Abstract: A straddled vehicle, including a head pipe, a main frame extending rearward from the head pipe, a fuel tank supported by the main frame, an air cleaner arranged in front of the fuel tank, a side cover formed on a lateral side of the fuel tank to partially overlap the fuel tank in a side view of the straddled vehicle, an intake port provided at an edge of the side cover and opening toward an outside of the straddled vehicle, an air cleaner chamber in which at least a part of the air cleaner is arranged, and an intake passage including a first passage between the side cover and a side surface of the fuel tank, the intake port communicating with the air cleaner chamber through the intake passage. The side cover includes a front portion located forward of the air cleaner, and the intake port is arranged rearward of the air cleaner.

Abstract: A light irradiation device includes a first reflective portion that is arranged at a concave inner surface formed so as to have a substantially arcuate shape and that permits wire-like member to be inserted into an interior thereof, at least one light-emitting portion that emits light in such fashion as to be directed toward the wire-like member from a direction which is circumferential with respect to the wire-like member, and a second reflective portion that is formed in planar fashion, at least a portion of the second reflective portion is arranged between an end of the first reflective portion and an end of the light-emitting portion in a direction circumferential with respect to the first reflective portion.

Abstract: The present invention provides an anticancer agent containing the following (1) and (2): (1) HVJ-E (hemagglutinating virus of Japan envelope), (2) an inhibitor of an immune checkpoint protein.

Abstract: To provide a high-quality and high-performance micro-channel device which can be manufactured by a simple method. Provided is a micro-channel device used in analyzing a sample. The micro-channel device includes at least two substrates and an elastic film interposed between the two substrates. The substrates are thermally fused to the elastic film in at least a part thereof. Also provided is a method for manufacturing a micro-channel device used in analyzing a sample. The method includes a surface activation step of activating a joining surface of a substrate and/or an elastic film, a lamination step of laminating the elastic film between at least two of the substrates, and a thermal fusion step of thermally fusing the substrates to the elastic film in at least a part thereof.

Abstract: A sensor monitors a treatment status of a predetermined manufacturing device, and an abnormality detection device detects an abnormality of a sensor signal that is a monitoring result of the sensor. The sensor signal is a digital data group obtained by sampling an analog waveform at a predetermined sampling period. A management apparatus learns characteristics of a plurality of digital data groups accumulated in past times through use of artificial intelligence to generate a learned model. An abnormality detection device holds the learned model and determines whether an abnormality is present in the digital data group of a current processing target by using the learned model.

Abstract: A light irradiation device includes at least one irradiation unit including a reflective surface which is disposed in a concave inner surface formed to have a substantially arc shape and into which a wire member is inserted, and a light source which is configured to emit light toward the wire member and is disposed so as to face the reflective surface in a direction of an optical axis of the emitted light, and an insertion portion configured to interiorly form an insertion path for inserting the wire member into the reflective surface. The reflective surface is disposed such that a center of the substantially arc shape is eccentric with respect to a center of the insertion path.

Abstract: To provide a screening method for a substance having an anti-obesity action and an anti-obesity drug. A screening method including: a step for contacting a test substance and a synoviolin-gene-expressing cell; and a step for verifying the effect of the test substance on the synoviolin gene expression, or the effect thereof on synoviolin protein activity. An action which reduces the amount of adipose tissue and an action which inhibits induction of adipocyte differentiation are examples of an anti-obesity action. An anti-obesity drug containing, as an active ingredient thereof, an siRNA of synoviolin, a decoy nucleic acid of synoviolin, or an antisense nucleic acid of synoviolin.

Abstract: Provided is a double container in which an inner container and an outer container are difficult to be separated in a case where the inner container is attached to the outer container. It is a cup-shaped double container, having an inner container and an outer container in which a part of a cross section are non-circular, having a space provided between the inner container and the outer container, and having an open upper end portion, the container including: on an outer peripheral surface of a cylindrical side surface member of the inner container, a rib extending in a vertical direction and disposed in plural numbers at predetermined intervals; and a rotation regulating unit disposed on an inner peripheral surface of a cylindrical side surface member of the outer container and capable of regulating relative rotation of the inner container and the outer container by interfering with the rib.

Abstract: The present invention relates to a medicament for preventing and/or treating cognitive impairment and/or a neurodegenerative disease with accumulation of a prionoid, comprising a Sendai virus envelope as an active ingredient and combined application of the medicament and an immune checkpoint inhibitor.

Abstract: The present invention provides, as a new anti-cancer agent obtained by combining HVJ-E and a molecule synergistically acting therewith, an anti-cancer agent containing the following (1) and (2): (1) HVJ-E (hemagglutinating virus of Japan envelope), (2) CXCL2, a nucleic acid comprising a base sequence encoding CXCL2 or a CXCL2 expression inducing agent.

Abstract: The present invention provides an anticancer agent containing the following (1) and (2): (1) HVJ-E (hemagglutinating virus of Japan envelope), (2) an inhibitor of an immune checkpoint protein.

Abstract: A synoviolin expression inhibitor for inhibiting the expression of a synoviolin gene and a synoviolin protein is provided. A synoviolin expression inhibitor, which inhibits an expression of a synoviolin gene or an expression of a synoviolin protein, the inhibitor comprising, as an active ingredient, a mesenchymal stem cell or a culture supernatant thereof and a method of producing a synoviolin expression inhibitor comprising the step of obtaining a mesenchymal stem cell or a culture supernatant thereof by culturing a mesenchymal stem cell using a serum-free medium, and the step of preparing the synoviolin expression inhibitor, which inhibits an expression of a synoviolin gene or an expression of a synoviolin protein, by using the mesenchymal stem cell or the culture supernatant thereof obtained in the previous step.

Abstract: A light irradiation device includes a first reflective portion that is arranged at a concave inner surface formed so as to have a substantially arcuate shape and that permits wire-like member to be inserted into an interior thereof, at least one light-emitting portion that emits light in such fashion as to be directed toward the wire-like member from a direction which is circumferential with respect to the wire-like member, and a second reflective portion that is formed in planar fashion, at least a portion of the second reflective portion is arranged between an end of the first reflective portion and an end of the light-emitting portion in a direction circumferential with respect to the first reflective portion.

Abstract: A sensor monitors a treatment status of a predetermined manufacturing device, and an abnormality detection device detects an abnormality of a sensor signal that is a monitoring result of the sensor. The sensor signal is a digital data group obtained by sampling an analog waveform at a predetermined sampling period. A management apparatus learns characteristics of a plurality of digital data groups accumulated in past times through use of artificial intelligence to generate a learned model. An abnormality detection device holds the learned model and determines whether an abnormality is present in the digital data group of a current processing target by using the learned model.

Abstract: A light irradiation device includes a plurality of light-emitting portions that emit light by being supplied with a current. The light-emitting portions each have a first power supply terminal, and a second power supply terminal; a plurality of light-emitting elements; and a wiring pattern. The wiring pattern has a first wiring region and a second wiring region. Two of the light-emitting portions that are disposed adjacent to each other are disposed such that the space between the respective first wiring regions or the space between the respective second wiring regions is smaller than the space between the first wiring region of one of the light-emitting portions and the second wiring region of the other of the light-emitting portions.

Abstract: A sensor monitors a treatment status of a predetermined manufacturing device, and an abnormality detection device detects an abnormality of a sensor signal that is a monitoring result of the sensor. The sensor signal is a digital data group obtained by sampling an analog waveform at a predetermined sampling period. A management apparatus learns characteristics of a plurality of digital data groups accumulated in past times through use of artificial intelligence to generate a learned model. An abnormality detection device holds the learned model and determines whether an abnormality is present in the digital data group of a current processing target by using the learned model.

Abstract: To provide an obesity risk diagnosis kit and a method for analyzing the risk of obesity onset. An obesity risk diagnosis kit including a probe for analyzing genetic information of an obese person and a non-obese person and identifying a synoviolin gene as an obesity marker by utilizing elevated expression of the synoviolin gene in the obese person. A method for analyzing the risk of obesity onset, including a step for measuring the expression level of the synoviolin gene in a sample collected from a subject organism, and a step for determining the risk of obesity onset using the expression level of the synoviolin gene.

Abstract: This light irradiation device has a plurality of light emitting units that emit light when current is supplied. Each of the plurality of light emitting units has a first feeding terminal indicating anode polarity, a second feeding terminal indicating cathode polarity, a plurality of light emitting elements, and a wiring pattern. The wiring pattern has a first wiring area located between the first feeding terminal and a light emitting element arranged in a position electrically the closest to the first feeding terminal, and a second wiring area located between the second feeding terminal and a light emitting element arranged in a position electrically the closest to the second feeding terminal. In two adjacently arranged light emitting units out of the plurality of light emitting units, first wiring areas or second wiring areas are arranged with an interval narrower than an interval between the first wiring area of one light emitting unit and the second wiring area of the other light emitting unit.

Abstract: A light irradiation device includes at least one irradiation unit including a reflective surface which is disposed in a concave inner surface formed to have a substantially arc shape and into which a wire member is inserted, and a light source which is configured to emit light toward the wire member and is disposed so as to face the reflective surface in a direction of an optical axis of the emitted light, and an insertion portion configured to interiorly form an insertion path for inserting the wire member into the reflective surface. The reflective surface is disposed such that a center of the substantially arc shape is eccentric with respect to a center of the insertion path.

Abstract: To provide a high-quality and high-performance micro-channel device which can be manufactured by a simple method. Provided is a micro-channel device used in analyzing a sample. The micro-channel device includes at least two substrates and an elastic film interposed between the two substrates. The substrates are thermally fused to the elastic film in at least a part thereof. Also provided is a method for manufacturing a micro-channel device used in analyzing a sample. The method includes a surface activation step of activating a joining surface of a substrate and/or an elastic film, a lamination step of laminating the elastic film between at least two of the substrates, and a thermal fusion step of thermally fusing the substrates to the elastic film in at least a part thereof.