Abstract: The present invention provides a pharmaceutical composition containing a substance which inhibits the proliferation of synovial tissue or synovial cells and the interleukin-6 production. It also provides a pharmaceutical composition for inhibiting the proliferation of synovial tissue or synovial cells and the interleukin-6 production, which is useful for diagnosing and treating at least one selected from the group consisting of rheumatoid arthritis, fibrosis, arthritis, cancers, and cerebral neural diseases. In addition, it provides a method for inhibiting the proliferation of synovial cells and the interleukin-6 production by inhibiting the expression of hsHRD3 in synovial cells.

Abstract: The present invention provides a nerve cell differentiation inducing drug containing a Synoviolin expression inhibitor which is a useful drug for treatments of neural disorders, particularly Alzheimer's disease, Parkinson's disease, peripheral nerve disorders or spinal injury. As Synoviolin expression inhibitors, there are siRNA against gene coding Synoviolin (SEQ ID No. 1 or 2), or shRNA, a decoy nucleic acid that inhibits the promoter activity by binding to the transcription factor of the promoter of the Synoviolin gene or antisense oligonucleotide against gene coding the Synoviolin. The nerve cell differentiation inducing drug of the present invention is used for the treatment of neural disorders including Alzheimer's disease, Parkinson's disease, peripheral nerve disorders or spinal injury.

Abstract: An optical fiber positioning method comprises the steps of: preparing an optical fiber, an optical fiber holder, and a positioning plate; fitting the optical fiber holder in the fitting hole and inserting the optical fiber into an optical fiber holding hole of the optical fiber holder and an optical fiber positioning hole of the optical fiber positioning plate; abutting the optical fiber on the abutting position of the optical fiber positioning hole in the state that the end of the optical fiber holder is fitted in the fitting hole and the optical fiber is inserted into an optical fiber holding hole of the optical fiber holder and an optical fiber positioning hole of the optical fiber positioning plate; and fixing the optical fiber to the optical fiber positioning plate in the state that the optical fiber is abutted on with the abutting position of an optical fiber positioning hole.

Abstract: A positive resist layer formed on a translucent substrate is subjected to exposure and development to form circular resist patterns disposed near each other at a predetermined distance. The exposure pattern has an opening of a plurality of circular ring shape surrounding the plurality of resist patterns. The opening may have a width equal to the predetermined distance. Since the width of the opening is constant over the whole outer periphery of each resist pattern, uniform exposure can be realized at all positions along the periphery to form a perfect circle shape. After a convex lens shape is given to each resist pattern by heating and reflow process, the convex lens shape is transferred to the substrate by dry etching process using the resist patterns as a mask to form a microlens array with convex lenses.

Abstract: The present invention provides methods for evaluating the regulation on prolyl 4-hydroxylase activity. The present invention also provides screening methods using the evaluation methods. Furthermore, the present invention provides methods of screening for compounds that are useful for treating or preventing fibrosis or rheumatoid arthritis. The present invention relates to methods for detecting regulatory activity on the synoviolin ubiquitination of prolyl 4-hydroxylase ? subunit (P4HA1). It also relates to methods of screening for compounds with regulatory effect on the ubiquitination activity of synoviolin on P4HA1 based on these methods. Compounds discovered in the screening are useful for treating and/or preventing diseases caused by abnormalities in the prolyl 4-hydroxylase activity, such as fibrosis and rheumatoid arthritis.

Abstract: Pluralities of lens parts 20, 22 are formed on a lens substrate 16 by dry-etching. The lens parts 20 and 22 have same structures, and the lens part 20 includes toroidal lens surfaces S1 and S2 opposing to each other on one principal surface and another principal surface of the substrate 16. Assuming that a cross section in a y-axis direction of a laser beam emitted from a laser active layer in a z-axis direction is long and narrow in an x-axis direction, the lens surface S2 is formed to have a radius of curvature R21 in the x-axis direction smaller than a radius of curvature R22 in the y-axis direction, and the lens surface S1 is formed to have a radius of curvature R11 in the x-axis direction smaller than a radius of curvature R12 in the y-axis direction.

Abstract: The invention intends to provide a manufacturing method of a semiconductor integrated circuit device, which can detect an off-specification faulty wafer in real time. An abnormality detection server stores apparatus log data outputted from semiconductor manufacturing apparatus that processes a semiconductor wafer in an apparatus log data memory. Thereafter, in a lot end signal receiver, when a lot end signal outputted from the semiconductor manufacturing apparatus is received, an abnormal data detector, after referencing an abnormality detection condition setting file stored in a first detection condition memory, based on the referenced content, judges whether there are abnormal data in the apparatus log data stored in the apparatus log data memory or not. Upon detecting an abnormality, a detection result is outputted to an engineer PC and an operator terminal unit.

Abstract: The present invention provides therapeutic formulations for hematopoietic diseases comprising as effective ingredient, synoviolin which is reported to be isolated as a synovial cell protein and its gene, and therapeutic methods and such comprising the step of administering the protein or polynucleotide. The present invention also provides as models of hematopoietic diseases, animals whose synoviolin is homozygously deficient and cells derived from such animals; and additionally provides methods that use these models in the screening of therapeutic agents for hematopoietic diseases.

Abstract: A rotary encoder scale and a linear encoder scale both made of plastic are provided in operating directions of a printing paper feed motor and a print head driving motor respectively in an inkjet printer. In one or each surface of each of the rotary encoder scale and the linear encoder scale, a metal film is formed in a portion excluding a region to be read by the encoder sensor for reading divisions. The surface of the metal film is grounded to a metal chassis or the like of the inkjet printer. Thus, an inkjet printer for preventing ink mist from adhering thereto can be obtained.

Abstract: A thermal processing unit is connected to a substrate position detector, which is in turn connected to a bake unit controller. The thermal processing unit includes a temperature control plate and a lifting device. The temperature control plate and lifting device are connected to the bake unit controller. The operations of the temperature control plate and lifting device are controlled by the bake unit controller. A pressure measuring pipe is provided at a lower part of at least one of a plurality of pin inserting holes in the temperature control plate. The pressure measuring pipe is connected to a low differential pressure sensor. The low differential pressure sensor detects the pressure in an airflow exhausted from a space surrounded by a substrate and an upper face of the temperature control plate via the pressure measuring pipe.

Abstract: A positive resist layer formed on a translucent substrate is subjected to exposure and development to form circular resist patterns disposed near each other at a predetermined distance. The exposure pattern has an opening of a plurality of circular ring shape surrounding the plurality of resist patterns. The opening may have a width equal to the predetermined distance. Since the width of the opening is constant over the whole outer periphery of each resist pattern, uniform exposure can be realized at all positions along the periphery to form a perfect circle shape. After a convex lens shape is given to each resist pattern by heating and reflow process, the convex lens shape is transferred to the substrate by dry etching process using the resist patterns as a mask to form a microlens array with convex lenses.

Abstract: A holder for holding optical fibers has pin inserting holes to which corresponding positioning pins are pierced from one end to another. An optical fiber fixing plate has fixing holes corresponding to the optical fibers and pin inserting holes corresponding to the positioning pins. On an equipping surface of the fixing plate is formed a reinforcement layer having piercing holes corresponding to the fixing holes and pin piercing holes corresponding to the pin inserting holes. Each optical fiber is fixed and adhered by inserting to each fixing hole while the pins are inserted to the pin inserting holes of the holder, pin piercing holes of the reinforcement layer and the pin inserting holes of the fixing plate. A front surface of the fixing plate is planarized by polishing the surface. Positions of the optical fibers are easily defined at an end surface of the optical fiber holder with high precision.

Abstract: The present invention pertains to a DNA encoding a polypeptide including an entire sequence of the amino acid sequence as shown by SEQ ID NO: 2 or a partial sequence thereof, or a polypeptide including the polypeptide described above, wherein any of the polypeptides has an activity of a receptor capable of binding to a murine PBSF/SDF-1; a polypeptide encoded by the DNA described above, wherein the polypeptide has an activity of a receptor capable of binding to a murine PBSF/SDF-1; cells expressing the polypeptide described above and a human CD4 protein; and a method of screening an AIDS onset inhibitor or an HIV-1 infection inhibitor, characterized by the use of the cells described above. According to the present invention, there can be provided a novel murine CXC chemokine receptor gene, a method of screening an HIV-1 infection inhibitor, and the like, each of which is useful in studies of a therapeutic agent for AIDS and the functional mechanism of HIV-1 infection.

Abstract: An optical fiber positioning method comprises the steps of: preparing an optical fiber, an optical fiber holder, and a positioning plate; fitting the optical fiber holder in the fitting hole and inserting the optical fiber into an optical fiber holding hole of the optical fiber holder and an optical fiber positioning hole of the optical fiber positioning plate; abutting the optical fiber on the abutting position of the optical fiber positioning hole in the state that the end of the optical fiber holder is fitted in the fitting hole and the optical fiber is inserted into an optical fiber holding hole of the optical fiber holder and an optical fiber positioning hole of the optical fiber positioning plate; and fixing the optical fiber to the optical fiber positioning plate in the state that the optical fiber is abutted on with the abutting position of an optical fiber positioning hole.

Abstract: A support table holds a working fluid in an inner space thereof, and has four cylindrical heaters arranged to surround a cooling plate disposed centrally of the support table. In time of heating, vapor generated from each cylindrical heater spreads toward a central region and peripheral regions of the support table (as schematically shown in two-dot chain line arrows). The vapor can reach peripheral ends, without flows of the vapor colliding with one another, in a way to suppress generation of stagnation points. Since the support table can be heated uniformly, a substrate is heat-treated uniformly over the entire surface thereof. The support table is cooled efficiently by the cooling plate disposed centrally of the support table.

Abstract: The present invention pertains to a DNA encoding a polypeptide comprising an entire sequence of the amino acid sequence as shown by SEQ ID NO:2 of Sequence Listing or a partial sequence thereof, or a polypeptide comprising the polypeptide described above, wherein any of the polypeptides has an activity of a receptor capable of binding to a murine PBSF/SDF-1; a polypeptide encoded by the DNA described above, wherein the polypeptide has an activity of a receptor capable of binding to a murine PBSF/SDF-1; cells expressing the polypeptide described above and a human CD4 protein; and a method of screening an AIDS onset inhibitor or an HIV-1 infection inhibitor, characterized by the use of the cells described above. According to the present invention, there can be provided a novel murine CXC chemokine receptor gene, a method of screening an HIV-1 infection inhibitor, and the like, each of which is useful in studies of a therapeutic agent for AIDS and the functional mechanism of HIV-1 infection.

Abstract: In a wafer polishing method, a within-wafer distribution model of a removal rate and a within-wafer distribution model of a polishing process are selected, and a within-wafer distribution of a removal rate is obtained by determining parameters of a within-wafer distribution model of a removal rate based on the within-wafer distribution of the film thickness before/after CMP, polishing condition data, and the selected within-wafer distribution model of the polishing process of the polished wafer. Then, a film thickness in the polishing process is estimated from passage of time based on the obtained within-wafer distribution of the removal rate, the selected within-wafer distribution model of the polishing process, and the film thickness before CMP of the wafer to be processed, thereby determining the polishing conditions with a restriction that the film thickness at each position in the within-wafer distribution of the film thickness after CMP satisfies the control limit.

Abstract: A micro lens array has a quartz substrate and a coupling plate made of plated metal and mounted on the substrate. On one principal surface of the substrate, lenses and fitting pins made of plated metal are formed. The coupling plate has a transparent window which allows light from the lenses to pass therethrough and guide pin insertion holes gradually increasing the size from one principal surface toward the other principal surface. A taper of an opening end of each guide pin insertion hole defined by a plated layer can be formed by forming a plating seed layer and a plating area defining pillar on the substrate, with the plating seed layer being spaced apart from the pillar by a predetermined distance.

Abstract: A micro lens array has a translucent substrate of glass or the like and convex lenses formed on a principal surface of the substrate. Guide pin insertion holes are formed through the substrate 30 on opposite sides of a line of lenses. A metal layer 38 with at least three metal projections is formed only in an inner wall section of each of the holes by a plating process so as to gradually increase an opening size of the hole at higher positions. The inner wall section has a depth of about 50 to 100 ?m from the opening end on the guide pin insertion side. The metal layer may be omitted. Instead of the metal projections, a metal layer forming the hole having a polygonal shape may be used.

Abstract: An anisotropic light diffusion adhesive layer includes an adhesive material, and an acicular filler whose refractive index is different from that of the adhesive material, wherein the acicular filler is dispersed as oriented substantially in the same direction. It is desirable for the acicular filler to be colorless or white colored. An anisotropic light diffusion adhesive laminated assembly may also be manufactured by adhering together several such anisotropic light diffusion adhesive layers. This anisotropic light diffusion adhesive layer and anisotropic light diffusion adhesive laminated assembly may suitably be employed as an illumination device such as a backlight for a liquid crystal display device or the like.