Abstract: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.

Abstract: A video target tracking method is provided to a computing device, the method includes: obtaining a partial detection map corresponding to a target image frame in a to-be-detected video; obtaining a relative motion saliency map corresponding to the target image frame; determining constraint information corresponding to the target image frame according to the partial detection map and the relative motion saliency map; adjusting a parameter of an image segmentation model by using the constraint information, to obtain an adjusted image segmentation model; and extracting a target object from the target image frame by using the adjusted image segmentation model.

Abstract: Provided are antibodies that specifically bind to T-cell immunoglobulin domain and mucin domain 3 (Tim-3). The anti-Tim-3 antibodies can be used to treat, prevent or diagnose immune, cancerous, infectious diseases or other pathological disorders that may be modulated by Tim-3-mediated functions.

Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a chemotherapeutic agent. Also, disclosed a pharmaceutical combination comprising a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor, or a chemotherapeutic agent and the use thereof.

Abstract: There is described herein an assay comprising, for each of DNMT3B, ZBTB46, NYNRIN, ARHGAP22, LAPTM4B, MMRN1, DPYSL3, KIAA0125, CDK6, CPXM1, SOCS2, SMIM24, EMP1, NGFRAP1, CD34, AKR1C3, GPR56, a pair of probes complementary and hybridizable thereto on an array, optionally with a set of reference genes.

Abstract: Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) and inhibit PD1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD1-mediated functions.

Abstract: This disclosure relates to IL-2 variants and methods of use thereof, including methods of treating or inhibiting a cancer or tumor. The IL-2 variants may have reduced ability in binding to or activating IL-2R?. The IL-2 variants may retain the ability in binding to or activating IL-2R? and/or IL-2R??. In addition, the IL-2 variants may have decreased Treg activity but maintain the capacity to activate NK cells and T effector cells.

Abstract: Berberine or its derivatives are used in the preparation of myocardial perfusion imaging agents It has been verified using in vitro investigations, in vivo biodistribution, and small animal PET dynamic imaging, etc., that 18F-labeled berberine derivatives can specifically accumulate in cardiomyocytes or heart tissues, and has good distribution properties of targetting heart muscle in living animals, together with high contrast values of heart v.s. peripheral tissue (liver, lung, blood, muscle, bone, etc.).

Abstract: A communications apparatus, a base station, and a communications method. The communications apparatus includes processing circuitry configured to: group users in a 3D beam-forming space of a current cell into multiple space user groups; determine group configuration information of the users in the 3D beam-forming space of the current cell; notify a neighbor cell of the group configuration information of the users in the 3D beam-forming space of the current cell to assist inter-cell interference coordination, wherein the current cell is configured with an antenna array having multiple physical antennas to achieve 3D beam-forming.

Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a targeted therapy agent. Also, disclosed a pharmaceutical combination comprising a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor, or a targeted therapy agent and the use thereof.

Abstract: The present invention provides a surface plasmon-optical-electrical hybrid conduction nano heterostructure and a preparation method therefor. The structure includes an exciting light source, a semiconductor nano-structure array, a two-dimensional plasmonic micro-nano structure, a sub-wavelength plasmon polariton guided wave, an emergent optical wave, a one-dimensional plasmonic micro-nano structure, a wire, a metal electrode, a conductive substrate, a probe molecule, an atomic-force microscopic conductive probe and a voltage source. The method achieves a semiconductor seed crystal with controllable distribution and density by controlling free metal ions, air, water or oxygen on a metal substrate to achieve highly uniform control of the seed crystal, and then strictly controls a length-to-diameter ratio and distribution of a semiconductor structure by continuous growth. Therefore, a new nano optics platform is provided for studying various novel effects produced by interaction between light and substances.

Abstract: An earthworm reactor comprises a main body frame and multilayered reactor box bodies located in the main body frame. A bottom plate is arranged at the bottom of each layer of the main body frame, and the reactor box body is movably arranged on the bottom plate of each layer; an aerator pipe and a filtrate collecting pipe are arranged in the reactor box body of each layer; an aerating air supply pipe connected to the aerator pipe of each layer and a filtrate centralizing pipe connected to the filtrate collecting pipe of each layer are separately arranged on one side of the main body frame; the aerating air supply pipe is connected to an external aerating device and the bottom of the filtrate centralizing pipe is connected to an external liquid storage tank.

Abstract: An aerial device includes a body, an optical system having gimbal supporting a camera, a lift mechanism coupled to the body, a haptic sensor coupled to the body and configured to generate haptic data, and a processing system disposed in the body and in data communication with the haptic sensor. The processing system is configured to process the haptic data to understand an intended position of the aerial device and/or an intended orientation of the gimbal and convert the intended position to a target position of the aerial device and/or the intended orientation to a target orientation of the gimbal utilizing said processed data irrespective of an initial position of said aerial device and an initial orientation of said gimbal. Also disclosed is a method for controlling the aerial device.

Abstract: A controllable preparation method for a plasmonic nanonail structure is provided. A size of a nanomaterial can be controlled at sub-wavelength. The nanomaterial has good localized surface plasmon resonance effect, and the optical, electrical and mechanical properties of the nanometer material all can be regulated. The plasmonic nanonail is composed of two parts, i.e., a silver nanorod, a gold nanorod or a silver-gold-silver alloy nanorod and an approximate equilateral triangular nano-silver plate growing on the nanorod. A length of the nanorod is controlled within 20-30 nanometers, a diameter of the nanorod is controlled within 10-200 nanometers, a side length of the triangular nano-silver plate is controlled within 20 nanometers to 2 microns, and a size of the triangular plate is less than or equal to the length of the nanorod.

Abstract: Disclosed herein is a pharmaceutical combination for use in the prevention, delay of progression or treatment of cancer, wherein the pharmaceutical combination exhibits a synergistic efficacy. The pharmaceutical combination comprises a humanized antagonist monoclonal antibody against PD- and a RAF inhibitor. Also disclosed herein is a combination for use in the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject a therapeutically effective amount of a humanized antagonist monoclonal antibody against PD-1 and a therapeutically effective amount of a RAF inhibitor.

Abstract: Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) and inhibit PD1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD1-mediated functions.

Abstract: An aerial system, including a processing system, an optical system, an actuation system and a lift mechanism, includes an autonomous photography and/or videography system 70, implemented, at least in part, by the processing system 22, the optical system 26, the actuation system 28 and the lift mechanism 32. The autonomous photograph and/or videography system performs the steps of establishing a desired flight trajectory, detecting a target, controlling the flight of the aerial system as a function of the desired flight trajectory relative to the target using the lift mechanism and controlling the camera to capture pictures and/or video.

Abstract: The present disclosure provides an unmanned flight system and a control system for an unmanned flight system. The unmanned flight system comprises: a body and a lift mechanism connected to the body, wherein the lift mechanism includes two rotor assembly arm structures respectively provided on two sides of the body, wherein each of the rotor assembly arm structures respectively includes: an arm, a pivotable rotor assembly, a motor for driving the rotor assembly to pivot about a pivot axis, and a motor base for mounting the motor, wherein one end of the arm is pivotally connected to one side of the body, the motor base is pivotally provided on the other end of the arm, and a rotational axis of the motor base is higher than a center of gravity of the unmanned flight system. The unmanned flight system according to the present disclosure can achieve a longer flight time, a simple rotor assembly structure, and easier overall assembly and maintenance.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind to human OX40 (ACT35, CD134, or TNFRSF4), a pharmaceutical composition comprising said antibody, and use of the antibody or the composition for treating a disease, such as cancer. In particular, the anti-OX40 antibody of the present invention does not interfere with the binding of OX40-ligand to its receptor.

Abstract: An adjustable hyperspectral detection chip enhanced by a multi-resonance plasmonic mechanism. The detection chip consists of an array of metal nanonail resonator detection units. Each detection unit (1) comprises: a bottom electrode (2), a semiconductor material layer (3), a spacer layer (4), a nanonail array (5), a control material layer (6), a top electrode (7), a peripheral control signal (8), and a driving circuit (9). The positional relationship from top to bottom is the top electrode (7), the control material layer (6), the nanonail array (5), the spacer layer (4), the semiconductor material layer (3), and the bottom electrode (2). The nanonail array (5) is loaded inside the control material layer (6), and the peripheral control signal (8) and the driving circuit (9) are connected to both sides of the control material layer (6).