Abstract: Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) ligand (PD-L1) and inhibit PD-L1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD-L1-mediated functions.

Abstract: A method for computation may include performing a first computation using a first system, wherein the first computation may be based, at least in part, on a first computation basis, performing a second computation using a second system, wherein the second computation may be based, at least in part, on a second computation basis, and coordinating the first computation and the second computation. The first computation basis may include a clock basis, and the second computation basis may include an event basis. The first computation may include a first operation, the second computation may include a second operation, and the coordinating the first computation and the second computation may include coordinating the first computation and the second computation based on the first operation and the second operation. The first operation may include an application computation operation, and the second operation may include a device computation operation.

Abstract: The present invention relates to the field of biomedical technology and discloses a cartridge and a testing device. The cartridge comprises a sample lysis compartment, a first sample mixing compartment and a first PCR compartment; a first valve is disposed between the sample lysis compartment and the first sample mixing compartment, the first valve controls the flowing or blocking of the sample between the sample lysis compartment and the first sample mixing compartment; a fourth valve is disposed between the first PCR compartment and the first sample mixing compartment, the fourth valve controls the flow or blocking of the sample between the first sample mixing compartment and the first PCR compartment; a first reagent is provided in the first sample mixing compartment. In the compartment, nucleic acids in the sample mix with the first reagent and is then sent to the first PCR compartment for amplification.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: Provided is a sounding device, including frame and vibration system and magnetic circuit unit fixed to the frame. The vibration system includes diaphragm, voice coil driving the diaphragm to vibrate and sound, holder fixed to diaphragm, and auxiliary diaphragm spaced from diaphragm. The holder includes holder main body, first connection portion formed from holder main body to magnetic circuit unit and second connection portion spaced from first connection portion. The voice coil is fixed to second connection portion. One end of the auxiliary diaphragm is fixed to frame. One end of first connection portion away from holder main body bends and extends away from second connection portion to form flange. One end of auxiliary diaphragm away from frame is fixed to flange. The sounding device may reduce accuracy deviation and hidden dangers of gluing failure caused by rear assembling of the auxiliary diaphragm.

Abstract: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.

Abstract: A method for preparing a porous nano-fiber heterostructure photocatalytic filter screen includes: preparing a noble metal nanostructure with tunable spectra and a heterostructure composite photocatalyst of a photocatalytic material; and preparing a large area and multilayer porous nano-fiber filter screen structure, while utilizing a scattering enhancement effect of metal nanoparticles in an porous optical fiber to realize repeated conduction of sunlight in the optical fiber and finally interact with the composite photocatalyst on a surface to improve photocatalytic efficiency.

Abstract: The present disclosure provides a fire test system and method for tunnel structure based on real-time fusion of numerical and physical spaces. The fire test system includes: a physical test unit, to perform a holographic fire test on the typical segment components of tunnel structure system in a physical space, to obtain holographic characteristic parameter data of the typical components; a numerical analysis unit, to establish a full-scale numerical model of the tunnel-stratum composite system in a numerical space, to obtain multi-field coupling boundary data of the typical components; and a fusion control unit, to control and adjust a multi-field coupling boundary of the physical space according to the multi-field coupling boundary data, and to update and adjust an input parameter of the numerical space according to the holographic characteristic parameter data.

Abstract: An aerial system includes a body, a lift mechanism coupled to the body, a processing system, and at least one camera. The aerial system also includes a first motor configured to rotate the at least one camera about a first axis and a second motor configured to rotate the at least one camera about a second axis. The processing system is configured to determine a direction of travel of the aerial system and to cause the first motor and the second motor to automatically orient the at least one camera about the first axis and the second axis such that the at least one camera automatically faces the direction of travel of the aerial system.

Abstract: Provided are antibodies that specifically bind to TIGIT (T cell immunoreceptor with Ig and ITIM domains, WUCAM or Vstm3) and inhibit Tigit-mediated cellular signaling and activities in immune cells. The anti-TIGIT antibodies can be used to treat or diagnose cancer, infectious diseases or other pathological disorders that may be modulated by Tigit-mediated functions.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: Methods for enhancing the speed performance of solid-state storage devices using stream-aware garbage collection. A garbage collection method in according to an embodiment includes: searching, in each of a plurality of super-block groups G, for a super-block set C that satisfies: all of the super-blocks m within the super-block set C in the super-block group G contain a lesser amount of valid data than the other super-blocks within the super-block group G; and a total amount of valid data within the super-block set C are just enough to complete an entire super-block; selecting the super-block group G that includes the super-block set C with the maximum number of super-blocks m; and performing garbage collection on the super-block set C in the selected super-block group G.

Abstract: Provided is a speaker, including a frame; a vibration unit; and a magnetic circuit unit. The magnetic circuit unit is provided with a magnetic gap; the vibration unit includes a diaphragm, and a voice coil; the magnetic circuit unit includes a yoke, a main magnet unit, and auxiliary magnet units, and the auxiliary magnet units and the main magnet unit define the magnetic gap; the vibration unit further includes two elastic support assemblies; each of which includes an elastic member and an auxiliary diaphragm; the elastic member includes a first fixing arm, a second fixing arm and an elastic arm; the auxiliary diaphragm includes an auxiliary suspension, and a first connecting portion and a second connecting portion; and the auxiliary suspension has a racetrack shape with notches. With this structure, the service life and reliability of the speaker are improved.

Abstract: Provided is a speaker, including a frame; a vibration unit fixed to the frame; and a magnetic circuit unit driving the vibration unit to vibrate and produce sound. The vibration unit includes a diaphragm and a voice coil; the diaphragm includes a first suspension, a second suspension and a vibrating portion; the magnetic circuit unit is provided with a magnetic gap, and the voice coil is inserted in the magnetic gap; the magnetic circuit unit includes a yoke; and the yoke and the diaphragm are arranged at two opposite sides of the frame; and the vibration unit further includes a fixing ring connected to the magnetic circuit unit; the second suspension surrounds the fixing ring; and an inner peripheral side of the second suspension is fixed to an end of the fixing ring away from the yoke. With this structure, the acoustic performance of the speaker can be improved.

Abstract: Provided is a speaker, including a frame, a vibration unit fixed to the frame; and a magnetic circuit unit driving the vibration unit to vibrate and produce sound. The vibration unit includes a diaphragm and a voice coil; the diaphragm includes a first suspension, a second suspension and a vibrating portion; the magnetic circuit unit includes a magnetic gap, and the voice coil is inserted in the magnetic gap; the magnetic circuit unit includes a yoke; and the vibration unit further includes a fixing ring connected to the magnetic circuit unit; an inner peripheral side of the second suspension is fixed to an outer side of the fixing ring; and a connection position of the second suspension and the fixing ring is located between two opposite ends of the fixing ring along a vibrating direction of the diaphragm. With this structure, sealing performance of the speaker is improved.

Abstract: A speaker device includes a frame, a vibration unit fixedly connected to the frame, a magnetic circuit unit having a magnetic gap, and a screen cloth. The vibration unit includes a diaphragm and a voice coil. The magnetic circuit unit includes a carrier, a first main magnet, an auxiliary magnet and a magnetic conductive plate. The magnetic conductive plate is fixed to the frame. The magnetic conductive plate includes a first central portion and a first edge portion; the auxiliary magnet is located at the first central portion. The first edge portion is provided with a through hole. The screen cloth is provided at a side of the carrier away from the diaphragm, and includes a second central portion and a second edge portion. The second edge portion is provided with a first groove recessed toward the magnetic conductive plate, corresponding to the through hole.

Abstract: Provided is a speaker, including a frame; a vibration unit fixed to the frame; and a magnetic circuit unit driving the vibration unit to vibrate and produce sound. The vibration unit includes a diaphragm and a voice coil; the diaphragm includes a first suspension, a second suspension and a vibrating portion; the magnetic circuit unit is provided with a magnetic gap, and the voice coil is inserted in the magnetic gap; the magnetic circuit unit includes a yoke; and the yoke and the diaphragm are arranged at two opposite sides of the frame; and the vibration unit further includes a fixing ring connected to the magnetic circuit unit; the second suspension surrounds the fixing ring; and the inner peripheral side of the second suspension is fixed to an end of the fixing ring close to the yoke. With this structure, the acoustic performance of the speaker is improved.

Abstract: The present disclosure provides a diaphragm forming mold, including includes a mold body, the mold body includes forming regions and material removing regions connected with the forming regions, diaphragm bodies are formed in the forming regions, and at least one corrugated structure is formed in the material removing regions. The present disclosure may effectively improve a contraction effect of a material of diaphragm disposed in the material removing regions, thereby improving an overall contraction effect of the material of the diaphragm, reducing an amount of the compensation of the diaphragm forming mold for a size of the diaphragm, so that a flatness of the diaphragm after being molded is better.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.