Abstract: Methods and apparatus to perform serial communications are disclosed. An example serial data transmitter includes: a clock signal generator to generate a digital clock signal; a clock signal controller to enable the clock signal generator; a line break signal generator to, in response to an expiration of a time period, trigger the transmission of a transmission line check frame; a data integrity check generator to generate error detection data corresponding to first data to be transmitted via the transmission port; a signal framer to: generate a first data frame having a preamble, second data, third data, the first data, the error detection data, and fourth data; and generate the transmission line check frame.

Abstract: A method and device for packing a chromatography column formed of one or more vibration devices attached to top and/or bottom flanges of the column. Media is added in one or more steps to the column, allowed to settle under the effects of gravity and then subjected to one or more treatments of vibration from the vibration devices until a suitably packed column is obtained. Liquid used to suspend the media while being placed into the column may be at least partially removed before or during the vibration step(s). The remaining liquid is then removed or replaced after the packing has been obtained.

Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.

Abstract: A method and device for packing a chromatography column formed of one or more vibration devices attached to top and/or bottom flanges of the column. Media is added in one or more steps to the column, allowed to settle under the effects of gravity and then subjected to one or more treatments of vibration from the vibration devices until a suitably packed column is obtained. Liquid used to suspend the media while being placed into the column may be at least partially removed before or during the vibration step(s). The remaining liquid is then removed or replaced after the packing has been obtained.

Abstract: A method and device for packing a chromatography column formed of one or more vibration devices attached to top and/or bottom flanges of the column. Media is added in one or more steps to the column, allowed to settle under the effects of gravity and then subjected to one or more treatments of vibration from the vibration devices until a suitably packed column is obtained. Liquid used to suspend the media while being placed into the column may be at least partially removed before or during the vibration step(s). The remaining liquid is then removed or replaced after the packing has been obtained.

Abstract: An application specific integrated circuit (ASIC) that includes a digital signal processing (DSP) core and a configurable logic block coupled to the DSP core. The configurable logic block including a plurality of interconnected logic modules to apply a pre-configured logic function to an input. Each of the plurality of logic modules including a controller and a plurality of logic components, the controller of each logic module dynamically reconfigures the connections between the controller's logic module and another logic module.

Abstract: An application specific integrated circuit (ASIC) that includes a digital signal processing (DSP) core and a configurable logic block coupled to the DSP core. The configurable logic block including a plurality of interconnected logic modules to apply a pre-configured logic function to an input. Each of the plurality of logic modules including a controller and a plurality of logic components, the controller of each logic module dynamically reconfigures the connections between the controller's logic module and another logic module.

Abstract: A method for determining mixing time for a variety of vessels is disclosed. This method utilizes information about the configuration, such as vessel diameter, impeller diameter and speed, fluid density and viscosity, and fluid height to determine the appropriate mixing time. In another embodiment, the parameters used to create small batches of material can be used to scale up to larger vessel sizes.

Abstract: A chromatographic apparatus is provided comprising a housing, a fluid inlet to the housing, a fluid outlet from the housing, an optional vent and a chromatographic packed bed in the housing. The fluid inlet and fluid outlet and optional vent are provided with connectors that connect a fluid inlet and a fluid outlet on other such chromatographic apparatus.

Abstract: In one embodiment, a method includes deriving a user intent from user information associated with a user, selecting an advertiser intent that aligns with the user intent, and then advertising to the user based on the advertiser intent that aligns with the user intent.

Abstract: A method for determining mixing time for a variety of vessels is disclosed. This method utilizes information about the configuration, such as vessel diameter, impeller diameter and speed, fluid density and viscosity, and fluid height to determine the appropriate mixing time. In another embodiment, the parameters used to create small batches of material can be used to scale up to larger vessel sizes.

Abstract: This invention discloses reagents and methods for identifying peptides that modulate biological activities in cells, tissues, organs and organisms.

Abstract: A method and device for packing a chromatography column formed of one or more vibration devices attached to top and/or bottom flanges of the column. Media is added in one or more steps to the column, allowed to settle under the effects of gravity and then subjected to one or more treatments of vibration from the vibration devices until a suitably packed column is obtained. Liquid used to suspend the media while being placed into the column may be at least partially removed before or during the vibration step(s). The remaining liquid is then removed or replaced after the packing has been obtained.

Abstract: A chromatographic apparatus is provided comprising a housing, a fluid inlet to the housing, a fluid outlet from the housing, an optional vent and a chromatographic packed bed in the housing. The fluid inlet and fluid outlet and optional vent are provided with connectors that connect a fluid inlet and a fluid outlet on other such chromatographic apparatus.

Abstract: A programmable address decoder is common to the on-chip ROM and on-chip RAM. The programmable address decoder conditionally routes accesses to portions of the ROM to the RAM. The ROM address space is mapped to RAM via a set of configuration registers. This permits patched ROM program code and data table to be stored in on-chip RAM. The patched code and configuration data is stored in an off-chip non-volatile memory. This patch code and the configuration to use is loaded into the RAM and configuration registers on system bootstrap procedure.

Abstract: An aspect of the present invention simplifies the implementation of complex clock designs in field programmable devices (FPD). To implement a circuit logic containing base sequential elements (e.g., D flip-flops) with corresponding circuit clocks, a number of modified sequential elements equaling the number of base sequential elements may be employed. Each modified sequential element (contained in FPD) receives a global clock, corresponding circuit clock and a data value. A base sequential element (contained in modified sequential element) transitions to a next state only after occurrence of a transition on a corresponding circuit clock and the transition to said next state may be timed according to the global clock. By timing the transitions according to the global clock, several undesired results may be avoided.

Abstract: A monoclonal antibody to a steroid hormone is used for the isolation from a combinatorial peptide library of a peptide mimicking the biological activity of said steroid hormone. Peptides having estrogenic-like and progestational-like activity were synthesized and assayed for their ability to compete with the respective steroid hormone for binding to the monoclonal antibody and for binding to said steroid hormone receptor. Peptides having estrogenic-like activity were found to be selective to estrogen receptor alpha or beta and thus may have more clinical applications than the non-selective steroid hormone estradiol.

Abstract: An aspect of the present invention simplifies the implementation of complex clock designs in field programmable devices (FPD). To implement a circuit logic containing base sequential elements (e.g., D flip-flops) with corresponding circuit clocks, a number of modified sequential elements equaling the number of base sequential elements may be employed. Each modified sequential element (contained in FPD) receives a global clock, corresponding circuit clock and a data value. A base sequential element (contained in modified sequential element) transitions to a next state only after occurrence of a transition on a corresponding circuit clock and the transition to said next state may be timed according to the global clock. By timing the transitions according to the global clock, several undesired results may be avoided.

Abstract: A programmable address decoder is common to the on-chip ROM and on-chip RAM. The programmable address decoder conditionally routes accesses to portions of the ROM to the RAM. The ROM address space is mapped to RAM via a set of configuration registers. This permits patched ROM program code and data table to be stored in on-chip RAM. The patched code and configuration data is stored in an off-chip non-volatile memory. This patch code and the configuration to use is loaded into the RAM and configuration registers on system bootstrap procedure.

Abstract: A circuit determining whether a present value transmitted on a bus equals any of several desired values. The circuit may contain a monitor random access memory (RAM) and a monitor circuit. The bits of a desired value at a second set of positions are stored in a location (of the monitor RAM) having an address formed by the bits of the desired value at the a first set of positions. When a value (“present value”) is transmitted on the bus, the bits of the present value at the first set of positions are provided as an address to the monitor RAM, which generates the bits stored in the addressed location as output. The monitor circuit compares the output of monitor RAM with the bits of the present value at the second set of positions to generate a result. The result indicates if the a desired value has occurred on the bus.