Abstract: Processes and compositions for the therapeutic treatment of pathogenic Gram-negative bacterial infection are provided whereby arginino succinate synthetase or PEGylated arginino succinate synthetase is administered to a subject to inactivate endotoxin thereby reducing the likelihood of bacterial sepsis and improving patient outcome.

Abstract: The present invention identifies biomarkers that are diagnostic of neural injury, neuronal disorder or neurotoxicity and is related to the discovery that proteases are selectively activated in subjects suffering from nervous system damage as compared to healthy subjects. Breakdown products reflecting protease activation are produced and detection of these different biomarkers of the invention is also diagnostic of the degree of severity and type of nerve damage in a subject.

Abstract: The present invention provides materials and methods for detecting, quantifying, and/or high-throughput-profiling microRNAs. Advantageously, the present invention is more sensitive and specific than other currently-available miRNA qPCR assays. In addition, the present invention is convenient, easy-to-perform, and cost-effective. In one embodiment, the present invention provides a universal primer for reverse transcription of all miRNAs, a universal reverse primer for PCR amplification reaction, and universal probes. In another embodiment, the present invention provides assays that allow simultaneous detection and/or quantification of a plurality of target miRNAs using a single reverse transcription reaction.

Abstract: A pumping device includes a barrel (1), a top cover (2), a switching valve (3), a cylinder (4), a piston (53), a connecting unit (6), an operation unit (5), a delivery unit (7), a pressure gauge (8), and a pressure release unit (9). Thus, the user has to pull or push the switching valve to extract or suck the air in the barrel so as to deflate or inflate the barrel so that the pumping device has a security process and is operated in a safer manner. In addition, the flow of the fluid is proceeded in the barrel so that the pumping device is operated smoothly and conveniently.

Abstract: MicroRNAs are shown to be up- and/or down-regulated in inflammation and immune cells using a mouse model of asthma and regulatory T cells as source of RNA, respectively. Modulating the expression of these microRNAs can be effective in redirecting inflammation and immunity and hence, can be beneficial as biomarkers or as therapeutic agents against diverse human immunologic and inflammatory diseases.

Abstract: The present invention provides materials and methods for detecting, quantifying, and/or profiling microRNAs. Advantageously, the present invention is sensitive, specific, convenient, and cost-effective. In one embodiment, the present invention provides a universal primer for reverse transcription of miRNAs, a universal reverse primer for PCR amplification reaction, and a universal probe. In another embodiment, the present invention provides assays that allow the detection and/or quantification of a plurality of target miRNAs using a single reverse transcription reaction and a single qPCR reaction.

Abstract: A process and assay for determining the neurological condition in a subject is provided whereby the level of one or more neuroactive biomarkers is measured in a sample obtained from the subject. The processes and assay include measurement of multiple neuroactive biomarkers for synergistic determination of a neurological condition such as neurological damage due to injury, disease, contact with a compound, or other source.

Abstract: A process and assay for diagnosing neurotoxicity in a subject is provided. The extent of a neurotoxic insult to a subject is assessed through the measurement of one or more biomarkers in a biological fluid, such as CSF or serum. Other uses and advantages afforded include pre-market drug discovery, monitoring, drug neurotoxicity screening and post market assessment of safety and monitoring for drug of known potential neurotoxicity.

Abstract: Processes and materials are provided for the detection, diagnosis, or determination of the severity of a neurological injury or condition, including traumatic brain injury, multiple-organ injury, stroke, Alzeimer's disease, Pakinson disease and Chronic Traumatic Encephalopathy (CTE). The processes and materials include biomarkers detected or measured in a biological sample such as whole blood, serum, plasma, or CSF. Such biomarkers include Tau and GFAP proteins, their proteolytic breakdown products, brain specific or enriched micro-RNA, and brain specific or enriched protein directed autoantibodies. The processes and materials are operable to detect the presence of absence of acute, subacute or chronic brain injuries and predict outcome for the brain injury.

Abstract: The present invention provides miRNA biomarkers useful for diagnosis, prognosis, and/or treatment of airway diseases such as asthma, asthma exacerbation and nasal polyps.

Abstract: Processes and assays are provided for detecting and determining the magnitude of traumatic brain injury such as that from impact or percussive trauma or stroke. The inventive assays and processes recognize a synergistic correlation between detection of S-IOOb and one or more other injury specific biomarkers.

Abstract: A retaining device for a wood sawing machine contains an index table fixed on a cutting deck of the wood sawing machine to displace straightly and reciprocately along the cutting deck; a guiding plate fixed on the cutting deck, connected with the index table, and including a slot disposed thereon; a vertically moving set including at least one sliding block, at least one screw rod, a longitudinally displacing holder, at least one first adjusting nuts, and at least one first second adjusting nuts; wherein the sliding block is slidably connected with the slot of the guiding plate and displaces along the slot reciprocately, the screw rod is coupled on the sliding block respectively; a retaining and pressing assembly including a handle, two arms, two connecting posts, two stems, and a pressing panel.

Abstract: A swing device for a grinding machine includes a motor located on a fixed table beside the sanding unit which includes a frame with two mandrels and a sanding belt is mounted to the two mandrels. A movable member is movably mounted to the shaft of the motor so as to move back and forth to activate two limit switches which are activated to stop the motor. The movable member is connected to a fixed plate connected to an end plate on the sanding unit and a link is connected between the fixed plate and an elongate slot of the movable member. The sanding unit together with the sanding belt swing when the movable member moves. The sanding belt swings and activates two micro switches to change the rotation direction of the shaft. The sanding belt swings to change the sanding portion contacting the objects to be polished.

Abstract: The present invention provides a reciprocating lifting motion of abrasive band grinding machine, wherein two control boxes are arranged correspondingly at lower part of the grinding mechanism of the grinding machine; the grinding mechanism is driven by the drive axle of the control box; a motor is coupled below the control box, and the control box is provided with a lifting mechanism, which is adapted with the cam via a main drive axle with worm gear; based on the eccentric rotation characteristic of the cam, the main drive axle could generate reciprocating lifting motion, driving the continuous operation of the grinding mechanism for uniform grinding of the abrasive band surface.

Abstract: A safe pushing device for table saws contains a sliding member fitted into a guide way of a fence so as to be pushed to slide in the guide way straightly; a seat fixed on the sliding member; a first axial arm including one side face axially coupled with the seat; a second axial arm including one side face axially connected with the seat; a retaining member axially connected with free ends of the first and the second axial arms; a handle member disposed on the second axial arm, such that the safe pushing device is capable of pushing the wood workpiece during a cutting process without using hands, thus obtaining a safety purpose.

Abstract: A retaining device for a wood sawing machine contains an index table fixed on a cutting deck of the wood sawing machine to displace straightly and reciprocately along the cutting deck; a guiding plate fixed on the cutting deck, connected with the index table, and including a slot disposed thereon; a vertically moving set including at least one sliding block, at least one screw rod, a longitudinally displacing holder, at least one first adjusting nuts, and at least one first second adjusting nuts; wherein the sliding block is slidably connected with the slot of the guiding plate and displaces along the slot reciprocately, the screw rod is coupled on the sliding block respectively; a retaining and pressing assembly including a handle, two arms, two connecting posts, two stems, and a pressing panel.

Abstract: A process of tissue regeneration is provided that includes the administration of a stem cell topically to a surface of a tissue. The tissue being in vivo in a subject or in vitro. The tissue has a biocompatible matrix applied around the stem cell and in contact with the surface. After sufficient time, the stem cell infiltrates and regenerates the tissue. A composition is also provided that includes an injured or diseased tissue with a plurality of stem cells proximal to the tissue surface in a biocompatible. A process of increasing a level of cytokines, chemokines, growth factors, anti-apoptotic or anti-necrotic factors in a tissue is provided that includes the administration of a stem cell topically to a surface of a tissue in a biocompatible matrix. After sufficient time, the stem cell releases soluble pro-regenerative factors to increase the levels in the tissue.

Abstract: A process of measuring blast shock includes exposing a shock model to an output of a shockwave generator. The propagation of the output is sensed with a sensor platform to generate sensor wave propagation data. The data recorded by the sensor platform is analyzed to measure the blast shock. The blast shock alone or as a component of a cumulative blast exposure can be correlated with an injury metric. A system for measuring cumulative blast shock is provided that includes a sensor platform and an algorithm operating on a microprocessor for analyzing the data recorded by the sensor platform to measure the cumulative blast exposure to injury metrics.

Abstract: An automatic display device use for scale of saw blade comprising a base including a seat having a vertical moving member mounted on a lower side thereof to receive a saw blade, two brackets disposed on two sides thereof respectively, and a coupling piece fixed on one end thereof, the coupling piece including a retaining projection secured on an outer side thereof; a levering device installed to the bracket by using a positioning member and including a support shaft to connect with a lateral shank including an elongated slot arranged on a front end and a third auxiliary wheel disposed on a rear end; a turning pedestal disposed on an inner side of the base and including a second auxiliary wheel; a scale wheel including a returning spring fixed therein; a steel rope including two ends to connect with the scale wheel and the vertical moving member.

Abstract: The subject invention provides a robust, quantitative, and reproducible process and assay for diagnosis of a neurological condition in a subject. The invention provides measurement of two or more biomarkers in a biological fluid such as CSF or serum resulting in a synergistic mechanism for determining the extent of neurological damage in a subject with an abnormal neurological condition and for discerning subtypes thereof or tissue types subjected to damage.