Abstract: a billet made of high Cr-high Ni alloy, which contains, by mass percent, 20 to 30% of Cr, 30 to 50% of Ni, and at least one element selected from Mo and W with a value “Mo+0.5W” of 1.5% or more is heated under conditions satisfying the following formula (1), and then the billet is pierced and rolled using an inclined roll type piercing mill with a roll gouge circumferential speed of 2.28 m/sec or higher. This prevents melted rash on the inner surface and lengthens the plug life. T?1575?4.45×Vf?104.7×{?ln(th/ro)}??(1) wherein T indicates a heating temperature (° C.) of the billet, Vf indicates the roll gouge circumferential speed (m/sec), ro indicates a radius (mm) of a billet at an entry-side, and th indicates a radial thickness (mm) of a pipe after piercing.

Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet) 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?1.

Abstract: Seamless pipes excellent in quality features with high productivity is made by a by carrying out piercing-rolling using a piercer provided with a pair of inclined rolls. The piercing-rolling is carried out under conditions such that the plug tip draft (TDFT) or the root of the product of the plug tip draft (TDFT) are controlled along with the number of billet revolutions (N), namely (TDFT×N)0.5. In addition, positions of the inclined rolls are controlled in connection with the gorge draft (GDFT) indicating the ratio of the roll gap (Rg) which is minimal in the gorge section between the inclined rolls to the billet outside diameter (Bd). The piercing-rolling is carried out using a plug having a particular shape.

Abstract: The present invention provides a lubricant composition for hot metal working which is capable of inhibiting generation of flaws on the surface of materials to be provided for hot metal working, and provides a method of hot metal working. The invention provides a lubricant composition for hot metal working comprising a plurality of glass frits respectively having different softening point from each other.

Abstract: A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPAR?. wherein Ga is O, CH2 or the like; Aa is thiazole, oxazole, or thiophene, which can have a substituent such as C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like; Ba is a C1-8 alkylene or C2-8 alkenylene chain; and each of R1a and R2a independently is hydrogen, C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like.

Abstract: The invention relates to compounds of the following formula (I) or their salts: in which R1 is a group of phenyl, naphthyl, pyridyl or the like which may have a substituent such as an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, carboxyl, halogen, hydroxyl, nitro, or cyano; R2 is cyano, nitro, or the like; R3 is hydroxyl or the like; X is oxygen, sulfur, or the like; and Y is oxygen or sulfur, and a xanthine oxidase inhibitor containing the compound.

Abstract: A compound or its salt having the following formula (II) is used as an activator for PPAR ?: in which each of R11 and R13 is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms and a halogen atom substituent, etc.; R12 is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms and a halogen atom substituent, etc.; each of R14 and R15 is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or an alkyl group having 1 to 8 carbon atoms and a halogen atom substituent; X1 is CH or N; Z1 is an oxygen atom or a sulfur atom; W1 is an oxygen atom or CH2; and q is an integer of 2 to 4.

Abstract: The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet): 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm?1.

Abstract: The present invention is to provide a method for producing duplex stainless steel seamless pipe in which a duplex stainless steel billet can be inhibited from generating an oxide scale on the surface thereof during heating and the generation of outer surface flaw can also be prevented. The billet is heated in the a heating furnace for 1.5 hours or more and 4.0 hours or less at a heating temperature of 1250° C. or more and 1320° C. or less while regulating the average concentration of sulfur dioxide (SO2) gas in the atmosphere within the furnace to 0.01 volume % or less.

Abstract: To provide a method and apparatus for seamless tubes in which the occurrence of material peeling can be prevented even when the skew angle ? and tube expansion ratio are increased. A piercing-rolling method for seamless tubes using a piercer, which is provided with a pair of cone-shaped main rolls and a pair of disk rolls, each pair being arranged in an opposing manner with a pass line therebetween as a center axis, and a plug whose center axis coincides with the pass line, wherein a billet to be pierced and rolled is advanced while being spirally rotated by a drive rotation of the main rolls; the method of which is characterized in each of the disk rolls being arranged in an inclined state at a fixed skew angle ? to the pass line.

Abstract: A compound having the following formula or its salt is used as an activator for PPAR: in which W2 represents a bond, C(?O) or CH2; Z2 represents an oxygen or sulfur atom; R21, R22 and R23 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, an alkyl group having 1 to 8 carbon atoms which is substituted with a halogen atom or the like; and R24 and R25 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an alkyl group having 1 to 8 carbon atoms which is substituted with a halogen atom.

Abstract: A compound represented by the following formula (I) is used as a xanthine oxidase inhibitor: in which R1 is phenyl or pyridyl each optionally having, as a substituent, C1-8 alkyl, C1-8 haloalkyl, C1-8 alkoxy, carboxyl, halogeno, hydroxyl, nitro, cyano, amino, etc.; R2 is cyano, nitro, etc.; X is oxygen, sulfur, etc.; and Y is sulfur, NH, etc.

Abstract: A high quality hollow shell in which the occurrence of internal surface flaws caused by the rotary forging effect and/or shear deformation is prevented by suppressing the rotary forging frequency and shear deformation in a transient region at the stage of billet gripping and a worsening of thickness deviations in the top portion of the hollow shell is also prevented is reliably produced with preventing miss-rolling such as incomplete billet gripping and troubles in bottom withdrawal and an increase in the outer diameter of the hollow shell in the bottom portion.

Abstract: A plug has a tip end portion, a taper portion, and a middle portion. The surface of the tip end portion is a spherical surface whose radius of curvature is R1 and length is L1 that is shorter than R1. The outer diameter of the taper portion on the front end side is D1, and the outer diameter on the back end side is D2 that is larger than D1, and the length is L2. The plug satisfies Expression (1), Expression (2) if 0<L1/R1<0.5 and Expression (3) if 0.5?L1/R1<1. The curve of the spherical surface of the tip end portion is gentler than that of the semi-spherical surface, and the diameter of a hole formed in a billet by the tip end portion is larger than that in the case of the semi-spherical surface. Therefore, the taper portion does not contact with the billet 0.5D1<L1+L2?2.5D1??(1) 1.0<D2/D1?1.4??(2) 1.0<D2/D1<1.8?0.8L1/R1??(3).

Abstract: The present invention provides a seamless tube piercing/rolling plug and a seamless tube producing method in which piercing/rolling is performed with an inclined rotary piercing mill while the seamless tube piercing/rolling plug is used as a piercing tool. The seamless tube piercing/rolling plug is used while a front part and a rear part of the split plug are held as an integral plug, at least the front part is made of low alloy steel, and oxide films are formed on surfaces of the front part and rear part. The present invention also provides a seamless tube piercing/rolling apparatus and a seamless tube producing method in which the front part and/or rear part is replaceable in a tube making process line using the seamless tube piercing/rolling apparatus.

Abstract: A high quality hollow shell in which the occurrence of internal surface flaws caused by the rotary forging effect and/or shear deformation is prevented by suppressing the rotary forging frequency and shear deformation in a transient region at the stage of billet gripping and a worsening of thickness deviations in the top portion of the hollow shell is also prevented is reliably produced with preventing miss-rolling such as incomplete billet gripping and troubles in bottom withdrawal and an increase in the outer diameter of the hollow shell in the bottom portion.

Abstract: In straightening a tube using a roll straightening machine provided with drum type straightening roll pairs vertically opposingly disposed, at least an outer layer portion of a roll main body is made of elastic material having spring type hardness Hs (JIS K 6301 A type) of 50 to 100 in at least three pairs of straightening rolls on an outlet side of the roll straightening machine, and an offset amount is imparted to a tube engaged in the three pairs, at least, of straightening opposing rolls such that ? defined by an equation (1) ranges from 1.0×10?3 to 1.5×10?3. The offset amount is set at each of three positions along a tube axis where the upper and lower rolls of each pair horizontally cross. Therefore, an S/N ratio can be enhanced in an eddy current test from inside of the tube to improve inspection efficiency, and excellent quality accuracy can be ensured in a heat transfer tube used in a steam generator and the like.

Abstract: A billet is provided on a pass line between a pusher and a plug, and the billet is advanced and caught between a plurality of inclined rolls. At least between when said caught billet contacts said plug and when the piercing and rolling reaches a steady state, the advancing speed of the billet is not less than the advancing speed of the billet when the piercing and rolling is carried out without pushing the billet forward by the pusher in the steady state. By this manufacturing method, inner surface defects at a tip end of a hollow shell can be restrained.

Abstract: An N-substituted N-(4-piperininyl)amide derivative represented by the following formula (I): (wherein R1 represents C1-6 alkyl, furyl, etc.; R2 represents amino, acetylamino, ureido, etc.; R3 represents hydrogen, C2-8 alkoxycarbonyl, etc.; R4 represents optionally substituted phenyl, etc.; R5 represents hydroxyl, benzyloxy, etc.; R6 represents hydrogen or methyl; and m is 1 or 2) or a salt of the derivative, and an analgesic containing the derivative or salt.

Abstract: A plug has a tip end portion, a taper portion, and a middle portion. The surface of the tip end portion is a spherical surface whose radius of curvature is R1 and length is L1 that is shorter than R1. The outer diameter of the taper portion on the front end side is D1, and the outer diameter on the back end side is D2 that is larger than D1, and the length is L2. The plug satisfies Expression (1), Expression (2) if 0<L1/R1<0.5 and Expression (3) if 0.5?L1/R1<1. The curve of the spherical surface of the tip end portion is gentler than that of the semi-spherical surface, and the diameter of a hole formed in a billet by the tip end portion is larger than that in the case of the semi-spherical surface. Therefore, the taper portion does not contact with the billet. 0.5D1<L1+L2?2.5D1??(1) 1.0<D2/D1?1.4??(2) 1.0<D2/D1<1.8?0.