Abstract: A self-managed DRAM module configured to reduce energy consumption. A module is described that includes a plurality of DDR channels and a management engine configured to read and write data blocks to DDR channels according to a process that includes: allocating a set of sub-channels for each DDR channel, wherein each sub-channel includes a subset of the set of DRAM chips; wherein a write operation of a data block includes: encoding the data block to generate an ECC codeword; and writing the ECC codeword into the subset of DRAM chips of a specified sub-channel; and wherein a read operation of the data block includes: reading the ECC codeword from the subset of DRAM chips of the specified sub-channel; and decoding the ECC codeword to obtain the data block.

Abstract: The present disclosure provides a method for improving bioavailability of an NAD+ derivative. The method improves the bioavailability of the NAD+derivative by arranging a CD38 inhibitor and the NAD+ derivative in a same preparation, and controlling the CD38 inhibitor to release first rapidly, and then the NAD+ derivative releases after the CD38 inhibitor has taken effect, thereby increasing the level of NAD+ in vivo.

Abstract: The application discloses a vibration sounding device including a housing body with a containment cavity, a sounding unit placed in the containment cavity, a weight, a drive coil and a spring plate. The spring plate includes a first fixed section for fixed connection with the weight and a second fixed section for fixed connection with the housing body. The first fixed section and the second fixed section are fixed by laser spot welding. Compared with the prior art, the first fixed section and the second fixed section are fixed by laser spot welding, which can improve the bonding strength between the first fixed section and the second fixed section, and ensures the strength of the spring plate when the vibration sounding device is working.

Abstract: The application relates to a vibration sounding device including: a housing body with a containment cavity and a sounding unit arranged in the containment cavity. The sounding unit includes a vibration system and a magnetic circuit system. The magnetic circuit system includes a main magnet and a secondary magnet assembly. The vibration sounding device also includes an elastic assembly, a weight assembly, and a drive coil. The second direction is perpendicular to the first direction. By virtue of the configuration, it is beneficial to simplify the forming process of the weight assembly, reduce the production cost, and also facilitate the replacement of the drive coil.

Abstract: The present invention provides a multifunctional sounding device including a housing, a first vibration system, a second vibration system, a magnetic circuit system, an elastic component and a flexible circuit board. The elastic component includes a deformation part fixed to the second vibration system and an installation part extended from both ends of the deformation part and fixed to the housing. The second vibration system is suspended in the containment cavity through the elastic component. The flexible circuit board is connected with the elastic component, so that the vibration of the flexible circuit board is coupled with the vibration of the elastic component. Therefore, the damping of the elastic component is reduced, the force received by the elastic component during vibration is reduced, and the service life of the elastic component is extended.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: The present invention discloses a multi-energy complementary system for a co-associated abandoned mine and a use method. The multi-energy complementary system for a co-associated abandoned mine includes a mining mechanism, a grouting mechanism and an energy mechanism. In the present invention, the mining of coal and uranium resources is realized through the mining mechanism, the subsidence and seepage reduction of the stratum is realized through the grouting mechanism, and the effective utilization of waste resources is realized through the energy mechanism. Finally, with the efficient cooperation of the three mechanisms, safe and efficient development and utilization of co-associated resources in the full life cycle are realized, and the purposes of green and efficient mining of coal and uranium resources and secondary development of a coal seam goaf are achieved, thereby facilitating the realization of dual-carbon goals and the development of low-carbon green energy.

Abstract: An intelligent experimental device for collaborative mining of associated resources includes a signal transmission mechanism, a pressure maintaining mechanism, a feeding mechanism, and a reaction mechanism. The signal transmission mechanism includes a centralized controller, an annunciator, signal receivers, a power supply, a power cord, signal transmitters, and signal sensing valves. The pressure maintaining mechanism includes ambient and axial pressure oil chambers, ambient and axial pressure pumps, ambient and axial pressure liquid distribution tanks, a comprehensive pressure distribution pipe, and hydraulic transmission pipes. The feeding mechanism includes monitoring analyzers, temperature controllers, solution transfer pipes, seepage pumps, mixture conveying pipes, a comprehensive liquid distributor, an aggregate chamber, a liquid chamber, an oil chamber, a gas chamber, a mixing chamber and an analytical purifier.

Abstract: A pulse diagnostic device and a system of pulse diagnosis are provided. The pulse diagnostic device includes a cuff and a main monitor. The cuff includes a tube and an air bag arranged with an air path interface. A gas medium is received in the air bag. The tube is connected to the air path interface. The main monitor includes a pressure sensor and a controller. The tube extends to reach the main monitor and is connected to the pressure sensor, and the pressure sensor further connects to the controller. When the pulse diagnostic device is working, the cuff contacts an artery, the pressure sensor senses a pressure of the gas medium in the tube. The pressure sensor transmits the pressure of the gas medium to the controller. The controller obtains the pulse information and the blood pressure information based on the pressure of the gas medium.

Abstract: The present invention provides a multifunctional sounding device including a housing, a first vibration system, a second vibration system, a magnetic circuit system, an elastic component and a flexible circuit board. The elastic component includes a deformation part fixed to the second vibration system and an installation part extended from both ends of the deformation part and fixed to the housing. The second vibration system is suspended in the containment cavity through the elastic component. The flexible circuit board is connected with the elastic component, so that the vibration of the flexible circuit board is coupled with the vibration of the elastic component. Therefore, the damping of the elastic component is reduced, the force received by the elastic component during vibration is reduced, and the service life of the elastic component is extended.

Abstract: The present disclosure provides interferon receptor agonists with improved safety profiles and therapeutic indices. The interferon receptor agonists are attenuated through masking and/or reduced receptor binding as compared to a wild-type interferon. IFN receptor agonists optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor- or immune cell-associated antigen and directs the interferon receptor agonist to a tumor site and/or tumor-reactive immune cells. The disclosure further provides pharmaceutical compositions comprising the interferon receptor agonists, and methods of use of the interferon receptor agonists in therapy, as well as nucleic acids encoding the interferon receptor agonists, recombinant cells that express the interferon receptor agonists and methods of producing the interferon receptor agonists.

Abstract: Provided are antibodies that specifically bind to T-cell immunoglobulin domain and mucin domain 3 (Tim-3). The anti-Tim-3 antibodies can be used to treat, prevent or diagnose immune, cancerous, infectious diseases or other pathological disorders that may be modulated by Tim-3-mediated functions.

Abstract: This disclosure relates to IL-2 variants and methods of use thereof, including methods of treating or inhibiting a cancer or tumor. The IL-2 variants may have reduced ability in binding to or activating IL-2R?. The IL-2 variants may retain the ability in binding to or activating IL-2R? and/or IL-2R??. In addition, the IL-2 variants may have decreased Treg activity but maintain the capacity to activate NK cells and T effector cells.

Abstract: The present disclosure provides interferon receptor agonists with improved safety profiles and therapeutic indices. The interferon receptor agonists are attenuated through masking and/or reduced receptor binding as compared to a wild-type interferon. IFN receptor agonists optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor- or immune cell-associated antigen and directs the interferon receptor agonist to a tumor site and/or tumor-reactive immune cells. The disclosure further provides pharmaceutical compositions comprising the interferon receptor agonists, and methods of use of the interferon receptor agonists in therapy, as well as nucleic acids encoding the interferon receptor agonists, recombinant cells that express the interferon receptor agonists and methods of producing the interferon receptor agonists.

Abstract: The present disclosure provides an aerial system, comprising: a body; a lift mechanism coupled to the body; an optical system coupled to the body; and a computer system having at least one processor and at least one memory comprising first program instructions. When the first program instructions are executed by the at least one processor, the at least one processor may be configured to: receive a target operation, the target operation associated with a flight trajectory and a predefined action performed by the optical system and execute the target operation.

Abstract: An apparatus may include at least one memory, and at least one processor configured to determine an accessibility of a first version of a page, wherein the first version of the page may be stored in the at least one memory, and perform, based on the accessibility of the first version of the page, an access of at least a portion of a second version of the page, wherein the second version of the page is stored in the at least one memory. The accessibility of the first version of the page may be based on an erase operation of the first version of the page. The access of the at least a portion of the second version of the page may include an access of a cache line of the second version of the page.

Abstract: A system and method for inference using an embedding table. In some embodiments, the method includes forming a culled index vector including a first index, and requesting a weight vector corresponding to the first index. The first index may be a first element of a first index vector, the first index being culled within the culled index vector.

Abstract: The invention is directed to T cells and other cells that express chimeric NK-p30 receptors (“chimeric NKp30 T cells”), methods of making and using chimeric NKp30 T cells, and methods of using these chimeric NKp30 T cells, isolated populations thereof, and compositions comprising the same. In another aspect, said chimeric NKp30 T cells are further designed to express a functional non-TCR receptor. The disclosure also pertains to methods of making said chimeric NKp30 T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said chimeric NKp30 T cells, populations thereof, or compositions comprising the same.

Abstract: The present disclosure describes a method, apparatus, and storage medium for generating network representation for a neural network. The method includes obtaining a source-side vector sequence corresponding to an input sequence.

Abstract: The present disclosure provides a speaker including a housing and a vibration system and a magnetic circuit unit that are received in the housing. The magnetic circuit unit includes lower clamp plate and magnetic circuit assembly arranged on lower clamp plate. A central area of lower clamp plate abuts against bottom wall of the housing. An edge area of lower clamp plate is spaced from the bottom wall. The edge area is provided with flange portion bending and extending from lower clamp plate toward the bottom wall. The flange portion abuts against the bottom wall. The flange portion abuts against the bottom wall. In this way, when speaker falls off, flange portions come in contact with bottom wall, such that stability of magnetic circuit unit can be improved, then operational performance and service life can be improved.