Patents by Inventor Tomio Yamakawa
Tomio Yamakawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20060065032Abstract: A method of manufacturing a seamless tube by the invention can duly control the rotary forging effect without miss-rolling such as defective onset engagement with rolls by satisfying either of (1)-(3) formulas below, dependent on a given range of roll diameter ratio Dg/D1, prevent the occurence of internal surface flaws at the top of the work material attributable to deteriorated hot workability, and further prevent the occurrence of said flaws over the remaining length without altering parameters for piercing-rolling process. Thus, the invention can be widely utilized as an excellent manufacturing method for said tube: in case of Dg/D1<1.1, 23?N/(Df/100)?40 ??(1) in case of 1.1 ?Dg/D1<1.5, 20?N/(Df/100)?44 ??(2) in case of 1.5?Dg/D1?1.Type: ApplicationFiled: November 18, 2005Publication date: March 30, 2006Inventors: Tomio Yamakawa, Kazuhiro Shimoda
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Patent number: 6988387Abstract: The present invention relates to a making method for a seamless metallic tube with a tilting roll type piercing rolling mill (piercer). According to the making method for a seamless metallic tube of the present invention, the rotary forging effect and the circumferential shearing strain can be significantly suppressed without generating uncompleted engagement of a billet. Accordingly, a product having reduced inside defects and excellent inside quality can be produced in high productivity. Further, by strengthening a plug nose rolling portion, a sharpened plug nose is obtained and an engagement limit can be increased. Additionally, a product further excellent in the inside quality can be efficiently produced. Accordingly, the present invention can be applied to wide fields of the piercing rolling of the seamless metallic tube.Type: GrantFiled: May 24, 2005Date of Patent: January 24, 2006Assignee: Sumitomo Metal Industries, Ltd.Inventors: Hirotsugu Nakaike, Kazuhiro Shimoda, Tomio Yamakawa, Toshiro Anraku
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Publication number: 20050288530Abstract: The invention relates to (1S)-1-isobutoxymethyl-3-methylbutylamine useful as an intermediate in the synthesis of sodium (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylate and a process for production thereof. The process comprises reacting L-leucinol with a compound represented by the following formula in the presence of a base and reducing the obtained (1S)-1-(2-methyl-2-propenoxymethyl)-3-methylbutyl-amine: [in which X is a leaving group].Type: ApplicationFiled: September 9, 2003Publication date: December 29, 2005Applicant: NIPPON CHEMIPHAR CO., LTDInventors: Atsushi Tendo, Toshihiro Takahashi, Tomio Yamakawa
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Publication number: 20050210944Abstract: The present invention relates to a making method for a seamless metallic tube with a tilting roll type piercing rolling mill (piercer). According to the making method for a seamless metallic tube of the present invention, the rotary forging effect and the circumferential shearing strain can be significantly suppressed without generating uncompleted engagement of a billet. Accordingly, a product having reduced inside defects and excellent inside quality can be produced in high productivity. Further, by strengthening a plug nose rolling portion, a sharpened plug nose is obtained and an engagement limit can be increased. Additionally, a product further excellent in the inside quality can be efficiently produced. Accordingly, the present invention can be applied to wide fields of the piercing rolling of the seamless metallic tube.Type: ApplicationFiled: May 24, 2005Publication date: September 29, 2005Inventors: Hirotsugu Nakaike, Kazuhiro Shimoda, Tomio Yamakawa, Toshiro Anraku
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Publication number: 20050096363Abstract: A compound represented by the formula (I) or a salt of the compound, and a PPAR-? activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B1 represents N, etc.; B2 represents O, etc.; each of X1 and X2 represents O, S, a bond, etc.; Y represents C1-8 alkylene chain; Z represents O or S; R1 represents aryl, etc. which can have substituents; R2 represents C1-8 alkyl, etc.; R3 represents C1-8 alkyl, C2-8 alkenyl, etc.; each of R4 and R5 represents hydrogen, C1-8 alkyl, etc.; and R6 represents hydrogen, etc.; provided that each of Z and R3 is attached to the benzene ring, and X2 is not attached to the benzene ring).Type: ApplicationFiled: October 9, 2002Publication date: May 5, 2005Inventors: Shogo Sakuma, Tomio Yamakawa, Takashi Kanda, Seiichiro Masui
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Publication number: 20050090472Abstract: The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which may have a substituent or the like; R2 is halogen, nitro, cyano, carboxyl, or the like; R3 is hydrogen, halogen, hydroxyl, amino, carboxyl, or the like; X is NR11, oxygen, or sulfur, in which R11 is hydrogen, or an alkyl group having 1-8 carbon atom which may have a substituent; and each of Y and Z is CR12 or nitrogen, in which R12 has the same meaning as R3 above, and a xanthine oxidase inhibitor containing the compound as an active ingredient.Type: ApplicationFiled: November 14, 2002Publication date: April 28, 2005Inventors: Shinichi Yoshida, Atsushi Tendo, Kunio Kobayashi, Nobutaka Mochiduki, Tomio Yamakawa, Yoriko Shinohara
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Publication number: 20050054674Abstract: A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(?O), CH?CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-? activator which contains the compound or salt as the active ingredient.Type: ApplicationFiled: August 2, 2002Publication date: March 10, 2005Inventors: Shogo Sakuma, Tomio Yamakawa, Takashi Kanda, Seiichiro Masui
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Patent number: 6787552Abstract: Compounds of the general formula (I) or salts thereof and activators of PPAR&dgr; (peroxisome proliferator activated receptor &dgr;) containing the compounds or the salts as the active ingredient: wherein R1 and R2 each are hydrogen, C1-8 alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X1 and X2 are each a free valency, oxygen, S(O)p (wherein p is an integer of 0 to 2), C(═O), C(═O)NH, NHC(═O), CH═CH, or the like; Y is optionally substituted C1-8 alkylene; Z is oxygen or sulfur; R3 and R4 are each optionally substituted C1-8 alkyl; and R8 is hydrogen or C1-8 alkyl, with the proviso that when X1 is a free valency, X2 is not O or S(O)p, while when X1 is C(═O)NH, X2 is not a free valency.Type: GrantFiled: February 11, 2003Date of Patent: September 7, 2004Assignee: Nippon Chemiphar Co., Ltd.Inventors: Shogo Sakuma, Tsuyoshi Endo, Atsushi Tendo, Toshihiro Takahashi, Shinichi Yoshida, Kunio Kobayashi, Nobutaka Mochizuki, Tomio Yamakawa, Takashi Kanda, Seiichiro Masui
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Publication number: 20040097739Abstract: Compounds of the general formula (I) or salts thereof and activators of PPAR&dgr; (peroxisome proliferator activated receptor &dgr;) containing the compounds or the salts as the active ingredient: wherein R1 and R2 each are hydrogen, C1-8 alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X1 and X2 are each a free valency, oxygen, S(O)p (wherein p is an integer of 0 to 2), C(═O), C(═O)NH, NHC(═O), CH═CH, or the like; Y is optionally substituted C1-8 alkylene; Z is oxygen or sulfur; R3 and R4 are each optionally substituted C1-8 alkyl; and R8 is hydrogen or C1-8 alkyl, with the proviso that when X1 is a free valency, X2 is not O or S(O)p, while when X1 is C(═O)NH, X2 is not a free valency.Type: ApplicationFiled: February 11, 2003Publication date: May 20, 2004Inventors: Shogo Sakuma, Tsuyoshi Endo, Atsushi Tendo, Toshihiro Takahashi, Shinichi Yoshida, Kunio Kobayashi, Nobutaka Mochizuka, Tomio Yamakawa, Takashi Kanda, Seiichiro Masui
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Patent number: 5713234Abstract: A piercing and rolling method involves the use of a piercer provided with cone-shaped main rolls and disk rolls. When a piercing and rolling operation is performed at an expansion ratio of 1.15 or more, the following relations (1), (2), (3), (4), and (5) are satisfied:3.ltoreq.D1/d.ltoreq.7 (1)9.ltoreq.D2/d.ltoreq.16 (2)2<D2/D1.ltoreq.3 (3)2.5.degree..ltoreq..theta.1.ltoreq.4.5.degree. (4),and3.degree. .ltoreq..theta.2.ltoreq.6.5.degree. (5).wherein D1: diameter of the gorge portion of a main roll; D2: diameter at the grooved portion of a disk roll; d: outer diameter of a billet; .theta. 1: inlet face angle of a main roll, and .theta. 2: outlet face angle of a main roll. The apparatus of the present invention is designed so that D1 is between 510 and 2000 mm inclusive and D2 is between 1,530 and 4,000 mm inclusive, and that the above-described relations (3), (4), and (5) are satisfied.Type: GrantFiled: August 27, 1996Date of Patent: February 3, 1998Assignee: Sumitomo Metal Industries, Ltd.Inventors: Tomio Yamakawa, Kazuhiro Shimoda
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Patent number: 5636542Abstract: A method for manufacturing seamless steel tubes by the Mannnesmann tube making process wherein a billet is passed through a piercer and the center of the billet is pierced through to obtain a hollow shell. A pair of disk rolls are disposed to incline by a skew angle .delta. with respect to a pass line toward cone-type main roll located at the entry side, where a material to be rolled enters into the disk roll sliding face, thereby to become unparallel with the outlet face angle of the main roll, while the skew angle .delta. is set to satisfy the following conditions related to the skew angle .delta., the inlet face angle .theta.1 and the outlet face angle .theta.2 of the main roll, thereby to obtain expansion ratio of outer diameter of 1.15 or higher value..theta.2+2.degree.<.delta.<9.degree., .delta.+.theta.1<12.degree.Type: GrantFiled: May 5, 1995Date of Patent: June 10, 1997Assignee: Sumitomo Metal Industries, Ltd.Inventors: Tomio Yamakawa, Chihiro Hayashi, Kazuhiro Shimoda
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Patent number: 5576341Abstract: 2-[[2-(N-Isobutyl-N-methyl)amino]benzylsulfinyl]benzimidazole is effective for treating or preventing Helicobacter infections by administration to patients suffering from the infection.Type: GrantFiled: April 18, 1994Date of Patent: November 19, 1996Assignee: Nippon Chemiphar Co., Ltd.Inventors: Mitsuo Masaki, Tomio Yamakawa, Yutaka Nomura, Hitoshi Matsukura
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Patent number: 5477719Abstract: An inclined-rolling apparatus for piercing and rolling a tube material by the use of a pair of piercing rolls and a pair of disk rolls, wherein rolling operation is executed with the disk rolls being positioned such that a skew angle opposite to the revolving direction of the tube material is added to the outlet sides thereof and their shaft center lines are inclined. In order to get rid of the interference between the piercing rolls and the disk rolls, there is provided a circular groove at the periphery of a side face of each disk roll.Type: GrantFiled: August 10, 1994Date of Patent: December 26, 1995Assignee: Sumitomo Metal Industries, Ltd.Inventors: Masayoshi Akiyama, Tomio Yamakawa
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Patent number: 5446146Abstract: A therapeutic agent for liver disease containing as an active ingredient a piperazine derivative having the formula: ##STR1## wherein, A represents a phenyl, p-benzoquinonyl or cumarinyl group which may have at least one substituent selected from the group consisting of halogen, alkyl, fluoroalkyl, formyl, alkoxycarbonyl, acyl, hydroxy, alkoxy, acyloxy, glycosyloxy, amino, alkylamino, mercapto, alkylthio and nitro; B represents a single bond or a straight chain alkylene group containing 1-4 carbon atoms which may have at least one substituent selected from the group consisting of alkyl, aryl, aralkyl, hydroxy and oxo; R represents an atom or a group selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, alkyl, cycloalkyl, aralkyl and aryl; and n is 2 or 8, or its pharmaceutically acceptable salt is diclosed.Type: GrantFiled: June 7, 1994Date of Patent: August 29, 1995Assignee: Nippon Chemiphar Co., Ltd.Inventors: Mitsuo Masaki, Tomio Yamakawa, Masaru Satoh, Hiromitsu Takeda, Yasushi Yoshino, Hitoshi Matsukura
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Patent number: 5180836Abstract: Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R.sup.1 and R.sup.2 are combined to form a heterocyclic ring; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R.sup.3 is combined with R.sup.2 to form a heterocyclic ring; R.sup.8 and R.sup.9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substituent, or R.sup.8 and R.sup.9 are combined to form an alicyclic ring; R.sup.7 is, where R.sup.8 and R.sup.9 are not combined, H, and, where R.sup.8 and R.sup.9 are combined, H, alkyl which may have a substituent, aryl which may have a substituent, arylcarbonyl which may have a substituent, or a sulfur-containing heterocyclic group; and n is 0 or 1.Type: GrantFiled: November 1, 1991Date of Patent: January 19, 1993Assignee: Nippon Chemiphar Co., Ltd.Inventors: Susumu Okabe, Mitsuo Masaki, Tomio Yamakawa, Hitoshi Matsukura, Yutaka Nomura
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Patent number: 5106976Abstract: Novel sulfoxide derivatives having the formula (I) 5 or (V) show a gastric acid-secretion inhibitory effect: ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen, lower alkyl, hydroxyalkyl, phenyl, phenylalkyl or cycloalkyl, R.sup.1 and R.sup.2 may form together with the adjacent N atom a heterocyclic group; each of R.sup.3, R.sup.4, R.sup.4a, R.sup.4b, R.sup.5, R.sup.6, and R.sup.7 is hydrogen, halogen, lower alkoxy, lower alkyl, trifluoromethyl, or fluorine atom-containing lower alkoxy; Y is CH or N; and Z is unsubstituted or substituted 2-pyridine or 2-aminophenyl.Type: GrantFiled: April 9, 1990Date of Patent: April 21, 1992Assignee: Nippon Chemiphar Co., Ltd.Inventors: Susumu Okabe, Masaru Satoh, Tomio Yamakawa, Yutaka Nomura, Masatoshi Hayashi
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Patent number: 5091403Abstract: Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 is hydrogen or an alkyl group having 1-6 carbon atoms, R.sup.2 is an alkyl group having 2-6 carbon atoms substituted with an alkoxy group having 1-4 carbon atoms, each of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 independently is hydrogen, a halogen, an alkyl group having 1-6 carbon atoms, an alkoxy group having 1-6 carbon atoms, a fluorine-substituted alkyl group having 1-6 carbon atoms, or a fluorine-substituted alkoxy group having 1-6 carbon atoms. The new imidazole derivatives are effective particularly as anti-ulcer agents.Type: GrantFiled: August 10, 1990Date of Patent: February 25, 1992Assignee: Nippon Chemiphar Co., Ltd.Inventors: Susumu Okabe, Mitsuo Masaki, Tomio Yamakawa, Hitoshi Matsukura, Yutaka Nomura
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Patent number: 5082943Abstract: Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R.sup.1 and R.sup.2 are combined to form a heterocyclic ring; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R.sup.3 is combined with R.sup.2 to form a heterocyclic ring; R.sup.8 and R.sup.9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substituent, or R.sup.8 and R.sup.9 are combined to form an alicyclic ring; R.sup.7 is, where R.sup.8 and R.sup.9 are not combined, H, and, where R.sup.8 and R.sup.9 are combined, H, alkyl which may have a substituent, aryl which may have a substituent, arylcarbonyl which may have a substituent, or a sulfur-containing heterocyclic group; and n is 0 or 1.Type: GrantFiled: February 20, 1991Date of Patent: January 21, 1992Assignee: Nippon Chemiphar Co., Ltd.Inventors: Susumu Okabe, Mitsuo Masaki, Tomio Yamakawa, Hitoshi Matsukura, Yutaka Nomura
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Patent number: 5070089Abstract: A therapeutic agent for liver disease containing as an active ingredient a piperazine derivative having the formula: ##STR1## wherein, A represents a phenyl, p-benzoquinonyl or cumarinyl group which may have at least one substituent selected from the group consisting of halogen, alkyl, fluoroalkyl, formyl, alkoxycarbonyl, acyl, hydroxy, alkoxy, acyloxy, glycosyloxy, amino, alkylamino, mercapto, alkylthio and nitro; B represents a single bond or a straight chain alkylene group containing 1-4 carbon atoms which may have at least one substituent selected from the group consisting of alkyl, aryl, aralkyl, hydroxy and oxo; R represents an atom or a group selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, alkyl, cycloalkyl, aralkyl and aryl; and n is 2 or 3, or its pharmaceutically acceptable salt is disclosed.Type: GrantFiled: January 26, 1989Date of Patent: December 3, 1991Assignee: Nippon Chemiphar Co., Ltd.Inventors: Mitsuo Masaki, Tomio Yamakawa, Masaru Satoh, Hiromitsu Takeda, Yasushi Yoshino, Hitoshi Matsukura
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Patent number: 4933458Abstract: Sulfoxide derivatives having the formula (I) or (V) show a gastric acid-secretion inhibitory effect: ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen, lower alkyl, hydroxyalkyl, phenyl, phenylalkyl or cycloalkyl, R.sup.1 and R.sup.2 may form together with the adjacent N atom a heterocyclic group; each of R.sup.3, R.sup.4, R.sup.4a, R.sup.4b, R.sup.5, R.sup.6, and R.sup.7 is hydrogen, halogen, lower alkoxy, lower alkyl, trifluoromethyl, or fluorine atom-containing lower alkoxy; Y is CH or N; and Z is unsubstituted or substituted 2-pyridine or 2-aminophenyl.Type: GrantFiled: May 24, 1988Date of Patent: June 12, 1990Assignee: Nippon Chemiphar Co., Ltd.Inventors: Susumu Okabe, Masaru Satoh, Tomio Yamakawa, Yutaka Nomura, Masatoshi Hayashi