Abstract: Provided herein are compositions, systems, kits, and methods for administering a gel composition into a tumor of a subject and treating with laser light (e.g., for photoacoustic destruction of the tumor and tumor debris generation), where the gel comprises functionalized fullerenes (FFs) and a biocompatible polymer. In certain embodiments, 0.1-5% (e.g., about 1-2%) by weight of the gel is the functionalized fullerenes (e.g., polyhydroxy fullerenes). In other embodiments, the FFs have a generally symmetrical spherical structure.

Abstract: The present disclosure is directed to systems and methods for virtualizing communications within a plurality of telematics channels operatively connected to a target machine. The method includes (i) generating a virtualized channel in addition to the plurality of telematics channels operatively connected to the target machine; (ii) predicting one or more values for the virtualized channel based on a mathematical function derived from a first set of telematics channels of a source machine; (iii) receiving measurements from the plurality of telematics channels from the target machine; and (iv) applying the mathematical function to the target machine based upon the one or more predicted values of the virtualized channel and the received measurements from the plurality of telematics channels from the target machine.

Abstract: A method, computer system, and a computer program product for predicting animal testing measurement levels is provided. The present invention may include referencing a human gene expression profiles data obtained under in vitro chemical treatment. The present invention may include referencing an animal measurements data obtained under in vivo chemical treatment. The present invention may include assigning an animal measurement level to a human gene expression profile by matching at least one identified compound. The present invention may include creating a chemical fingerprint of the identified compound. The present invention may include creating a machine learning feature space as a function of a human gene expression feature and a chemical fingerprint feature of the identified compound for predicting an associated animal measurement level assigned to the at least one human gene expression profile. The present invention may include training a model using the machine learning feature space.

Abstract: Classifying genetic sequences by receiving genetic sequence data according to sequence features associated with gene expression, determining a genetic sequence feature set, determining a first classification for the genetic sequence feature set according to a machine learning model, defining a causal feature set associated with the first classification for the genetic sequence according to the machine learning model, altering the causal feature set for the genetic sequence, yielding an altered causal feature set, determining a second classification for the altered causal feature set according to the machine learning model, wherein the second classification differs from the first classification, and defining a set of target features, wherein the target features include causal features the altered causal feature set.

Abstract: Systems, methods, and computer-readable media for data protection management are provided. Failure notifications corresponding to backup failures of client servers in a healthcare facility are received and a dashboard associated with the backup failures is provided. The dashboard comprises user information that identifies users assigned to each backup failure. In embodiments, the dashboard enables a user to update a status of a backup failure and add, access, and modify records corresponding to a backup failure. In some embodiments, the dashboard is integrated with a service management application that enables the user to create a service request from the dashboard. A report corresponding to the dashboard is generated and communicated to a leadership team. The report includes statistics corresponding to backup failures addressed by each associate and backup failures identified per region or unit of a healthcare facility.

Abstract: The present disclosure relates to methods and systems for protecting cloud resources. The methods and systems may use a virtual gatekeeper resource to enforce secure access controls to cloud resources for a list of privileged operations. The cloud resources and the virtual gatekeeper resource may be in different security domains within a cloud computing system and the cloud resources may be linked to the virtual gatekeeper resource. A request may be sent to perform a privileged operation on the cloud resource. Access may be provided to the virtual gatekeeper resource in response to approval of the request and the access to the virtual gatekeeper resource may be used to perform the privileged operation on the cloud resource.

Abstract: A fullerene-metal nanocomposite is described that comprises a metal nanoparticle bonded to a functionalized fullerene compound. A useful method of making a fullerene-metal nanocomposite is also described. The method consists essentially of the steps of mixing a solution of metal salt or metal ion with a functionalized fullerene compound, and purifying the fullerene-metal nanocomposite from the solution. Also described are antimicrobial surfaces, comprising a substrate surface and a coating on the substrate surface comprising a fullerene-metal nanocomposite that includes a metal nanoparticle bonded to a functionalized fullerene compound.

Abstract: Methods, computer systems, and computer storage media are provided that provide an interactive web-based alerts system. The system provides a combination of features including a mail application and a dashboard for reporting. Initially, automated emails sent from a plurality of sources are received and stored in a database. The automated emails are classified based on criteria including source, subject line, acknowledgement, and/or status. Using these classifications, various reports can be generated to provide insight into the alert quality and quantity. A dashboard interface displays the classified alerts and enables various interactions with the classified plurality of alerts. Based on the interactions, the dashboard interface is automatically updated, in real-time. In some embodiments, the interactions comprise causing an incident to be created for the alert, causing a category of the alert to be updated, or causing a shift report to be generated.

Abstract: Provided herein are compositions, systems, kits, and methods for treating a subject with a disease or condition by administering a composition comprising fullerenes to the subject such that H2S is generated in said subject. In certain embodiments, the disease or condition is associated with inflammation and/or below normal H2S levels. In certain embodiments, the fullerenes are polyhydroxy fullerenes (PHFs).

Abstract: A method of managing a worksite is provided. The method includes tracking a position of a machine travelling on the worksite. The method includes segmenting a route of the machine on the worksite into at least two topographic segments based on the tracked position of the machine. The method includes receiving at least one operational parameter of the machine along the route. Further, the method includes generating a feedback based, at least in part, on the at least one operational parameter and the segmented route.

Abstract: Sunscreen compositions comprising a dermatologically acceptable carrier and a polyhydroxy fullerene compound are described. The sunscreen compositions can be used to protect a substrate such as the skin of a subject from the effects of ultraviolet radiation.

Abstract: Provided are methods for assessment of surface rugosity of a layer of live cells using tools that determine contact angle and contact angle hysteresis.

Abstract: A visible light photocatalyst coating includes a metal oxide that in the presence of a organic contaminate that absorbs at least some visible light or includes the metal oxide and an auxiliary visible light absorbent, where upon absorption of degradation of the organic contaminate occurs. Contaminates can be microbes, such as bacteria, viruses, or fungi. The metal oxide is nanoparticulate or microparticulate. The metal oxide can be TiO2. The coating can include an auxiliary dye having an absorbance of light in at least a portion of the visible spectrum. The coating can include a suspending agent, such as NaOH. The visible light photocatalyst coating can cover a surface of a device that is commonly handled or touched, such as a door knob, rail, or counter.

Abstract: Sunscreen compositions comprising a dermatologically acceptable carrier and a polyhydroxy fullerene compound are described. The sunscreen compositions can be used to protect a substrate such as the skin of a subject from the effects of ultraviolet radiation.

Abstract: Embodiments of the present disclosure relate to systems, methods, and user interfaces for optimizing resource allocation for an organization. More particularly, embodiments of the present disclosure utilize multiple data sets to enable organizations to make intuitive business decisions and plan resources accordingly. To do so, various data is collected at a resource engine that utilizes the data to determine resource utilization, occupancy density, and a recommendation. In various embodiments, the resource utilization, occupancy density, and a recommendation may be provided to a user as an alert, a report, or a user interface. The user interface may additionally enable the user to apply the recommendation. In some embodiments, the recommendation may be automatically applied or the user may be directed to perform the recommendation. The alert, report, or user interface may additionally inform the user of the impact of performing or not performing the recommendation.

Abstract: A fullerene-metal nanocomposite is described that comprises a metal nanoparticle bonded to a functionalized fullerene compound. A useful method of making a fullerene-metal nanocomposite is also described. The method consists essentially of the steps of mixing a solution of metal salt or metal ion with a functionalized fullerene compound, and purifying the fullerene-metal nanocomposite from the solution. Also described are antimicrobial surfaces, comprising a substrate surface and a coating on the substrate surface comprising a fullerene-metal nanocomposite that includes a metal nanoparticle bonded to a functionalized fullerene compound.

Abstract: Methods, computer systems, and computer-storage medium are provided for monitoring, analyzing, and providing reports regarding direct access technologies, for example DirectAccess, VPN, or VPN-like technologies. User activity associated with DirectAccess servers can be filtered by server location to allow administrators to determine which users, and how many users, utilized or are utilizing each DirectAccess server, which can be identified by geographic locations. In some cases, this information can be used to address technical support issues or to determine which resources of an entity may be under- or over-utilized.

Abstract: Forward and/or backward compatibility between an invoking program and the invoked program can be maintained by using compatibility indicators and/or annotations to configuration settings that specify the desired behavior of the invoked program. Compatibility indicators and/or annotations can be used to override default behavior to ensure compatibility between a version of a program and a version or revision of a dependency of the program. Annotations can be made to configuration settings or to initialization programs and/or files. Configuration and/or initialization settings for the program can be annotated to indicate when default behavior of the dependency is to be overridden to provide alternate behavior. Configuration settings for the program can be annotated to indicate when future revisions to the dependency are to be applied.

Abstract: A multi-horizon predictor system that predicts a future parameter value for multiple horizons based on time-series data of the parameter, external data, and machine-learning. For a given time horizon, a time series data splitter splits the time into training data corresponding to a training time period, and a validation time period corresponding to a validation time period between the training time period and the given horizon. A model tuner tunes the prediction model of the given horizon fitting an initial prediction model to the parameter using the training data thereby using machine learning. The model tuner also tunes the initial prediction model by adjusting an effect of the external data on the prediction to generate a final prediction model for the given horizon using the validation data. A multi-horizon predictor causes the time series data splitter and the model tuner to operate for each of multiple horizons.

Abstract: Systems, methods, and computer-readable media for data protection management are provided. Failure notifications corresponding to backup failures of client servers in a healthcare facility are received and a dashboard associated with the backup failures is provided. The dashboard comprises user information that identifies users assigned to each backup failure. In embodiments, the dashboard enables a user to update a status of a backup failure and add, access, and modify records corresponding to a backup failure. In some embodiments, the dashboard is integrated with a service management application that enables the user to create a service request from the dashboard. A report corresponding to the dashboard is generated and communicated to a leadership team. The report includes statistics corresponding to backup failures addressed by each associate and backup failures identified per region or unit of a healthcare facility.