Patents by Inventor Walter Pfefferle

Walter Pfefferle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleotide sequences coding for the glbO gene
    Publication number: 20030166173
    Abstract: The present invention provides an isolated polynucleotide containing a polynucleotide sequence selected from the group
    Type: Application
    Filed: May 7, 2002
    Publication date: September 4, 2003
    Inventors: Bettina Mockel, Achim Marx, Walter Pfefferle
  • Nucleotide sequences coding for the export of branched chain amino acids, process for the isolation thereof and use thereof
    Patent number: 6613545
    Abstract: This invention relates to isolated polynucleotides containing at least one of the polynucleotide sequences selected from the group a) polynucleotide which is at least 70% identical to a polynucleotide which codes for a polypeptide containing at least one amino acid sequence of SEQ ID no. 3 or 5, b) polynucleotide which codes for a polypeptide which contains an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID no. 3 or 5, c) polynucleotide which is complementary to the polynucleotides of a), b) or c), and d) polynucleotide containing at least 15 successive bases of the polynucleotide sequences of a), b) or c). wherein the polypeptides exhibit the biological activity of the enzymes for which the brnE or bernF (sic) gene codes and a process for the fermentative production of branched-chain L-amino acids with amplification of the stated genes.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: September 2, 2003
    Assignees: Degussa-Huls Aktiengesellschaft, Forschungszentrum Julich GmgH
    Inventors: Nicole Kennerknecht, Hermann Sahm, Lothar Eggeling, Walter Pfefferle
  • L-lysine-producing corynebacteria and process for the preparation of L-lysine
    Publication number: 20030162269
    Abstract: The invention relates to L-lysine-producing strains of corynebacteria with enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are enhanced and, in particular, over-expressed, and to a process for the preparation of L-lysine.
    Type: Application
    Filed: January 8, 2003
    Publication date: August 28, 2003
    Inventors: Caroline Kreutzer, Stephan Hans, Mechthild Rieping, Bettina Mockel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm, Miroslav Patek
  • Novel nucleotide sequences coding for the citE gene
    Publication number: 20030157666
    Abstract: The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group
    Type: Application
    Filed: February 28, 2003
    Publication date: August 21, 2003
    Applicant: Degussa AG
    Inventors: Mike Farwick, Klaus Huthmacher, Achim Marx, Brigitte Bathe, Walter Pfefferle
  • Pourable feed additives containing D-pantothenic acid and/or salts thereof, and process for their preparation
    Patent number: 6596327
    Abstract: A composition including at least one of D-pantothenic acid and a salt of D-panthothenic acid, greater than 50 percent of non-biomass constituents of a D-pantothenic fermentation liquor, and 0 to 100% of the biomass from D-pantothenic fermentation liquor wherein composition is a solid, pourable composition in the form of particles.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: July 22, 2003
    Assignee: Degussa AG
    Inventors: Michael Binder, Matthias Moll, Dieter Greissinger, Alexander Moeller, Walter Pfefferle
  • Process for the fermentative preparation of L-amino acids using coryneform bacteria
    Patent number: 6596516
    Abstract: A process for the preparation of L-amino acids, in which the following steps are carried out, a) fermenting the desired L-amino acid-producing bacteria in which at least the glyA gene is attenuated, in particular by removal of the natural promoter, and optionally b) concentrating the desired product in the medium or in the cells of the bacteria and c) isolating the L-amino acid, and optionally bacteria in which further genes of the biosynthesis pathway of the desired L-amino acid are additionally amplified are employed, or bacteria in which the metabolic pathways which reduce the formation of the desired L-amino acid are at least partly eliminated are employed, and nucleotide sequences of the lacI-tac-5′glyA or lacI-tac-glyA unit.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: July 22, 2003
    Assignees: Degussa AG, Forschungszentrum Jülich GmbH
    Inventors: Petra Ziegler, Lothar Eggeling, Hermann Sahm, Georg Thierbach, Walter Pfefferle
  • Process for the preparation of alkaline earth salts of D-pantothenic acid
    Patent number: 6582939
    Abstract: The preparation of alkaline earth salts of D-pantothenic acid, in which the fermentation is carried out in the presence of alkaline earth compounds.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: June 24, 2003
    Assignee: Degussa AG
    Inventors: Michael Binder, Walter Pfefferle, Ulrich Becker, IIona Walger, Klaus Erich Uffmann, Georg Thierbach, Achim Marx, Thomas Hermann
  • Novel nucleotide sequences coding the citE gene
    Publication number: 20030113879
    Abstract: The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group
    Type: Application
    Filed: June 6, 2001
    Publication date: June 19, 2003
    Inventors: Mike Farwick, Klaus Huthmacher, Achim Marx, Brigitte Bathe, Walter Pfefferle
  • Nucleotide sequences which code for the sahH gene
    Publication number: 20030100080
    Abstract: An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of
    Type: Application
    Filed: August 2, 2001
    Publication date: May 29, 2003
    Applicant: DEGUSSA AG
    Inventors: Mike Farwick, Klaus Huthmacher, Jennifer Brehme, Walter Pfefferle, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Novel nucleotide sequences coding for the genes sdhA, sdhB and sdhC
    Publication number: 20030100079
    Abstract: This invention relates to isolated polynucleotides containing a polynucleotide sequence related to selected SEQ ID nos and to processes for the fermentative production of L-amino acids with attenuation of the sdhA, sdhB or sdhC gene which code for subunit A, B or C of the enzyme succinate dehydrogenase.
    Type: Application
    Filed: December 11, 2000
    Publication date: May 29, 2003
    Inventors: Bettina Mockel, Walter Pfefferle, Achim Marx
  • Nucleotide sequences which code for the metD gene
    Publication number: 20030092026
    Abstract: The invention relates to polynucleotides comprising polynucleotide sequences corresponding to the metD gene and parts thereof that encode polypeptide sequences and parts thereof possessing varying degrees of MetD transcription regulator activity, methods for preparation of L-amino acids, and methods of screening and amplifying polynucleotides encoding polypeptide sequences which comprise varying degrees of MetD transcription regulator activity. Further, the invention relates to animal food additives based on fermentation liquor and containing L-methionine, and to the preparation of such additive.
    Type: Application
    Filed: May 30, 2002
    Publication date: May 15, 2003
    Applicant: DEGUSSA AG
    Inventors: Daniel Rey, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Brigitte Bathe, Klaus Huthmacher, Walter Pfefferle
  • Nucleotide sequences coding for the cls gene
    Patent number: 6562607
    Abstract: This invention relates to a genetically modified coryneform bacterium, the cls gene of which is amplified, and to an isolated polynucleotide, which codes for cardiolipin synthase from coryneform bacteria and to a process for the fermentative production of L-amino acids with amplification of the cls gene in the bacteria and to the use of the polynucleotide as a primer or hybridization probe.
    Type: Grant
    Filed: May 4, 2001
    Date of Patent: May 13, 2003
    Assignees: Degussa-Huls Aktiengesellschaft, Forschungszentrum Julich GmbH
    Inventors: Madhavan Nampoothiri K., Bettina Möckel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm
  • Process for the fermentative production of L-lysine using coryneform bacteria
    Publication number: 20030087400
    Abstract: The invention relates to a process for the production of L-amino acids, and in particular L-lysine, in which the following steps are performed,
    Type: Application
    Filed: June 25, 2002
    Publication date: May 8, 2003
    Inventors: Bettina Mockel, Walter Pfefferle, Sven Brand, Alfred Puhler, Jorn Kalinowski, Brigitte Bathe
  • Pourable feed additives containing D-pantothenic acid and/or salts thereof, and process for their preparation
    Publication number: 20030044485
    Abstract: A composition including at least one of D-pantothenic acid and a salt of D-panthothenic acid, greater than 50 percent of non-biomass constituents of a D-pantothenic fermentation liquor, and 0 to 100% of the biomass from D-pantothenic fermentation liquor wherein composition is a solid, pourable composition in the form of particles.
    Type: Application
    Filed: September 27, 2002
    Publication date: March 6, 2003
    Applicant: DEGUSSA AG
    Inventors: Michael Binder, Matthias Moll, Dieter Greissinger, Alexander Moeller, Walter Pfefferle
  • Process for the production of L-amino acids by fermentation using coryneform bacteria
    Publication number: 20030044943
    Abstract: The invention relates to a process for the production of L-amino acids, in which the following steps are carried out:
    Type: Application
    Filed: April 9, 2002
    Publication date: March 6, 2003
    Inventors: Mike Farwick, Brigitte Bathe, Thomas Hermann, Achim Marx, Walter Pfefferle
  • Nucleotide sequences coding for the glk-gene
    Publication number: 20030022320
    Abstract: The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group comprising:
    Type: Application
    Filed: July 18, 2002
    Publication date: January 30, 2003
    Applicant: Degussa-Huls Aktiengesellschaft
    Inventors: Bettina Mockel, Walter Pfefferle
  • Nucleotide sequences coding for the lrp gene
    Publication number: 20030017555
    Abstract: The present invention relates to an isolated polynucleotide coding for the lrp gene and to a process for the fermentative production of L-amino acids by altering the expression of this gene.
    Type: Application
    Filed: April 30, 2002
    Publication date: January 23, 2003
    Inventors: Brigitte Bathe, Jorn Kalinowski, Alfred Puhler, Bettina Mockel, Walter Pfefferle
  • Nucleotide sequences which code for the luxS gene
    Publication number: 20020182689
    Abstract: The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of
    Type: Application
    Filed: August 1, 2001
    Publication date: December 5, 2002
    Inventors: Brigitte Bathe, Caroline Kreutzer, Achim Marx, Walter Pfefferle
  • Process for the fermentative preparation of D-pantothenic acid and/or salts thereof
    Publication number: 20020176884
    Abstract: The invention provides a process for the fermentative preparation of D-pantothenic acid and/or salts thereof or feedstuffs additives comprising these by fermentation of coryneform bacteria, in particular those which already produce D-pantothenic acid, wherein the nucleotide sequence(s) in the coryneform bacteria which code(s) for the glyA gene is (are) enhanced, in particular over-expressed.
    Type: Application
    Filed: October 23, 2001
    Publication date: November 28, 2002
    Applicant: Degussa AG
    Inventors: Nicole Dusch, Achim Marx, Walter Pfefferle, Georg Thierbach
  • Process for the fermentative preparation of L-amino acids using coryneform bacteria
    Publication number: 20020168732
    Abstract: The invention relates to a process for the preparation of L-amino acids in which the following steps are carried out,
    Type: Application
    Filed: March 26, 2001
    Publication date: November 14, 2002
    Inventors: Bettina Moeckel, Thomas Hermann, Walter Pfefferle