydroponic system for plant cultivation are also disclosed.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: November 23, 2021
    Assignee: Hydra Unlimited, LLC
    Inventors: Mark W. Herrema, Timothy J. Miller
  • Publication number: 20210345561
    Abstract: A synthetic growing media, such as for a hydroponic growing system, includes a plastic body having multiple legs pointing in different directions. One or more of the legs has a bulbous tip. A synthetic growing medium comprising an aggregate of synthetic growing media and hydroponic system for plant cultivation are also disclosed.
    Type: Application
    Filed: May 8, 2020
    Publication date: November 11, 2021
    Inventors: Mark W. Herrema, Timothy J. Miller
  • Patent number: 11154604
    Abstract: The present disclosure provides for an adjuvant composition that is suited for injectable as well as transdermal administration. The adjuvant composition generally comprises a lipophile, a polymer of acrylic or methacrylic acid, saline, cholesterol, a saponin, and sodium hydroxide. A vaccine composition is also provided for that generally includes the vaccine composition of the present disclosure and an antigen. A method for vaccinating animals and humans utilizing the adjuvant composition of the present disclosure is also provided.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: October 26, 2021
    Assignee: Huvepharma, Inc.
    Inventors: Timothy J. Miller, Mary Ann Pfannenstiel
  • Patent number: 11127601
    Abstract: A method of processing and passivating an implanted workpiece is disclosed, wherein, after passivation, the fugitive emissions of the workpiece are reduced to acceptably low levels. This may be especially beneficial when phosphorus, arsine, germane or another toxic species is the dopant being implanted into the workpiece. In one embodiment, a sputtering process is performed after the implantation process. This sputtering process is used to sputter the dopant at the surface of the workpiece, effectively lowering the dopant concentration at the top surface of the workpiece. In another embodiment, a chemical etching process is performed to lower the dopant concentration at the top surface. After this sputtering or chemical etching process, a traditional passivation process can be performed.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: September 21, 2021
    Assignee: Applied Materials, Inc.
    Inventors: Cuiyang Wang, Timothy J. Miller, Jun Seok Lee, Il-Woong Koo, Deven Raj Mittal, Peter G. Ryan, Jr.
  • Patent number: 11120973
    Abstract: An apparatus may include a main chamber, a substrate holder, disposed in a lower region of the main chamber, and defining a substrate region, as well as an RF applicator, disposed adjacent an upper region of the main chamber, to generate an upper plasma within the upper region. The apparatus may further include a central chamber structure, disposed in a central portion of the main chamber, where the central chamber structure is disposed to shield at least a portion of the substrate position from the upper plasma. The apparatus may include a bias source, electrically coupled between the central chamber structure and the substrate holder, to generate a glow discharge plasma in the central portion of the main chamber, wherein the substrate region faces the glow discharge region.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: September 14, 2021
    Assignee: Applied Materials, Inc.
    Inventors: Vikram M. Bhosle, Christopher J. Leavitt, Guillermo Colom, Timothy J. Miller
  • Publication number: 20200373170
    Abstract: A method of processing and passivating an implanted workpiece is disclosed, wherein, after passivation, the fugitive emissions of the workpiece are reduced to acceptably low levels. This may be especially beneficial when phosphorus, arsine, germane or another toxic species is the dopant being implanted into the workpiece. In one embodiment, a sputtering process is performed after the implantation process. This sputtering process is used to sputter the dopant at the surface of the workpiece, effectively lowering the dopant concentration at the top surface of the workpiece. In another embodiment, a chemical etching process is performed to lower the dopant concentration at the top surface. After this sputtering or chemical etching process, a traditional passivation process can be performed.
    Type: Application
    Filed: May 21, 2019
    Publication date: November 26, 2020
    Inventors: Cuiyang Wang, Timothy J. Miller, Jun Seok Lee, Il-Woong Koo, Deven Raj Mittal, Peter G. Ryan, Jr.