Abstract: A transmission includes a fork mechanism in which a plurality of fork rods to which a plurality of shift forks are connected are each attached to a pedestal so as to be moveable in an axial direction. An assembly guide portion is disposed on the pedestal and a guide pin is erected on a clutch housing. As a result, even in cases where an input shaft and a main shaft, on which driving and driven gears and synchro devices are assembled, are assembled on the clutch housing in a state that the driving and driven gears are engaged and, thereafter the fork mechanism is assembled on this clutch housing, the assembly of the fork mechanism on the clutch housing can be easily performed.

Abstract: The present invention provides, as a new anti-cancer agent obtained by combining HVJ-E and a molecule synergistically acting therewith, an anti-cancer agent containing the following (1) and (2): (1) HVJ-E (hemagglutinating virus of Japan envelope), (2) CXCL2, a nucleic acid comprising a base sequence encoding CXCL2 or a CXCL2 expression inducing agent.

Abstract: To provide an antiobesity agent. An antiobesity agent containing an extract of walnut branches, shells, or leaves as an active ingredient.

Abstract: Provided is a double container in which an inner container and an outer container are difficult to be separated in a case where the inner container is attached to the outer container. It is a cup-shaped double container, having an inner container and an outer container in which a part of a cross section are non-circular, having a space provided between the inner container and the outer container, and having an open upper end portion, the container including: on an outer peripheral surface of a cylindrical side surface member of the inner container, a rib extending in a vertical direction and disposed in plural numbers at predetermined intervals; and a rotation regulating unit disposed on an inner peripheral surface of a cylindrical side surface member of the outer container and capable of regulating relative rotation of the inner container and the outer container by interfering with the rib.

Abstract: To provide a screening method for a substance having an anti-obesity action and an anti-obesity drug. A screening method including: a step for contacting a test substance and a synoviolin-gene-expressing cell; and a step for verifying the effect of the test substance on the synoviolin gene expression, or the effect thereof on synoviolin protein activity. An action which reduces the amount of adipose tissue and an action which inhibits induction of adipocyte differentiation are examples of an anti-obesity action. An anti-obesity drug containing, as an active ingredient thereof, an siRNA of synoviolin, a decoy nucleic acid of synoviolin, or an antisense nucleic acid of synoviolin.

Abstract: A sensor monitors a treatment status of a predetermined manufacturing device, and an abnormality detection device detects an abnormality of a sensor signal that is a monitoring result of the sensor. The sensor signal is a digital data group obtained by sampling an analog waveform at a predetermined sampling period. A management apparatus learns characteristics of a plurality of digital data groups accumulated in past times through use of artificial intelligence to generate a learned model. An abnormality detection device holds the learned model and determines whether an abnormality is present in the digital data group of a current processing target by using the learned model.

Abstract: A monitoring method that can detect a sign of disconnection of a heat generation source is provided. Further, a highly reliable semiconductor device is provided. The monitoring method uses a first control device that samples outputs of a plurality of thermometers at a first frequency (100 Hz sampling in S10) and controls a plurality of heat generation sources based on temperature information obtained by sampling, and a second control device that forms information based on temperature information obtained by sampling at the first frequency (100 Hz sampling in S20) and pieces of heat-generation-source information obtained by sampling of outputs of the respective heat-generation sources at the first frequency (100 Hz sampling in S20). Based on the temperature information obtained by sampling at the first frequency (100 Hz sampling in S20) and the pieces of heat-generation-source information obtained by sampling at the first frequency (100 Hz sampling in S20), states of the heat generation sources are monitored.

Abstract: A transmission includes a fork mechanism in which a plurality of fork rods to which a plurality of shift forks are connected are each attached to a pedestal so as to be moveable in an axial direction. An assembly guide portion is disposed on the pedestal and a guide pin is erected on a clutch housing. As a result, even in cases where an input shaft and a main shaft, on which driving and driven gears and synchro devices are assembled, are assembled on the clutch housing in a state that the driving and driven gears are engaged and, thereafter the fork mechanism is assembled on this clutch housing, the assembly of the fork mechanism on the clutch housing can be easily performed.

Abstract: [Problem] To provide a mitochondria-function regulator effective for treatment or prevention of obesity, and a screening method therefore. [Solution] The mitochondria-function regulator of the present invention contains, as an active ingredient, a PGC-1?-protein function regulator synoviolin. The screening method of the present invention includes a step for causing a test substance to act on an adipose tissue cell or an individual animal, and measuring or detecting one or more of the following in the adipose tissue cell: (1) expression level of synoviolin; (2) a bond between synoviolin and PGC-1? protein; and (3) the ubiquitination of the PGC-1? protein by synoviolin.

Abstract: An object is to find a substance which inhibits IL-2 production. IL-2 production can be inhibited by a compound represented by the following formula (I): wherein R1 to R4 and A are as defined in the present specification, or a pharmaceutically acceptable salt thereof.

Abstract: An object is to find a substance which inhibits IL-2 production. IL-2 production can be inhibited by a compound represented by the following formula (I): wherein R1 to R4 and A are as defined in the present specification, or a pharmaceutically acceptable salt thereof.

Abstract: To provide an antiobesity agent. An antiobesity agent containing an extract of walnut branches, shells, or leaves as an active ingredient.

Abstract: A monitoring method that can detect a sign of disconnection of a heat generation source is provided. Further, a highly reliable semiconductor device is provided. The monitoring method uses a first control device that samples outputs of a plurality of thermometers at a first frequency (100 Hz sampling in S10) and controls a plurality of heat generation sources based on temperature information obtained by sampling, and a second control device that forms information based on temperature information obtained by sampling at the first frequency (100 Hz sampling in S20) and pieces of heat-generation-source information obtained by sampling of outputs of the respective heat-generation sources at the first frequency (100 Hz sampling in S20). Based on the temperature information obtained by sampling at the first frequency (100 Hz sampling in S20) and the pieces of heat-generation-source information obtained by sampling at the first frequency (100 Hz sampling in S20), states of the heat generation sources are monitored.

Abstract: The present invention relates to a method for screening substances having weight-regulating action.

Abstract: [Problem] To provide a screening method for a substance having an anti-obesity action and an anti-obesity drug. Solution A screening method including: a step for contacting a test substance and a synoviolin-gene-expressing cell; and a step for verifying the effect of the test substance on the synoviolin gene expression, or the effect thereof on synoviolin protein activity. An action which reduces the amount of adipose tissue and an action which inhibits induction of adipocyte differentiation are examples of an anti-obesity action. An anti-obesity drug containing, as an active ingredient thereof, an siRNA of synoviolin, a decoy nucleic acid of synoviolin, or an antisense nucleic acid of synoviolin.

Abstract: An object is to find a substance which inhibits IL-2 production. IL-2 production can be inhibited by a compound represented by the following formula (I): wherein R1 to R4 and A are as defined in the present specification, or a pharmaceutically acceptable salt thereof.

Abstract: [Problem] To provide a mitochondria-function regulator effective for treatment or prevention of obesity, and a screening method therefore. [Solution] The mitochondria-function regulator of the present invention contains, as an active ingredient, a PGC-1?-protein function regulator synoviolin. The screening method of the present invention includes a step for causing a test substance to act on an adipose tissue cell or an individual animal, and measuring or detecting one or more of the following in the adipose tissue cell: (1) expression level of synoviolin; (2) a bond between synoviolin and PGC-1? protein; and (3) the ubiquitination of the PGC-1? protein by synoviolin.

Abstract: The present invention relates to a method for screening substances having weight-regulating action.

Abstract: Annular reflecting rings are removably mounted on the upper and lower sides of a chamber side portion of a chamber. An annular recessed portion is formed sandwiched between the lower end face of the upper reflecting ring and the upper end face of the lower reflecting ring to surround a holding part for holding a semiconductor wafer. The outer peripheral surface of the recessed portion communicates with a transport opening. The formation of the recessed portion prevents the light emitted from halogen lamps and flash lamps from being non-uniformly reflected around the holding part to enter a semiconductor wafer, thus improving the uniformity of the in-plane temperature distribution in the semiconductor wafer during heat treatment.

Abstract: In a heat treatment apparatus, a reflector is provided to cover a plurality of flash lamps arranged in an array for emitting a flash of light, and a cooling box is provided over the reflector. The cooling box has a buffer space incorporated therein, and a plurality of jet openings in communication with the buffer space are formed through a bottom surface of the cooling box and the reflector. The plurality of jet openings are positioned just over gaps between the plurality of flash lamps in the lamp array. Nitrogen gas ejected from the plurality of jet openings passes through the gaps between adjacent ones of the flash lamps in the lamp array, and is then blown against a lamp light radiation window. The flash lamps are effectively cooled down by the direct cooling using the nitrogen gas and the decrease in temperature of the lamp light radiation window.