Abstract: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.

Abstract: The present disclosure provides a negative electrode material, a preparation method thereof, and an all-solid-state lithium battery. The negative electrode material includes a core and an amorphous lithium-silicon alloy layer cladding the core. The core includes a glassy solid electrolyte and amorphous lithium-silicon alloy particles dispersed in the glassy solid electrolyte. The material of the amorphous lithium-silicon alloy particles is LixSi, 0<x?4.4. The material of the amorphous lithium-silicon alloy layer is LiySi, 0<y?4.4.

Abstract: A method of establishing an image set for image recognition includes obtaining a single-label image set comprising an image annotated with a single label, and a multi-label image set comprising an image annotated with a plurality of labels; converting content of each label into a corresponding word identifier according to a semantic network, to obtain a word identifier set, a converted single-label image set, and a converted multi-label image set; and constructing a hierarchical semantic structure according to the word identifier set and the semantic network. The method also includes performing label supplementation on the image in the converted single-label image set to obtain a supplemented single-label image set; performing label supplementation on the supplemented single-label image set to obtain a final supplemented image set; and establishing a target multi-label image set to train an image recognition model by using the target multi-label image set.

Abstract: A system is disclosed. The system may include a processor that may issue a byte level protocol request including a byte address. The system may also include a first storage device and a second storage device. The first storage device and the second storage device may support a cache coherent interconnect protocol, the cache coherent interconnect protocol including a block level protocol and a byte level protocol. The first storage device and the second storage device are included in a redundant array of independent disks (RAID). The first storage device may include a first address range, and the second storage device may include a second address range. The second storage device may provide a RAID address range associated with the first address range and the second address range. A decoder associated with the second storage device may be configured to receive the request from the processor. The decoder may determine that the byte address in the RAID address range is associated with a target address range.

Abstract: A method and redundant array of independent disks (RAID) system are provided. An operation is received from an application at a file system (FS) of the RAID system. A memory mapping module of the RAID system receives at least an FS logical block address (LBA) in accordance with the operation. The memory mapping module creates a mapping from a virtual memory of the application to a RAID array in a system memory of the RAID system using at least the FS LBA.

Abstract: A system is disclosed. A first storage device may supporting a cache coherent interconnect protocol, the cache coherent interconnect protocol including a block level protocol and a byte level protocol. A second storage device may also support the cache coherent interconnect protocol. A redundant array of independent disks (RAID) circuit may communicate with the first storage device and the second storage device. The RAID circuit may apply a RAID level to the first storage device and the second storage device. The RAID circuit may be configured to receive a request using the byte level protocol and to access data on the first storage device.

Abstract: Provided are methods of treating cancer or increasing, enhancing, or stimulating an immune response with antibodies that specifically bind to TIGIT (T cell immunoreceptor with Ig and ITIM domains, WUCAM or Vstm3) and antigen-binding fragments thereof in combination with an anti-PD1 antibody.

Abstract: An electronic device, including a first circuit, a second circuit, a coil, and one or more resonant circuits. The first circuit may transmit a first signal through the coil, and the second circuit may transmit a second signal through the coil. Frequencies of the first signal and the second signal are different. The resonant circuit may be disposed between the first circuit and the coil to prevent the second signal from passing or disposed between the second circuit and the coil to prevent the first signal from passing, so as to prevent the first signal from interfering with the second circuit or prevent the second signal from interfering with the first circuit.

Abstract: The present disclosure provides IL2 proproteins comprising an IL2 moiety that is masked with an IL2R? moiety and a protease-cleavable linker, configured such that the IL2R? moiety is released from the IL2 moiety upon the action of a protease, e.g., at a tumor site. The IL2 proproteins optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor-associated antigen and directs the proprotein to a tumor site. The disclosure further provides pharmaceutical compositions comprising the IL2 proproteins, and methods of use of the IL2 proproteins in therapy, as well as nucleic acids encoding the IL2 proproteins, recombinant cells that express the IL2 proproteins and methods of producing the IL2 proproteins.

Abstract: An intelligent experimental device for collaborative mining of associated resources includes a signal transmission mechanism, a pressure maintaining mechanism, a feeding mechanism, and a reaction mechanism. The signal transmission mechanism includes a centralized controller, an annunciator, signal receivers, a power supply, a power cord, signal transmitters, and signal sensing valves. The pressure maintaining mechanism includes ambient and axial pressure oil chambers, ambient and axial pressure pumps, ambient and axial pressure liquid distribution tanks, a comprehensive pressure distribution pipe, and hydraulic transmission pipes. The feeding mechanism includes monitoring analyzers, temperature controllers, solution transfer pipes, seepage pumps, mixture conveying pipes, a comprehensive liquid distributor, an aggregate chamber, a liquid chamber, an oil chamber, a gas chamber, a mixing chamber and an analytical purifier.

Abstract: This disclosure relates to IL-2 variants and methods of use thereof, including methods of treating or inhibiting a cancer or tumor. The IL-2 variants may have reduced ability in binding to or activating IL-2R?. The IL-2 variants may retain the ability in binding to or activating IL-2R? and/or IL-2R??. In addition, the IL-2 variants may have decreased Treg activity but maintain the capacity to activate NK cells and T effector cells.

Abstract: The present disclosure provides IL2 proproteins comprising an IL2 moiety that is masked with an IL2R? moiety and a protease-cleavable linker, configured such that the IL2R? moiety is released from the IL2 moiety upon the action of a protease, e.g., at a tumor site. The IL2 proproteins optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor-associated antigen and directs the proprotein to a tumor site. The disclosure further provides pharmaceutical compositions comprising the IL2 proproteins, and methods of use of the IL2 proproteins in therapy, as well as nucleic acids encoding the IL2 proproteins, recombinant cells that express the IL2 proproteins and methods of producing the IL2 proproteins.

Abstract: The present invention provides a coal-based solid waste transport and filling integrated machine mining system, comprising a filling hydraulic support (6) and a coal winning machine (7), said filling hydraulic support (6) comprises a hydraulic top plate and a base (601), said hydraulic top plate comprises a hinged front top beam (602) and a rear top beam (603), with a front probe beam (604) attached to front end of said front top beam (602) and a telescopic slide rod (1) connected to rear end of said rear top beam (603), a double transport and single filling non-stop equipment is fixed on the telescopic slide rod (1). The apparatus and method of the present invention weaken the impact of groundwater pollution on mine production and mine ecology, bring good economic and environmental benefits to the mine and promoting safe and green coal mining.

Abstract: A method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazo-lo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a targeted therapy agent. A pharmaceutical combination comprising a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-( 4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a targeted therapy agent.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: The present disclosure provides an unmanned flight system and a control system for an unmanned flight system. The unmanned flight system comprises: a body and a lift mechanism connected to the body, wherein the lift mechanism includes two rotor assembly arm structures respectively provided on two sides of the body, wherein each of the rotor assembly arm structures respectively includes: an arm, a pivotable rotor assembly, a motor for driving the rotor assembly to pivot about a pivot axis, and a motor base for mounting the motor, wherein one end of the arm is pivotally connected to one side of the body, the motor base is pivotally provided on the other end of the arm, and a rotational axis of the motor base is higher than a center of gravity of the unmanned flight system. The unmanned flight system according to the present disclosure can achieve a longer flight time, a simple rotor assembly structure, and easier overall assembly and maintenance.

Abstract: Provided is a multifunctional sounding device and an electronic device. The multifunctional sounding device includes a casing, a sounding body accommodated in the casing, a vibrator assembly and an elastic supporting member for suspending the vibrator assembly in the accommodating space and providing elastic restoring force. The sounding body includes a vibration system and a magnetic circuit system for driving the vibration system to sound. The elastic supporting member includes a first supporting arm fixed to the vibrator assembly, bent portions bent and extended from both ends of the first supporting arm, and second supporting arms extended away from the first supporting arm and both fixed to the casing. A thickening member is arranged on each bent portion, and a sum of a thicknesses of each bent portion and the thickening member is greater than a thicknesses of the first supporting arm and the second supporting arm.

Abstract: Disclosed is a characterization method of closed pores and connectivity of coal measure composite reservoirs, including collecting samples of coal seams and shales reservoirs, carrying out low-field NMR experiments and NMR freeze-thaw experiments on plunger samples and crushed samples with different particle sizes to obtain cumulative pore volume distribution and differential pore size distribution of the crushed samples, comparing crushed samples with plunger samples for optimal crushed particle sizes, and preliminarily determining a distribution range of closed pores; carrying out SAXS experiments on crushed samples to obtain size distribution and volume of total pores of 1-100 nanometers; calculating pore volume of total pores and closed pore volume in composite reservoirs by low-field NMR experiments results; carrying out non-steady overburden permeability experiments and variable factors on plunger samples of coal seams, shales and tight sandstone to characterize the connectivity under influence of pores

Abstract: The present invention provides a multifunctional sounding device including a housing, a first vibration system, a second vibration system, a magnetic circuit system, an elastic component and a flexible circuit board. The elastic component includes a deformation part fixed to the second vibration system and an installation part extended from both ends of the deformation part and fixed to the housing. The second vibration system is suspended in the containment cavity through the elastic component. The flexible circuit board is connected with the elastic component, so that the vibration of the flexible circuit board is coupled with the vibration of the elastic component. Therefore, the damping of the elastic component is reduced, the force received by the elastic component during vibration is reduced, and the service life of the elastic component is extended.